• cutoff
  • Levels as high as 8 nanograms per milliliter have been reported, and with 2 nanograms per milliliter being the cutoff, this will result in a positive cotinine test for someone exposed to tobacco smoke, according to Mayo Clinic. (reference.com)
  • Measurement
  • 2 However, because BP measurement was performed 3 times during the same visit, it would be interesting to know the in-visit BP variability, given that subjects with high cotinine levels might demonstrate a higher variability with respect to those residing in the low cotinine levels group. (ahajournals.org)
  • 5 In these lines, the association of a clinically guided serum cotinine measurement with BP levels could not be definitive without ambulatory BP evaluation. (ahajournals.org)
  • Measurement of cotinine levels might not have clinical importance when measured separately of structured questionnaires evaluating smoking dynamics, but potentially could refine the clinical research in the field. (ahajournals.org)
  • At this time, cotinine measurement has not been routinely used in clinical settings mainly due to the time involved, the methods required to collect the sample, and the cost and inconvenience of sending samples to laboratories. (aacrjournals.org)
  • binds
  • Similarly to nicotine, cotinine binds to, activates, and desensitizes neuronal nicotinic acetylcholine receptors, though at much lower potency in comparison. (wikipedia.org)
  • Humans
  • Nonetheless, treatment with cotinine in humans was reported to have no significant physiologic, subjective, or performance effects in one study, though others suggest that this may not be the case. (wikipedia.org)
  • determination
  • Micro-plate EIA provides a rapid, simple and reliable screening method for the determination of cotinine in meconium following hydrolysis and extraction. (ehesp.fr)
  • smoker
  • Signal-to-noise comparison between the m/z 179→80 and 179→100 mass transitions for d 2 -cotinine, obtained from HILIC-ESI MS/MS analysis of plasma from a non-smoker administered d 2 -nicotine orally. (nih.gov)
  • stable
  • In this study, we developed a method to label the 5' ends of aptamers with cotinine, which allows formation of a stable complex with anti-cotinine antibodies for the purpose of providing another affinity unit for the application in biological assays using aptamers. (archive.org)
  • method
  • Thus, we aimed to establish a simple, inexpensive and sensitive method based on HPLC/UV with column switching for measuring nicotine and cotinine in hair. (scirp.org)
  • As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 times greater, respectively, than those without the column-switching method. (scirp.org)
  • We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. (scirp.org)
  • results
  • Our results show that cotinine-conjugated aptamer/anti-cotinine antibody complexes are an effective alternative and complementary technique for aptamer use in multiple assays and experiments. (archive.org)