• Cholangiocarcinoma or bile duct cancer is a form of cancer that is composed of mutated epithelial cells (or cells showing characteristics of epithelial differentiation) that originate in the bile ducts. (wikipedia.org)
  • Cholangiocarcinoma is a slow-growing malignancy of the bile duct. (medscape.com)
  • Intrahepatic cholangiocarcinoma constitutes about 15% of all primary liver tumors. (medscape.com)
  • According to the World Health Organization classification, there are 2 subtypes of intrahepatic cholangiocarcinoma, small duct (SD) and large duct (LD), each with distinct clinicopathologic features. (medscape.com)
  • On the basis of the site of origin, cholangiocarcinoma can be classified as intrahepatic (arising proximally to the second-order bile ducts, in the context of liver parenchyma), perihilar (originating between second-order bile ducts and the insertion of the cystic duct into the common bile duct), and extrahepatic or distal (below the insertion of common bile duct). (medscape.com)
  • Main international guidelines recommend computed tomography (CT) and/or magnetic resonance imaging (MRI) as the principal imaging modalities for the diagnosis of intrahepatic cholangiocarcinoma. (medscape.com)
  • however, the association of gallstones with cholangiocarcinoma is less marked than with carcinoma of the gallbladder. (medscape.com)
  • Cholangiocarcinoma was classified as intrahepatic, extrahepatic and gall bladder cancer. (archive.org)
  • Cancer of the bile duct (also called cholangiocarcinoma) is extremely rare. (tri-kobe.org)
  • AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
  • Most patients with malignant obstructive jaundice caused by carcinoma of the gallbladder, carcinoma of the pancreas, and cholangiocarcinoma present with advanced disease2,3 and only 20% to 30% of such tumors are resectable at the time of diagnosis.2,4 Palliation of the malignant obstruction relieves the patient of itching and jaundice, reduces the risk of infection and septicemia, and generally improves the quality of life. (kipdf.com)
  • A study of 66 patients with unresectable intrahepatic cholangiocarcinoma treated with hypofractionated radiation therapy reported 2-year outcomes of 84% local control and 58% overall survival. (medscape.com)
  • In a study of 1636 patients with unresectable localized intrahepatic cholangiocarcinoma, the addition of radiation to chemotherapy was associated with an improvement in overall survival. (medscape.com)
  • Cholangiocarcinoma may arise in the intrahepatic (least common), perihilar, or distal (extrahepatic) biliary tree. (gastrotraining.com)
  • Intrahepatic cholangiocarcinoma is treated by resection of the involved segments or lobe of the liver. (gastrotraining.com)
  • Choledochal cyst is a premalignant condition with substantial risk of malignant transformation into cholangiocarcinoma, bile duct cancer. (iswantosucandyliversurgery.com)
  • The right and left hepatic ducts join outside the liver in its hilum (porta hepatis) to form the common hepatic duct (CHD). (medscape.com)
  • Right and left hepatic ducts exit the liver at the porta hepatis (together with v. portae and a. hepatica propria ). (wikilectures.eu)
  • Extrahepatic bile ducts connect to intrahepatic bile ducts at the porta hepatis . (wikilectures.eu)
  • It consists of a rounded fundus, smooth body and tapering neck, which becomes contiguous with the cystic duct and attaches to the porta hepatis. (cdc.gov)
  • [ 16 ] Disadvantages of MRCP include its inability to distend the duct and equivocal findings because of long segments and minimal narrowing in diffuse sclerosing tumors. (medscape.com)
  • Patients undergoing yttrium‐90 ( 90 Y)‐microspheres therapy for hepatic tumors must first be evaluated with liver imaging using arterially infused 99m Tc‐ macroaggregated albumin ( MAA ) as part of the planning process for a safe and effective procedure. (radiologykey.com)
  • Traditionally, bile duct tumors located within the liver had been classified with hepatocellular carcinoma as primary liver tumors. (tri-kobe.org)
  • [ 1 ] In contrast, bile duct tumors located outside of the liver had been classified with gallbladder cancer as extrahepatic biliary tract tumors. (tri-kobe.org)
  • [ 1 ] The classification of bile duct tumors has changed to include intrahepatic tumors of the bile ducts and extrahepatic tumors (perihilar and distal) of the bile ducts. (tri-kobe.org)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (tri-kobe.org)
  • These tumors are also known as intrahepatic cholangiocarcinomas. (tri-kobe.org)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • Hendriquez R, Keihanian T, Goyal J, Abraham RR, Mishra R, Girotra M. Radiofrequency ablation in the management of primary hepatic and biliary tumors. (wjgnet.com)
  • In the United States, 80%-90% of primary hepatic tumors are hepatocellular carcinomas and 10%-15% are cholangiocarcinomas (CCA), both with high mortality rate, particularly CCA, which portends a worse prognosis. (wjgnet.com)
  • Tumors or cancer of the gallbladder. (lookformedical.com)
