Cytoplasmic mitogen activated protein kinase 3. Medical search. Frequent questions

Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) phospholipase C γ protein kinase C (PKC) Signal transducer and activator of transcription (STAT) In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. (wikipedia.org)
The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. (genome.jp)
Mechanistically, the root part of IKN suppressed RANKL-induced p38 mitogen-activated protein kinase (MAPK) activation, effectively abrogating the induction of c-Fos and nuclear factor of activated T cells 1 (NFATc1) expression. (e-jbm.org)
Mitogen-activated proteins kinases (MAPK) transmit cell-proliferation indicators from plasma membrane to nucleus. (techuniq.com)
Among the MAPKs ERK could be the main for arousal of cell proliferation [2 3 Intestinal epithelial differentiation would depend on activation from the ERK MAPK pathway and raising proof also suggests participation from the ERK pathway in the pathogenesis and development of individual cancer of the colon [4]. (techuniq.com)
Consequently, MAPK-dependent Smurf1 binding leads Smad1 alternatively to degradation or cytoplasmic retention. (mdc-berlin.de)
and regulation of stress-activated MAPK cascade. (nih.gov)

Subsequently, the phosphatidylinositol-3-kinase and mitogen-activated protein kinase pathways can be activated, resulting in proliferation and inhibition of apoptosis ( 13 , 14 ). (snmjournals.org)
Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (wikipedia.org)
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. (genome.jp)
Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. (genome.jp)
Three major intracellular signaling pathways linked to EGFR activation have been identified: the Ras-Raf-mitogen-activated protein (MAP) kinase pathway the phosphatidylinositol 3-kinase (PI-3 K)/Akt pathway and the Janus-kinase/signal transducer and activator of transcription (Jak2/STAT3) pathway. (ecolowood.com)
Once activated these pathways contribute to the development of a malignant cellular phenotype including resistance to apoptosis increased proliferation invasion metastasis and stimulation of angiogenesis (Figure 1).1 Figure 1 Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process. (ecolowood.com)
5 , 6 ] Stimulation of osteoclast precursors with RANKL recruits cytoplasmic tumor necrosis factor receptor-associated factors (TRAFs) and activates downstream signaling pathways. (e-jbm.org)
p38, c-Jun N-terminal kinase, extracellular signal-regulated kinase), and phosphoinositide 3-kinase/Akt serine/threonine kinase (Akt) signaling pathways are known to be activated during osteoclast differentiation. (e-jbm.org)
7 - 9 ] Activation of these signaling pathways induces the expression of transcription factors such as c-Fos and nuclear factor of activated T cells (NFATc1), a master transcription factor for osteoclastogenesis. (e-jbm.org)
We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
What pathways are this gene/protein implicaed in? (cancerindex.org)

VEGFA-165 signals by activating its receptor tyrosine kinase VEGF receptor-2 (VEGFR-2). (jneurosci.org)
Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
Neurotrophins serve long-term trophic functions by with activation of Trk receptor tyrosine kinase (Lohof et al. (eddoctor24h.com)
Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation. (nih.gov)

Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. (genome.jp)
Cells stressed by osmotic shock (OSM) activate the mitogen-activated protein kinase kinase(3/6)-p38 signaling pathway, which in turn results in accumulation of hnRNP A1 in the cytoplasm. (pasteur.fr)
Transforming growth factor-β1 (TGF-β) signals through a serine/threonine-kinase receptor pathway. (janechin.net)
An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
Because the effects of local anesthetics on cellular signal transduction in neuronal cells are not well-known, the authors investigated whether they affect the MAP kinase signaling pathway using PC12 cells. (asahq.org)
Although probable targets of these local anesthetics might be L-type Ca2+ channels or components between Ca2+ and Ras in MAP kinase pathway, the possibility that they directly affect MAP kinase still remains. (asahq.org)
The suppression of MAP kinase pathway may thus be a potential target site for the actions of dibucaine and tetracaine, including the modification of the synaptic functions. (asahq.org)
AE2 interacted with tumor suppressor P16 in the cytoplasmic region of colon cancer cells leading to activation of a novel EGR1/AE2/P16/P-ERK signaling pathway. (techuniq.com)
There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. (nih.gov)
We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. (nih.gov)
Macroautophagy (hereafter referred to as autophagy) is a vacuolar lysosomal degradation pathway for organelles and cytoplasmic macromolecules ( 9 ). (spandidos-publications.com)

Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. (genome.jp)
CaM Kinase Makes LTP or LTD Depending on Phosphorylation State Hyun Jae Pi, Nikolai Otmakhov, David Lemelin, Paul De Koninck, and John Lisman (see pages 8704C8709) Calcium entering through NMDA receptors activates calcium/calmodulin-dependent kinase II (CaMKII). (healthyconnectionsinc.com)
The HER Alosetron family is comprised of four unique receptors: EGFR (also known as HER1 or ErbB-1) HER2 (ErbB-2 Neu) HER3 (ErbB-3) and HER4 (ErbB-4). (ecolowood.com)
Its structure consists of an extracellular ligand-binding website a Alosetron single transmembrane hydrophobic helix and a cytoplasmic carboxy-terminal website to which tyrosine kinase activity is definitely limited.1 HER receptors are usually located in the basolateral membrane of the epithelial cells where they can interact with their ligands present in the stroma thus mediating signaling between the epithelium and the extra-cellular matrix. (ecolowood.com)
Factors mandating cellular consequence include cell surface-receptors, cytoplasmic proteins, and nuclear proteins. (janechin.net)
Signaling specificity is conferred by receptors and mediated through associated-kinases. (janechin.net)
The mammalian cell is furnished with receptors linked to interactive series of cytoplasmic networks for controlling cellular processes. (janechin.net)
5 MAP kinase has been shown to be activated by calcium influx through both N -methyl-D-aspartate (NMDA) receptors and L-type Ca 2+ channels. (asahq.org)
However, recent data indicate that a number of heat shock proteins, including HSP27, are also found in the extracellular space where they may signal via membrane receptors to alter gene transcription and cellular function. (bvsalud.org)

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. (nyu.edu)

The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. (asahq.org)
VEGF-induced pMF was attenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis( o -aminophenylmercapto)butadiene] and was abolished by the phosphotidinositol 3 kinase/Akt inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one hydrochloride], demonstrating that ERK mitogen-activated protein kinases and Akt are both required for full expression of VEGF-induced pMF. (jneurosci.org)
In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)

Growth factors that signal through tyrosine-kinase receptor families include the epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and transforming-growth factor-α (TGF-α). (janechin.net)
chromosome 13q12 and encodes the FLT3 tyrosine kinase receptor. (bioxorio.com)

Mitogen Activated Protein Kinases (MAPKs) are a conserved family of enzymes that form distinct signaling cascades. (smith.edu)
In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. (edu.sa)
Among the chromatin targets, we characterized the AT-hook motif containing nuclear localized (AHL) DNA-binding protein AHL13 as a substrate of immune MAPKs. (edu.sa)

Ras CAAX peptidomimetic FTI277 selectively blocks oncogenic ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. (nyu.edu)
The American Physiological Society (2018) Retraction: Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats. (gemologue.com)
We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)

111 In-R1507 specifically and efficiently accumulated in the SUM149 xenografts: the tumor uptake was 20 percentage injected dose per gram (%ID/g), 33 %ID/g, and 31 %ID/g at 1, 3, and 7 d after injection, respectively. (snmjournals.org)
Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are highly expressed in degenerative IVDs and contribute to a degenerative IVD phenotype by inhibiting the production of ECM ( 3 , 4 ). (spandidos-publications.com)

The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). (wikipedia.org)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Receptor tyrosine-protein kinase erbB-2 , also known as CD340 (cluster of differentiation 340), proto-oncogene Neu , Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. (iiab.me)

To determine that the C2C12 cell line underwent myogenesis, two proteins PCNA and cyclin D1 whose expression are linked to the cell cycle were utilized. (smith.edu)
PMC free article] [PubMed] [Google Scholar]Bailly E., Pines J., Hunter T., Bornens M. Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. (iahrgrenoble2016.org)
PubMed] [Google Scholar]Berthet C., Kaldis P. Cell-specific responses to loss of cyclin-dependent kinases. (iahrgrenoble2016.org)

We have characterized the molecular mechanism involved in the cytoplasmic accumulation of hnRNP A1 in NIH 3T3 cells subjected to OSM. (pasteur.fr)
These proteins aggregate at presynaptic active zones (AZs) to form the cytomatrix at the active zone (CAZ), which controls the recruitment, docking, and priming of synaptic vesicles and enhances calcium channel accumulation ( Gundelfinger and Fejtova, 2012 ). (eneuro.org)

The also acutely modulate the efficacy of basal synaptic transmission downstream actions of these cytoplasmic signals may increase at developing neuromuscular junctions in cell cultures (Lohof et phosphorylation of synaptic vesicle-associated proteins (Jo- al. (eddoctor24h.com)
Use of effector domain mutants of Rac suggest that Nischarin acts downstream of Rac, probably at the level of PAK-family kinases. (nih.gov)

Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. (genome.jp)
Following dimerization there is increased intracellular kinase activity of the receptor through a proximity effect resulting in phosphorylation of critical tyrosine residues on the cytoplasmic domain which then triggers the signal transduction cascade. (ecolowood.com)

1993), PI-3 (phosphoinositide-3) kinase (Yang et al. (eddoctor24h.com)

This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)

As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. (eneuro.org)

The ErbB family consists of four individual plasma membrane-bound receptor tyrosine kinases. (wikipedia.org)
It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
LTA are amphiphilic di- and triacylated lipopeptides anchored on the outer side of the cytoplasmic membrane of Gram-positive bacteria. (actanaturae.ru)
The blood LBP protein, which binds to LPS and transfers it as a monomer to the membrane-bound receptor CD14, then to MD-2 and TLR4, is involved in the delivery of LPS to the receptor [ 8 ]. (actanaturae.ru)
Human being anion exchanger 2 (AE2) is definitely a plasma membrane protein that regulates intracellular pH and cell volume. (techuniq.com)
6-9 Under regular conditions, cytoplasmic FLT3 goes through glycosylation, which promotes localization from the receptor towards the membrane. (bioxorio.com)
Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. (uc.edu)
We also established the presence of SP high affinity NK1 transcripts and the NK1 protein localization in the membrane of a sub-population of CGCs. (torvergata.it)
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)

SIGNALS initiated by neurotransmitter release are transferred to the nuclei of the postsynaptic cells to activate specific programs of gene expression, thus influencing synaptic functions. (asahq.org)
Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals. (nature.com)
Innate immune cells integrate environmental signals to rapidly activate target genes and perform specialized cellular functions 5 . (nature.com)
However, how microglia integrate extracellular signals at sites of cerebrovascular damage and the specificity of blood proteins controlling innate immune cell polarization in disease remain poorly understood. (nature.com)

At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. (eneuro.org)
We show here that Rab3-GEF is required for controlling the protein composition of release sites in the Drosophila neuromuscular junction (NMJ). (eneuro.org)

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. (wikipedia.org)
The cells were stimulated with either 50 mM KCl or 1 microM ionomycin, and activated MAP kinase was thus immunoprecipitated. (asahq.org)
Pretreatment of the cells with 1 mM (ethylenedioxy)-diethyl-enedinitrilotetraacetic acid or 5 micron nifedipine blocked the MAP kinase activation induced by 50 mM KCl, whereas pretreatment with 2 microM omega-conotoxin GIVA did not. (asahq.org)
Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
Cytoplasmic P16 enhanced ERK phosphorylation and advertised proliferation of colon cancer cells. (techuniq.com)
Overexpression of heat shock protein 27 (HSP27/HSPB1)-a multifunctional protein chaperone-has been shown to protect cells from oxidative damage and apoptosis triggered by Cd exposure. (bvsalud.org)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
Ma et al ( 15 ) revealed that compression activated autophagy in NP cells and that compression-induced autophagy was closely associated with intracellular reactive oxygen species production. (spandidos-publications.com)
However, how blood proteins polarize innate immune cells remains largely unknown. (nature.com)

Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
We now report that AE2 was overexpressed in colon cancer in a largely cytoplasmic distribution and under regulation of the Gastrodin (Gastrodine) transcription factor EGR1. (techuniq.com)

Journal of Bone Metabolism 2023;30(3):253-262. (e-jbm.org)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
The metabolism of 2,3,7,8-TCDD and related compounds is required for urinary and biliary excretion, and the rate of metabolism is thought to play a major role in regulating the rate of elimination (and detoxification) of these compounds (Van den Berg et al. (cdc.gov)

The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)

These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase. (genome.jp)

The EGFR is definitely a 170-kd protein encoded by a 110-kb-long gene localized in the short arm of chromosome 7. (ecolowood.com)
It has recently been suggested that MAP kinase plays a role in coupling the synaptic excitation to gene expression in the nucleus of postsynaptic neurons. (asahq.org)
What does this gene/protein do? (cancerindex.org)

