Aqueous solubilityStabilityIntrinsicTitration CurvesSolventTemperatureWater absorptionKineticsBioactivityConcentrationViscosityAbsorptionEquilibriumCompoundEnzymesDataLogSDependentGraphMethodsCrystalBreakthroughVivoActivityFlourTestSignificantlyPointsLimitShowsProfileSolutionsImportanceAbilitySolutionMetalValuesModel
Aqueous solubility3
- Aqueous solubility is one of the most important physico-chemical properties in modern drug discovery. (chemaxon.com)
- Completion of an in vitro ADME and physicochemical profile for the starting compound that includes measures of aqueous solubility, microsome stability, CYP inhibition, and permeability (e.g. (nih.gov)
- Proposed compounds should give defensible results in tests for Ames mutagenicity, hERG activity, microsome stability, CYP inhibition, plasma protein binding, and aqueous solubility. (nih.gov)
Stability5
- Considering the high water solubility of the test substance and its stability it is reasonable to assume that the actual concentrations were identical to the nominal concentrations during the entire test. (europa.eu)
- However, their poor metabolic stability and limited water solubility make them difficult to use pharmacologically. (nih.gov)
- 2009. Determining the conformational stability of a protein using urea denaturation curves . (gcc.edu)
- 2001. The effect of net charge on the solubility, activity, and stability of ribonuclease Sa . (gcc.edu)
- While it is known that food allergens share common properties, such as stability to enzymes and solubility, they also exhibit differential properties, and exceptions to the common characteristics exist. (bvsalud.org)
Intrinsic11
- intrinsic and pH-dependent solubility. (chemaxon.com)
- The intrinsic solubility (usually denoted as logS 0 ) of an ionizable compound is the solubility that can be measured after the equilibrium of solvation between the dissolved and the solid state is reached at a pH where the compound is fully neutral. (chemaxon.com)
- The intrinsic solubility of phenol can be measured at pH 6. (chemaxon.com)
- Our predictor uses a fragment-based method that identifies different structural fragments in the molecule and assigns an intrinsic solubility contribution to them. (chemaxon.com)
- The contributions then are summed up to get the intrinsic solubility value. (chemaxon.com)
- The figure below shows a molecule split up into fragments that are used in the intrinsic solubility prediction. (chemaxon.com)
- With increasing ionization solubility increases compared to the intrinsic solubility. (chemaxon.com)
- The solubility of aniline in an acidic environment will be greater than its intrinsic solubility as the protonation of the compound shifts the equilibrium between the pure liquid aniline and its dissolved form to the right. (chemaxon.com)
- The pH-dependent solubility (usually denoted as logS pH ) can be derived from the Henderson-Hasselbalch equation and the above definition of intrinsic and pH-dependent solubility. (chemaxon.com)
- The logS Predictor gives -0.98 logS as intrinsic solubility. (chemaxon.com)
- The therapeutic potential of atazanavir (BCS Class II drug), a highly selective inhibitor of human immunodeficiency virus (HIV-1) has been largely limited due to its low intrinsic solubility at elevated pH resulting in low oral bioavailability. (researchsquare.com)
Titration Curves1
- Interpret graphical representation of titration curves. (com.ng)
Solvent3
- 2000. Linear extrapolation method of analyzing solvent denaturation curves . (gcc.edu)
- In addition, the low solubility of DNM in any solvent other than concentrated acid presents challenges for its biological evaluation and limits its potential in-vivo . (nature.com)
- Solubility is affected by increasing the temperature of the solvent because the _________________________________ of the particles increases. (studylib.net)
Temperature9
- The saturation point is often represented by a solubility curve, which depicts the relationship between solute concentration and temperature. (imsaethics.org)
- For ammonia solution, the solubility curve shows that as the temperature increases, the amount of ammonia gas that can dissolve in water also increases. (imsaethics.org)
- Specifically, the transition occurs when the ammonia concentration reaches the solubility limit at each respective temperature. (imsaethics.org)
- A: The solubility of ammonia in water can be increased by either increasing the temperature or applying pressure. (imsaethics.org)
