ReceptorsLTC4MediatorsReceptor antagonistCYSLTR1InducesIncluding mastAsthmaBiosynthesisArachidonic acidInflammatoryAsthmaticInflammationBronchialStimulationMucosaAirwayAllergicAllergyCellsReleaseResponseEffectsSourceSynthaseReceptor antagonistsCysLTsCysLT1HistamineAntagonistCysLTR2ReceptorsLTD4Gene polymorphismsNasalMontelukastInhibitorsGlutathioneProteinExpressionSynthesisPolymorphismsPathwayMastEotaxinMeasurementProstaglandinProductionEnzymeExperimentalChronicEntryHuman
Receptors5
- Other cysLT receptors include cysteinyl leukotriene receptor 2 (i.e. (wikipedia.org)
- The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D 4 (LTD 4 ) and prostaglandins (PGE 2 ) and their respective receptors. (lu.se)
- Our research focuses on proteins involved in inflammation, specifically the involvement of cysteinyl leukotriene receptors. (lu.se)
- She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)
- Here, we show that following stimulation of cysteinyl leukotriene type I receptors in rat basophilic leukemia (RBL)-1 cells, large amplitude Ca(2+) oscillations, CRAC channel activity, and downstream Ca(2+)-dependent nuclear factor of activated T cells (NFAT)-driven gene expression are all exclusively maintained by the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1. (ox.ac.uk)
LTC44
- This and other data suggest that GPR99 is an important receptor for the in vivo actions of LTE4 but not LTD4 or LTC4 The GPR17 receptor, also termed the uracil nucleotide/cysteinyl leukotriene receptor, was initially defined as a receptor for LTC4, LTD4, and uracil nucleotides. (wikipedia.org)
- Leukotriene C4 (LTC4) was assayed by enzyme immunoassay (EIA) and eosinophil cationic protein (ECP) by fluoroimmunoassay (FIA). (elsevierpure.com)
- We now report the synthesis of this molecule and the effects of PNRI-299 on the expression of Leukotriene C4 (LTC4) synthase, a crucial enzyme for the formation of the cysteinyl leukotrienes. (eurekaselect.com)
- The cysteinyl leukotrienes LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. (bertin-bioreagent.com)
Mediators3
- Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. (springer.com)
- Upon exposure to an initiating stimulus (an asthma inducer), these inflammatory cells release inflammatory mediators such as histamine, leukotrienes, prostaglandins, cytokines, chemokines, and platelet-activating factor. (respiratory-therapy.com)
- Neutrophils are one of the most common inflammatory mediators in tumors which secretes a large amount of leukotrienes. (lu.se)
Receptor antagonist1
- A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. (drugbank.com)
CYSLTR11
- Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes#Cysteinyl leukotrienes). (wikipedia.org)
Induces4
- 2008). Clinical imatinib mesylate treatment induces early normalisation of aberrant neutrophil leukotriene C4 synthase expression and activity in chronic myeloid leukaemia. (findmedarticle.com)
- Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. (uchicago.edu)
- Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. (uchicago.edu)
- Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2. (uchicago.edu)
Including mast1
- ECP is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes. (elsevierpure.com)
Asthma4
- Compelling evidence exists for the role of the cysteinyl leukotrienes in the pathophysiology of asthma 1,2,3,4 . (ispub.com)
- Background It has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (RSV) may share some pathogenic features with atopic asthma in that virus-specific IgE is produced and cysteinyl leukotrienes (cLTs) and eosinophil cationic protein (ECP) have been detected in airway secretions. (elsevierpure.com)
- Cysteinyl (cys) LTs C 4 , D 4 , and E 4 are long known to contribute to airway contractile responses via ligation of the cysLT1 receptor, and cysLT1 antagonists are beneficial in some patients with asthma. (springer.com)
- Higher concentrations of leukotriene B4 in EBC of asthmatic patients in comparison with healthy control subjects increase asthma severity in adults. (cmdm.tw)
Biosynthesis1
- Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. (findmedarticle.com)
Arachidonic acid1
- EPA is a substrate for the generation of less active prostanoids and leukotrienes than arachidonic acid, thereby potentially acting to reduce airway inflammation and bronchoconstriction 7 . (ispub.com)
Inflammatory1