  • Bile duct tumors that involve the common hepatic duct bifurcation are referred to as Klatskin tumors regardless of whether they arise from the intrahepatic or extrahepatic portion of the biliary tree. (gastrotraining.com)
  • SD has been shown to develop more frequently in patients with chronic viral hepatitis without precursor lesions, whereas LD lesions have been found more frequently in patients with chronic bile duct disease. (medscape.com)
  • laparoscopic examination of the biliary system for screening of stones and evaluation of hepatic and pancreatic lesions, etc. (imagingsol.com.au)
  • Uptake patterns of incidentally identified focal hepatic lesions encountered on the hepatogram can inform the differential, but other modalities such as US, CT, and MRI are required for further workup. (radiologykey.com)
  • 3 We report a rare case of CC type IB that presented with eccentric features and was misdiagnosed for other cystic hepatic lesions because of the lack of technical quality of the examination. (org.pk)
  • The most distinctive lesions are cystic and measure 1-10 mm, although comedonal lesions can also be present. (cdc.gov)
  • Bile is isosmotic with plasma and consists primarily of water and electrolytes but also organic compounds: bile salts, phospholipids (mostly lecithin), cholesterol, bilirubin, and other endogenously produced or ingested compounds, such as proteins that regulate gastrointestinal function and drugs or their metabolites. (merckmanuals.com)
  • Bile salts (bile acids) are the major organic component in bile. (merckmanuals.com)
  • The liver uses active transport to secrete bile salts into the canaliculus, the cleft between adjacent hepatocytes. (merckmanuals.com)
  • Once secreted, bile salts draw other bile components (particularly sodium and water) into the canaliculus by osmosis. (merckmanuals.com)
  • Bile salts are also biologic detergents that enable the body to excrete cholesterol and potentially toxic compounds (eg, bilirubin, drug metabolites). (merckmanuals.com)
  • The function of bile salts in the duodenum is to solubilize ingested fat and fat-soluble vitamins, facilitating their digestion and absorption. (merckmanuals.com)
  • most intestinal bile salts reach the terminal ileum, which actively absorbs 90% of bile salts into the portal venous circulation. (merckmanuals.com)
  • Returned to the liver, bile salts are efficiently extracted, promptly modified (eg, conjugated if they arrive in the free form), and secreted back into bile. (merckmanuals.com)
  • Bile salts circulate through this pathway from liver to gut to liver-the enterohepatic circulation-10 to 12 times/day. (merckmanuals.com)
  • Cholesterol, ordinarily insoluble in water, comes into solution by forming vesicles with phospholipids (principally lecithin) or mixed micelles with bile salts and phospholipids. (medscape.com)
  • When the ratio of cholesterol, phospholipids, and bile salts is outside an optimum range, cholesterol monohydrate crystals may come out of solution from multilamellar vesicles. (medscape.com)
  • Results of epidemiologic studies have implicated bacteria-induced carcinogens derived from bile salts (eg, lithocholate) as a causative factor in the pathogenesis of cholangiocarcinomas . (medscape.com)
  • It contains cholesterol and waste products, such as bilirubin and bile salts, which aid in the digestion of fats. (thehealthboard.com)
  • Bile is a fluid of yellowish-brown colour which consists of bile salts , bile pigments ( bilirubin , biliverdin ), fatty acids, lipids, cholesterol etc. (wikilectures.eu)
  • BILIARY DRAINAGE FOR MALIGNANT STRICTURES Biliary obstruction is potentially fatal because of the adverse pathologic effects including depressed immunity, impaired phagocytic activity, reduced Kupffer cell function, and paucity of bile salts reaching the gut, with consequent endotoxemia, septicemia, and renal failure. (kipdf.com)
  • Secreted by the liver, bile is composed largely of bile salts, bile pigments and small amounts of organic materials such as cholesterol, lecithin, fatty acid and mucin. (cdc.gov)
  • Bile salts are produced by the liver and are essential for the digestion and absorption of fat in the small intestine. (cdc.gov)
  • The extrahepatic bile ducts can be further divided into the perihilar (hilum) region and distal region. (tri-kobe.org)
  • Obstructed biliary system due to an obstruction in the distal CBD [common bile duct]. (hdc.org.nz)
  • As a special entity of infantile choledochal cysts (CCs), ADCCs are known as a stenotic distal bile duct or blind-ending cyst, and cholestatic jaundice, liver fibrosis and cirrhosis start from an early stage of life [ 3 ]. (biomedcentral.com)
  • Combined liver and bile duct resection for advanced bile duct cancers are being performed regularly. (apollohospitals.com)
  • Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)
  • Here, we report a case of Type VI CC confirmed intraoperatively, managed by cyst resection with bile duct reconstruction by means of Roux-en-Y hepaticojejunostomy (RYHJ). (jiaps.com)
