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Creatine KinaseCreatineCreatine Kinase, MM FormCreatine Kinase, BB FormCreatine Kinase, Mitochondrial FormIsoenzymesCreatine Kinase, MB FormPhosphatidylinositol 3-KinasesClinical Enzyme TestsPhosphocreatineMAP Kinase Signaling SystemProtein KinasesProtein-Serine-Threonine KinasesArginine KinaseMusclesProtein Kinase InhibitorsCalcium-Calmodulin-Dependent Protein Kinasessrc-Family KinasesL-Lactate DehydrogenaseMyocardiumProtein Kinase CRhabdomyolysisp38 Mitogen-Activated Protein KinasesMuscle, SkeletalElectrophoresis, Cellulose AcetateAdenosine TriphosphateCyclic AMP-Dependent Protein KinasesKineticsMitogen-Activated Protein Kinase 1Pyruvate KinaseAdenylate Kinasep21-Activated KinasesAdenosine DiphosphateMitogen-Activated Protein Kinase KinasesJNK Mitogen-Activated Protein KinasesGuanidinoacetate N-MethyltransferaseMitogen-Activated Protein Kinase 3Muscular DiseasesMagnetic Resonance SpectroscopyAmidinotransferasesProtein-Tyrosine KinasesRabbitsMyoglobinTime FactorsCDC2 Protein KinaseCyclin-Dependent KinasesPhosphorylationMAP Kinase Kinase KinasesMyocardial InfarctioneIF-2 KinaseCasein Kinase IICasein KinasesMitochondria, HeartRibosomal Protein S6 KinasesMolecular Sequence DataMAP Kinase Kinase 1MyositisEnergy MetabolismAspartate AminotransferasesReceptor Protein-Tyrosine KinasesThymidine KinaseElectrophoresis, Agar GelProtein BindingExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase 4BrainAmino Acid SequenceTroponin TTroponin ISignal Transduction1-Phosphatidylinositol 4-KinasePhosphotransferases (Alcohol Group Acceptor)Mitogen-Activated Protein KinasesCDC2-CDC28 KinasesEnzyme ActivationMuscular DystrophiesBase SequenceBlotting, WesternI-kappa B KinaseGlycogen Synthase Kinase 3Aurora Kinasesrho-Associated KinasesTransfectionMutationBinding SitesProtein Kinase C-deltaProtein Kinase C-alphaBiological MarkersCell LineAMP-Activated Protein KinasesSubstrate SpecificityProto-Oncogene ProteinsMyocardial Reperfusion InjuryHeartCalciumRNA, MessengerDiacylglycerol KinaseMuscle ProteinsCells, CulturedMyofibrils
Serum creatine kinaseIsoenzymesPhosphokinaseEnzymeMitochondrialIsoenzymePolyclonal AntibodyPhosphocreatineELISA KitAssayMyocardialProteinSpecificitySedentarySkeletalCytosolicDiagnosisHomeostasisMuscle creatineBrainInterpretationSupplementationIntracellularTestActivitySurvivalMedicineLevels in patientsTotalDescriptionPatientsListPlasmaImportantStructure
Serum creatine kinase9
  • Serum creatine kinase levels and renal function measures in exertional muscle damage. (cdc.gov)
  • Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls. (lww.com)
  • Subgroup analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy controls. (lww.com)
  • Spearman's correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised score, or progression rate. (lww.com)
  • serum creatine kinase levels were decreased at the second blood test, which was sampled at least 6 months after the first blood test. (lww.com)
  • Together, our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis patients. (lww.com)
  • 6. Nanji AA, Blank D, "Low Serum Creatine Kinase Activity in Patients With Alcoholic Liver Disease," Clin Chem 1981, 27(11):1954. (unitedlabservice.com)
  • Serum creatine kinase levels (CK) can vary among healthy subjects, even when correcting for muscle mass. (medscape.com)
  • Increased serum creatine kinase (CPK) activity has been reported to be present during acute exacerbations of psychosis in the majority of patients with the major "functional" psychoses. (northwestern.edu)
Isoenzymes1
  • In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous form and the sarcomeric form. (wikipedia.org)
Phosphokinase11
  • Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. (wikipedia.org)
  • questions CKQ010 CKD070) collects survey participant interview data to help interpret NHANES laboratory data for serum Creatine Phosphokinase (CPK). (cdc.gov)
  • CK is also called creatine phosphokinase (CPK). (medlineplus.gov)
  • Creatine kinase (CK), also known as creatine phosphokinase. (kekaibio.com)
  • Creatine kinase, also known as phosphocreatine kinase or creatine phosphokinase, is an enzyme or type of protein that is found in several tissue types of the human body, including the muscle and the brain. (creatinejournal.com)