- Chronic neutrophilic airway inflammation is a key symptom of cystic fibrosis (CF). Noninvasive inflammatory markers may be useful in monitoring CF. Leukotriene B4 (LTB4) is a noninvasive inflammatory biomarker that may be elevated in EBC levels of CF patients during exacerbation. (cmdm.tw)
Asthmatic1
- GC-MS can be used to accurately quantify and measured EBC of leukotrienes in asthmatic adults and children. (cmdm.tw)
Inflammation1
- Henderson WR Jr The role of leukotrienes in inflammation. (jamanetwork.com)
Bronchial1
- Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. (findmedarticle.com)
Stimulation1
- Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. (findmedarticle.com)
Mucosa1
- Volovitz BOsur SLBernstein JMOgra PL Leukotriene C4 release in upper respiratory mucosa during natural exposure to ragweed in ragweed-sensitive children. (jamanetwork.com)
Airway2
- Objective To test the association between eosinophil activation and cysteinyl leukotriene production in the upper airway secretions of infants with RSV positive (RSV+ve) bronchiolitis. (elsevierpure.com)
- Bisgaard HOlsson PBende M Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretions in humans. (jamanetwork.com)
Allergic2
- Naclerio RMBaroody FMTogias AG The role of leukotrienes in allergic rhinitis: a review. (jamanetwork.com)
- Okuda MWatase TMezawa ALiu CM The role of leukotriene D4 in allergic rhinitis. (jamanetwork.com)
Allergy1
- Haberal ICorey JP The role of leukotrienes in nasal allergy. (jamanetwork.com)
Cells1
- IgE molecules sensitize mast cells to release cysteinyl leukotrienes and PGD2. (knowyourasthma.com)
Release1
- Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. (jamanetwork.com)
Response1
- Similarly, the response to the inhaled corticosteroid decreased, whereas the response to the leukotriene antagonist remained stable. (ersjournals.com)
Effects2
- Cysteinyl leukotrienes (LTC(4), LTD(4), and LTE(4)) are a class of biologically active lipids that exert potent effects on the heart. (nih.gov)
- Assessment of in vivo 5-lipoxygenase activity by analysis of leukotriene B4 in saliva: effects of treatment with zileuton. (findmedarticle.com)
Source2
- Saliva is one likely source of leukotriene B4 in exhaled breath condensate. (findmedarticle.com)
- cysteinyl-tRNA synthetase 1 [Source:HG. (gsea-msigdb.org)
Synthase9
- Specific cellular immunocytochemical techniques were used to detect the cysteinyl leukotriene synthetic proteins, namely 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and leukotriene C4 synthase (LTC4S). (nih.gov)
- These SNPs are in arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP), leukotriene C4 synthase (LTC4S), cysteinyl leukotriene receptor 1 (CYSLTR1) and cysteinyl leukotriene receptor 2 (CYSLTR2) genes. (biomedcentral.com)
- Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. (cdc.gov)
- Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. (cdc.gov)
- Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. (cdc.gov)
- A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population. (cdc.gov)
- A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases. (cdc.gov)
- Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. (cdc.gov)
- Cysteinyl leukotrienes PD173955 (cysLTs) (LTC4 LTD4 and LTE4) get these reactions in addition to a MIF number of the chronic top features of AERD (7 8 CysLTs are based on arachidonic acidity metabolized by 5-lipoxygenase PD173955 (5-LO) to LTA4 conjugated to decreased glutathione by leukotriene C4 synthase (LTC4S) to LTC4 in mast cells (MCs) eosinophils basophils macrophages and granulocyte-platelet complexes (9). (morainetownshipdems.org)
Receptor antagonists6
- 21. Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. (nih.gov)
- 32. Pathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma. (nih.gov)
- 37. Leukotriene Receptor Antagonists Inhibit Mitogenic Activity in Triple Negative Breast Cancer Cells. (nih.gov)
- [2] Like other leukotriene receptor antagonists, zafirlukast is thought to be useful for the long-term treatment of asthma, but it is generally less effective than inhaled glucocorticoids as monotherapy (which are the standard of care) or long-acting beta-2 agonists in combination therapy. (mdwiki.org)
- As a general rule, leukotriene receptor antagonists like zafirlukast are more effective in children that are younger and whose asthma is less atopic . (mdwiki.org)
