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  • Roles
  • For example, the widespread use of the newer generation of COX-2-selective compounds demonstrated that COX-2 also has other physiological roles, e.g. in the maintenance of fluid balance by the kidneys. (wikipedia.org)
  • NSAIDs
  • It is thought that inhibiting COX-2 leads to the anti-inflammatory, analgesic and antipyretic effects, whereas those NSAIDs also inhibiting COX-1, particularly aspirin, may cause gastrointestinal bleeding and ulcers in large doses. (wikipedia.org)
  • Even though COX-2 inhibitors are as active as traditional NSAIDs in inflammatory models, there were still some unexplained issues. (wikipedia.org)
  • COX-3 was actually discovered in 2002, and been found to be selectively inhibited by paracetamol, phenacetin, antipyrine, dipyrone, and some NSAIDs in rodent studies. (wikipedia.org)
  • A number of arguments counted against the COX-3 hypothesis: COX-2-selective inhibitors react weakly with the COX-3 enzymatic site, because the site is identical to that in COX-1, but they are as good at reducing fever as older NSAIDs. (wikipedia.org)
  • All these considerations appeared to argue against COX-3 being the site of the antipyretic actions of NSAIDs and COX-2-selective agents. (wikipedia.org)
  • However, the results could be read as showing that paracetamol acts at a different site than the other NSAIDs and that more than one COX isoform contribute to the fever response. (wikipedia.org)
  • tissues
  • The results revealed a significantly reduced expression of PLA2G4A in gastric tumors compared to in non-cancerous tissues, as opposite to the increased expression of COX-2. (springer.com)
  • protein
  • Finally, the sites of COX-3 expression do not appear to fit in well with those sites associated with fever, and the protein should be present within the hypothalamus rather than the cerebral cortex. (wikipedia.org)
  • cells
  • Interestingly, activation of EP4 receptors reduced the expression of different cytokines, COX-2 and iNOS in BV-2 and primary mouse microglial cells [ 20 ]. (hindawi.com)
  • expression
  • For example, PGE 2 and EP agonists inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) generation [ 17 ] and enhanced the expression of cyclooxygenase (COX)-2 induced by lypopolysaccharide (LPS) in cultured microglia [ 18 ]. (hindawi.com)
  • In this study, the mRNA expression of PLA2G4A and COX-2 in 60 pairs of fresh gastric tumors and corresponding adjacent non-cancerous mucosa was detected by using real-time quantitative PCR and the immunostaining of the both proteins in paired samples from 866 gastric cancer patients were assessed by using immunohistochemistry method. (springer.com)
  • The clinicopathological and the prognostic relevance of PLA2G4A and COX-2 expression were determined. (springer.com)
  • Moreover, the reduced PLA2G4A and increased COX-2 expression was both associated with unfavorable survival for patients with gastric cancer. (springer.com)
  • pain
  • It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body. (wikipedia.org)
  • traditional
  • If a COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time. (wikipedia.org)