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PeroxidasesCytochrome P-450 Enzyme SystemCytochrome c GroupCytochromesHorseradish PeroxidaseGlutathione PeroxidaseCytochrome b GroupCytochromes cCytochrome-c PeroxidasePeroxidaseCytochromes b5Ascorbate PeroxidasesElectron Transport Complex IVCytochromes c1Cytochromes fCytochrome P-450 CYP3AOxidation-ReductionEosinophil PeroxidaseHemeCytochromes bCytochrome P-450 CYP2E1Iodide PeroxidaseSpectrophotometryCytochrome b6f ComplexCytochromes c2Cytochrome P-450 CYP1A2Cytochrome ReductasesElectron TransportCytochrome P-450 CYP1A1Microsomes, LiverCytochrome P-450 CYP2B1Hydrogen PeroxideCytochrome P-450 CYP2D6NADPH-Ferrihemoprotein ReductaseKineticsMitochondriaCytochromes a1GuaiacolCytochrome d GroupCatalaseOxidoreductasesAryl Hydrocarbon HydroxylasesMixed Function OxygenasesMolecular Sequence DataAmino Acid SequenceSeleniumElectron Spin Resonance SpectroscopyHydroxylationLactoperoxidaseCytochromes aCyanidesCytochromes c6PhenobarbitalCytochromes c'Superoxide DismutaseHorsesIsoenzymesSpectrum AnalysisPeroxiredoxinsLigninMicrosomesChloride PeroxidaseEnzyme InductionCarbon MonoxideLiverOxygenBasidiomycotaPeroxidesHemeproteinsHydrogen-Ion ConcentrationAntioxidantsBiotransformationParacoccus denitrificansCatalysisBase SequenceOxidative StressCattleProtein ConformationCytochrome-B(5) ReductaseOxidoreductases, N-DemethylatingSteroid HydroxylasesL-Lactate Dehydrogenase (Cytochrome)Benzyl AlcoholsDithioniteModels, MolecularGlutathioneBinding SitesApoptosisSubstrate SpecificityNADH, NADPH OxidoreductasesGlutathione ReductaseElectron Transport Chain Complex ProteinsCamphor 5-MonooxygenasePotentiometryBenzoflavonesCaspasesSpectrophotometry, UltravioletAntimycin AChromatography, High Pressure LiquidFerricyanides

CatalaseP450Horseradish peroxidaseGlutathioneProteinEnzymesPseudomonasProteinsAscorbateMitochondriaGenesFerrocytochromeHydrogenCompoundReactionActivityEnzymeOxidativeMetabolismPorphyrinPeroxidesLiverActive siteActivationProperties

Catalase9

• In addition to its peroxidase activity, it acts as a sensor and a signaling molecule to exogenous H2O2, which activates mitochondrial catalase activity. (wikipedia.org)
• Ascorbate peroxidase (APX), cytochrome c peroxidase (CcP), and the catalase - peroxidases (KatG) share very similar active site structures and are distinguished from other peroxidases by the presence of a distal tryptophan residue. (bris.ac.uk)
• M. Kathiresan, D.Martins and A.M. English ( 2014 ) Respiration triggers heme transfer from cytochrome c peroxidase to catalase in yeast mitochondria , Proc. (concordia.ca)
• Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
• Ozone also causes an increase in the NADH reducing process and helps to oxidize cytochrome C. There is a stimulation of the production of the enzymes which act as free radical scavengers and cell wall protectors: glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase. (silvermedicine.org)
• A series of seven hemeproteins, cytochromes P-450LM2, P-450LM4, and P-420LM2, horseradish peroxidase, chloroperoxidase, catalase, and metmyoglobin, as well as hemin were tested for their ability to catalyze a set of five oxidative reactions. (lookformedical.com)
• All hemeproteins were able to carry out peroxidation, but three (horseradish peroxidase, chloroperoxidase, and catalase) were much better catalysts than the others. (lookformedical.com)
• Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities and uric acid (UA) levels were measured in plasma and saliva. (bvsalud.org)
• To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)

