• mechanism
  • This mechanism is due to the fact that the spliced intron has 93 bases in dogs, resulting in the loss of 93:3 = 31 amino acids in the COX-3 sequence, which apparently does not impair its functionality. (wikipedia.org)
  • cells
  • This prostaglandin modulates the expression of inflammatory mediators by microglial cells. (hindawi.com)
  • Interestingly, activation of EP4 receptors reduced the expression of different cytokines, COX-2 and iNOS in BV-2 and primary mouse microglial cells [ 20 ]. (hindawi.com)
  • expression
  • For example, PGE 2 and EP agonists inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) generation [ 17 ] and enhanced the expression of cyclooxygenase (COX)-2 induced by lypopolysaccharide (LPS) in cultured microglia [ 18 ]. (hindawi.com)
  • pain
  • It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body. (wikipedia.org)
  • traditional
  • If a COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time. (wikipedia.org)