  • The top half of the common bile duct is associated with the liver, while the bottom half of the common bile duct is associated with the pancreas, through which it passes on its way to the intestine. (wikipedia.org)
  • The bile flows through this duct, which travels through the pancreas, joins with the pancreatic duct , and enters the small intestine. (thehealthboard.com)
  • It is a form of protection against the reflux of the bile into the pancreas. (wikilectures.eu)
  • If bile enters the pancreas, severe damage to the pancreas would follow, i.e. acute pancreatic necrosis . (wikilectures.eu)
  • These make up the vast majority of all pancreatic cancers (around 90%) and come from the cells that line the ducts in the pancreas which carry digestive juices into the intestine. (apollohospitals.com)
  • This chapter presents an approach to the processing of surgical specimens of the gallbladder, extrahepatic biliary tract, and pancreas. (clinicalgate.com)
  • However, in a minority of individuals, the common bile duct and pancreatic duct remain separate when they pass through the pancreas and ampulla. (clinicalgate.com)
  • It is possible to violate the concentration( the ability to make bile more concentrated, which allows the liver to produce it uninterruptedly) and motor function of the gallbladder, a moderate change in liver function, exocrine function of the pancreas. (womensecr.com)
  • Violated the concentration and motor functions of the gallbladder, liver function and exocrine function of the pancreas. (womensecr.com)
  • The majority of strictures of the mid and lower common bile ducts, which are mainly caused by carcinoma of the head of the pancreas, can be drained effectively by the endoscopic approach.5 Many hilar biliary strictures are difficult to treat endoscopically, however, and are best dealt with interventional radiologic techniques.6 The indications for PTBD are summarized in Table 15.1. (kipdf.com)
  • Even when the catheter is advanced to the proximal common hepatic duct, contrast dye preferentially fills the cystic duct and gallbladder rather than allowing visualization of the intrahepatic ductal system (same patient as in previous image). (medscape.com)
  • Gallbladder carcinoma is 9 times more common than bile duct malignancy. (medscape.com)
  • Should the extrahepatic bile duct be resected or preserved in R0 radical surgery for advanced gallbladder carcinoma? (cancercentrum.se)
  • Indications for pancreatoduodenectomy in patients undergoing lymphadenectomy for advanced gallbladder carcinoma. (cancercentrum.se)
  • Factors influencing recurrence after surgical treatment for T2 gallbladder carcinoma. (cancercentrum.se)
  • Xanthogranulomatous cholecystitis (XGC) mimics Gallbladder carcinoma (GBC) in both preoperative and intra-operative settings and the patient may undergo an unnecessary radical cholecystectomy which is associated with a greater morbidityrather than a cholecystectomy alone.We postulated that a pre-operative diagnosis of XGC might benefit patients by avoiding radical procedures and attempted to identify the features of XGC which would differentiate it from GBC before and during surgery. (medicinelakex1.com)
  • 1] The ERCP was performed on 21 June 1999 by Dr J. The report concluded that Mrs K had a mildly dilated extra and intrahepatic biliary system, the cause of which was uncertain, and queried whether she had an obstructed cystic duct from a cystic duct stone obstruction or stone in the neck of the gall bladder. (hdc.org.nz)
  • When partially digested food passes from the stomach into the small intestine, the gall bladder expels bile to aid digestion. (targetwoman.com)
  • It defines a duct, or small tube within the liver, that through a biliary network, carries bile from the liver to the small intestine to aid in digestion. (thehealthboard.com)
  • The hepatic duct is responsible for carrying bile from the liver to the small intestine. (thehealthboard.com)
  • From the common bile duct, bile can either go directly into the small intestine, or may be temporarily stored in the gallbladder. (thehealthboard.com)
  • Typically, about half the bile travels to the small intestine and half travels to the gall bladder . (thehealthboard.com)
  • The bile and pancreatic enzymes that are released into the small intestine aid in the breakdown and digestion of the meal. (thehealthboard.com)
  • When a person consumes a meal, the bile released by the gall bladder travels through the pancreatic duct and enters the small intestine. (thehealthboard.com)
  • Most of the problems result from the failure of bile to reach the small intestine and help the digestive process. (thehealthboard.com)
  • This region includes the common bile duct and inserts into the small intestine. (tri-kobe.org)
  • Biliary atresia is a rare condition in newborn infants in which the common bile duct (that carry a liquid called bile from the liver to the gallbladder) between the liver and the small intestine is blocked or absent. (findmeacure.com)
  • Choledochal cysts, are rare congenital dilations (enlargements) of the bile ducts, a biliary tube that drains bile produced by the liver into small intestine for food digestion. (iswantosucandyliversurgery.com)
