• tumor
  • In contrast, expression of the pro-inflammatory cytokine tumor necrosis factor alpha (Tnfa) was consistently downregulated in mecp2- -null animals during development, representing the earliest developmental phenotype described for MeCP2-deficiency to date. (biologists.org)
  • T cell receptor (TCR)-dependent regulatory T cell (T reg ) activity controls effector T cell (T eff ) function and is inhibited by the inflammatory cytokine tumor necrosis factor-α (TNF-α). (sciencemag.org)
  • Blocking the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) failed to stop overall structural progression of hand osteoarthritis, a randomized trial found. (medpagetoday.com)
  • inflammatory
  • Mecp2-deficiency resulted in an increase in neutrophil infiltration and upregulated expression of the pro- and anti-inflammatory cytokines Il1b and Il10 as a secondary response to disturbances in tissue homeostasis. (biologists.org)
  • T reg freed of PKC-θ-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases. (sciencemag.org)
  • The destructive events, i.e., the osteolytic processes and the disappearance of the articular cartilage in osteoarthritis, are most likely mediated by the same cytokine cascades operational in other inflammatory rheumatic conditions such as rheumatoid arthritis and psoriatic arthritis," Verbruggen and colleagues observed. (medpagetoday.com)