LysosomesCytosolProteasome Endopeptidase ComplexEndosomesProteolysisLysosome-Associated Membrane GlycoproteinsEndocytosisUbiquitinProtein TransportCell LinePhagosomesAutophagyMolecular Sequence DataUbiquitinationAmino Acid SequenceKineticsBiodegradation, EnvironmentalAcid PhosphataseCysteine EndopeptidasesSubcellular FractionsCathepsin DUbiquitin-Protein LigasesEndoplasmic ReticulumCells, CulturedBiological TransportVacuolesLiverCell MembraneProtein BindingLysosomal-Associated Membrane Protein 2MutationMicroscopy, ElectronHydrogen-Ion ConcentrationHeLa CellsCathepsinsMultienzyme ComplexesCell FractionationUbiquitinsGolgi ApparatusMembrane ProteinsProtein Processing, Post-TranslationalEndoplasmic Reticulum-Associated DegradationIntracellular MembranesCell CompartmentationHydrolysisCarrier ProteinsProteinsChloroquineModels, BiologicalOrganellesCytoplasmMicroscopy, FluorescenceSignal TransductionRecombinant Fusion ProteinsFibroblastsPeptide HydrolasesProtein Structure, TertiaryMitochondriaTime FactorsCysteine Proteinase Inhibitorsrab GTP-Binding ProteinsCell NucleusCathepsin BPhosphorylationElectrophoresis, Polyacrylamide GelBlotting, WesternEndopeptidasesCricetinaebeta-N-AcetylhexosaminidasesSubstrate SpecificityAmmonium ChlorideRNA, MessengerMacrophagesMicroscopy, ConfocalHydrolasesBase SequenceMolecular WeightReceptor, IGF Type 2Chediak-Higashi SyndromeProtease InhibitorsGlucuronidaseApoptosisCell Line, TumorSaccharomyces cerevisiaeRecombinant ProteinsVesicular Transport ProteinsSaccharomyces cerevisiae ProteinsProteasome InhibitorsHEK293 CellsGreen Fluorescent ProteinsEnzyme ActivationLysosomal Storage DiseasesOrganoidsMolecular ChaperonesImmunoblottingRats, Inbred StrainsRNA InterferenceMannosephosphatesCOS CellsEndosomal Sorting Complexes Required for Transport