• toxicity
  • The purpose of this study is to determine the plasma concentration and exposure time required for cyclophosphamide to produce optimal immunosuppressive activity with minimal toxicity in participants with severe systemic sclerosis. (clinicaltrials.gov)
  • chemotherapy
  • Cyclophosphamide ( CP ), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system . (wikipedia.org)
  • The main use of cyclophosphamide is with other chemotherapy agents in the treatment of lymphomas , some forms of brain cancer , neuroblastoma , leukemia and some solid tumors. (wikipedia.org)
  • Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair and lethargy. (wikipedia.org)
  • Disease
  • In children whose disease fails to respond adequately to appropriate adrenocorticosteroid therapy or in whom the adrenocorticosteroid therapy produces or threatens to produce intolerable side effects, cyclophosphamide may induce a remission. (nih.gov)
  • Cyclophosphamide is not indicated for the nephrotic syndrome in adults or for any other renal disease. (nih.gov)
  • Case presentation: Pres in the setting of goodpasture disease treated with cyclophosphamide. (springer.com)
  • therapy
  • No prior therapy with cyclophosphamide or anthracyclines. (knowcancer.com)
  • Recommended first line therapy often includes: cyclophosphamide alternating with a corticosteroid. (wikipedia.org)
  • Chlorambucil Cyclosporine Tacrolimus Cyclophosphamide Mycophenolate mofetil Rituximab Perhaps the most difficult aspect of membranous glomerulonephritis is deciding which people to treat with immunosuppressive therapy as opposed to simple "background" or anti-proteinuric therapies. (wikipedia.org)