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  • neutrophil
  • Leukemias with a predominant myeloid component, in contrast to those with a predominant monocytoid component, had more neutrophil cells showing immunodeficiencies for one or more granule markers. (docphin.com)
  • In addition, no correlation could be found between any of the immunoreactivity deficiencies for the neutrophil granule glycoproteins elastase, lactoferrin, lysozyme and myeloperoxidase and the abundance of a particular set of ultrastructural features in the circulating leukemic cells from any of the nine patients. (docphin.com)
  • for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally staining cytoplasmic granules. (wikipedia.org)
  • mRNA
  • Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. (abcam.com)
  • abundant
  • Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. (uniprot.org)
  • secondary
  • Decreased immunoreactivity patterns were found more for the primary granule markers elastase and myeloperoxidase than for the secondary granule marker lactoferrin. (docphin.com)
  • synapse
  • The granules are released into an immune synapse formed with a target cell, where perforin mediates the delivery of the granzymes into endosomes in the target cell, and finally into the target cell cytosol. (wikipedia.org)
  • electron
  • Examination of granules exposed to calcium in the electron microscope using negative staining showed that calcium treatment of granules results in the formation of ring-shaped structures previously described to be associated with LGL-mediated cytotoxicity. (rupress.org)
  • types
  • more variation was obtained for elastase, lactoferrin and myeloperoxidase than for lysozyme, possibly because lysozyme is a marker for both granule types. (docphin.com)
  • cerebellar
  • Tg(PG14) mice having the mouse PrP homologue of the 9-octapeptide do it again insertion associated with a hereditary prion disease create a intensifying neurological disease with substantial apoptosis of cerebellar granule neurons , . (stopvivisection.info)
  • In comparison, the cerebellar granule cell axon is characterized by a single T-shaped branch node from which two parallel fibers extend. (wikipedia.org)
  • stress
  • Here, we exploited a Drosophila model of ALS and neuronal cell lines to elucidate the role of the RNA-binding ability of FUS in regulating FUS-mediated toxicity, cytoplasmic mislocalization and incorporation into stress granules (SGs). (mendeley.com)