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  • aqueous
  • 1 . A pharmaceutical composition comprising a matrix capable of delivering at least one therapeutic agent to a bodily compartment under controlled release conditions, said matrix comprising a homogeneous mixture of aqueous phase and at least one other phase, at least one therapeutic agent present in at least one of said phases, and at least one cross-linked polymer physically entrapping said at least one therapeutic agent. (google.com.au)
  • maleimide
  • 10. The compound of claim 9, wherein at least one of Z 1 and Z 2 is --C(═Y)NH-T 3 -Z 3 wherein Z 3 is selected from an iodoacetyl group, a maleimide, a photoreactive linking group, an aldehyde and an epoxide. (patentsencyclopedia.com)
  • Collagen
  • Data obtained in this laboratory, from peptides which were originally isolated from an extensive proteolytic digest of reconstituted calf skin collagen are consistent with a crosslink between the hydroxylysine at residue 927 in αl-CB6 and the allysine at residue 9N in αl-CB(0,1). (springer.com)
  • The amino acid sequence of a peptide derived from limited alkaline hydrolysis of insoluble calf bone collagen indicates the presence of the crosslink S,ô'-dihydroxylysinonorleucine at residue 671 in αl-CB7. (springer.com)
  • Bailey, A.J. and Peach, C.M. (1968) "Isolation and Structural Identification of a Labile Intermolecular Crosslink in Collagen" Biochem. (springer.com)
  • Bensusan, H.B. (1972) "Investigation of Crosslinks in Collagen Following an Enzymic Hydrolysis," Biochim. (springer.com)
  • oligomeric
  • Crosslinked Polymers Having Activated Groups-A Versatile Support Material[**] Ester by Merrifield['], variously functionalized polymers have found application in the synthesis of oligomeric natural products, as polymeric reagents, for immobilization of enzymes, and in affinity chromatography. (docme.ru)
  • modification
  • Labeling" generally refers to any form of crosslinking or modification whose purpose is to attach a chemical group (e.g., a fluorescent molecule) to aid in detection of a molecule and is described in other articles . (thermofisher.com)
  • The resulting modification of mechanical properties depends strongly on the cross-link density. (wikipedia.org)
  • molecule
  • The cross-linked derivative was a heterodimer consisting of one molecule each of flavoprotein and cytochrome, and it was purified to 90% or more homogeneity. (biomedsearch.com)
  • groups
  • We use SPDP to prepare a reactive R-phycoerythrin derivative ( P806 , Phycobiliproteins-Section 6.4 ), providing researchers with the optimal number of pyridyldisulfide groups for crosslinking the phycobiliprotein to thiolated antibodies, enzymes and other biomolecules through disulfide linkages. (thermofisher.com)
  • It is a thiolating reagent that reacts with primary amine groups, such as those of amino acids, to form sulfhydryl groups. (wikipedia.org)
  • identification
  • Experiments using different amine-, carboxyl- or sulfhydryl-reactive reagents can assist in the identification and quantification of particular amino acids or for determination of the number, location, and size of subunits. (thermofisher.com)
  • methods
  • Basically, three traditional methods of enzyme immobilization can be distinguished: binding to a support(carrier), entrapment (encapsulation) and cross-linking. (wikipedia.org)
  • interactions
  • The guide also contains a discussion on various applications where crosslinking has been applied, including the powerful label transfer technique for identifying or confirming protein interactions. (thermofisher.com)
  • The benefit of in vivo crosslinking is that the protein-protein interaction can be captured in its native environment, which limits the risk of false positive interactions or the loss of complex stability during cell lysis. (thermofisher.com)
  • method
  • The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. (google.com.au)
  • results
  • Assessment of crosslinking results is usually accomplished by some form of electrophoresis (1D or 2D), followed by staining or Western blot detection. (thermofisher.com)
  • process
  • How the crosslinking process works and how it improves the properties of polymers is nicely illustrated in this video-animation. (wikipedia.org)
  • In some cases, though, if the cross-link bonds are sufficiently different, chemically, from the bonds forming the polymers, the process can be reversed. (wikipedia.org)
  • high
  • Intermediate cross-link densities transform gummy polymers into materials that have elastomeric properties and potentially high strengths. (wikipedia.org)
  • Very high cross-link densities can cause materials to become very rigid or glassy, such as phenol-formaldehyde materials. (wikipedia.org)
  • effects
  • Rowland CR, Lennon DP, Caplan AI, Guilak F. The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs. (springer.com)
  • agent
  • The mixed disulfide can then be reacted with a reducing agent such as DTT ( D1532 ) or TCEP ( T2556 ) to yield a 3-mercaptopropionyl conjugate or with a thiol-containing biomolecule to form a disulfide-linked tandem conjugate. (thermofisher.com)