• S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. (wikipedia.org)
  • This class of proteins has been implicated in the regulation of cytoskeleton assembly, cytosolic enzymes, and membrane dynamics. (wikipedia.org)
  • Unlike other S-100 proteins, the second EF-hand of protein p11 is incapable of binding calcium due to a series of mutations caused by deletions and substitutions. (wikipedia.org)
  • P11 and annexin II form a heterotetrameric protein complex that imitates the structure and function of S-100 proteins activated by the binding of calcium. (wikipedia.org)
  • It works together with cytosolic and peripheral membrane-associated proteins such as AHNAK in the development of the intracellular membrane. (wikipedia.org)
  • Complexed with the annexin II, p11 binds receptor and channel proteins and guides them to the cell surface, resulting in increased membrane localization and consequent magnified functional expression of these proteins. (wikipedia.org)
  • In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. (embl.de)
  • The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins [ ( PUBMED:9007998 ) ] involved in many biological processes. (embl.de)
  • Residues that compose the RNA-binding surface are conserved in a subgroup of SAM domain-containing proteins, suggesting that the function of the domain is conserved from yeast to humans. (embl.de)
  • Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. (lookformedical.com)
  • Low molecular weight, calcium binding muscle proteins. (lookformedical.com)
  • Proteins to which calcium ions are bound. (lookformedical.com)
  • Secretagogins are EF HAND MOTIF-containing calcium-binding proteins that are involved in early neuronal migration and neurogenesis. (lookformedical.com)
  • These motifs are found in many proteins that are regulated by calcium. (lookformedical.com)
  • Since the last overview of sPLA 2 -binding proteins (sPLA 2 -BPs) 10 years ago, several important discoveries have occurred in this area. (ijbs.com)
  • Y-box proteins act via diverse mechanisms, as they work by DNA binding and non-DNA binding mechanisms. (biomedcentral.com)
  • Linear motifs are brief sections of multidomain protein offering regulatory features independently of proteins tertiary structure. (insulin-receptor.info)
  • Using the links, experts can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation. (insulin-receptor.info)
  • Experimentalists are similarly afflicted: while trying to identify LMs, they are likely to spend a lot of resources, time and ACY-1215 kinase inhibitor effort carrying out experiments within the false motif candidates, which usually vastly outnumber the genuine ones in any set of proteins of interest (1). (insulin-receptor.info)
  • The p11 monomer is an asymmetric protein composed of four alpha helices. (wikipedia.org)
  • Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)
  • These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
  • The structure of p11 is classified by a pair of the helix-loop-helix motif, also known as the EF-hand-type that recognizes and binds calcium ions. (wikipedia.org)
  • The dimerized form of the protein is created by packing between the H1 and H4 helices in an antiparallel arrangement with the hydrophobic regions residing in the core. (wikipedia.org)
  • The 3D crystal structure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain, which could be the RNA-binding surface. (embl.de)
  • Substrate-binding channel residues are conserved to an extent, with a lower channel volume in human as compared to target enzymes. (bvsalud.org)
  • sPLA 2 s contain 6 to 8 disulphide bonds, a highly conserved His/Asp catalytic dyad, and a Ca 2+ -binding loop [ 1 ]. (ijbs.com)
  • Mutations in four genes have been identified in familial hemiplegic migraine (FHM), from which CACNA1A (FHM type 1) and SCN1A (FHM type 3) code for neuronal voltage-gated calcium or sodium channels, respectively, while ATP1A2 (FHM type 2) encodes the α 2 isoform of the Na + ,K + -ATPase's catalytic subunit, thus classifying FHM primarily as an ion channel/ion transporter pathology. (frontiersin.org)
  • These differences result in certain specific molecules being potent inhibitors of the target enzymes while simultaneously having weaker binding to human homologue. (bvsalud.org)
  • In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. (lookformedical.com)
  • The RPA gene is the structural excretion loss-of-function, However Binding it from the corresponding growth( De Laat et al. (evakoch.com)
  • The ELM datasets have been used by bioinformaticians to develop and benchmark novel prediction strategies such as hunting for motifs in connection data and to provide likelihood estimations for motif candidates based on structural and series conservation contexts (37C41). (insulin-receptor.info)
  • These molecules fulfill Lipinski's rules for drug likeness and also bind with less affinity to the human counterpart, thereby establishing a high selective index. (bvsalud.org)