  • CREATINE KINASE (CK), also known as creatine phosphokinase (CPK), is an enzyme (EC 2.7.3.2) expressed predominantly in skeletal muscle, smooth muscle and the brain. (gentaur.nl)
  • Description - CPK is a short form of Creatine Phosphokinase which is an essential enzyme found in muscle that helps them function effectively. (maxlab.co.in)
  • The CPK test is generally performed to determine the health and condition of the Creatine Phosphokinase levels in an individual’s body. (maxlab.co.in)
  • CPK is a diagnostic test that measures the levels of creatine phosphokinase (CPK) in your blood. (maxlab.co.in)
  • Creatine phosphokinase (CPK) is an enzyme in the body. (stlukes-stl.com)
  • Blood tests often monitor the level of serum creatine phosphokinase (CPK), however, this test can only detect the disease in later stages and is generally non-specific, as high levels of CPK can be found in an individual's blood after experiencing a heart attack, drinking alcohol in excess, or participating in strenuous exercise. (nature.com)
Enzyme7
  • Thus creatine kinase is an important enzyme in such tissues. (wikipedia.org)
  • Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. (lww.com)
  • 2019). Creatine kinase (CK), a muscle enzyme, is used to differentiate between neurogenic and myopathic disorders. (lww.com)
  • The function of this enzyme is to catalyze the conversion of creatine to phosphocreatine by applying itself in the consumption of adenosine triphosphate, the generation of adenosine diphosphate, and the reverse reaction. (creatinejournal.com)
  • Creatine kinase is an enzyme which catalyses the interconversion of creatine and phosphocreatine (PCr). (unboundmedicine.com)
  • BioAssay Systems' EnzyChromTM Creatine Kinase Assay Kit is based on enzyme coupled reactions in which creatine phosphate and ADP is converted to creatine and ATP by CK, the generated ATP is used to phosphorylate glucose by hexokinase to generate glucose-6-phosphate, which is then oxidized by NADP in the presence of glucose-6-phosphate dehydrogenase. (gentaur.nl)
  • Purpose: This study investigated the release and clearance of plasma CK- MM (muscle) isoforms following two bouts of eccentric exercise to determine whether enhanced enzyme clearance could in part explain the blunted creatine kinase (CK) response to a second bout of exercise. (elsevierpure.com)
Mitochondrial6
  • While mitochondrial creatine kinase is directly involved in the formation of phosphocreatine from mitochondrial ATP, cytosolic CK regenerates ATP from ADP, using PCr. (wikipedia.org)
  • The first structure of a creatine kinase solved by X-ray protein crystallography was that of the octameric, sarcomeric muscle-type mitochondrial CK (s-mtCK) in 1996. (wikipedia.org)
  • Mitochondrial creatine kinase (CKm) is present in the mitochondrial intermembrane space, where it regenerates phosphocreatine (PCr) from mitochondrially generated ATP and creatine (Cr) imported from the cytosol. (wikipedia.org)
  • A screen using pooled short hairpin RNAs (shRNAs) identified the ATP-buffering, mitochondrial creatine kinase CKMT1 as necessary for survival of EVI1-expressing cells in subjects with EVI1-positive AML. (northwestern.edu)
  • CKMT1 inhibition altered mitochondrial respiration and ATP production, an effect that was abrogated by phosphocreatine-mediated reactivation of the arginine-creatine pathway. (northwestern.edu)
  • Then we examined the possible roles and mechanisms of the ubiquitous mitochondrial creatine kinase (uMtCK) in vitro. (elsevierpure.com)
Isoenzyme4
  • Time Changes of Creatine Kinase and Creatine Kinase-MB Isoenzyme versus Discrimination Values in the Diagnosis of Acute Myocardial Infarction: What is the Optimal Method for Displaying the Data? (degruyter.com)
  • With the purpose of studying the influence of prolonged phyisical exercise causing myocardial lesion and disqualifying horses in endurance competitions, 87 blood samples were collected from adult Arabian and crossbred horses, to determine the serum concentration of the isoenzyme MB (CKMB), the serum activity of creatine kinase (CK), and the CKMB/CK index. (usp.br)
  • Recent results from studies of experimental animals suggest that prompt detection of reperfusion is possible based on analysis of sequential changes in the relative activities of individual isoforms of the MM isoenzyme of creatine kinase (CK) in plasma. (elsevierpure.com)
