• calcineurin
  • The resulting ciclosporin/cyclophilin complex inhibits the phosphatase activity of calcineurin which in turn is required for the activation of transcription factors that up regulate the expression of inflammatory cytokines. (wikipedia.org)
  • This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. (wikipedia.org)
  • Drugs
  • Cyclosporine can interact with several drugs. (verywell.com)
  • Trichodysplasia spinulosa (also known by many other names, including viral-associated trichodysplasia spinulosa, viral-associated trichodysplasia, pilomatrix dysplasia and ciclosporin-induced folliculodystrophy, although the last is a misnomer) is a rare cutaneous condition that has been described almost exclusively in immunocompromised patients, usually organ transplant recipients, on regimens of immunosuppressive drugs. (wikipedia.org)
  • psoriasis
  • You should not be treated with PUVA, UVB, or medications that suppress the immune system while you are taking cyclosporine (modified) to treat psoriasis. (empowher.com)
  • You should not use cyclosporin if you are receiving other treatment for psoriasis, including PUVA or UVB therapy, coal tar, or radiation treatment. (umm.edu)
  • In 2009, Dr. Debeeka Hazarika, president of the North East States branch of the Indian Association of Dermatologists, Venereologists and Leprologists (IADVL), published an article titled "Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine" in Indian J Dermatol Venereol Leprol. (wikipedia.org)
  • dose
  • Subsequent trials using lower doses of cyclosporine showed that these problems were dose related, although there was considerable variability in the incidence of AKI in various centers. (uptodate.com)
  • Experimental support for this hypothesis is derived from a study examining the effect of raising the cyclosporine dose in eight pairs of stable, unrelated renal transplant recipients who had received a cadaver kidney from the same donor [ 12 ]. (uptodate.com)
  • systemic
  • citation needed] First-line therapy for disseminated or localized instances of pyoderma gangrenosum is systemic treatment by corticosteroids and ciclosporin. (wikipedia.org)
  • renal
  • Studies have demonstrated that cyclosporine causes vasoconstriction of the afferent and efferent glomerular arterioles [ 7 ] and reductions in renal blood flow and glomerular filtration rate (GFR). (uptodate.com)
  • There may also be an intrinsic renal susceptibility to cyclosporine-induced renal vasoconstriction. (uptodate.com)
  • The use of cyclosporin A (CyA) with a protocol designed to avoid the effects of nephrotoxicity resulted in a one-year survival of 86% in recipients of renal allografts from unmatched cadaveric donors. (bmj.com)
  • Use of ciclosporin in post renal transplantation is associated with hyperuricemia and, in some cases, gout. (wikipedia.org)
  • acute
  • citation needed] Ciclosporin has also been used to help treat people with acute severe ulcerative colitis and autoimmune urticaria that do not respond to treatment with steroids. (wikipedia.org)
  • transplantation
  • 5 These individuals had been doing well after transplantation while taking standard immunosuppressive therapy that included cyclosporine. (portsmouthhospital.com)
  • The BENEFIT (Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression Trial) study compared the efficacy and safety of three regimens, an intensive belatacept-based regimen, a less intensive belatacept-based regimen, and a cyclosporine-based regimen taken for 7 years following kidney transplantation. (medindia.net)
  • clinical
  • Available as Nulojix, it appears to several benefits over cyclosporine, as demonstrated by a 7-year clinical trial recently published in the New England Journal of Medicine . (medindia.net)
  • Unfortunately, the apparent success of aerosolized ciclosporin in animal studies and these early clinical studies was not duplicated in a subsequent randomized, placebo-controlled trial of aerosolized ciclosporin that was published in the New England Journal of Medicine. (wikipedia.org)
  • prevent
  • The surprising finding that aerosolized ciclosporin may prevent or delay development of this insidious condition has led to renewed interest with aerosolized ciclosporin formulations and one early stage trial involving a dry powder inhaler is recruiting while another phase III trial involving nebulized ciclosporin in propylene glycol is underway. (wikipedia.org)