• Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. (wikipedia.org)
  • Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis. (nih.gov)
  • Induction of Activity-Regulated Cytoskeleton-Associated Protein and c-Fos Expression in an Animal Model of Anorexia Nervosa. (bvsalud.org)
  • The activity-regulated cytoskeleton -associated protein ( Arc ) is an immediate early gene that modulates several forms of synaptic plasticity and has been linked to neuropsychiatric illness. (bvsalud.org)
  • The Arc transcript is dependent upon activation of the mitogen-activated protein kinase or MAP kinase (MAPK) cascade, a pathway important for regulation of cell growth and survival. (wikipedia.org)
  • We have investigated the role of the actin cytoskeleton in noradrenaline (NA)-induced and endothelin (ET)-induced activation of the calcium-dependent nonreceptor tyrosine kinase PYK2 and subsequent phosphorylation of paxillin in rat small mesenteric arteries. (manchester.ac.uk)
  • NA and ET induced a rapid and prolonged activation of PYK2, as shown by increased phosphorylation at Y402 and Y881, and a concomitant association of the kinase with a Triton X-100 insoluble membrane (cytoskeleton) compartment. (manchester.ac.uk)
  • cAMP-dependent protein kinase (PKA) mediates intracellular signaling in response to neurotransmitters such as dopamine and norepinephrine. (yu.edu)
  • A novel brain-enriched RII{dollar}\beta{dollar}-binding protein, AKAP (A Kinase Anchor Protein), has been identified and characterized in two species in the Rubin laboratory (Bregman et al. (yu.edu)
  • This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
  • This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • The stimulation by cadmium or calcium/CaM dependent protein-kinase-II, resulting in MAP phosphorylation and MT disassembly and inhibition of assembly was not investigated. (cdc.gov)
  • Increased adhesion of the cancer cells depended on activation of cyclooxygenase-2, an enzyme that is involved in progression of colon cancers, whereas adhesion of the intestinal epithelial cells was augmented by LTD4-induced translocation of protein kinase C to areas where integrins bind to matrix proteins (focal adhesions). (lu.se)
  • How do motor proteins transport cargo along the cytoskeleton? (mechanobio.info)
  • Similar to a freight train, motor proteins capable of carrying cargo also face restrictions in the direction they can travel, the speed at which they travel and the possibility of traffic jams along the route. (mechanobio.info)
  • Specific members of the Myosin superfamily of motor proteins are known to transport cargo along actin filaments. (mechanobio.info)
  • The mRNA (and aggregate protein) is carried along microtubules radiating out from the nucleus by kinesin (specifically KIF5) and likely translocated into dendritic spines by the actin-based motor protein myosin-Va. Arc has been shown to be associated with polyribosomes at synaptic sites, and is translated in isolated synaptoneurosomal fractions in vitro indicating that the protein is likely locally translated in vivo. (wikipedia.org)
  • The protein is associated with microtubules , and Chatterjee and colleagues silenced the gene via short interfering RNA (siRNA) a molecular biological mechanism to study genes, targeting the CKAP5 encapsulated in lipid nanoparticles for in vivo delivery. (medicalxpress.com)
  • One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)
  • The arrangement of microtubules seems to be unrelated to the presence of LETS protein in the cells studied. (rupress.org)
  • The cell cytoskeleton, a unique intracellular matrix found in all eukaryotes, is composed of three main protein structures, microtubules, microlaments and intermediate laments. (wright.edu)
  • It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. (cshlpress.com)
  • This protein interacts with microtubules and regulates the activity of a variety of proteins that are involved in their function. (medlineplus.gov)
  • The abnormal PAFAH1B1 protein is less able to interact with microtubules and to attach (bind) to other subunits to form the PAFAH1B complex, both of which are needed for neuronal migration. (medlineplus.gov)
  • Cell mitosis is an attractive target to effectively treat a variety of cancer forms, where microtubule-associated proteins (MAPs) assist cells to maintain the stability of cell dynamics. (medicalxpress.com)
  • In this review, we will focus on how comprehensive and adaptable modeling allows investigators to explain experimental observations and develop testable hypotheses on the intracellular dynamics of the actin cytoskeleton. (nih.gov)
  • Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
  • It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
  • Water 2H and 17O spin relaxation is used to study water dynamics in the hydration layers of two small peptides, two globular proteins and in living cells of two microorganisms. (lu.se)