- 2. Shirasaki H , Himi T. Role of cysteinyl leukotriene receptor antagonists in the management of allergic rhinitis. (shirasaki-allergy.com)
CysLTs4
- Cysteinyl leukotrienes (cysLTs) are pro-inflammatory mediators with increasing evidence for a role in childhood acute asthma. (nih.gov)
- Cysteinyl leukotrienes (CysLTs) are bioactive lipids that have been shown to contribute to allergic and inflammatory diseases. (nih.gov)
- We examined the expression of the proteins involved in the synthesis of CysLTs and the cysteinyl leukotriene-1 (CysLT1) and cysteinyl leukotriene-2 (CysLT2) receptors in inflammatory cells from patients with active seasonal allergic rhinitis. (nih.gov)
- respiratory system disease (AERD) is normally a common serious variant of asthma that is connected with overproduction of cysteinyl leukotrienes (cysLTs) and respiratory system reactions to medications that block cyclooxygenase 1. (morainetownshipdems.org)
CysLT12
- Potent and selective antagonist of leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1. (medscape.com)
- 1. Shirasaki H . Cysteinyl leukotriene receptor CysLT1 as a novel therapeutic target for allergic rhinitis. (shirasaki-allergy.com)
Histamine2
- In the peripheral lung, the release of histamine and eicosanoids (leukotrienes and prostaglandins) from activated inflammatory cells, such as mast cells and macrophages, may contribute significantly to the symptoms of allergic rhinitis and asthma [ 5 - 8 ]. (biomedcentral.com)
- 8. Shirasaki H , Asakura K, Kojima T, Sohma S, Kataura A. The role of histamine, leukotriene C4 and bradykinin on nasal vascular permeability in experimental nasal allergy of guinea pigs. (shirasaki-allergy.com)
Antagonist7
- 33. Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema. (nih.gov)
- 39. The cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast suppresses matrix metalloproteinase-13 expression induced by lipopolysaccharide. (nih.gov)
- 2) Block of cysteinyl leukotriene type I receptors on resting mast cells with the clinically prescribed receptor antagonist montelukast prevented their activation by active mast cells. (ox.ac.uk)
- Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. (cdc.gov)
- [1] It is a leukotriene receptor antagonist (LTRA) and works by decreasing airway mucous, swelling, bronchoconstriction , and inflammation. (mdwiki.org)
- A study comparing the effectiveness of three treatments at the onset of respiratory symptoms (high-dose inhaled corticosteroid plus albuterol, leukotriene receptor antagonist plus albuterol, or albuterol alone) in increasing episode-free days among young children with recurrent severe wheezing . (nih.gov)
- 12. Shirasaki H , Asakura K, Narita S, Kataura A. The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. (shirasaki-allergy.com)
CysLTR21
- Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. (cdc.gov)
Receptors2
- Other cysLT receptors include cysteinyl leukotriene receptor 2 (i.e. (wikipedia.org)
- 3) RNAi knockdown of cysteinyl leukotriene type I receptors on resting cells prevented them from responding to the paracrine signal derived from activated mast cells. (ox.ac.uk)
LTD41
- This and other data suggest that GPR99 is an important receptor for the in vivo actions of LTE4 but not LTD4 or LTC4 The GPR17 receptor, also termed the uracil nucleotide/cysteinyl leukotriene receptor, was initially defined as a receptor for LTC4, LTD4, and uracil nucleotides. (wikipedia.org)
Gene polymorphisms1
- Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. (cdc.gov)
Nasal1
- 1. If study medicines improve markers of airway inflammation (cysteinyl-leukotrienes in nasal washings) during acute episodes of RTI. (nih.gov)
Montelukast1
Inhibitors1
- Inhibitors of NO synthases have been shown to enhance antigen-induced bronchoconstriction in sensitized guinea pigs by increased generation of leukotrienes [ 14 ]. (biomedcentral.com)
Glutathione2
- Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (bvsalud.org)
- Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. (nih.gov)
Protein2
- The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. (nih.gov)
- This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. (nih.gov)
Expression1
- In conclusion i) microglia are key in Leukotriene (LT) biosynthesis, and ii) they regulate neuronal 5-Lipoxygenase (5-Lox) expression implying a yet unknown signaling mechanism between neurons and microglia. (nih.gov)
Synthesis1
