Antineutrophil cytoplasANCAOxygenSpeciesAnti-neutrophil cyAntibodiesAutoantibodiesErythrocyteNeutrophilsCross-reactiveVasculitisUrinalysisCytoplasmOxidativeMitochondrialExcretionAmyloid precursExtracellularUrineInflammationProcessesBindsDistinctNitrogenConcentrationSerumHydrogen peroxide2000DegradationBloodCharacteristicKidneyExpressionHydrolaseNeuralCancerLevelCellsFunctionTestHumanInduction
Antineutrophil cytoplas3
- It has been demonstrated that antineutrophil cytoplasmic antibody (ANCA) positivity could be detected in many cases of vasculitis associated with viruses. (hindawi.com)
- Granulomatosis with polyangiitis (GPA, previously called Wegener's granulomatosis) is a rare, systemic, antineutrophil cytoplasmic antibody (ANCA)-associated form of vasculitis whose lesions usually affect the respiratory tract and kidneys [ 1 ]. (ejao.org)
- An elevated classic antineutrophil cytoplasmic antibody (C-ANCA) level is 80% specific for granulomatosis with polyangiitis. (medscape.com)
ANCA11
- Perinuclear-ANCA (P-ANCA), cytoplasmic-ANCA (C-ANCA), myeloperoxidase ANCA (MPO-ANCA), and proteinase 3-ANCA (PR3-ANCA) were studied. (hindawi.com)
- We aimed in the present study to identify the frequency of perinuclear-ANCA (P-ANCA), cytoplasmic-ANCA (C-ANCA), myeloperoxidase-ANCA (MPO-ANCA), and proteinase 3-ANCA (PR3-ANCA) subgroups of CHB patients in comparison with healthy controls. (hindawi.com)
- Blood is tested for abnormal antibodies, such as antineutrophil cytoplasmic antibodies (ANCA), which attack certain white blood cells. (merckmanuals.com)
- Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against cytoplasmic constituents of neutrophils and monocytes (2). (calbiotech.com)
- Staining by indirect immunofluorescence (IFA) shows two main staining patterns: cytoplasmic (c-ANCA) and perinuclear (p-ANCA) (3,4). (calbiotech.com)
- Necrotizing and crescentic glomerulonephritis (NCGN) is frequently associated with circulating antineutrophil cytoplasmic autoantibodies (ANCA). (rupress.org)
- The purpose of this study was to identify membrane proteins of PMNs, and/or glomerular cells, as additional autoantigenic ANCA targets. (rupress.org)
- When membrane protein fractions were prepared from PMNs and isolated human glomeruli, and immunoblotted with ANCA sera of NCGN patients, two bands with apparent molecular masses of 170 and 80-110 kD (gp170/80-110) were labeled in PMNs, and a 130-kD glycoprotein (gp130) in glomeruli. (rupress.org)
- To investigate whether serum chitinase-3-like 1 protein (YKL-40) is associated with disease activity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (biomedcentral.com)
- Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a rare disease characterised by necrotizing inflammation of predominantly small vessels [ 1 ]. (biomedcentral.com)
- Serologic studies, such as antinuclear antibody, ANCA (cytoplasmic ANCA [cANCA], perinuclear ANCA [pANCA], atypical ANCA), and rheumatoid factor, should be obtained in patients without an obvious cause of their disease. (medscape.com)
Oxygen8
- The GL-induced apoptosis was associated with reactive oxygen species (ROS) production and c-Jun NH 2 -terminal kinase (JNK) activation. (aspetjournals.org)
- These suggest the possibility that Ci-VSP is regulated by reactive oxygen species as found in PTEN. (rcsb.org)
- Along the way of encapsulation carbohydrate ligand binding by haemocyte receptors initiates creation of poisonous reactive oxygen varieties (ROS) (Hahn et al. (immune-source.com)
- Characteristic early signaling events include Ca 2+ influx, protein phosphorylation and generation of reactive oxygen species (ROS). (biomedcentral.com)
- Various samples were processed to quantify mitochondrial reactive oxygen species (mt-ROS), mt-DNA, cytochrome c, TFAM, mitochondrial stress markers and mt-DNA-induced signaling via cGAS-STING and TLR9. (cdc.gov)
- Activated inflammatory cel s, in- persistent inflammation cluding neutrophils and macrophag- es, produce reactive oxygen species and reactive nitrogen species. (who.int)
- Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)
- 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
Species1
- It's primary function is to destroy phagocytosed microorganisms by generating highly reactive oxidative species within the phagosome (1). (calbiotech.com)
Anti-neutrophil cy1
- Perinuclear anti-neutrophil cytoplasmic antibody test (pANCA): People with this protein are more likely to have ulcerative colitis. (webmd.com)
Antibodies7
- Antineutrophil cytoplasmic antibodies (ANCAs) are sensitive and specific markers for vasculitides. (hindawi.com)
- Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies, usually of IgG structure, formed against azurophilic granules and lysosomal components in the cytoplasm of neutrophils and monocytes [ 16 ]. (hindawi.com)
- the result of another ANA test was positive (higher than 1:160), rheumatoid factor (RF) was 14.9 IU/mL (normal, lower than 15 IU/mL), and the ribonucleic protein (U1RNP) antibodies level was 134 AU/mL (normal, lower than 100 AU/mL). (hcplive.com)
- Immunological investigations, including rheumatoid factor, antinuclear antibodies and antineutrophil cytoplasmic antibodies were negative. (ersjournals.com)
- called antineutrophil cytoplasmic antibodies in their blood. (merckmanuals.com)
- A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (rupress.org)
- Extra serological work-up for glomerulonephritis was adverse, including hepatitis C and B, HIV, and antineutrophil and antinuclear cytoplasmic antibodies. (museopedrogocial.org)
Autoantibodies2
- Autoantibodies against cytoplasmic components of neutrophil granulocytes (ACPA) were detected in 18 of 32 patients with Wegener's granulomatosis (WG), but in none of the controls (n = 900), including patients with glomerulonephritis, sarcoidosis, tuberculosis, polyarteritis nodosa, and connective tissue diseases, and healthy blood donors. (uni-luebeck.de)
- Ludemann, G & Gross, WL 1987, ' Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis ', Clinical and Experimental Immunology , vol. 69, no. 2, pp. 350-357. (uni-luebeck.de)
Erythrocyte3
- The erythrocyte sedimentation rate (ESR) and levels of C-reactive protein, white blood cells, and platelets can be very high, indicating active inflammation. (merckmanuals.com)
- Laboratory evaluation includes elevated inflammatory indicators, such as C-reactive protein and erythrocyte sedimentation rate (ESR). (medscape.com)
- Erythrocyte sedimentation price and C-reactive proteins were normal. (museopedrogocial.org)
Neutrophils2
- The white blood cell count and C-reactive protein were 11,800 G·L −1 with 83% neutrophils and 91 mg·L −1 , respectively. (ersjournals.com)
- The myeloperoxidase (MPO) antigen is a heme-containing protein found in the primary granules of neutrophils and monocytes. (calbiotech.com)
Cross-reactive2
- Using these probes, evidence was provided that gp170/80-110 is identical with human lysosomal-associated membrane protein 2 (h-lamp-2), because both proteins were immunologically cross-reactive and screening of a cDNA expression library from human promyelocytic leukemia cells with anti-gp130 Ab yielded a clone derived from h-lamp-2. (rupress.org)
- This clone is cross reactive with non-human primate * Diagnosis of acute myelogenousnleukemia. (ipa2014.org)
Vasculitis1
- I have chosen to study a group of severe autoimmune diseases with acute inflammation in the vessels, called anti-neutrophil cytoplasmic antibody associated systemic vasculitis (AAV). (lu.se)
Urinalysis1
- Urinalysis revealed macroscopic proteinuria and hematuria using a 24-h urinary proteins excretion of 55 mg/m2/h. (cell-signaling-pathways.com)
Cytoplasm1
- The cytologic characteristics of the tumor can provide sufficient clues for PEComa diagnosis, which includes loosely cohesive, epithelioid morphology with abundant clear or eosinophilic cytoplasm, low-grade nuclear atypia, cytoplasmic melanin pigments. (biomedcentral.com)
Oxidative1
- 2007 Schistosomes make quantities of protein that may scavenge ROS probably a strategy in order to avoid oxidative harm (Mour?o et al. (immune-source.com)
