AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
Arachidonate 12-LipoxygenaseLipoxygenaseArachidonate 5-LipoxygenaseLipoxygenase InhibitorsArachidonate 15-LipoxygenaseArachidonate LipoxygenasesLeukocytes12-Hydroxy-5,8,10,14-eicosatetraenoic AcidMasoprocolArachidonic AcidArachidonic AcidsLeukotrienes5-Lipoxygenase-Activating ProteinsHydroxyeicosatetraenoic AcidsLeukotriene B4Cyclooxygenase Inhibitors4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineCyclooxygenase 2Cyclooxygenase 1Prostaglandin-Endoperoxide Synthases5,8,11,14-Eicosatetraynoic AcidIndomethacinSRS-AEicosanoidsLeukotriene A4CalcimycinLinoleic AcidsCyclooxygenase 2 InhibitorsDinoprostonePhospholipases AThromboxane B2Linoleic AcidProstaglandinsLipid PeroxidesPhospholipases A2Chromatography, High Pressure LiquidNeutrophilsQuinacrineLinolenic AcidsReceptors, LeukotrieneAutacoidsBlood PlateletsFlavanonesLeukotriene E4Fatty Acids, UnsaturatedCatechols8,11,14-Eicosatrienoic AcidProstaglandins EPyrazolonesLeukotriene C4LipoxinsEpoxide HydrolasesCells, CulturedLeukotriene D4UmbelliferonesIsoenzymesZymosanGas Chromatography-Mass SpectrometryPyrazolesLeukocyte RollingPlatelet Activating FactorKineticsRabbitsRNA, MessengerFactor XII DeficiencyMembrane ProteinsSolanum tuberosumEicosanoic AcidsAnti-Inflammatory Agents, Non-SteroidalSoybeansEpoprostenolDose-Response Relationship, DrugOxidation-ReductionEnzyme ActivationIbuprofenMacrophagesLeukotriene AntagonistsEnzyme InhibitorsThromboxanesDocosahexaenoic AcidsAspirinIntramolecular OxidoreductasesLeukocyte CountChemotaxis, LeukocyteHydroxyureaFatty AcidsSpectrophotometry, UltravioletCaffeic AcidsPhospholipidsCalciumSignal TransductionRats, Inbred Strains6-Ketoprostaglandin F1 alphaSulfonamidesThromboxane-A SynthasePhospholipasesMolecular Sequence DataThromboxane A2PeroxidesCarbon Radioisotopes
ProstaglandinsBiosynthesisAcidActivityHuman
Prostaglandins1
  • Structures of the first six prostaglandins (PGs) were established by 1962, before their individual biosynthetic pathways were studied. (jci.org)
Biosynthesis1
  • The Δ4-desaturation pathway for DHA biosynthesis is operative in the human species: differences between normal controls and children with the Zellweger syndrome. (springer.com)
Acid5
  • see 15-Hydroxyeicosatetraenoic acid). (wikipedia.org)
  • The function of ALOX12 is further clouded by human ALOX15 which metabolizes arachidonic acid primarily to 15(S)-HpETE but also makes lesser but still significant amounts of 12(S)-HpETE (see ALOX15). (wikipedia.org)
  • ALOX12 is also distinguished from arachidonate 12-lipoxygenase, 12R type (ALOX12B), which metabolizes arachidonic acid to the R stereoisomer of 12(S)-HpETE viz. (wikipedia.org)
  • 12(R)-hydroperoxy-5Z,8Z,10E,14Z-icosatetraenoic acid (12(R)-HpETE), a product with very different pathophysiological roles than that of 12(S)-HpETE (see ALOX12B). (wikipedia.org)
  • Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and resveratrol, which are both radical scavengers and cyclooxygenase inhibitors exhibiting anticancer activity. (nature.com)
Activity2
  • this activity was the first mammalian lipoxygenase activity to be characterized. (wikipedia.org)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Human3
  • human ALOX15B makes 15(S)-HpETE but not 12(S)-HpETE and therefore is not regarded as a 12/15-lipoxygenase. (wikipedia.org)
  • Based predominantly on the presence of its mRNA, human ALOX12 is distributed predominantly in blood platelets and leukocytes and at lower levels in the basal layer of the epidermis (particularly in the skin lesions of psoriasis), islets of Langerhans within the pancreas, and certain cancers. (wikipedia.org)
  • it also promotes the malignant behavior of cultured human cancer cells as well as the growth of certain cancers in animal models (see 12-HETE). (wikipedia.org)