Molecular Evaluation for FLT3 Mutations Genomic DNA extracted from new BM aspiration specimens 1314890-29-3 manufacture using the Autopure extractor (QIAGEN/Gentra, Valencia, CA) was utilized for mutation evaluation. (bioxorio.com)
Molecular recognition of proteins: Sequence selective binding of aspartate pairs in helical peptides. (nyu.edu)
Our studies reveal that Rab3 and Rab3-GEF act within the same molecular mechanism and support a model wherein Rab3-GEF serves as a Rab3 effector to control active zone protein composition. (eneuro.org)
To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)

ERKs are activated predominantly by growth factors and as a result regulate cell growth and promote hypertrophy (Chang and Karin 2001). (smith.edu)
Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). (eneuro.org)

We carried out transfection experiments using three pancreatic cancer cell lines (MiaPaCa-2, BxPC-3, and SW1990) and one pancreatic duct epithelial cell line (HPDE6c7). (nagoya-u.ac.jp)

Here, we demonstrate that CHI3L1 augments epithelial cell infection by pseudoviruses that express the alpha, beta, gamma, delta, or omicron S proteins and that the CHI3L1 inhibitors anti-CHI3L1 and kasugamycin inhibit epithelial cell infection by these VOC pseudovirus moieties. (elifesciences.org)

Each stage of the cell cycle is profiled by distinct protein complexes and phosphorylation events. (janechin.net)

2000). There are three specifically regulated MAP kinases: extracellular signal-related kinases (ERK 1/2/5), p38 proteins (p38α/β/γ/δ)) and c-Jun amino-terminal kinases (JNK1/2/3). (smith.edu)

HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis. (wikipedia.org)
3,4 MAP kinase is highly expressed in the central nervous system, primarily in such postsynaptic structures as neuronal cell bodies and the bases of the proximal dendrites. (asahq.org)
It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)

regulating expression of synaptic proteins (Wang et al. (eddoctor24h.com)

So far, knowledge on these events is scarce in plants and no attempts have been made to focus on phosphorylation events of chromatin-associated proteins. (edu.sa)

Substitution of a valine for a glutamic acid or a glutamine in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (wikipedia.org)
An N-terminal cytoplasmic domain is followed by a transmembrane domain and completed by a short c-terminal cytoplasmic domain. (techuniq.com)

Lately, it's been reported that time mutations 1314890-29-3 manufacture may confer in vitro level of resistance to FLT3 inhibitors.24,25 The frequency with which these mutations occur in the clinic among patients treated with FLT3 inhibitors and their clinical significance is not fully described. (bioxorio.com)
For codon CD22 835 stage mutation evaluation, PCR products had been digested with ITD mutation, 4 (6%) experienced a D835/I836 kinase website mutation, and 5 (7%) experienced mixed ITD and D835/I836 mutations. (bioxorio.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Journal of the American Chemical Society 1995 , 117(3), 1143-1144. (nyu.edu)
Drug News and Perspectives 1995 , 3, 138. (nyu.edu)

Western blotting was performed to detect protein expression or activation. (e-jbm.org)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
The anti-inflammatory actions of corticosteroids occur with a considerable delay (within hours or days) because of the multiple steps of cellular actions required to change protein expression. (ersjournals.com)

Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)

On binding of insulinlike growth factors to the receptor, adaptor proteins, such as insulin-receptor substrate-1 (IRS-1) and IRS-2, are recruited to the phosphorylation site of the cytoplasmic domain ( 19 - 21 ). (snmjournals.org)
lacks kinase domain), and erbB-4. (wikipedia.org)
Once the ligand binds to the extracellular domain the receptor undergoes a conformational change of this region which allows homodimerization or heterodimerization with another activated receptor of the HER family. (ecolowood.com)
The N-terminus of Nischarin interacts with a short segment of the cytoplasmic domain of the alpha5 integrin subunit. (nih.gov)

Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)

Anatomy20

Organisms8

Chemicals and Drugs173

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes39

Information Science3

MAPK7

Pathways11

Receptor tyrosi4

Pathway12

Receptors9

Phosphatidylinositol1

Inhibitor3

Tyrosine-kinase receptor2

MAPKs3

Signaling3

Tumor2

Differentiation3

Cyclin3

Accumulation2

Downstream2

Resulting in phosphorylation2

Phosphoinositide1

Murine1

Guanine Nucleo1

Membrane10

Signals4

Neuromuscular2

Cells9

Transcription2

Metabolism3

Genes1

Phospholipase1

Gene3

Molecular4

Regulate2

Pancreatic Cancer1

Inhibit1

Complexes1

Signal1

Cell3

Synaptic1

Phosphorylation events1

Transmembrane domain2

Mutations3

19952

Expression3

Induce1

Domain4

Cytokines1