P4503

• NADPH-cytochrome P450 reductase (CPR) and cytochrome- b 5 ( b 5 ) together with NADH- b 5 reductase ( b 5 R) play important roles in cytochrome P450 3A-mediated drug metabolism via electron transfer. (aspetjournals.org)
• and Galanthus elwesii we have identified a para-para' C-C phenol coupling cytochrome P450, CYP96T1, capable of forming the products (10b R ,4a S )-noroxomaritidine and (10b S ,4a R )-noroxomaritidine from 4′- O -methylnorbelladine. (frontiersin.org)
• Liver microsomes from four rats of each sex per group were assayed for protein and cytochrome P450 content, and the activities of UDP-glucuronyltransferase and several monooxygenases were determined (Vermeir, 1996). (inchem.org)

Horseradish peroxidase2

• Plant peroxidase such as horseradish peroxidase and pineapple peroxidase B have low lysine, tryptophan, and tyrosine contents and high cysteine content. (wikipedia.org)
• This study reports on the metabolic activation of BHT by two peroxidase enzymes: horseradish peroxidase and prostaglandin H synthase. (cdc.gov)

Glutathione2

• The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
• therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. (nih.gov)

Protein6

• The enzyme contains a 68-residue sequence at the N-terminus of its monomeric protein, which targets it to the inter-membrane space of the mitochondria where it can the complex with cytochrome c and where it carries out its sensor, signaling and catalytic roles. (wikipedia.org)
• Collectively, the data show that all three members of the class I heme peroxidases can support radical formation on the distal tryptophan and that the reactivity of this radical can be controlled either by the protein structure or by the nature of the compound I intermediate. (bris.ac.uk)
• Peroxidase activity assay shows this protein contains heme. (nasa.gov)
• In addition, the present study indicated that treatment with GP suppressed the I/R-induced increase in the pro-apoptotic protein levels of Bax and cytochrome c and the activity of caspase-3/8, as well as the I/R-induced decrease in the levels of anti-apoptotic protein Bcl‑2. (spandidos-publications.com)
• In particular, ultrafast XFEL spectroscopy is used to evaluate the methionine-S-Fe bond in cytochrome c, and its entatic control by the protein in determining function (electron transfer vs. apoptosis). (stanford.edu)
• Radiation also dramatically decreased the protein and mRNA expression of bcl-2 and increased that of bax, cytochrome c, and capase-3. (biomedcentral.com)

Enzymes3

• This phytopathogen has an abundance of secreted oxidases, peroxidases, and hydrolytic enzymes for degrading cell wall polysaccharides and lignocelluloses to penetrate into the host tissue. (biomedcentral.com)
• Peroxidase enzymes have recently been shown to catalyze the activation of a wide variety of xenobiotic compounds to reactive intermediates and these enzymes, particularly prostaglandin H synthase, have been suggested to play a role in the extrahepatic toxicity and carcinogenicity of several compounds. (cdc.gov)
• Since antioxidants are good electron donors we investigated whether BHT might be metabolically activated to BHT-quinone methide by peroxidase enzymes. (cdc.gov)

Pseudomonas1

• In addition, MauG has sequence similarity to cytochrome c peroxidase from Pseudomonas sp. (caltech.edu)

Proteins2

• One of these genes is of particular interest, a di-heme cytochrome c peroxidase, occurs in an gene cluster with five other genes which encode for other proteins involved in electron transport. (nasa.gov)
• Western blotting and reverse transcriptase PCR were used to determine the expression levels of apoptosis-related proteins and genes, including bcl-2 , bax , cytochrome c , and capase-3 . (biomedcentral.com)

Ascorbate1

• CCP has high sequence identity to the closely related ascorbate peroxidase enzyme. (wikipedia.org)

Mitochondria2

• The negative charge transfer process is carried out by a complex formed between cytochrome c and cytochrome c peroxidase which occurs in the inter-membrane space of mitochondria. (wikipedia.org)
• M. Kathiresan and A.M. English ( 2018 ) LC-MS/MS proteoform profiling exposes cytochrome c peroxidase self-oxidation in mitochondria and functionally important hole hopping from its heme , J. Am. Chem. (concordia.ca)

