Correlate gene expression regulation developmental. Medical search. Frequent questions

Certain lncRNAs are involved in important biological processes in cancer development through the regulation of target genes, including DNA methylation, histone modification and chromatin remodeling ( 13 ), and have considerable roles in the processes of proliferation, migration and invasion in a variety of tumors, which are closely related to treatment strategies and prognoses of these patients. (spandidos-publications.com)
Combining miRNA-based therapies with other anticancer treatments is of interest due to the ability of miRNAs to target multiple target genes. (biomedcentral.com)
Winzer-Serhan U.H. (2011) Expression and regulation of brain SIRT1 and its target genes by aging and neuronal heteromeric nicotinic cholinergic receptors. (tamu.edu)
In contrast to 4Tran-PCR, Capture-4Tran can uniquely identify both ends of an interaction that involve retroviral repeat sequences, providing a powerful tool for uncovering the individual transposable element insertions that interact with and potentially regulate target genes. (biomedcentral.com)
4Tran provides new insight into the manner in which transposons contribute to chromosome architecture and identifies target genes that transposable elements can potentially control. (biomedcentral.com)

Among our differentially expressed lncRNAs, 17% showed significant correlation with genes. (frontiersin.org)
Through comparative analysis, 19,356 differentially expressed genes were found and enriched into 208 GO terms and 146 KEGG pathways, among which plant hormone signal transduction was the most significantly enriched pathway. (biomedcentral.com)
A total of 121 oil content accumulation and 189 seed formation candidate genes were screened from differentially expressed genes. (biomedcentral.com)
For different developmental stages of Jiyu-72, and a total of 11,592, 16,594 and 16,255 differentially expressed genes (DEGs) were screened at 35 days after flowering (DAF), 55 DAF and 65 DAF compared with 15 DAF, respectively. (biomedcentral.com)
We identified a subset of genes differentially regulated and specific to either stage. (genprofiling.com)
Using a genome-wide approach, we identified differentially expressed genes in the hippocampus of Foxp1 cKO mice associated with synaptic function and development. (jneurosci.org)

First, we describe the expression pattern of Necdin in developing DRGs and report a reduction of one-third in specified sensory neurons in dorsal roots ganglia and show that this neuronal loss is achieved by E13.5, when DRGs sensory neurons are specified. (nih.gov)
The neuronal transcriptomes were highly correlated with adult hypothalamus compared to any other brain region from the GTEx. (duke.edu)
Also, approximately 25% of the transcripts showed substantial changes in expression across neuronal development and potential co-regulation of biological processes that mirror neuronal development in vivo. (duke.edu)
The modulation was enriched near the stop codon of mRNAs, including genes related to neuronal plasticity. (jneurosci.org)
Here, we show that FEZF2 functions as a transcriptional repressor, and it regulates subtype-specific identities of both corticothalamic and subcerebral neurons by selectively repressing expression of genes inappropriate for each neuronal subtype. (stanford.edu)
By recording the activity of single MT neurons while animals report the perceived configuration, I showed that the neuronal activity was correlated with the animals reported sensation. (nih.gov)
Shep is required for neuronal remodeling during development and is highly enriched in the CNS, perhaps serving to negatively regulate insulator function in these cell types to promote CNS-specific gene expression programs. (nih.gov)

Scholars@Duke publication: Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Hypothalamic Neurones Provides Developmental Insights into Genetic Loci for Body Weight Regulation. (duke.edu)
We confirmed the utility of this in vitro human model for studying the development of key hypothalamic neurones involved in energy balance and show that genes at loci associated with body weight regulation may share a pattern of developmental regulation. (duke.edu)
While we and others have proposed the origination of human de novo genes from lncRNA loci, the detailed evolutionary process of this lncRNA-mRNA transition has yet to be fully delineated at the molecular level. (xnetics.com)
Insulators enforce the strict specific and temporal expression of loci with complex enhancer and/or promoter configuration. (nih.gov)

Transcriptome data of different developmental stages of spurs were obtained, and a series of candidate genes related to spur development were identified. (biomedcentral.com)
Substantial changes regarding colour parameters, both between peel and flesh and among the different developmental stages, were monitored, concomitant with a significant increment in carotenoid content. (biomedcentral.com)

