• cleavable
  • To test this hypothesis in vivo, differentiated N1E-115 neuroblastoma cells were labeled with [ 35 S]-amino acids and were treated with a cleavable crosslinking reagent. (mdpi.com)
  • The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population. (google.fr)
  • A method consistent with the present invention relates to targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker. (google.fr)
  • Mono-BOC-cystamine is used as a crosslinker for the synthesis of cleavable photo-cross-linking reagent. (wikipedia.org)
  • molecules
  • When cross links are added to long rubber molecules, the flexibility decreases, the hardness increases and the melting point increases as well. (wikipedia.org)
  • Mono- and bismaleimide-based polymers are used for high temperature applications up to 250 °C. Maleimides linked to rubber chains are often used as flexible linking molecules to reinforce the rubber (tire). (wikipedia.org)
  • group
  • and Z 3 is a protein linking group. (patentsencyclopedia.com)
  • and P 1 and P 2 each independently comprise a linked polypeptide and a carbonyl or a heterosubstituted carbonyl group in a position adjacent to T 11 and T 12 respectively. (patentsencyclopedia.com)
  • The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. (google.com)
  • invention
  • The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. (google.com.au)
  • form
  • The mixed disulfide can then be reacted with a reducing agent such as DTT ( D1532 ) or TCEP ( T2556 ) to yield a 3-mercaptopropionyl conjugate or with a thiol-containing biomolecule to form a disulfide-linked tandem conjugate. (thermofisher.com)
  • process
  • How the crosslinking process works and how it improves the properties of polymers is nicely illustrated in this video-animation. (wikipedia.org)
  • In some cases, though, if the cross-link bonds are sufficiently different, chemically, from the bonds forming the polymers, the process can be reversed. (wikipedia.org)
  • agent
  • 1 . A pharmaceutical composition comprising a matrix capable of delivering at least one therapeutic agent to a bodily compartment under controlled release conditions, said matrix comprising a homogeneous mixture of aqueous phase and at least one other phase, at least one therapeutic agent present in at least one of said phases, and at least one cross-linked polymer physically entrapping said at least one therapeutic agent. (google.com.au)
  • materials
  • Intermediate cross-link densities transform gummy polymers into materials that have elastomeric properties and potentially high strengths. (wikipedia.org)
  • Very high cross-link densities can cause materials to become very rigid or glassy, such as phenol-formaldehyde materials. (wikipedia.org)
  • Cross-linking can also be induced in materials that are normally thermoplastic through exposure to a radiation source, such as electron beam exposure, gamma-radiation, or UV light. (wikipedia.org)
  • Cross-links are the characteristic property of thermosetting plastic materials. (wikipedia.org)
  • material
  • In most cases, cross-linking is irreversible, and the resulting thermosetting material will degrade or burn if heated, without melting. (wikipedia.org)
  • These polymers may be melted at low temperatures, contacted with the filler material or substrate to be laminated and cured or cross-linked to the resinous state. (google.com.au)
  • high
  • Items in OPUS are enhanced with high quality metadata and seeded to search engines such as Google Scholar as well as being linked to your UTS research profile, increasing discoverability and opportunities for citation of your work and collaboration. (edu.au)