  • Increases in the level of creatine-kinase-isoenzyme-BB have been detected in the blood of boxers and head trauma patients. (cdc.gov)
Polyclonal Antibody3
  • The best Muscle polyclonal Antibody, Recombinant Cyclin-dependent kinases regulatory subunit (cks-1) products, quick delivery, high quality. (creatinekinases.com)
  • Quick contact, quick delivery, greatests prices of Recombinant Dog Creatine kinase B-type (CKB), Rabbit anti-human creatine kinase, Muscle polyclonal Antibody products and else. (creatinekinases.com)
  • Our advisers will certainly help you choose the best Bovine Phosphatidylinositol-3-kinases 2a ELISA Kit[Phosphatidylinositol-3-kinases 2a], Porcine Phosphatidylinositol-3-kinases 2a ELISA Kit[Phosphatidylinositol-3-kinases 2a], Recombinant Dog Creatine kinase B-type (CKB), Rabbit anti-human creatine kinase, Muscle polyclonal Antibody products nad else and advise you on the best solutions for you and your business. (creatinekinases.com)
Phosphocreatine4
ELISA Kit3
  • You need info about Rat Creatine kinase M-type (CKM) ELISA Kit or any other Gentaur produtct? (gentaurshop.com)
  • Human IgG antibody Laboratories manufactures the creatine kinase porcine elisa kit reagents distributed by Genprice. (toll-likereceptors.com)
  • The Creatine Kinase Porcine Elisa Kit reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (toll-likereceptors.com)
Assay2
  • The customer observed error code 1054 unable to calculate result, reaction check failure using the architect creatine kinase assay (list number (b)(4), lot number 99632un18). (fda.gov)
  • Detection range: 5 to 300 U/L creatine kinase in 96-well plate assay. (gentaur.nl)
Myocardial3
  • Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides, and acute kidney injury. (wikipedia.org)
  • The determination of creatine kinase activity can be used for the diagnosis of skeletal muscle disease and myocardial disease. (kekaibio.com)
  • Myocardial Energetics in Obesity: Enhanced ATP Delivery Through Creatine Kinase With Blunted Stress Response. (ox.ac.uk)
Protein1
  • Furthermore, evidence is accumulating to suggest that creatine supplementation can beneficially impact on muscle protein and glycogen synthesis. (nih.gov)
Specificity1
  • Additional issues discussed in this review are the fibre-type specificity of muscle creatine metabolism, the identification of responders versus non-responders to creatine intake, and the scientific background concerning potential side effects of creatine supplementation. (nih.gov)
Sedentary2
  • Initial Muscle Quality Affects Individual Responsiveness of Interleukin-6 and Creatine Kinase following Acute Eccentric Exercise in Sedentary Obese Older Women. (bvsalud.org)
  • This study aimed to evaluate the time course and responsiveness of plasma interleukin-6 ( IL-6 ) and creatine kinase (CK) levels following acute eccentric resistance exercise in sedentary obese older women with a different muscle quality index (MQI). (bvsalud.org)
Skeletal2
  • In this review, we attempt to summarise recent advances in the understanding of potential mechanisms of action of creatine supplementation at the level of skeletal muscle cells. (nih.gov)
  • The content of creatine kinase in skeletal muscle, myocardium and smooth muscle is the most, followed by brain tissue, and the content in gastrointestinal tract, lung and kidney is less. (kekaibio.com)
Cytosolic1
  • The three-dimensional structure of cytosolic bovine retinal creatine kinase. (expasy.org)
Diagnosis1
  • Creatine kinase in the diagnosis and prognostic prediction o. (lww.com)
Homeostasis1
  • Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis. (ox.ac.uk)
Muscle creatine1
  • The crystal structure of human muscle creatine kinase has been determined by the molecular-replacement method and refined at 3.5A resolution. (rcsb.org)
Brain2
  • On the other hand, if the test reveals that the level of creatine kinase circulating in the blood is higher than it should be in normal conditions, then chances are that the human body in question has suffered damage either to the muscle or the brain. (creatinejournal.com)
  • RESULTS: B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase, D-dimer, high-sensitivity cardiac Troponin I and T were significantly higher in the AF than non-AF group. (lu.se)
