• selectivity
  • Structure activity relationship (SAR) studies for diaryl heterocyclic compounds have indicated that a cis-stilbene moiety and changes in the para-position of one of the aryl rings play an important role in COX-2 selectivity. (wikipedia.org)
  • therapeutic
  • Some studies have demonstrated that gestational age, birth weight, B-type natriuretic peptide (BNP), and ductal diameter can predict the therapeutic responsiveness to COX inhibitors. (springer.com)
  • potent
  • The researchers were able to achieve similar heart-stopping results in rat cardiac cells, whereas aspirin, another potent COX-2 inhibitor, had no effect, confirming that another mechanism is at work. (newsinferno.com)
  • clinical
  • However, as observed in clinical practice, not all PDAs in preterm infants can be closed using COX inhibitors. (springer.com)
  • After several COX-2 inhibiting drugs were approved for marketing, data from clinical trials revealed that COX-2 inhibitors caused a significant increase in heart attacks and strokes, with some drugs in the class having worse risks than others. (wikipedia.org)
  • Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer. (wikipedia.org)
  • vascular events
  • A 2006 review of 138 randomized trials and almost 150,000 participants revealed selective COX-2 inhibitors were associated with a moderately increased risk of vascular events, mainly due to a twofold-increased risk of myocardial infarction. (newsinferno.com)
  • effects
  • To study the effects of COX-2 on PanIN progression, Dr. Eibl and colleagues focused on the KrasG12D mouse, an animal model that mimics the early stages of pancreatic cancer. (innovations-report.com)
  • In the future, Dr. Eibl and others plan to study the long-term effects of nimesulide and additional COX-2 inhibitors on the onset and progression of pancreatic cancer. (innovations-report.com)
  • Singh and colleagues point out that since these arrhythmia effects bypass COX-2, it is unclear if other COX-2 inhibitors would yield similar results. (newsinferno.com)
  • They also stress it is too early to speculate on human effects, although their results suggest Drosophilaâ€"one of the most valuable of organisms in biological research and has been used as a model research organism for almost a centuryâ€"are a valuable tool to investigate other COX-2 drugs. (newsinferno.com)
  • The inhibitors of the target effects of thromboxane are the thromboxane receptor antagonist, including terutroban. (wikipedia.org)
  • novel
  • In 1991, during the investigation of the expression of early-response genes in fibroblasts transformed with Rous sarcoma virus, a novel mRNA transcript that was similar, but not identical, to the seminal COX enzyme was identified. (wikipedia.org)
  • Another group discovered a novel cDNA species encoding a protein with similar structure to COX-1 while studying phorbol-ester-induced genes in Swiss 3T3 cells. (wikipedia.org)
  • The same laboratory showed that this gene truly expressed a novel COX enzyme. (wikipedia.org)
  • pathways
  • COX-2 inhibitors have been found to be effective in suppressing inflammatory neurodegenerative pathways in mental illness, with beneficial results in trials for major depressive disorder as well as schizophrenia . (wikipedia.org)
  • studies
  • This GMI PUB document will greatly reduce your research time due to the Cumulative Knowledge feature, and contains a condensed form of the studies that we have accumulated on Cyclooxygenase Inhibitors. (greenmedinfo.com)
  • The National Cancer Institute has done some studies on COX-2 and cancer. (wikipedia.org)
  • Studies of breast, colon, and pancreatic cancers have led researchers to believe COX-2 plays a key role in the development and growth of tumors. (innovations-report.com)
  • However, with additional studies, we may find COX-2 inhibitors could help prevent pancreatic cancer in high risk populations. (innovations-report.com)
  • Previous studies in models of Type I diabetes have suggested that COX-2 may contribute to diabetic nephropathy. (innovations-report.com)