- A: Heating a saturated ammonia solution would cause an increase in temperature, which in turn increases the solubility of ammonia gas. (imsaethics.org)
- In conclusion, the transition from unsaturated to saturated ammonia solution occurs between two temperature points based on the solubility curve. (imsaethics.org)
- How is the solubility of gases affected by temperature? (studylib.net)
- Solubility of gases _______________________with an increase in temperature This is why soda at room temperature goes flat _______________________than soda in the refrigerator Thermal pollution What do fish breathe? (studylib.net)
- MODEL NAME: O2CO2_SOLY2016MPC // SHORT DESCRIPTION: Calculates O2 and CO2 solubilities based on temperature. (nih.gov)
Water absorption3
- Nitrogen solubility, emulsification capacity, foam capacity, fat and water absorption capacity of raw and heat-processed winged bean flour were compared with those of raw soy flour, both as a function of pH and NaCl concentration. (researchgate.net)
- Solubility and swelling power was determined according to the method described by Takashi & Sieb [22], while the method of Abbey & Ibeh [23] was adopted for determination of water absorption capacity. (researchgate.net)
- The water solubility index (WSI) and water absorption index (WAI) were used to compare the instant properties of yam flour. (bvsalud.org)
Kinetics4
- Dissolution kinetics of calcite in the H 2 O-CO 2 system along the steam saturation curve to 210°C - Talman, S.J. et al. (geochemsoc.org)
- For CO 2 solubility and kinetics measurement without contaminants, a dynamic pressure-step method was applied, while a continuous flow operation was used for CO 2 breakthrough measurement in the presence of H 2 O and H 2 S. Effects of H 2 O and H 2 S on these solvents physiochemical properties will be discussed. (aiche.org)
- H 2 O and H 2 S, on solvents physiochemical properties, including CO 2 solubility, CO 2 absorption kinetics, viscosity, and so on. (aiche.org)
- The columns simulate field weathering conditions in order to provide data for sulphide reactivity, oxidation kinetics, metal solubility and leaching behavior of test materials. (actlabs.com)
Bioactivity1
- Quinoa protein isolate-gum Arabic (QPI-GA) conjugates were developed by ultrasound-assisted wet heating to improve the water solubility and bioactivity of spice essential oils (EOs) in this study. (bvsalud.org)
Concentration1
- The use of active concentration travo z and dosage forms show a higher solubility than any plotted curve. (drapikowski.pl)
Viscosity2
- Especially, all viscosity parameters obtained on the basis of swelling curve could be used for rye flour baking quality evaluation. (springer.com)
- The hydrolysis of water unextractable pentosans changes their solubility and causes an increase dough viscosity and reduction of water binding capacity [ 12 ]. (springer.com)
Absorption2
- Absorption classes listed for UO3 and The compound of the material is not considered during the dose (solubility) classes for U3O8 appear to be incorrect. (cdc.gov)
- The study revealed that the absorption and bioavailability of CoQ10 in the novel formulations are significantly increased, probably due to the enhanced water solubility. (karger.com)
Equilibrium1
- Reversed equilibrium solubility of a high-magnesium calcite - Lafon, G.M. (geochemsoc.org)
Compound1
- In case only an estimation about how well soluble the compound is needed, the plugin can give a solubility category as a qualitative measure. (chemaxon.com)
Enzymes1
- One method use to determined properties of dough association with pentosans content and activity cell wall degradation enzymes is the swelling curve test [ 15 ]. (springer.com)
Data3
- There you can find solubility data of all compounds from the project in different solvents. (crystalls.info)
- The binodal curves and tie-line data for the ternary systems of water + ethanol + 1-octanol, water + ethanol + 4-methyl-2-pentanone, and water + ethanol + ethyl acetate were investigated at 293.15 K. All these three ternary systems fo. (researchgate.net)
- This is when I show up asking for data such as a solubility curve, and pose a lot of questions about the crystals and the process. (chemicalprocessing.com)
LogS5
- This page summarizes the theoretical background behind ChemAxon's Aqeous Solubility (logS) Predictor. (chemaxon.com)
- The logS is a common unit for measuring solubility. (chemaxon.com)
