Transneuronal degeneration is the death of neurons resulting from the disruption of input from or output to other nearby neurons. (wikipedia.org)
The technical cause of transneuronal degeneration is the death of neurons resulting from the disruption of input from or output to other nearby neurons. (wikipedia.org)
We found that tension in neurons modulates active transport of vesicles by increasing the probability of active motion, effective diffusivity and induces a retrograde bias. (nature.com)
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons in the midbrain. (springer.com)
Nuclear and cytoplasmic staining of CNS neurons demonstrates the presence of these antibodies. (medscape.com)
Axonal transport2
The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. (utsouthwestern.edu)
For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell interaction and internalization, intracellular sorting, long-range retrograde axonal transport, endosomal liberation, and nuclear import. (frontiersin.org)
Neuronal degeneration2
Despite these findings suggesting that mitochondria might be a key link between αSyn toxicity and neuronal degeneration in PD, the field still lacks an understanding of how αSyn abnormality and mitochondrial functional deficiency influence each other. (springer.com)
In the TLE rat model, neuronal degeneration and necrosis in the hippocampal dentate gyrus increased and RPL6 expression level decreased. (bvsalud.org)
Photoreceptor degeneration3
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders that often lead to photoreceptor degeneration. (nature.com)
The ablation of in mice leads to impaired OS ciliogenesis and growth and photoreceptor degeneration. (monossabios.com)
To help expand investigate the tasks of in the introduction of mouse retinas we performed a pathological evaluation of gene in the mouse leads to photoreceptor degeneration. (monossabios.com)
Inclusions1
Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic support and demyelination, leading to neurodegeneration. (biomedcentral.com)
Dynein3
Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. (utsouthwestern.edu)
Cytoplasmic dynein 1 is definitely fundamentally very important to transporting a number of important cargoes along microtubules within eukaryotic cells. (monossabios.com)
The genes for cytoplasmic dynein 1 ((gene. (monossabios.com)
Induces1
Loss of Pcs impairs Rab11 localization on the trans-side of Golgi units and induces the cytoplasmic accumulation of post-Golgi vesicles bearing rhabdomere proteins, as observed in Rab11-deficiency. (sdbonline.org)
Aggregates1
Thus, aberrantly increased LRRK2 kinase activity is probably associated with the reduced activity of Rab10 and its effectors, allowing the accumulation of neuronal cytoplasmic aggregates, such as the protein involved in PD, ±-synuclein. (fapesp.br)
Retinal2
Biallelic variants in the cilia gene DYNC2H1 have been associated with two severe ciliopathies: Jeune asphyxiating thoracic dystrophy (JATD, MIM 613091) and short-rib polydactyly (SRP, MIM 613091) with only four documented cases of associated complex early retinal degeneration at ages 2 months, and 2, 5, and 11 years old. (nature.com)
Modified … Retinal degeneration in in mice the expression was examined by all of us pattern of in mature like a reporter. (monossabios.com)
Accumulation1
The primary cause of degeneration is still under debate- whether cell loss in MSA is secondary to disruptions in the oligo-myelin-axon complex [ 29 , 64 ], or if MSA is a primary neuron disease, with the secondary formation of GCIs following pathological accumulation of α-syn that is neuronal in origin [ 55 ]. (biomedcentral.com)
Protein2
It is hypothesized that anterograde transneuronal degeneration causes the hyperphosphorylation of the tau protein and redistributing those proteins from the axon to the dendrites, which begins the breakdown of routing and sorting mechanisms. (wikipedia.org)
Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)
Proteins1
CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)
Substantia1
A study done shows that after excitotoxic injury to the striatum of adult rats, anterograde transneuronal degeneration occurs in the substantia nigra pars reticulata. (wikipedia.org)
Involves1
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). (elifesciences.org)
Adult1
To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
Interaction1
There are varying causes for transneuronal degeneration such as brain lesions, disconnection syndromes, respiratory chain deficient neuron interaction, and lobectomies. (wikipedia.org)
Function1
it occurs when a neuron in the central nervous system is damaged and causes the degeneration of a postsynaptic neuron associated with a similar function as the presynaptic neuron. (wikipedia.org)
Motor1
Heterozygotes display motor neuron degeneration and muscle spasms. (utsouthwestern.edu)
Expression1
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
Result3
Anterograde degeneration can occur at a late stage of brain injury and result in diaschisis. (wikipedia.org)
Loss of sensory receptors in the cochlea, vestibules, and retina result in ganglion degeneration and transneuronal degeneration. (wikipedia.org)
Obstructive nephropathy may result from inflammation associated with deposition of crystals, retrograde nephropathy, or a lower urinary tract outflow blockage. (nih.gov)
Thought1
Transneuronal degeneration is thought to be linked to a number of diseases, most notably Huntington's disease and Alzheimer's disease, and researchers recently have been performing experiments with monkeys and rats, monitoring lesions in different parts of the body to study more closely how exactly the process works. (wikipedia.org)
Types1
This can be either anterograde or retrograde, indicating the direction of the degeneration relative to the original site of damage (see types). (wikipedia.org)
Loss1
Retrograde transneuronal degeneration is degeneration caused by loss of trophic support from the target. (wikipedia.org)