Correspond lamp1 carbohydrate lysosome associated membrane glycoproteins. Medical search. Frequent questions

LAMP1/CD107a was detected in formaldehyde fixed HeLa human cervical epithelial carcinoma cell line using Sheep Anti-Human LAMP1/CD107a Alexa Fluor® 488‑conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # IC7985G) at 1:10 dilution for 3 hours at room temperature and counterstained with DAPI (blue). (rndsystems.com)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)

Lysosomes were previously believed to be the sites of the degradation of intracellular and extracellular substances. (biomedcentral.com)

Mature human LAMP1 is a 389 amino acid (aa) type I transmembrane glycoprotein. (rndsystems.com)
6) Lysosomes are the pools of metabolites in cells, including amino acids, sugars, lipids and nucleotides. (biomedcentral.com)

Sequential mannose trimming of N -glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). (elifesciences.org)
These functionally inappropriate proteins are somehow detected in the ER lumen and then transferred to the retrotranslocational channel embedded within the ER membrane, termed the retrotranslocon, followed by ubiquitin-dependent degradation by the proteasome in the cytoplasm. (elifesciences.org)

Designed to visualize the expression of LAMP1 by fluorescence microscopy for staining cells and tissues. (rndsystems.com)
It is expressed in lysosomal and plasma membranes of macrophages, NK and T-cells, and with LAMP2, is essential for the formation of phagolysosomes. (rndsystems.com)
Productive folding of the protein moiety is facilitated during this period by the calnexin/calreticulin cycle in mammalian cells, which relies on G1M9-specific lectin-type chaperones (calnexin and calreticulin) associated with the oxidoreductase ERp57, and UDP-glucose:glycoprotein glucosyltransferases 1 and 2, which are capable of re-adding glucose to M9 if the protein moiety is not yet folded. (elifesciences.org)
Therefore, researchers called lysosomes the "garbage disposals" of cells [ 1 ]. (biomedcentral.com)

1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)

This study demonstrates the details of mannose trimming in the ER by EDEM1 and EDEM3, filling an important gap in how mannose trimming creates an ERAD signal and shunts glycoproteins to the ERAD pathway. (elifesciences.org)
Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)

Conjugated LAMP1 antibodies are ideal for immunocytochemistry colocalization studies in lysosomes. (rndsystems.com)
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)

The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). (nih.gov)

The activity and function of GBA is regulated by several accessory proteins including lysosomal integral membrane protein 2 (LIMP2) and progranulin (PGRN). (biomedcentral.com)
The protein encoded by this gene is a member of a family of membrane glycoproteins. (antibodies-online.com)
Both domains have hydrophobic beta sheets which anchor the protein in the membrane. (tu-muenchen.de)

Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)

CLN7/MFSD8 gene encodes a lysosomal membrane glycoprotein, but the biochemical processes affected by CLN7-loss of function are unexplored thus preventing development of potential treatments. (nature.com)

Helices and sheets are stabilized by hydrogen bond interactions between the backbone atoms of the corresponding residues and are the only regular secondary structural elements present in proteins (cf. (tu-muenchen.de)
depicts the secondary structure elements of the corresponding crystal structure which coincide with the DSSP assignments. (tu-muenchen.de)