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  • 2002
  • Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC (2002) Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway. (springer.com)
  • isoform
  • The isoform of protein kinase C (PKC ) has emerged as a critical second messenger in sensitization toward mechanical stimulation in models of neuropathic (diabetes, alcoholism, and cancer therapy) as well as acute and chronic inflammatory pain. (semanticscholar.org)
  • The inducible protein isoform, iPFK2, is named as such because its expression has been shown to be induced by hypoxic conditions. (wikipedia.org)
  • genes
  • When activated by the second messengers such as cAMP and calcium ions, enzymes such as PKA and MAP kinase can translocate to the nucleus and phosphorylate CREB to initiate transcription of target genes. (wikipedia.org)
  • PKA inhibitors can block the development of long-lasting LTP, and this is accompanied by a reduction in the transcription of genes modulated by the CREB protein. (wikipedia.org)
  • molecules
  • Unfortunately, the lack of an evident druggability of this protein, since it has no defined binding or active sites, makes the quest for VDAC interacting molecules a difficult tale. (frontiersin.org)
  • VDACs are the most abundant pore-forming proteins of the MOM and, differently from other structurally similar proteins such as Tom40 or Sam50, they serve as unspecific channels allowing the exchanges of molecules up to a molecular weight of 1,500 Da. (frontiersin.org)
  • Beyond the metabolic functions, the peculiar position of VDACs, at the interface between cytosol and mitochondria, makes porins the mitochondrial docking site for several cytosolic proteins, including molecules involved in the regulation of cell life and death. (frontiersin.org)
  • receptors
  • Frizzled receptors, G protein-coupled receptors, are the major proteins that bind to Wnt proteins on the plasma membrane and trigger Wnt pathway signaling, which leads to activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription. (aacrjournals.org)
  • vitro
  • The in vivo effect of indomethacin was confirmed by in vitro experiments with small intestine and heart protein kinases. (docphin.com)
  • C ) GST-Drp1 GED (aa 643-755) fusion proteins were phosphorylated in vitro with PKA and [γ‐ 32 P]ATP. (embopress.org)
  • Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments. (springer.com)
  • neuronal
  • Here, we report that cannabidiol inhibits hyperphosphorylation of tau protein in Aβ-stimulated PC12 neuronal cells, which is one of the most representative hallmarks in AD. (springer.com)
  • Here we show that glycogen synthase kinase 3β (GSK-3β) is required for radiation-induced hippocampal neuronal apoptosis and subsequent neurocognitive decline. (aacrjournals.org)
  • At the neuronal level, cells with higher levels of excitability (for example lower slow afterhyperpolarization) are more likely to be recruited into a memory trace, and substantial evidence exists implicating the cellular transcription factor CREB (cyclic AMP responsive element-binding protein) in this process. (wikipedia.org)
  • regulator
  • In this perspective, VDAC proteins appear as regulator of apoptosis, exerting both pro- and/or anti-apoptotic functions in physiological and pathological condition. (frontiersin.org)
  • putative
  • The sFRPs are a family of soluble glycoproteins, which contain cysteine-rich domains homologous to the putative Wnt-binding sites of Frizzled proteins. (aacrjournals.org)
  • structurally
  • There are two active pockets within iPFK2 for fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase which are structurally different. (wikipedia.org)
  • The F-2,6-BP active site structurally open, while the active pocket of 6-phosphofructo-2-kinase is more rigid. (wikipedia.org)
  • PRKAR2A
  • RUNX1T1 has been shown to interact with: CBFA2T2, CBFA2T3, Calcitriol receptor GFI1, Nuclear receptor co-repressor 1, Nuclear receptor co-repressor 2, PRKAR2A, and Zinc finger and BTB domain-containing protein 16. (wikipedia.org)
  • intracellular
  • Central to its antidiuretic action in mammals is the redistribution of the water channel aquaporin 2 ( AQP2 ) from intracellular vesicles to the apical membrane of kidney epithelial cells , an event initiated by an increase in cAMP and activation of protein kinase A . The subsequent steps of the signaling cascade are not known. (ndif.org)
  • apoptosis
  • While necessary for biogenesis of the organelle, Drp1‐dependent mitochondrial fragmentation is also an early and critical event in apoptosis, coinciding roughly with activation of the pro‐apoptotic B‐cell lymphoma 2 (Bcl2) family member Bax and permeabilization of the outer mitochondrial membrane ( Martinou & Youle, 2006 ). (embopress.org)
  • It was more recently discovered that PFKFB3 promotes cell cycle progression (cell proliferation) and suppresses apoptosis by regulating cyclin-dependent kinase 1 (Cdk-1). (wikipedia.org)
  • Neurons