  • tHGA is able to preserve barrier integrity of LPS-induced endothelial cells via preservation of actin cytoskeleton and junctional proteins. (upm.edu.my)
  • The junctional proteins ZO-1 and p120 redistribute in a dotted circle peripheral to the brush border, in the absence of cell-cell contacts. (nih.gov)
  • Arc protein is widely considered to be important in neurobiology because of its activity regulation, localization, and utility as a marker for plastic changes in the brain. (wikipedia.org)
  • Tyrosine phosphorylation of the adaptor protein paxillin has been implicated in regulation of actin filament formation and force development. (manchester.ac.uk)
  • Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). (hmdb.ca)
  • ARC mRNA is localized to activated synaptic sites in an NMDA receptor-dependent manner, where the newly translated protein is believed to play a critical role in learning and memory-related molecular processes. (wikipedia.org)
  • These results show that in mesenteric arteries an intact cytoskeleton and force development are not prerequisites for G-protein-coupled receptor-induced activation of PYK2 and paxillin, by tyrosine phosphorylation, in vascular tissue, but are necessary for the translocation of PYK2 and paxillin to the membrane. (manchester.ac.uk)
  • Ohanian, V, Gatfield, K & Ohanian, J 2005, ' Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle ', Hypertension , vol. 46, no. 1, pp. 93-99. (manchester.ac.uk)
  • These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. (lu.se)
  • ARC is a member of the immediate-early gene (IEG) family, a rapidly activated class of genes functionally defined by their ability to be transcribed in the presence of protein synthesis inhibitors. (wikipedia.org)
  • The ARC gene, located on chromosome 15 in the mouse, chromosome 7 in the rat, and chromosome 8 in the human, is conserved across vertebrate species and has low sequence homology to spectrin, a cytoskeletal protein involved in forming the actin cellular cortex. (wikipedia.org)
  • CUL3 ASD-associated genetic variants are most often de novo missense or loss of function (loF) mutations, dispersed throughout the entire gene and affecting distinct protein domains. (nature.com)
  • Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts « Dott. (carinci.org)
  • The BICD2 gene provides instructions for making one of a family of proteins called golgins. (medlineplus.gov)
  • The BICD2 gene mutations that cause SMA-LED replace single protein building blocks (amino acids). (medlineplus.gov)
  • This change and the other BICD2 gene mutations increase the activity of the BICD2 protein. (medlineplus.gov)
  • The PAFAH1B1 gene (also known as LIS1 ) provides instructions for making a protein that is one part (subunit) of a complex called platelet activating factor acetyl hydrolase 1B (PAFAH1B). (medlineplus.gov)
  • Most of the PAFAH1B1 gene mutations that cause ILS lead to the production of an abnormally small, nonfunctional version of the PAFAH1B1 protein. (medlineplus.gov)
  • A deletion of one copy of the PAFAH1B1 gene in each cell reduces the amount of PAFAH1B1 protein by about half. (medlineplus.gov)
  • The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
  • Cargo that can be delivered or by cytoskeleton-dependent intracellular transport mechanisms can include other proteins and complex components. (mechanobio.info)
  • The cytoskeleton maintains cell shape and internal structures providing mechanical support that facilitates intracellular transport (Parker et al. (wright.edu)
  • The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. (cshlpress.com)
  • It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. (cshlpress.com)
  • Cytoskeleton Inc Laboratories manufactures the cytoskeleton protein list reagents distributed by Genprice. (fgf-4.com)
  • E3 ubiquitin ligases regulate cellular protein composition by providing target recognition and specificity to the ubiquitin-dependent proteasomal degradation pathway 12 . (nature.com)
  • Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)
  • Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction. (wikipathways.org)
  • The mature protein begins at aa 100 and has a 542 aa extracellular region, a 27 aa transmembrane region, and a 153 aa cytoplasmic region. (rndsystems.com)
  • It plays a structural role in the linking the CYTOSKELETON to the EXTRACELLULAR MATRIX. (bvsalud.org)
  • Agents that cause alterations in cell shape and cytoplasmic filaments have been used to explore the relationship of LETS protein to the internal cytoskeletal elements. (rupress.org)
  • A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. (wikipathways.org)
  • Cell-cell and cell-matrix complexes of epithelial cells are interconnected through cytoskeletal filaments and proteins, and they influence the activities and outcome of various cellular processes. (lu.se)
  • Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
