• phospholipase
  • Heterodimer CA-CB: Crotoxin is a potent presynaptic neurotoxin that possesses phospholipase A2 (PLA2) activity and exerts a lethal action by blocking neuromuscular transmission. (rcsb.org)
  • One of the protein structures in this search is crotoxin B ( 2QOG ), an enzyme (a "phospholipase") that cleaves lipid molecules in the vicinity of a rattlesnake bite, disrupting membrane barriers and thereby causing pain and severe tissue damage. (oregonstate.edu)
  • patients
  • In November 2016, Spotlight Innovation subsidiary Celtic Biotech Iowa received approval from the French National Agency for the Safety of Medicines and Health Products to commence Part 2 of the Phase 1 dose escalation safety study Crotoxin in Patients with Advanced Cancer using an Intravenous Route of Administration. (wikipedia.org)
  • found
  • In addition to neurotoxicity, crotoxin has been found to exert myotoxicity, nephrotoxicity, and cardiovascular toxicity (PubMed:20109480). (rcsb.org)