- This unit is the 10-based logarithm of the solubility measured in mol/l unit, that is logS = log (solubility measured in mol/l). (chemaxon.com)
- The predictor can provide quantitative results, giving the solubility in logS, mg/mL or mol/L units. (chemaxon.com)
- logS, log of the solubility in water. (nih.gov)
Dependent2
- Example of calculating pH-dependent solubility Let's calculate the solubility of L -tyrosine at pH=9.2. (chemaxon.com)
- To get the pH-dependent solubility we first need the instrisic solubility of L-tyrosine. (chemaxon.com)
Graph1
- Solubility graph worksheet answer key. (decoomo.com)
Methods2
- Solubility can also be a relevant descriptor for property-based computational screening methods in the drug discovery process. (chemaxon.com)
- Hence there is a significant interest in fast, reliable, structure-based methods for predicting solubility in water for promising drug candidates. (chemaxon.com)
Crystal1
- Even plants that have a curve are stymied when I ask about potential crystal phases such as polymorphs or solvates. (chemicalprocessing.com)
Breakthrough2
- The pentane breakthrough time at 500ppm was the closest to the carbon- tetrachloride baseline curve, while 1,250ppm heptane were needed to give breakthrough times of the same order as those seen with 1,000ppm carbon-tetrachloride. (cdc.gov)
- A 1-liter Continuous Stirred Tank Reactor (CSTR) equipped with a 2-liter gas buffer tank has been used to measure CO 2 isotherms and CO 2 breakthrough curves at different temperatures. (aiche.org)
Vivo1
- In this sense, precipitation technologies using compressed CO 2 (cCO 2 ) hold a great deal of promise in the pharmaceutical industry, which, as indicated above, is currently facing the challenge of drug formulation involving active ingredients or diagnostic agents with low solubilities, high toxicities, low stabilities or short in vivo half-lives, which need suitable nanocarriers to enhance their bioavailability. (medscape.com)
Activity1
- Enrich your students' study of solutions with an activity about the solubility of potassium nitrate. (teachervision.com)
Flour3
- In summary, the swelling curve test can be used as a useful tool for the evaluation of baking quality of rye flour. (springer.com)
- However there are no papers concerning possibility the use of swelling curve test for the evaluation of the baking quality of rye flour from milling industry. (springer.com)
- Heat processing of winged bean flour lowered nitrogen solubility. (researchgate.net)
Test3
- The objective of this work was to use the swelling curve test for the evaluation of the baking value of rye flours commonly used for bread production. (springer.com)
- Therefore, the aim of this work was to evaluate the possibility using the swelling curve test for the evaluation of the baking value of rye flours commonly used for bread production. (springer.com)
- Test swelling curve test was performed according to Drews [ 21 ]. (springer.com)
Significantly1
- Water solubility was increased significantly with the use of an inclusion complex with β-cyclodextrin. (karger.com)
Points1
- To identify the points at which the ammonia solution changes from being unsaturated to saturated, we need to examine the solubility curve. (imsaethics.org)
Limit1
- A: No, a saturated ammonia solution has reached its maximum solubility limit. (imsaethics.org)
Shows1
- 9.15 shows a higher solubility than any plotted curve. (nadiazillaparishad.in)
Profile1
- Nitrogen solubility vs pH profile showed only one minimum, at pH 4.5. (researchgate.net)
Solutions1
- Cassiterite solubility and tin speciation in supercritical chloride solutions - Wilson, G.A. and Eugster, H.P. (geochemsoc.org)
Importance1
- If you have a crystallizer or are planning to install a crystallization process, then you know the importance of solubility curves. (chemicalprocessing.com)
Ability1
- The water solubility, antioxidant ability, and antibacterial ability of tested EOs were improved after emulsification. (bvsalud.org)
Solution1
- People do not realize that even a relative low solubility permanganate like KMnO4 when saturated produces a BLACK solution, only the meniscus being purple. (sciencemadness.org)
Metal1
- This is required to maintain low metal solubilities. (actlabs.com)
Values1
- The Solubility Predictor predicts solubility values at 25 °C . (chemaxon.com)
Model1
- In this work, this same version of the CPA model is applied together with the hydrate van der Waals and Platteeuw model for the description of hydrate dissociation curves. (ua.pt)