  • At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)
  • The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
  • Protein phosphorylation regulates actomyosin-driven vesicle movement in cell extracts isolated from the green algae, Chara corallina. (bio.net)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • Gα12 couples to numerous G-protein-coupled receptors (GPCRs) and regulates multiple epithelial responses, including proliferation, apoptosis, permeability and the actin cytoskeleton. (medscape.com)
  • The organization of LETS protein on the surface of NIL8 hamster cells has been examined by immunofluorescence staining. (rupress.org)
  • Separate from its role in the PAFAH1B complex, the PAFAH1B1 protein is also likely involved in the organization of the cell's structural framework (the cytoskeleton). (medlineplus.gov)
  • Abcam: antibodies, proteins, kits. (abcam.com)
  • The aim of the study is to theoretically justify the need of studies of the aqueous component of neuroplasm and especially the interaction of protein molecules with water molecules for further development of neurophysiology. (1library.net)
  • that until this temperature there is spontaneously increasing hydration of cytoskeleton proteins, which causes an increase in its length and above it there is a spontaneously attenuation of hydration, as a consequence, reduction in the length of the protein molecules (Yashkichev, JSW, 2014). (1library.net)
  • Tubulin can bind an astonishing number of different proteins and small molecules, several hundred for sure," says Tobias Mühlethaler, a doctoral candidate in the PSI Laboratory of Biomolecular Research and first author of the study. (psi.ch)
  • In computer simulations conducted in collaboration with the Italian Institute of Technology in Genoa, the researchers combed through the structure of the protein: They identified places where other molecules could dock particularly well to tubulin. (psi.ch)
  • Overall, the researchers found 27 binding sites on tubulin where molecules or other proteins can dock. (psi.ch)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous. (lu.se)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
  • Many of these molecules activate G-protein-coupled receptors (GPCRs), which couple to multiple Gα subunits. (medscape.com)
  • We have previously reported the identification and characterization of an LKB1-specific adaptor protein, STRAD, which activates LKB1 and translocates it from nucleus to cytoplasm. (nih.gov)
  • The RII-binding protein is a neuronal dendritic protein that is highly expressed in forebrain regions such as basal ganglia and cerebral cortex. (yu.edu)
  • The results suggest that the bifunctional AKAP 150 protein tethers PKA-II{dollar}\beta{dollar} to the dendritic cytoskeleton, thereby creating a discrete target site for the reception and propagation of signals carried by cAMP. (yu.edu)
  • The patterns of staining for LETS protein are consistent with an involvement in cell-to-cell and cell-to-substrate adhesion. (rupress.org)
  • This thesis is focused primarily on the effect that LTD4 has on reorganisation of the actin cytoskeleton and on cell-cell and cell-matrix adhesion properties. (lu.se)
  • In general, cell adhesion favours cell survival signalling, and integrins are the main receptors responsible for mediating the attachment of different types of cells to matrix proteins. (lu.se)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)
  • in subconfluent, low-serum arrested cultures the LETS protein is predominantly located at the cell-substrate interface and also in regions of cell-cell contact, whereas in dense cultures the cells are surrounded by a network of LETS protein fibrils. (rupress.org)
  • The Cytoskeleton Protein List reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (fgf-4.com)
  • Description: A competitive ELISA for quantitative measurement of Rat Cytoskeleton associated protein 2(CKAP2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (fgf-4.com)
  • The cytoskeleton is a highly dynamic network of filamentous proteins that enables the active transport of cellular cargo, transduces force, and when assembled into higher-order structures, forms the basis for motile cellular structures that promote cell movement. (mechanobio.info)
  • The integrity of this monolayer can be disrupted by lipopolysaccharide (LPS), where LPS could increase the permeability of the endothelium via dissociation of cell-to-cell junctions and rearrangement of cytoskeleton. (upm.edu.my)
  • S. Ally, N. J. Sauer, J. J. Loureiro, S. B. Snapper, F. B. Gertler, M. B. GoldbergShigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteinsIn Cell Microbiol, volume 6, 2004. (fau.de)
  • 2014). Many viruses such as the herpesviruses use the cytoskeleton system of the cell for infectivity (Henry Sum, M. S. 2015). (wright.edu)
  • HSV-1 utilizes the cell cytoskeleton in many steps of its life cycle from entry through assembly to egress (Lyman et al. (wright.edu)