Interpretation1
  • Wu AH, Smith A, Wians F. Interpretation of creatine kinase and aldolase for statin-induced myopathy: Reliance on serial testing based on biological variation. (cdc.gov)
Supplementation3
  • The effect of oral creatine supplementation on high-intensity exercise performance has been extensively studied over the past ten years and its ergogenic potential in young healthy subjects is now well documented. (nih.gov)
  • Recently, research has shifted from performance evaluation towards elucidating the mechanisms underlying enhanced muscle functional capacity after creatine supplementation. (nih.gov)
  • Does creatine supplementation (i.e for body building) have any effect on the creatine kinase levels in the body? (creatinejournal.com)
Intracellular1
  • It is an important kinase that is directly related to intracellular energy transfer, muscle contraction and ATP regeneration. (kekaibio.com)
Test5
  • What is a creatine kinase (CK) test? (medlineplus.gov)
  • This test measures the amount of creatine kinase (CK) in a sample of your blood. (medlineplus.gov)
  • This test measures the amount of creatine kinase (CK) in the blood. (ohmatdet.com.ua)
  • Taking the creatine test is a good idea to find out where exactly it is that one stands when it comes to the prevalent level of creatine kinase in one's body. (creatinejournal.com)
  • or whether muscles in their bodies have been damaged as a result of any sort of activity, should make it a point to go for a creatine kinase test. (creatinejournal.com)
Activity1
  • We provide gene recombinant creatine kinase (CK), which is derived from animal muscle, with high activity and good stability. (kekaibio.com)
Survival2
  • After adjusting for prognostic covariates, higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis patients. (lww.com)
  • Suppression of arginine-creatine metabolism by CKMT1-directed shRNAs or by the small molecule cyclocreatine selectively decreased the viability, promoted the cell cycle arrest and apoptosis of human EVI1-positive cell lines, and prolonged survival in both orthotopic xenograft models and mouse models of primary AML. (northwestern.edu)
Medicine1
  • Hyatt, JPK & Clarkson, PM 1998, ' Creatine kinase release and clearance using MM variants following repeated bouts of eccentric exercise ', Medicine and science in sports and exercise , vol. 30, no. 7, pp. 1059-1065. (elsevierpure.com)
Levels in patients1
  • Creatine kinase levels in patients with bipolar disorder depressive, manic, and euthymic phases. (bvsalud.org)
Total1
  • Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/GDT/619114/all/Creatine_kinase__total. (unboundmedicine.com)
Description2
  • Description: A competitive ELISA for quantitative measurement of Porcine Creatine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (toll-likereceptors.com)
  • Description: A competitive ELISA for quantitative measurement of Human Creatine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (toll-likereceptors.com)
Patients3
  • Compared with patients with bulbar-onset amyotrophic lateral sclerosis, patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase levels. (lww.com)
  • Galileo Research Fact Sheet #91: Can Galileo Therapy decrease CreatineKinase levels in Duchenn (DMD) patients? (galileo-training.com)
  • Chez les patients hypertendus, le taux de mortalité était plus élevé uniquement chez les patients admis pour un infarctus du myocarde avec sus-décalage du segment ST. Après ajustement des résultats en fonction des variables de référence, l'hypertension s'est révélé être un facteur prédictif indépendant de l'insuffisance cardiaque (OR = 1,31) et de l'accident vasculaire cérébral (OR = 2,47). (who.int)
List1
  • A product recall letter was issued to all architect customers who have received architect creatine kinase, list number (b)(4), lot number 99632un18. (fda.gov)
Plasma1
  • Further, the ADP-scavenging action of creatine kinase has been implicated in bleeding disorders: persons with highly elevated plasma CK could be prone to major bleeding. (wikipedia.org)
Important1
  • This is a very important function, and even though it doesn't sound like much, creatine kinase definitely has its work cut out. (creatinejournal.com)
Structure1
  • Relating Structure to Mechanism in Creatine Kinase. (cdc.gov)