Mitochondrial2
- Differences in mechanical and fatigue properties of diaphragm motor units are the result of expression of different contractile proteins and mitochondrial volume densities in corresponding muscle fiber types. (mayo.edu)
- Organic dust-induced mitochondrial dysfunction could be targeted via cGAS-STING or cytoplasmic NOX-2 inhibition using microglial cells and brain slice culture models. (cdc.gov)
Excretion1
- Random RU-302 urine protein-creatinine percentage was 0.8 g/g (ref: 0-0.2 g/g), estimating 24-hour urine proteins excretion of 800 mg. (museopedrogocial.org)
Amyloid precurs2
- BLMH has been shown to interact with RPL29, RPL11, UBE2I and Amyloid precursor protein. (wikipedia.org)
- All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
Extracellular1
- Cytotactin, an extracellular matrix protein of neural and non-neural tissues that mediates glia-neuron interaction. (academicinfluence.com)
Urine4
- Blood, protein, and red blood cells appear in the urine, but often there is no sign of kidney malfunction until it is severe. (merckmanuals.com)
- A sample of urine is tested for red blood cells and protein. (merckmanuals.com)
- After 6 weeks of therapy, urine protein-creatinine ratio improved to 0.43 g/g and creatinine remained stable at 1.03 mg/dL. (museopedrogocial.org)
- But also large collaborative work on genetics (GWAS) and proteomics with screening of large number of immune related proteins in blood and urine. (lu.se)
Inflammation2
- These tests check for signs of infection, inflammation , internal bleeding, and low levels of substances such as iron, protein, or minerals. (webmd.com)
- It looks for this protein, which is a sign of inflammation . (webmd.com)
Processes2
- In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)
- Although the basic process of reactive astrocytosis is evolutionarily conserved and accompanies all forms of neural injuries, the precise molecular mechanisms underlying the reactive astrocytosis processes are presently far from clear. (jneurosci.org)
Binds1
- When Ca2+ channels are activated in response to a variety stimuli, a drastic increase in the [Ca2+]c is induced and the entered free Ca2+ binds to the sets of Ca2+-regulated proteins such as calmodulin and calcium dependent protein kinases to modify the activities or affinities of these proteins in binding to specific targets. (globalsciencebooks.info)
Distinct2
- Cells of hematopoietic origin are individual cells, mostly round in shape, and have a distinct cytoplasmic membrane. (vin.com)
- Here we determined the crystal structures of the Ci-VSP cytoplasmic region in three distinct constructs, wild-type (248-576), wild-type (236-576), and G365A mutant (248-576). (rcsb.org)
Nitrogen1
- A major portion of nitrogen (N) in bulb scales at harvest is storage protein. (globalsciencebooks.info)
Concentration1
- Among the ions taken up by the plant cells, Ca2+ plays an essential role as an intracellular secondary messenger in plants and thus the cytoplasmic free Ca2+ concentration ([Ca2+]c) is strictly regulated. (globalsciencebooks.info)
Serum2
- C-reactive protein (3.74 mg/dl), serum urea 66 mg/dl, serum creatinine 1.8 mg/dl. (cell-signaling-pathways.com)
- In patients without an identified etiology, laboratory analysis should include serum protein electrophoresis with immunofixation to assess for paraproteinemia, cryoglobulins, and hepatitis C antibody. (medscape.com)
Hydrogen peroxide1
- title{Protein Tyrosine Phosphatase Inhibition Mimics Fc$\varepsilon$RI-induced Anergy and Reveals the Immunomodulatory Role of Hydrogen Peroxide as a Signaling Molecule in Human Basophils\thanksref{grant}} %Really struggling with a title that captures this paper -- probably a bad sign! (openwetware.org)
20001
- Protein Expression and Purification Vol 18:pg 269-276 (2000). (calbiotech.com)
Degradation1
- Storage protein degradation is induced by cold temperature, and the accumulation of a soluble N fraction, especially glutamine, occurs. (globalsciencebooks.info)
Blood3
