• drugs
  • Intravenous administration of the P-gp substrate drugs [ 3 H]digoxin, [ 14 C]saquinavir, or paclitaxel to pregnant dams revealed that 2.4-, 7-, or 16-fold more drug, respectively, entered the Mdr1a -/- /1b -/- fetuses than entered wild-type fetuses. (jci.org)
  • adverse
  • The most frequent adverse events with saquinavir in either formulation are mild gastrointestinal symptoms, including diarrhea, nausea, loose stools & abdominal discomfort. (wikipedia.org)
  • drug
  • OX1001 (saquinavir-NO) is an experimental drug being developed by OncoNOx currently undergoing clinical studies and investigations for the treatment of cancer. (wikipedia.org)
  • Though the difference between OX1001 and saquinavir lies in the presence of a nitrate ester, it is not clear how exactly this modification directly affects the function of the drug. (wikipedia.org)
  • less
  • While cytochrome P450 (CYP)-mediated biosynthesis of arachidonic acid (AA) epoxides promotes tumor growth by driving angiogenesis, cancer cell intrinsic functions of CYPs are less understood. (springermedizin.de)