• Tadalafil is eliminated predominantly by hepatic metabolism, mainly by cytochrome P450 3A4 (CYP3A4). (theodora.com)
  • This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. (sigmaaldrich.com)
  • A reduced rate of lidocaine metabolism following tumescent liposuction may result from an inhibition of cytochrome P450 3A4 (CYP3A4) by sertraline (Zoloft) and flurazepam (Dalmane). (liposuction.com)
  • Thus patients coadministered with inhibitors of CYP3A4 such as macrolide antibiotics (e.g., erythromycin), azole antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritanovir) while receiving Buprenex should be carefully monitored and dosage adjustment made if warranted. (druglib.com)
  • Incidence was higher (4.2 per 100,000 person-years) with lovastatin, simvastatin, or atorvastatin (which are oxidized by cytochrome P450 3A4 [CYP3A4], which is inhibited by many drugs) than pravastatin or fluvastatin (which are not oxidized by CYP3A4). (scienceopen.com)
  • In persons taking simvastatin, lovastatin, or atorvastatin, 60% of cases involved drugs known to inhibit CYP3A4 (especially erythromycin and azole antifungals), and 19% involved fibrates, principally gemfibrozil. (scienceopen.com)
  • The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. (jci.org)
  • Before and after receiving grapefruit juice, small bowel and colon mucosal biopsies were obtained endoscopically, oral felodipine kinetics were determined, and liver CYP3A4 activity was measured with the [14C N-methyl] erythromycin breath test in each subject. (jci.org)
  • CYP3A4 is a major cytochrome P450 enzyme that is abundantly expressed in the liver and is responsible for the metabolism of more than 50% of all commonly prescribed drugs. (pharmacytimes.com)
  • Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. (scienceopen.com)
  • Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
  • Inactivation of Cytochrome P450 (CYP450) enzymes can lead to significant increases in exposure of comedicants. (aspetjournals.org)
  • Objectives: The objective of this study was to explore potential drug-drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. (researchgate.net)
  • Since 1994 there has been a rapid expansion of information about the specificity of hepatic microsomal enzymes of the cytochrome P450 family for the metabolism of different drugs. (liposuction.com)
  • CBD undergoes hepatic metabolism via the cytochrome P450 enzymes. (pharmacytimes.com)
  • Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. (ximbio.com)
  • 6-deoxyerythronolide B hydroxylase is an Actinomycetota Cytochrome P450 enzyme originally from Saccharopolyspora erythraea, catalyzes the 6S-hydroxylate of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) which is the first step of biosynthesis of the macrolide antibiotic erythromycin. (wikipedia.org)
  • This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. (sigmaaldrich.com)
  • The specific cytochrome P450 enzyme responsible for the metabolism of flurazepam has not been identified. (liposuction.com)
  • Diet, cardiac or liver disease, tobacco use, and medications (cimetidine, erythromycin, oral contraceptives) affecting the cytochrome P-450 system (CYP1A2) can affect the half-life. (medscape.com)
  • Erythromycin acts by inhibition of protein synthesis by binding 50S ribosomal subunits of susceptible organisms. (nih.gov)
  • Effects of uptake and efflux transporter inhibition on erythromycin breath test results. (ucsf.edu)
  • The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (sigmaaldrich.com)
  • It is primarily metabolised by the hepatic cytochrome P450 isoenzyme CYP3 A4. (pocketdrugguide.com)
  • The concomitant use of oxycodone and acetaminophen tablets with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. (nih.gov)
  • 1. Chronic renal failure (CRF) is associated with a decrease in liver cytochrome p450 (p450). (nih.gov)
  • The present study aimed to investigate the effects of the serum of rats with CRF on liver p450. (nih.gov)
  • In contrast, in vivo administration of the selective CYP3A inhibitor troleandomycin (TAO) reduced both potentiation of MMDX cytotoxicity and the rate of CYP3A-catalyzed N-demethylation of erythromycin by isolated liver microsomes (55.5 and 49% reduction, respectively). (unboundmedicine.com)
  • In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in oxycodone plasma concentration. (nih.gov)
  • Azithromycin demonstrates cross-resistance with erythromycin-resistant Gram-positive strains, including Streptococcus faecalis (Enterococcus) and to most strains of methicillin-resistant Staphylococci. (buysumamed.com)
  • Cyclosporine, has been widely used as immunosuppressant, is metabolized by intestinal and hepatic cytochrome p450 system and is a substrate of the P-glycoprotein transport system, which results in numerous drug interactions [ 1 ]. (journalmc.org)
  • This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. (sigmaaldrich.com)
  • protein expression and mRNA levels of major p450 isoforms, and (3). (nih.gov)
  • 4. In conclusion, uremic serum contains mediator(s) that down-regulate the cytochrome p450 of normal hepatocytes secondary to reduced gene expression. (nih.gov)
  • Interindividual variations in the absorption of erythromycin are, however, observed, and some patients do not achieve optimal serum levels. (nih.gov)
  • CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. (ximbio.com)
  • CBC is liable to change in patients treated with drugs metabolized by cytochrome p450 system, and the effect and magnitude of a multiple interaction is unpredictable. (journalmc.org)
  • ERY-TAB ® (erythromycin delayed-release tablets) is an antibacterial product containing erythromycin base in a specially enteric-coated tablet. (nih.gov)
  • ERY-TAB ® tablets for oral administration are available in three dosage strengths, each white oval tablet containing either 250 mg, 333 mg, or 500 mg of erythromycin as the free base. (nih.gov)
  • Erythromycin is largely bound to plasma proteins. (nih.gov)
  • Erythromycin crosses the placental barrier, but fetal plasma levels are low. (nih.gov)
  • Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. (nih.gov)