  • 2008). During infection, HSV-1 viral proteins cause drastic changes and rearrangement of the cellular actin and cell signaling during viral replication. (wright.edu)
  • Golgins help maintain the structure of a cell component called the Golgi apparatus, in which newly produced proteins are modified so they can carry out their functions. (medlineplus.gov)
  • The BICD2 protein helps the dynein complex with protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes. (medlineplus.gov)
  • Through a unique combination of computer simulations and laboratory experiments, researchers at the Paul Scherrer Institute PSI have discovered new binding sites for active agents - against cancer, for example - on a vital protein of the cell cytoskeleton. (psi.ch)
  • The protein tubulin is an essential building block of the so-called cell cytoskeleton. (psi.ch)
  • These give cells their shape, aid in transporting proteins and larger cellular components, and play a crucial role in cell division. (psi.ch)
  • The investigation of cell proteome highlighted how simulated microgravity affects a relatively low number of proteins compared to time and/or osteogenic factors and has allowed us to reconstruct a hypothetical pipeline for cell response to simulated microgravity. (lu.se)
  • In hereditary spherocytosis, the cell membrane surface area is decreased disproportionately to the intracellular content due to loss of proteins associated with the cell membrane. (msdmanuals.com)
  • In hereditary elliptocytosis, genetic mutations result in weakness of the cytoskeleton of the cell, leading to deformation of the cell. (msdmanuals.com)
  • The ARC protein can form virus-like capsids that package mRNA and can traffic between cells. (wikipedia.org)
  • Surface distribution of LETS protein in relation to the cytoskeleton of normal and transformed cells. (rupress.org)
  • Transformed derivatives of these cells exhibit only sporadic staining for LETS protein, in the form of short intercellular bridges. (rupress.org)
  • Previously proposed mechanism of cells ripple was used based on changes in the hydration of proteins of the cytoskeleton. (1library.net)
  • Mechanism of cells ripple was proposed in which changes in the hydration of proteins of the cytoskeleton play the main role. (1library.net)
  • Upon LKB1 activation, single cells rapidly remodel their actin cytoskeleton to form an apical brush border. (nih.gov)
  • The BICD2 protein is found in all cells. (medlineplus.gov)
  • In nerve cells (neurons), the BICD2 protein helps the dynein complex transport sac-like structures called synaptic vesicles. (medlineplus.gov)
  • Overactivity of the BICD2 protein changes its ability to bind with the dynein complex, leading to reduced movement of proteins, synaptic vesicles, and other materials within cells. (medlineplus.gov)
  • Enteropathogenic Escherichia coli (EPEC) and system that translocates multiple effector proteins into enterohemorrhagic E. coli (EHEC) are gastrointestinal host cells and manipulate host innate responses, which pathogens associated with asymptomatic carriage and are needed for colonization ( 5 - 7 ). (cdc.gov)
  • When inducing long-term potentiation (LTP) in the hippocampus, we observed an increase of Arc protein highly correlated with an increase in fluorescent intensity and the number of mCherry-positive cells. (lu.se)
  • Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. (nih.gov)
  • The particulate nature of PKA-II{dollar}\beta{dollar} is due to interactions between the regulatory subunit (RII{dollar}\beta{dollar}) and anchor proteins in intracellular structures. (yu.edu)
  • While Arc mRNA is subject to degradation by NMD, the translated protein contains a PEST sequence at amino acids 351-392, indicating proteasome-dependent degradation. (wikipedia.org)
  • From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
  • The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)
  • Cytoskeleton recommends using Tubulin protein (97% pure): Porcine brain (Cat. (cytoskeleton.com)
  • Tubulin protein has been isolated from bovine brain. (cytoskeleton.com)
  • The final product contains approximately 97% tubulin and 3% Microtubule Associated Proteins (MAPs). (cytoskeleton.com)
  • An ASSAY UNIT is defined as the amount of HTS02 protein needed to achieve a tubulin polymerization signal of OD340 of 0.1 - 0.15 in 30 minutes at 37°C in G-PEM buffer. (cytoskeleton.com)
  • The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
  • Methylmercury was used as a model for adverse effects to MT due to tubulin sulfhydryl binding in the extracted cytoskeleton model system and during the polymerization of purified MT proteins in-vitro. (cdc.gov)
  • The results indicated that, like calcium, the inhibitory effect of cadmium on the polymerization of purified MT proteins containing tubulin and microtubule associated proteins was enhanced by exogenously added CaM, suggesting that microtubule associated proteins were involved in mediating the sensitivity of MT to cadmium activated CaM. (cdc.gov)