  • An abdominal ultrasound was performed, which showed gallstones in the gallbladder, whereas the diameter of the common bile duct (CBD) was normal (3.7 mm), suggest- ing the absence of obstruction and the presence of gall- stones in the CBD. (klinikitsekoura.gr)
  • 3D-printed biliary system Section across the portal canal of a pig (× 250) An intraoperative cholangiogram, which is an X-ray of bile ducts during a laparoscopic cholecystectomy Deep dissection of a bile duct, anterior view Self-expanding endoprosthesis Standring S, Borley NR, eds. (wikipedia.org)
  • We report on a case of left-sided gallbladder discovered incidentally during laparoscopic cholecystectomy, and we discuss the different forms of this anatomic anomaly and its surgical relevance. (klinikitsekoura.gr)
  • Bile flows from the centre of the liver lobule to the periphery (portobiliary space) where intrahepatic bile ductules ( canals of Hering ) are formed. (wikilectures.eu)
  • Proliferation of the small bile ductules occur, and peribiliary fibroblasts become activated. (findmeacure.com)
  • The biliary tree also includes the cystic duct, the right and left hepatic ducts, and the common hepatic and common bile ducts, as well as a series of microscopic biliary vessels. (cdc.gov)
  • The sphincter of Oddi, which surrounds both the pancreatic duct and the common bile duct, includes a sphincter for each duct. (merckmanuals.com)
  • Eating releases gut hormones and stimulates cholinergic nerves, causing the gallbladder to contract and the sphincter of Oddi to relax. (merckmanuals.com)
  • Conversely, during fasting, an increase in sphincter tone facilitates gallbladder filling. (merckmanuals.com)
  • A smooth muscle sphincter (of Oddi) is present around the common channel of the CBD and the main pancreatic duct and prevents reflux of duodenal juice into the 2 ducts. (medscape.com)
  • After eating, the m. sphincter ductus choledochi opens and releases bile while the m. sphincter ductus pancreatici remains contracted. (wikilectures.eu)
  • The function of the gallbladder is to provide a reservoir for the storage and concentration of bile. (cdc.gov)
  • ERCP image showing the pancreatic duct and biliary tree . (wikipedia.org)
  • Biliary-type pain, the typical clinical presentation, is due to the obstruction of the bile duct lumen. (medscape.com)
  • Bile duct cancer may occur more frequently in patients with a history of primary sclerosing cholangitis, chronic ulcerative colitis, choledochal cysts, or infections with the liver fluke Clonorchis sinensis . (tri-kobe.org)
  • 3] Although some authors consider it a subtype of II, subtype VIa has recently been proposed for isolated CD dilation, and VIb if there are other associated cysts, mainly of the main bile duct (MBD). (jiaps.com)
  • The resulting inflammatory folliculitis stimulates keratinization of the sebaceous gland ducts and outer root sheath of the hair, leading to the formation of keratin cysts. (cdc.gov)
  • Biliary disease is caused by abnormalities in bile composition, biliary anatomy, or function. (medscape.com)
  • Anatomy of the intrahepatic bile duct. (tri-kobe.org)
  • Cholangiography - radiographic examination of the bile duct is performed after injecting with a special dye to check the condition of Cholangitis - infection or inflammation of the bile ducts. (targetwoman.com)
  • In resource-limited countries, USG is always the first line screening tool for biliary duct abnormalities which in some cases is comprehensibly enough for the diagnosis of a rare entity like CC, thus requiring a highly specific imaging test like MRCP to be performed to devise an effective treatment and surgical plan. (org.pk)
  • An oval thin-walled cystic structure was also seen of about 20 mm × 9 mm with echogenic sludge within it, inferomedial to the GB, representing a significantly dilated cystic duct joining the proximal CBD, findings suspicious of CC Type IVA with involvement of the cystic duct (Type VI). (jiaps.com)
  • The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)
  • The use of iminodiacetic acid (IDA) radiopharmaceuticals has led to hepatic IDA or HIDA as a generic term for these studies. (radiologykey.com)
  • Finally, gallbladder hypomotility and bile stasis appear to promote gallstone formation and growth, which may be important in diabetes, pregnancy, oral contraceptive use in women, and prolonged fasting in critically ill patients on total parenteral nutrition. (medscape.com)
  • As the biliary tract cannot transport bile to the intestine, bile is retained in the liver (known as stasis) and results in cirrhosis of the liver. (findmeacure.com)
  • Increased progesterone levels cause smooth muscle relaxation, decreased gallbladder contraction, and subsequent bile stasis with formation of gallstones . (amboss.com)
  • Such injury can be prevented by routinely using X-ray investigation of the bile ducts (intraoperative cholangiography). (wikipedia.org)
  • 3) The intraoperative cholangiogram (IOC) and intrahepatic biliary radicals (IHB) procedures were advocated for all patients. (biomedcentral.com)