• venom
  • Crotalus durissus terrificus venom, which contains crotoxin as a major active component, significantly inhibited edema and migration of polymorphonuclear cells in carrageenan-induced arthritis in mice [ 3 , 4 ]. (hindawi.com)
  • toxicity
  • In addition to neurotoxicity, crotoxin has been found to exert myotoxicity, nephrotoxicity, and cardiovascular toxicity (PubMed:20109480). (rcsb.org)
  • Multiple variants of each subunit give different crotoxin complexes that can be subdivided into 2 classes: (1) those of high toxicity, low PLA2 activity (CBb, CBc and CBd linked with high affinity to any CA) and high stability (K(d)=4.5 nM) and (2) those of moderate toxicity, high PLA2 activity (CBa2 linked with low affinity to any CA) and low stability (K(d)=25 nM). (rcsb.org)
  • Their research suggested that the toxicity of crotoxin was due to effects on nerve lipids. (wikipedia.org)
  • Researchers harnessed the unique combination of targeting and toxicity in crotoxin to create a cancer treatment, called CB24, which finds and kills tumor cells that are growing out of control. (medicarepharmabusiness.com)
  • Cancer
  • In November 2016, Spotlight Innovation subsidiary Celtic Biotech Iowa received approval from the French National Agency for the Safety of Medicines and Health Products to commence Part 2 of the Phase 1 dose escalation safety study Crotoxin in Patients with Advanced Cancer using an Intravenous Route of Administration. (wikipedia.org)