  • Nevertheless, as a consequence of low affinity binary binding interactions, they usually take action in a concerted and cooperative manner, enabling regulatory decisions to be made on the basis of multiple inputs (8C12). (insulin-receptor.info)
  • Contrasting an unpublished low-resolution, symmetric Nf1 model 15 , two distinct populations of the Nf1-23a dimer are present: (1) a major population with both protomers showing a closed, auto-inhibited conformation (closed Nf1 state) stabilized by Zn and (2) a second population (open Nf1 state) with one protomer in the auto-inhibited conformation and the other protomer in an open configuration necessary for Ras binding (Fig. 1d ). (nature.com)
  • NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
  • We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
  • Anteroposterior patterning in Drosophila melanogaster is dependent on the sequence-specific RNA-binding protein Smaug, which binds to and regulates the translation of nanos (nos) mRNA. (embl.de)
  • Using homology modeling and site-directed mutagenesis, we have localized the RNA-binding surface of the Smaug SAM domain and have elaborated the RNA consensus sequence required for binding. (embl.de)
  • INTRODUCTION Linear motifs (LMs) are short elements embedded within larger protein Rabbit polyclonal to ZFP161 sequence segments that operate as sites of regulation (1C5). (insulin-receptor.info)
  • Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos by repressing the translation of nanos (nos) mRNA, binds to the 3' untranslated region (UTR) of nos mRNA via two similar hairpin structures. (embl.de)
  • Corresponding structures show a globular conformation consisting of twisted ß-pleated sheets, flanked by α-helices on either side. (bvsalud.org)
  • Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. (lookformedical.com)
  • Zippering of the SNAREs is proposed to provide the required energy to initiate membrane fusion 6 , 7 and proceeds from the N-terminus towards the membrane-proximal C-terminus through interactions of their complementary SNARE motifs. (nature.com)
  • The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. (embl.de)
  • The B domain includes two functional domains: a receptor-binding domain, which defines the tropism of a toxin for a cell and a translocation domain that delivers the A domain across a lipid bilayer, either on the plasma membrane or the endosome. (springer.com)
  • Thermal stability assays show that ERKi do not destabilise ERK2 (or ERK1) in vitro, suggesting that ERK2 turnover is a cellular consequence of ERKi binding. (babraham.ac.uk)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • However, they show subtle variations in residue composition, secondary structure composition, substrate-binding channel volume, and conformational stability. (bvsalud.org)
  • In the closed conformation, HEAT/ARM core domains shield the GTPase-activating protein-related domain (GRD) so that Ras binding is sterically inhibited. (nature.com)
  • Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD-Sec14-PH linker. (nature.com)
  • These results suggest that the SAM domain might have a primary role in RNA binding. (embl.de)
  • Here we demonstrate that the sterile-alpha motif (SAM) domain of Smaug functions as an RNA-recognition domain. (embl.de)
  • We show here that the SAM domain of Saccharomyces cerevisiae Vts1 binds RNA with the same specificity as Smaug and that Vts1 induces transcript degradation through a mechanism involving the cytoplasmic deadenylase CCR4. (embl.de)
  • The chromo-domain binds histone H3 tails methylated on lysine 9. (cipsm.de)
  • Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. (lookformedical.com)
  • This cargo signals the union of including variant motifs co-translationally on during its nation, signaling historical members in music and form. (erik-mill.de)
  • loop kappa p21 D cell 4( ABCD4) is shown to reduce the CD127 performance of cobalamin( Cbl membrane parking B12) into the mitochondrion, interacting it ED for the composition of Cbl lives. (evakoch.com)
  • Glucose metabolism activates this pathway by means of increasing [Ca 2+ ] i via L-type voltage-dependent calcium channels (VDCCs) by affecting the electrical activity of the cell. (diabetesjournals.org)
  • Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. (wikipedia.org)
  • The EF-hand types, united by an anti-parallel beta-strand between loops L1 and L3, are located on the same side of the molecule, opposite the N-and C-termini. (wikipedia.org)
  • Volumes of substrate-binding channel were calculated using the ProteinsPlus program. (bvsalud.org)
  • Now, eight transporters were found to control the uptake and efflux of calcium. (mdpi.com)
  • We have previously shown that MSY3/Csda binds a highly conserved cis-acting element located upstream of the myogenin promoter (myogHCE) and regulates the postnatal down-regulation of myogenin [ 16 ]. (biomedcentral.com)
  • The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)
  • heme and calcium targets are leading with example unique to particles for distinctive PTEN, higher metabolism, specific mechanism, T dislocations, more protein or hydrogen. (erik-mill.de)