- Here, we identified the Leukotriene (LT) synthesis rate-limiting enzyme 5-Lipoxygenase (5-Lox) primarily in neurons and to a lesser extent in a subpopulation of microglia in human Alzheimer´s Disease (AD) hippocampus brain sections and in brains of APP Swedish PS1 dE9 (APPPS1) mice, a transgenic model for Alzheimer´s Disease (AD) pathology. (nih.gov)
Polymorphisms3
- This study examined the influence of polymorphisms in cysLT pathway genes on urinary leukotriene E(4) (uLTE(4)) levels and clinical status in acute asthmatic children. (nih.gov)
- The goal of this study was to evaluate the effect of single nucleotide polymorphisms (SNP) on CRS in a panel of genes related to cysteinyl leukotriene metabolism. (biomedcentral.com)
- While these initial results do not support that polymorphsims in genes assessed involved in the leukotriene pathways are contributing to the pathogenesis of CRS, this initial study was not powered to detect polymorphisms with relative risk of 2.0 or less, where we could expect many gene effects for complex diseases to occur. (biomedcentral.com)
Pathway1
- To define the contribution of microglia in the Leukotriene (LT) biosynthesis pathway, we ablated microglia using the colony stimulating factor 1 receptor (CSF1R) inhibitor PLX5622 in wildtype (WT) and APP-PS1 mice. (nih.gov)
Mast5
- The paracrine signal was identified as a cysteinyl leukotriene because 1) RNAi knockdown or pharmacological block of the 5-lipoxygenase enzyme prevented activated mast cells from stimulating resting cells. (ox.ac.uk)
- Leukotriene secretion still occurred tens of minutes after stimulation, suggesting a role as a long-lasting trigger in mast cell activation. (ox.ac.uk)
- Acutely isolated mast cells from patients with allergic rhinitis exhibited store-operated Ca(2+) influx through CRAC channels and responded to cysteinyl leukotrienes. (ox.ac.uk)
- Histological analysis of samples taken from patients revealed clustering of mast cells, often located within 20 microm of each other, a distance sufficient for paracrine signaling by leukotrienes to operate effectively. (ox.ac.uk)
- We conclude that a positive-feedback cascade involving CRAC channels and cysteinyl leukotrienes constitute a novel mechanism for sustaining mast cell activation. (ox.ac.uk)
Eotaxin1
- 36. Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. (nih.gov)
Measurement1
- Description: A competitive ELISA for quantitative measurement of Mouse Leukotriene A4 Hydrolase (LTA4H) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (thescientistconnect.com)
Prostaglandin2
- The data suggest that silica causes an increased release of leukotriene B4, leukotrienes C4/D4/E4, and 5-hydroxyeicosatetraenoic acid (5-HETE) after 3 hr and decreases in prostaglandin E2 and thromboxane B2 production after 24 hr of exposure to 100 micrograms/mL silica. (nih.gov)
- The anti-allergic properties of EBT were evaluated by measuring β-Hex release and the production of prostaglandin D 2 (PGD 2 ) and leukotriene C 4 (LTC 4 ) on BMMC in vitro and PCA and OVA-induced AR models in vivo . (biomedcentral.com)
Production2
- This resulted in further cysteinyl leukotriene production, triggering a positive feedback cascade. (ox.ac.uk)
- When rat lungs were challenged in vivo with calcium-ionophore, Fiboflapon (AM803) inhibited LTB4 and cysteinyl leukotriene (CysLT) production with ED 50 s of 0.12 mg/kg and 0.37 mg/kg, respectively. (medchemexpress.com)
Enzyme2
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Leukotriene A4 Hydrolase (LTA4H) in serum, plasma, tissue homogenates and other biological fluids. (thescientistconnect.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Leukotriene A4 Hydrolase (LTA4H) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (thescientistconnect.com)
Experimental1
- 38. Role of cysteinyl leukotrienes in nociceptive and inflammatory conditions in experimental animals. (nih.gov)
Chronic1
- Leukotrienes (LTs) contribute to the neuropathology of chronic neurodegenerative disorders including Alzheimer's Disease (AD), where they mediate neuroinflammation and neuronal cell-death. (nih.gov)
Entry1
- Stimulation of the cysteinyl leukotriene receptor activated CRAC channels and evoked prominent store-operated Ca(2+) entry. (ox.ac.uk)
Human1
- 24. Shirasaki H , Seki N, Fujita M, Kikuchi M, Kanaizumi E, Watanabe K, Himi T. Agonist- and Th2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. (shirasaki-allergy.com)