- The HaeMa laboratory in Mannheim covers a broad range of hematological diagnostics for detecting diseases and disorders affecting the blood cells - from reactive changes to leukemias. (jenoptik.com)
- Plasma and red blood cell protein maps: update 1993. (drugbank.com)
- Related tests include complete blood cell (CBC) count, C-reactive protein (CRP), blood culture, and cerebrospinal fluid (CSF) analysis. (medscape.com)
Characteristic1
- LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
Kidney1
- On kidney tissues obtained from AAGN patients, strong cytoplasmic staining of YKL-40 was found in cells present in inflammatory lesions. (biomedcentral.com)
Expression8
- In response to a brain injury, astrocytes proliferate and become hypertrophic with an increased expression of intermediate filament proteins. (jneurosci.org)
- Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)
- MATERIALS AND METHODS: Real-Time PCR (RT-PCR) and Western Blot were adopted to detect the mRNA and protein expression levels of calcium channel regulatory molecules. (bvsalud.org)
- The mRNA and protein expression levels of SERCA2a/CaV1.3/NCX and ß-tubulin decreased, while the mRNA and protein expression of RyR2 increased. (bvsalud.org)
- After treatment with TYHX, the mRNA and protein expression levels of SERCA2a/CaV1.3/NCX and ß-tubulin increased, while the mRNA and protein expression levels of RyR2 decreased and the cell structure was restored. (bvsalud.org)
- However, knockdown of PRMT5 significantly increased the percentage of senescent cells and retarded the cell proliferation of OS, as evidenced by SA-gal staining, 5-Ethynyl-2′-deoxyuridine (EdU) incorporation PU-H71 assay, as well as the protein expression of p-mTOR and p-p70 S6K, which distinguish quiescence and senescence [27] (Figure 2A and ?and2B,2B, Supplementary Figure 2DC2F). (ipa2014.org)
- However, knockdown of PRMT5 dramatically increased the protein expression of p21 (but not p53) in the U2 OS cells (Figure 2C). (ipa2014.org)
- Similar induction of p21 at the protein level was found in shP5#1 and shP5#3 Saos-2 cells, in which p53 expression is lost (Figure 2C). (ipa2014.org)
Hydrolase1
- Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. (wikipedia.org)
Neural1
- Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
Cancer1
- In fact, lectins (a form of protein) taken from the vegetable were found to have lowered the growth of breast cancer cells by over 50% (1). (vitanetonline.com)
Level1
- 2001 Extra proof for the part of ROS in parasite eliminating may be the association from the B allele from the cytoplasmic (with level of resistance to manifestation (Bender et al. (immune-source.com)
Cells4
- The induction of proapoptotic Bcl-2 family proteins Bax and Bak and a decrease of antiapoptotic Bcl-2 protein Bcl-2 were observed in GL-treated cells. (aspetjournals.org)
- ETHNOPHARMACOLOGICAL RELEVANCE: ß-tubulin is a skeletal protein of sinoatrial node cells (SANCs) that maintains the physiological structure of SANCs and inhibits calcium overload. (bvsalud.org)
- Chitinase-3-like 1 protein (YKL-40) is a secreted glycoprotein originally isolated from human osteosarcoma cells [ 9 ]. (biomedcentral.com)
- Procalcitonin (PCT), a protein that consists of 116 amino acids, is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and involved in calcium homeostasis. (medscape.com)
Function2
- Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. (wikipedia.org)
- This tennis racquet shaped cytoplasmic organelle has an unknown function. (thedoctorsdoctor.com)
Test1
- Anti-Saccharomyces cerevisiae antibody test (ASCA): People with this protein are more likely to have Crohn's. (webmd.com)
Human1
- Human liver protein map: a reference database established by microsequencing and gel comparison. (drugbank.com)
Induction1
- The GL-induced growth inhibition correlated with apoptosis induction as evidenced by an increase in cytoplasmic histone-associated DNA fragmentation and sub-G 0 /G 1 -DNA fraction, and cleavage of poly(ADP-ribose) polymerase. (aspetjournals.org)