Cytochrome high carcinogenicity acrylamide. Medical search. Frequent questions

In addition to these environmental sources of exposure which could be limited to certain occupations, the presence of a high ACR content in carbohydrate-rich heat-processed foods and cigarette smoke constitutes the key impact in human ACR burden [ 2 ]. (biomedcentral.com)
Due to the presence of carcinogens like polycyclic aromatic hydrocarbons, acrylamide, heterocyclic amines, and nitrites and nitrates in processed foods, understanding how processed foods impact human health is necessary. (nhsjs.com)

Phytochemical analysis of purslane has confirmed its high nutritional value due to its high content in α-linolenic acid, carotenoids, tocopherols and ascorbic acid [ 13 ]. (biomedcentral.com)

In 1775, Sir Percivall Pott wrote a paper on the high incidence of scrotal cancer in chimney sweeps, and suggested chimney soot as the cause of scrotal cancer. (wikipedia.org)
Acrylamide (ACR) is a reactive chemical widely used in several industrial processes, including the production of paper, dyes, soil conditioners, cosmetics, as well as for wastewater and municipal drinking water treatment [ 1 ]. (biomedcentral.com)

Principal scientist for multiple chronic in vivo rodent carcinogenicity/toxicity studies on persistent organic pollutants, conducted according to GLP by extramural testing facilities for the NTP. (nih.gov)

National and international health agencies regard carcinogenicity findings in well-conducted experimental animal studies as evidence of potential carcinogenic risk to humans. (nih.gov)
Carcinogenicity studies in animals have been inconsistent, with tumors of spleen, skin, and lymph systems in male but not female rats, and lung tumors and lymphoma in male mice and liver tumors in female mice. (cdc.gov)

There is not report showing the formation of such DNA adducts of the acrylamide in human body after the exposure of the acrylamide. (chinafloc.com)
Therefore, it is suggested that the acrylamide and the hemoglobin adducts can be used as the biomarker of the exposure level of the people to the acrylamide. (chinafloc.com)
Eye and respiratory tract irritation may occur with exposure to high vapor concentrations of most of these solvents, and allergic contact dermatitis has been reported following 1, 2-dichloroethane dermal exposure (Baruffini et al. (cdc.gov)

5, The United Nations Food and Agriculture Organization (FAQ) and the World Health Organization (WHO) Joint Expert Committee on Food Additive (JECFA) did a system risk assessment on the acrylamide in the foods on the No. 64 meeting, based on the new data in the recent two years. (chinafloc.com)
High doses of dimethoate, omethoate, and other organophosphate pesticides inhibit acetylcholinesterase enzymes in the nervous system, resulting in excess acetylcholine at nerve terminals. (cdc.gov)

The acrylamide and the hemoglobin adducts are detected in the animals which are given the acrylamide and in the human bodies who intake the foods containing the acrylamide. (chinafloc.com)

The human body can get in contact with the acrylamide through the multi ways, such as the digestive tract, the respiratory tract, the skin and the mucous membrane etc, among which the drinking water is an important way for the human body to intake the acrylamide substance. (chinafloc.com)
Therefore, the food is considered as the main source of the acrylamide intake to the human body. (chinafloc.com)
Besides, the human body can also get in contact with the acrylamide by smoking etc. (chinafloc.com)
The acrylamide can be absorbed by the human body through a variety of ways, while the gastrointestinal absorption is the fastest way, the acrylamide is widely distributed in different tissues of the human body, including the breast. (chinafloc.com)
About 90% of the acrylamide entered into the human body is metabolic, only a small amount of the acrylamide excretes via the urine as the prototype shape. (chinafloc.com)
When the acrylamide enters into the human body, in the role of the cytochrome P4502E1, the acrylamide is generated the reactive glycidamide (glycidamide). (chinafloc.com)

Because the acrylamide has the potential neurotoxicity, the genotoxicity and the carcinogenicity, the pollution caused by the acrylamide in the food attract great concerns of the international community and the governments. (chinafloc.com)

In April of 2002, the researchers from the Swedish National Food Administration (NFA) and the Stockholm University firstly reported that the acrylamide is detected to be existed in some fried and grilled starchy foods, such as the fried French fries and the fried potato chips, and the existing content exceeds the maximum allowed limit of 500 times to the drinking water standard. (chinafloc.com)
So, the WHO's acrylamide content limit in water is 1μg /L. In April, 2002, the research of the Stockholm University reported, that the acrylamide content in the fried French fries is more than 500 times of the maximum allowed limit in the drinking water which is recommended by the WHO. (chinafloc.com)
It is also used in canned fruits wherein water and sucralose take the place of much higher calorie corn syrup -based additives. (cloudfront.net)

In 1775, Sir Percivall Pott wrote a paper on the high incidence of scrotal cancer in chimney sweeps, and suggested chimney soot as the cause of scrotal cancer. (wikipedia.org)