Allogro® causes a significant induction of osteoblast transcriptional factor like osterix (RUNX2) and of the bone related genes osteopontin (SPP1), osteocalcin (BGLAP) and alkaline phosphatase (ALPL). (ispub.com)
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, like transcriptional factors (RUNX2), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were examined by means of real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). (ispub.com)
It was observed that this reduction in the average transcription level per gene is accompanied by the generation of transcriptional bursts. (aps.org)
MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. (biomedcentral.com)
Hannenhalli's current research focuses on comparative genomics, transcriptional regulation, and evolution. (umd.edu)
7. Transcriptional hierarchy in Xenopus embryogenesis: HNF4 a maternal factor involved in the developmental activation of the gene encoding the tissue specific transcription factor HNF1 alpha (LFB1). (nih.gov)
Open chromatin promotes gene activation, while condensed heterochromatin is associated with a repressive transcriptional state. (stratech.co.uk)
Overall, this relaxing of chromatin architecture allows greater accessibility for transcriptional machinery, which promotes gene expression 5,7,8 . (stratech.co.uk)
Chromatin insulators are DNA-protein complexes that influence gene expression by establishing chromatin domains subject to distinct transcriptional controls, likely through alteration of their spatial organization. (nih.gov)

We observed a strong correlation between synaptic plasticity and cFos expression, suggesting a synaptic mechanism for the association of cFos expression with memory engrams. (janelia.org)
Co-expression analyses revealed little to no correlation between genes affected by spinosad and nAChRα6 expressing neurons, but a positive correlation with glial cell markers. (janelia.org)
There was an inverse correlation of miR-376c-3p and GSTZ1 protein expression in the liver samples. (aspetjournals.org)

Gene Ontology and pathway enrichment analyses indicated that induction of helplessness altered expression of mRNAs enriched in fundamental biological functions implicated in stress/depression neurobiology such as synaptic, metabolic, cell survival and proliferation, developmental and chromatin modification functions. (frontiersin.org)
For instance, lncRNA hypoxia-inducible factor 1α-antisense 2 (AS2) is an oncogenic KRAS-inducible lncRNA and its high expression may promote lung cancer cell proliferation and tumor metastasis ( 14 ). (spandidos-publications.com)
Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. (thermofisher.com)
They have a critical role in regulation of cell proliferation and migration. (biomedcentral.com)

These three FABPs, along with their fatty acid ligands, have distinct and dynamic spatio-temporal expression profiles that correlate with specific developmental stages and processes in the brain. (ehu.eus)
Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (eurekalert.org)
Transcriptomic sequencing and analysis were performed on spurs and limbs of I. uliginosa at three developmental stages. (biomedcentral.com)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
The donor teeth of these DPC lines were categorized into three developmental stages: crown completed (CC), root forming (RF) and root completed (RC). (nature.com)
We randomly selected six lines isolated from various developmental stages to induce iPSCs and found that five DPC lines showed higher reprogramming efficiency than human dermal fibroblasts (HDFs). (nature.com)
Here, we focused on the relationship between the developmental stages of DPCs and reprogramming efficiency. (nature.com)
We profiled the transcriptomes of 86,024 single cells from C. elegans embryos at developmental stages ranging from gastrulation to terminal cell differentiation. (upenn.edu)
Obusa') in peel and flesh tissue during distinct on-tree developmental stages through a targeted analytical and molecular approach. (biomedcentral.com)
PSY1 , ZDS , CYCB and BCH were up-regulated and CRTISO , LCYE , ECH and VDE were down-regulated in most of the developmental stages compared with the immature stage in both peel and flesh tissue. (biomedcentral.com)
A link between gene up- or down-regulation during the developmental stages of the loquat fruit, and how their expression affects carotenoid content per tissue (peel or flesh) was established. (biomedcentral.com)

It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. (biomedcentral.com)
Together, these data suggest that proper expression of Foxp1 in the pyramidal neurons of the forebrain is important for regulating gene expression pathways that contribute to specific behaviors reminiscent of those seen in autism and intellectual disability. (jneurosci.org)
It turned out that to a very high percentage, these key genes were significantly enriched in Gene Ontology categories or KEGG pathways that fitted very well to the biological context of cardiomyocytes differentiation. (biomedcentral.com)
Further, functional genomics strategies resulted in the identification of genes and regulatory pathways involved in heat stress tolerance in maize. (benthamscience.com)

Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (eurekalert.org)
LncRNAs are non-protein transcripts that are able to regulate cellular processes and gene expression. (springer.com)
The "histone code" hypothesis posits that epigenetic features, specifically histone post-translational modifications (PTMs), act as a unique molecular language to regulate chromatin structure and gene expression1-3. (stratech.co.uk)
In this study, we addressed the hypothesis that microRNAs (miRNAs) could regulate expression of GSTZ1. (aspetjournals.org)

The cellular transportation and physiological actions of PUFAs are mediated by fatty acid binding proteins (FABPs) which are encoded by the intracellular lipid-binding protein gene family. (ehu.eus)
Second, developmental trajectories must be long enough in duration to permit multiple repeated measures, preferably using a within-subject design to control for what are sometimes large between-subject variances developmentally (e.g., rates of physiological or neural development), but short enough to enable time-efficient longitudinal studies. (hindawi.com)
Also, behavioural traits that develop gradually, rather than suddenly, provide a greater opportunity to examine quantitative physiological correlates that underlie a particular behaviour and its antecedents. (hindawi.com)
Studies over the past two decades have clearly demonstrated that microRNAs (miRNAs) have critical roles in regulation of physiological and pathophysiological cellular processes [ 3 ]. (biomedcentral.com)
Understanding the biological implication of PTMs is critical to understanding how chromatin controls gene expression, and disease development, and other physiological processes. (stratech.co.uk)

To better understand the molecular mechanisms of seed formation and oil content accumulation, WDD01514 (E1), ZYD00463 (E2), and two extreme progenies (E23 and E171) derived from RILs were used for weighted gene coexpression network analysis (WGCNA) combined with transcriptome analysis. (biomedcentral.com)
Using computational methods, gene expression patterns from the literature, and gene expression data obtained from three-dimensional (3D) movies of fluorescent reporter lines, we mapped each single-cell transcriptome to its corresponding position in the known C. elegans cell lineage tree. (upenn.edu)
1) A cell's lineage history and its transcriptome are transiently correlated. (upenn.edu)

The complex then cleaves the mRNA into smaller pieces, thereby preventing translation of the protein it encodes, and thus inhibiting or "silencing" gene expression. (eurekalert.org)
Arabidopsis ago1 mutants lacking the AGO1 protein have numerous severe developmental defects, supporting the notion that regulation by microRNAs is critical for normal plant growth. (eurekalert.org)
Elevated ASNS protein expression is associated with resistance to asparaginase therapy in childhood acute lymphoblastic leukemia. (nih.gov)
Although they are void of any protein-coding function and the roles of most lncRNAs have remained to be elucidated, they are newly discovered functional ncRNAs that may exert a wide range of regulatory effects through several mechanisms of action and are important regulators in gene expression networks ( 8-10 ). (spandidos-publications.com)
Gene therapy and functional genetic studies usually require precisely controlled and uniform gene expression in a population of cells for reliable level of protein production. (aps.org)
b , Western blots showing the protein expression of lamin-B and β-tubulin in nuclear and cytoplasmic fractions from human/macaque brain tissue. (xnetics.com)
The biologic function of LKB1 includes the regulation of downstream kinases, including adenosine monophosphate-activated protein kinase (AMPK) and the related kinases (microtube affinity-regulating kinase [MARK] 1 through MARK4 and brain-specific kinase/synapses of the amphid-defective kinase [Brsk/SAD]), which are involved in cellular metabolic regulation-stress response and cellular polarity, the latter through tubulin stabilization, tight junction formation, and E-cadherin localization. (medscape.com)
16. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. (nih.gov)
Expression studies and transgenic plant approaches showed that FvTFL1 protein integrates the photoperiod and temperature signals in the woodland strawberry. (luke.fi)
Histone PTMs can also promote an "open" chromatin structure, making DNA more accessible and/or creating protein binding sites, which support gene expression5. (stratech.co.uk)
Spinosad shows unique impacts on genes involved in lysosomal function, protein folding, and reproduction. (janelia.org)
Defined by the specific binding of the Su(Hw) zinc finger DNA-binding protein, gypsy insulator complexes tend to associate with gene-poor, transcriptionally inert regions of the genome. (nih.gov)
However, the mechanism regulating this change of expression is still unknown, and previous studies showed that GSTZ1 mRNA levels did not correlate with GSTZ1 protein expression. (aspetjournals.org)
Using cell culture, we confirmed that miR-376c-3p could downregulate GSTZ1 protein expression. (aspetjournals.org)