  • The findings that cadmium, like calcium, can support the binding of CaM to tubulin and MAPs in Western blots of purified MT proteins support the proposal that MAPs are important in the increased sensitivity of MT to cadmium activated CaM. (cdc.gov)
  • Synaptically localized Arc protein interacts with dynamin and endophilin, proteins involved in clathrin-mediated endocytosis, and facilitates the removal of AMPA receptors from the plasma membrane. (wikipedia.org)
  • Alterations in membrane proteins cause the RBC abnormalities in both disorders. (msdmanuals.com)
  • Sushmita Chatterjee and a research team in nanomedicine, materials science, nanotechnology and biology at the Tel Aviv University in Israel studied the therapeutic capacity of cytoskeleton-associated protein 5 , hitherto abbreviated as CKAP5. (medicalxpress.com)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
  • article{3ef64d42-e741-442e-a1b5-bd0843c8bfaa, abstract = {{The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
  • Biological process GO terms and their p-values for co-expressed proteins. (lu.se)
  • Once transported, the translated protein is 396 residues in length, with an N-terminus located at amino acids 1-25, a C-terminus at 155-396 (note that the spectrin homology located at 228-380 within the C-terminal), and a putative coiled coil domain at amino acids 26-154. (wikipedia.org)
  • CUL3 is a conserved protein of the Cullin family, comprising eight members, which contain a conserved cullin homology domain, named after its ability to select cellular proteins for degradation. (nature.com)
  • Based on proteome annotation and a homology search, 94 proteins associated with the endomembrane system were identified that exhibited significant changes in abundance during grain development. (nature.com)
  • This distribution comprises a small fraction of protein-specific hydration sites, where water rotation is strongly retarded, and a dominant fraction of generic hydration sites, where water rotation is as fast as in the hydration shells of small peptides. (lu.se)
  • The therapeutic potential of microtubule-associated protein targets for cancer therapy is a largely unexplored research area due to a lack of target-specific agents. (medicalxpress.com)
  • Despite the well-understood process of CUL3-mediated protein ubiquitination and degradation 12 , its target proteins in the developing central nervous system and its role in brain development remain utterly understudied. (nature.com)
  • P104-012 stopped protein degradation. (cdc.gov)
  • Thus, endomembrane-modifying proteins within the endomembrane system will have an influence on the final grain quality/yield and recombinant protein production. (nature.com)
  • Workplace exposures equivalent to no or low observable proteins and other molecular chaperones (valosin-containing pro- adverse effect concentrations in animals: Step by step tein or VCP) are up-regulated to handle the increase of misfolded approach and damaged proteins which are causing oxidative stress. (cdc.gov)
  • Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively. (wikipedia.org)
  • One mutation that has been found in multiple affected individuals and families replaces the amino acid serine with the amino acid leucine at position 107 in the BICD2 protein (written as Ser107Leu or S107L). (medlineplus.gov)
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • Mouse P-Cadherin is an 822 amino acid (aa) protein with a 27 aa signal sequence and a 795 aa propeptide. (rndsystems.com)
  • Most of these mutations change single amino acids in the PAFAH1B1 protein subunit. (medlineplus.gov)
  • Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. (rndsystems.com)
  • By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)
  • This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. (cshlpress.com)
  • The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. (portlandpress.com)
  • notably, integration of proteomics data with in situ subcellular microscopic analyses showed a high abundance of cytoskeleton proteins associated with acidified PBs at the early development stages. (nature.com)
  • During development, protein trafficking and storage require an extensive reorganization of the endomembrane system. (nature.com)
  • Consequently, endomembrane-modifying proteins will influence the final grain quality and yield. (nature.com)
  • Moreover, endosomal sorting complex required for transport (ESCRT)-related proteins and their transcripts are most abundant at early and mid-development. (nature.com)
  • The protein attaches (binds) to a group of proteins called the dynein complex, turning it on (activating it) and helping it bind to other cellular materials for transport. (medlineplus.gov)
  • A macromolecular complex of proteins that includes DYSTROPHIN and DYSTROPHIN-ASSOCIATED PROTEINS. (bvsalud.org)