• calcineurin
  • The resulting ciclosporin/cyclophilin complex inhibits the phosphatase activity of calcineurin which in turn is required for the activation of transcription factors that up regulate the expression of inflammatory cytokines. (wikipedia.org)
  • This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. (wikipedia.org)
  • psoriasis
  • You should not be treated with PUVA, UVB, or medications that suppress the immune system while you are taking cyclosporine (modified) to treat psoriasis. (empowher.com)
  • You should not use cyclosporin if you are receiving other treatment for psoriasis, including PUVA or UVB therapy, coal tar, or radiation treatment. (umm.edu)
  • In 2009, Dr. Debeeka Hazarika, president of the North East States branch of the Indian Association of Dermatologists, Venereologists and Leprologists (IADVL), published an article titled "Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine" in Indian J Dermatol Venereol Leprol. (wikipedia.org)
  • dose
  • Subsequent trials using lower doses of cyclosporine showed that these problems were dose related, although there was considerable variability in the incidence of AKI in various centers. (uptodate.com)
  • Experimental support for this hypothesis is derived from a study examining the effect of raising the cyclosporine dose in eight pairs of stable, unrelated renal transplant recipients who had received a cadaver kidney from the same donor [ 12 ]. (uptodate.com)
  • systemic
  • In addition to these indications, ciclosporin is also used in severe atopic dermatitis , Kimura disease , pyoderma gangrenosum , chronic hives , acute systemic mastocytosis , and posterior or intermediate uveitis with noninfective cause. (wikipedia.org)
  • citation needed] First-line therapy for disseminated or localized instances of pyoderma gangrenosum is systemic treatment by corticosteroids and ciclosporin. (wikipedia.org)
  • organ
  • Cyclosporine is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). (mayoclinic.org)
  • Cyclosporine works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ. (mayoclinic.org)
  • renal
  • Use of ciclosporin in post renal transplantation is associated with hyperuricemia and, in some cases, gout. (wikipedia.org)
  • Studies have demonstrated that cyclosporine causes vasoconstriction of the afferent and efferent glomerular arterioles [ 7 ] and reductions in renal blood flow and glomerular filtration rate (GFR). (uptodate.com)
  • There may also be an intrinsic renal susceptibility to cyclosporine-induced renal vasoconstriction. (uptodate.com)
  • Cyclosporine before Coronary Artery Bypass Grafting Does Not Prevent Postoperative Decreases in Renal Function: A Randomized Clinical Trial. (bioportfolio.com)
  • citation needed
  • citation needed] Ciclosporin has also been used to help treat people with acute severe ulcerative colitis and autoimmune urticaria that do not respond to treatment with steroids. (wikipedia.org)
  • severe
  • Ciclosporin has also been used in people with acute severe ulcerative colitis and hives that do not respond to treatment with steroids . (wikipedia.org)
  • prevent
  • The surprising finding that aerosolized ciclosporin may prevent or delay development of this insidious condition has led to renewed interest with aerosolized ciclosporin formulations and one early stage trial involving a dry powder inhaler is recruiting while another phase III trial involving nebulized ciclosporin in propylene glycol is underway. (wikipedia.org)