• pathways
  • Moreover, we found that taurine enhanced K(V) channels via intracellular protein kinase C-mediated pathways. (biomedsearch.com)
  • Although AKAPs have been identified on the basis of their interaction with PKA, they also bind other signaling molecules, mainly phosphatases and kinases, that regulate AKAP targeting and activate other signal transduction pathways.We suggest that AKAP forms a "transduceosome" by acting as an autonomous multivalent scaffold that assembles and integrates signals derived from multiple pathways. (embl-heidelberg.de)
  • Stathmin is a ubiquitous phosphorylated protein which makes it act as an intracellular relay for diverse regulatory pathways, functioning through a variety of second messengers. (wikipedia.org)
  • First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over forty different proteins in a variety of different pathways. (wikipedia.org)
  • 2002
  • Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC (2002) Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. (springer.com)
  • calcium
  • When activated by the second messengers such as cAMP and calcium ions, enzymes such as PKA and MAP kinase can translocate to the nucleus and phosphorylate CREB to initiate transcription of target genes. (wikipedia.org)
  • Inhibition
  • Inhibition of GSK-3β either by small molecules (SB216763 or SB415286) or by ectopic expression of kinase-inactive GSK-3β before irradiation significantly attenuated radiation-induced apoptosis in hippocampal neurons. (aacrjournals.org)
  • Tubulin-dependent suppression of ΔΨ m is further potentiated by protein kinase A activation and glycogen synthase kinase-3β inhibition. (aspetjournals.org)
  • OBJECTIVE: The role of diacylglycerol in the phosphatidylinositol-signaling pathway is to activate protein kinase C. In the myometrium, protein kinase C activation leads to inhibition of phasic contractions. (biomedsearch.com)
  • RESULTS: In myometrium from nonpregnant animals, inhibition of diacylglycerol lipase with RHC80267 had little effect on oxytocin-stimulated contractile activity, whereas inhibition of diacylglycerol kinase with R59022, although producing an increase in contractile frequency, markedly suppressed total oxytocin-stimulated contractile activity. (biomedsearch.com)
  • CONCLUSIONS: These studies have demonstrated that prevention of diacylglycerol degradation, especially in response to inhibition of myometrial diacylglycerol kinase, results in the paradoxic oxytocin-mediated suppression of total myometrial contractile activity. (biomedsearch.com)
  • These observations support the hypothesis that, when its catabolism is prevented, diacylglycerol produced in response to stimulation of the phosphatidylinositol-signaling pathway by oxytocin becomes available for protein kinase C activation, resulting in inhibition of myometrial contractile activity. (biomedsearch.com)
  • pathway
  • The Wnt proteins are palmitoylated secreted glycoproteins that activate the Wnt signaling pathway. (aacrjournals.org)
  • Frizzled receptors, G protein-coupled receptors, are the major proteins that bind to Wnt proteins on the plasma membrane and trigger Wnt pathway signaling, which leads to activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription. (aacrjournals.org)
  • The Wnt signaling pathway is partly regulated by Wnt antagonists, including members of the Dickkopf and secreted Frizzled-related protein (sFRP) families, and Wnt inhibitory factor 1 ( 6 , 7 ). (aacrjournals.org)
  • sFRPs are modulators of the Wnt signaling pathway, interact with Wnt proteins, and prevent Frizzled receptors from binding to Wnt proteins, thereby downregulating Wnt signaling ( 8 ). (aacrjournals.org)
  • These proteins, ropporin (a protein previously shown to interact with the Rho signaling pathway) and AKAP-associated sperm protein, are 39% identical to each other and share a strong sequence similarity with the conserved domain on the N terminus of RII that is involved in dimerization and AKAP binding. (embl-heidelberg.de)
  • These studies are designed to determine why stimulation of the phosphatidylinositol-signaling pathway caused by oxytocin does not cause a paradoxical suppression of contractions through diacylglycerol production and protein kinase C activation. (biomedsearch.com)
  • The signaling pathway of merlin is proposed to include several salient cell growth controlling molecules, including eIF3c, CD44, protein kinase A, and p21 activated kinases. (wikipedia.org)
  • intracellular
  • Central to its antidiuretic action in mammals is the redistribution of the water channel aquaporin 2 ( AQP2 ) from intracellular vesicles to the apical membrane of kidney epithelial cells , an event initiated by an increase in cAMP and activation of protein kinase A . The subsequent steps of the signaling cascade are not known. (ndif.org)
  • isoforms
  • The high '2-Kase' activity of PFKFB3 is also due to the lack of a specific Ser that is phosphorylated in the other PFKFB isoforms to decrease kinase activity. (wikipedia.org)
  • vitro
  • Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments. (springer.com)
  • In vitro contraction studies were performed with cumulative additions of oxytocin (8-64 nmol/L) with and without R59022 (a diacylglycerol kinase inhibitor) or RHC80267 (a diacylglycerol lipase inhibitor). (biomedsearch.com)
  • neuronal
  • Here, we report that cannabidiol inhibits hyperphosphorylation of tau protein in Aβ-stimulated PC12 neuronal cells, which is one of the most representative hallmarks in AD. (springer.com)
  • Here we show that glycogen synthase kinase 3β (GSK-3β) is required for radiation-induced hippocampal neuronal apoptosis and subsequent neurocognitive decline. (aacrjournals.org)
  • At the neuronal level, cells with higher levels of excitability (for example lower slow afterhyperpolarization) are more likely to be recruited into a memory trace, and substantial evidence exists implicating the cellular transcription factor CREB (cyclic AMP responsive element-binding protein) in this process. (wikipedia.org)
  • putative
  • The sFRPs are a family of soluble glycoproteins, which contain cysteine-rich domains homologous to the putative Wnt-binding sites of Frizzled proteins. (aacrjournals.org)
  • binds
  • When AVP binds with V2R , via the G-protein , it stimulates the enzyme , adenylyl cyclase (AdC). (ndif.org)
  • test the hypothesis
  • Here we test the hypothesis that the axoneme contains an A-kinase anchoring protein (AKAP). (embl-heidelberg.de)
  • Specifically, these studies were performed to test the hypothesis that diacylglycerol catabolism is significant in myometrial tissue, thereby precluding its availability for the activation of protein kinase C. STUDY DESIGN: For these studies, uterine tissue was obtained from Sprague-Dawley rats both nonpregnant and with timed gestations. (biomedsearch.com)
  • genes
  • PKA inhibitors can block the development of long-lasting LTP, and this is accompanied by a reduction in the transcription of genes modulated by the CREB protein. (wikipedia.org)
  • This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed. (wikipedia.org)
  • cellular
  • The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. (wikipedia.org)
  • Metabolism
  • Mitochondrial metabolism requires inward and outward flux of hydrophilic metabolites, including ATP, ADP and respiratory substrates, through voltage-dependent anion channels (VDACs) in the mitochondrial outer membrane. (aspetjournals.org)