Cell SurvivalCytoplasmSurvival RateApoptosisDisease-Free SurvivalSurvivalSurvival AnalysisSignal TransductionGraft SurvivalCell NucleusCell Line, TumorTime FactorsCells, CulturedCell LineTreatment OutcomeCell ProliferationPhosphorylationCell DeathImmunohistochemistryBlotting, WesternKaplan-Meier EstimateMolecular Sequence DataProto-Oncogene Proteins c-aktProtein-Serine-Threonine KinasesProto-Oncogene ProteinsMutationRetrospective StudiesRNA, MessengerRNA, Small InterferingPhosphatidylinositol 3-KinasesTransfectionAntineoplastic AgentsActive Transport, Cell NucleusMice, Inbred C57BLNeoplasm StagingModels, BiologicalEnzyme ActivationMice, KnockoutAmino Acid SequenceProportional Hazards ModelsProto-Oncogene Proteins c-bcl-2Protein Transportbcl-X ProteinTumor Cells, CulturedCell DivisionFollow-Up StudiesBreast NeoplasmsHeLa CellsAutophagyReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, Neoplasticbcl-Associated Death ProteinCaspase 3DNA-Binding ProteinsCell DifferentiationLung NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsMicroscopy, ElectronProtein BindingRNA InterferenceNuclear ProteinsNF-kappa BGene Expression RegulationMicroscopy, FluorescenceMembrane ProteinsCaspasesCombined Modality TherapyPrognosisNeoplasmsBase SequenceMitochondriaTranscription FactorsCell CycleMice, TransgenicCarrier ProteinsEnzyme InhibitorsRecombinant Fusion ProteinsTumor Suppressor Protein p53Up-RegulationApoptosis Regulatory ProteinsDose-Response Relationship, DrugGene ExpressionAdenocarcinomaTumor Markers, BiologicalFluorescent Antibody TechniqueIn Situ Nick-End LabelingDown-RegulationGene Knockdown TechniquesNeuronsFibroblastsNeoplasm MetastasisGreen Fluorescent ProteinsNeoplasm Recurrence, LocalTranscription, GeneticDNA DamageCisplatinNeoplasm ProteinsRecombinant ProteinsMultivariate AnalysisImmunoblotting