  • Monoclonal antibody to neurofilament protein (SM132) labels a subpopulation of pyramidal neurons in the human and monkey neocortex. (springer.com)
  • mechanism
  • In a manner similar to the endocytosis motor dynamin, Drp1 is thought to polymerize into ring‐ or spiral‐shaped superstructures that constrict and eventually sever mitochondria by a GTP hydrolysis‐dependent mechanism ( Hoppins et al , 2007 ). (embopress.org)
  • The group has subsequently published a number of papers on the dynamics and mechanism of PKA, or cyclic AMP-dependent protein kinase. (wikipedia.org)
  • transcriptional
  • It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha (zeige ESR1 ELISA Kits ) and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal. (antikoerper-online.de)
  • adenylate cyclase
  • Rosol TJ, Merryman JI, McCauley LK , Capen CC. Effects of transforming growth factor  on parathyroid hormone and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro . (dentisty.org)
  • The individual subunits of the G protein complex were first identified in 1980 when the regulatory component of adenylate cyclase was successfully purified, yielding three polypeptides of different molecular weights. (wikipedia.org)
  • calcium
  • Polycystin-1, the protein encoded by the PKD1 gene, is present on these cilia and is thought to sense the flow with its large extracellular domains, activating the calcium channels associated with polycystin-2, the product of gene PKD2, as a result of the genetic setting of ADPKD as explained in the genetics sub-section below. (wikipedia.org)
  • This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. (wikipedia.org)
  • yeast
  • Shortly after, the Gβγ complex associated with a mating factor receptor-coupled G protein in yeast was found to initiate a pheromone response. (wikipedia.org)
  • cAMP
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. (wikipedia.org)
  • CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. (wikipedia.org)
  • These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003). (wikipedia.org)
  • cellular
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. (wikipedia.org)
  • family
  • Placental growth factor (PGF) is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) family. (wikipedia.org)
  • This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. (wikipedia.org)
  • The Gβ subunit is a member of the β-propellor family of proteins, which typically possess 4-8 antiparallel β-sheets arranged in the shape of a propeller. (wikipedia.org)
  • activity
  • Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. (nih.gov)
  • Altered activity of this protein has been associated with schizophrenia and bipolar disorder. (wikipedia.org)
  • The activity of this protein has been implicated in controlling cell growth and differentiation. (wikipedia.org)
  • Casein kinase activity associated with the endoplasmic reticulum of mammary glands was first characterized in 1974, and its activity was shown to not depend on cyclic AMP. (wikipedia.org)
  • Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. (wikipedia.org)
  • membranes
  • The CFTR gene codes for an ABC transporter-class ion channel protein that conducts chloride and thiocyanate ions across epithelial cell membranes. (wikipedia.org)
  • human
  • McCauley LK , Rosol TJ, Merryman JI, Capen CC. Parathyroid hormone-related protein binding to human T cell lymphotropic virus type I-infected lymphocytes. (dentisty.org)
  • Werkmeister JR, Rosol TJ, McCauley LK , Merryman JI, Horton JE, Capen CC. Parathyroid hormone-related protein production by normal human keratinocytes in vitro is associated with a less differentiated phenotype. (dentisty.org)
  • affinity
  • In the heterotrimer form, the Gβγ dimer increases the affinity of Gα for GDP, which causes the G protein to be in an inactive state. (wikipedia.org)
  • receptor
  • The surface of these cilia is covered with olfactory receptors, a type of G protein-coupled receptor. (wikipedia.org)
  • Serum levels of PGF and sFlt-1 (soluble fms-like tyrosine kinase-1, also known as soluble VEGF receptor-1) are altered in women with preeclampsia. (wikipedia.org)
  • When a G protein-coupled receptor (GPCR) is activated, Gα dissociates from Gβγ, allowing both subunits to perform their respective downstream signaling effects. (wikipedia.org)
  • function
  • This may result in proteins that may not function, work less effectively, are more quickly degraded, or are present in inadequate numbers. (wikipedia.org)
  • cells
  • Cells expressing a mutant form of the CFTR protein are resistant to invasion by the Salmonella typhi bacterium, the agent of typhoid fever, and mice carrying a single copy of mutant CFTR are resistant to diarrhea caused by cholera toxin. (wikipedia.org)
  • antibodies
  • Rosol TJ, Merryman JI, McCauley LK , Werkmeister J, Steinmeyer C, Swayne D, Capen CC. Studies on chicken polyclonal antipeptide antibodies specific for parathyroid hormone-related protein (1-36). (dentisty.org)