Genes1

• Excessive oxidative stress alters the expression levels of apoptosis-related genes and triggers sperm apoptosis through bcl-2, bax, cytochrome c and caspase-3 signaling pathways. (biomedcentral.com)

Ferrocytochrome1

• Cytochrome c peroxidase, or CCP, is a water-soluble heme-containing enzyme of the peroxidase family that takes reducing equivalents from cytochrome c and reduces hydrogen peroxide to water: CCP + H2O2 + 2 ferrocytochrome c + 2H+ → CCP + 2H2O + 2 ferricytochrome c CCP can be derived from aerobically grown yeast strains and can be isolated in both native and recombinant forms with high yield from Saccharomyces cerevisiae. (wikipedia.org)

Hydrogen3

• The mechanism involves ferrous cytochrome c (Cc) providing electrons for the Cc-CcP system to reduce hydrogen peroxide to water. (wikipedia.org)
• Cytochrome c peroxidase can react with hydroperoxides other than hydrogen peroxide, but the reaction rate is much slower than with hydrogen peroxide. (wikipedia.org)
• Although the TMBZ solution is colorless, it turns bluish-green (λmax: 655 nm) in the presence of hydrogen peroxide and peroxidase. (dojindo.com)

Compound1

• Functional differences between peroxidase compound I and the cytochrome P-450 reactive oxygen intermediate. (lookformedical.com)

Reaction1

• This reaction is presumably catalyzed by a cytochrome P-450 related enzyme. (cdc.gov)

Activity4

• Herein, we demonstrate that cytochrome c (Cyt c ) showed peroxidase activity on IGA as a component of complexes III and IV. (biologists.com)
• The signals of IGA based on peroxidase activity were obtained using enhanced chemiluminescence solution. (biologists.com)
• An Improved Staining Procedure for the Detection of the Peroxidase Activity of Cytochrome p-450 on Sodium Dodecyl Sulfate Polyacrylamide Gels. (dojindo.com)
• 2,3,7,8-Tetrachlorodibenzo- p -dioxin as an antiestrogen: Effect on rat uterine peroxidase activity. (cdc.gov)

Enzyme1

• The enzyme shows an unusual amino acid pattern compared to other peroxidase. (wikipedia.org)

Oxidative2

• M. Kathiresan and A.M. English ( 2017 ) LC-MS/MS reveals that hole hopping in cytochrome c peroxidaseprotects its heme from oxidative modification by excess H 2 O 2 , Chem. (concordia.ca)
• Iron is a part of heme, which is the active site of peroxidases that protect cells from oxidative injury by reducing peroxides to water. (medscape.com)

Metabolism1

• M. Kathiresan and A.M. English ( 2016 ) Targeted proteomics identify metabolism-dependent interactors of yeast cytochrome c peroxidase: Implications in stress response and heme trafficking , Metallomics 8 , 434 -443. (concordia.ca)

Porphyrin1

• This is different from most peroxidases, which have the second oxidising equivalent on the porphyrin instead. (wikipedia.org)

Peroxides1

• Since the decarboxylation of peroxyacids is diagnostic of peroxide homolysis, these results indicate a fundamentally different manner of processing of peroxides by cytochrome P-450 than by the peroxidases. (lookformedical.com)

Liver2

• Preparation of Partially Purified, Lipid-depleted Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphatecytochrome c Reductase from Rat Liver Microsomes. (dojindo.com)
• A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (cdc.gov)

Active site1

• Heme is also the active site of electron transport in cytochromes. (medscape.com)

Activation1

• Structural characterization of cardiolipin-driven activation of cytochrome C into a peroxidase and membrane perturbation. (cdc.gov)

Properties1

• How Does Replacement of the Axial Histidine Ligand in Cytochrome c Peroxidase by N δ -Methyl Histidine Affect Its Properties and Functions? (bvsalud.org)