The proper localization of insulator bodies is highly correlated with gypsy chromatin insulator function, but their precise function and spatial relationship with respect to the genome is not well understood. (nih.gov)

6. Lowered amounts of the tissue-specific transcription factor LFB1 (HNF1) correlate with decreased levels of glutathione S-transferase alpha messenger RNA in human renal cell carcinoma. (nih.gov)
Both insecticides cause upregulation of Glutathione S-transferase and Cytochrome P450 genes in the brain and downregulation in the fat body, whereas reduced expression of immune-related genes is observed in both tissues. (janelia.org)

Importantly, 57% of the identified regulatory lncRNAs significantly correlated with 18 different synapse-related functions. (frontiersin.org)

This upregulation was correlated with tumor progression. (molvis.org)
We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
Other regulators than FvSOC1 are involved in the upregulation of the FvTFL1 gene: especially under SD conditions. (luke.fi)

We found that basal oxygen consumption rate and ATP-linked respiration positively correlate with lifespan extension and propose the testable hypothesis that the Bioenergetic Health Index can be used as a proxy to predict health-span outcomes. (nih.gov)
[ 2 ] Disruption of circadian clock rhythm, through the aging process or intentional behaviors (e.g., working the night shift), has been positively correlated with the onset and pathogenesis of a number of human diseases. (medscape.com)
In addition, several genes induced during pathological hypertrophy was also found elevated in human heart failure, with their expression was positively correlated with stress markers known NPPB and MYH7. (genprofiling.com)

He continued in the same department for six more years as Assistant Research Chemist studying gene expression and chromatin structure. (wikipedia.org)
Epigenetic regulators often constitute chromatin-modifying enzymes which catalyze the addition and removal of posttranslational modifications on histones and are involved in the control of gene expression by modulating chromatin structure and function. (elifesciences.org)
HDAC1 and HDAC2 belong to the family of class I HDACs, are highly similar (83% identity) and are involved in the control of gene expression by modulating chromatin structure and function. (elifesciences.org)

These developmentally expressed genes were significantly enriched for genes in proximity to BMI-associated variants. (duke.edu)

The review is expected to provide a theoretical basis for tumor treatment and prognosis evaluation based on the effective regulation of lncRNAs and lipid metabolism. (spandidos-publications.com)
Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. (thermofisher.com)
Moreover, aberrant expression of miRNAs has been associated with therapeutic resistance in cancer that suggests these factors as probable efficient therapeutic targets in tumor cells [ 8 ]. (biomedcentral.com)
The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
90%) appears to be a germline mutation of the STK11/LKB1 (serine/threonine kinase 11) tumor suppressor gene,[2, 116] located on chromosome 19p13. (medscape.com)
STK11 is a tumor suppressor gene, in that its overexpression can induce a growth arrest of a cell at the G1 phase of the cell cycle and that somatic inactivation of the unaffected allele of STK11 is often observed in polyps and cancers from patients with Peutz-Jeghers syndrome. (medscape.com)
Besides, CREC family was significantly correlated with advanced tumor stage and poor prognosis of CRC patients. (biomedcentral.com)
The Gene Expression Profiling Interactive Analysis (GEPIA) web server is a valuable resource for gene expression analysis based on tumor and normal samples from the TCGA and the GTEx databases. (biomedcentral.com)

Besides, steric blockage of the promoter as well as techniques affecting the genome allows for lncRNAs gene regulation. (springer.com)
Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. (aps.org)
The structural organization of the genome is regulated at different levels to establish a functional framework that facilitates cellular processes such as gene expression and programmed somatic recombination. (biomedcentral.com)
One of the main aims of functional genomics is to understand the dynamic features encoded in the genome such as the regulation of gene activities. (biomedcentral.com)
A second gene was identified in the Drosopohila genome with homology to scylla , and named charybdis . (sdbonline.org)
The fragmented nature of the genomes has hampered genome wide analysis of Plasmodium gene regulation and function. (biomedcentral.com)
We have produced RNA-seq data and utilised it to improve gene-model prediction and to provide quantitative, genome-wide, data on gene expression. (biomedcentral.com)
Comparison of the RMP genomes with the genome of the human malaria parasite P. falciparum and RNA-seq mapping permitted gene annotation at base-pair resolution. (biomedcentral.com)
Comparisons with the genome of the human parasite P. falciparum and other primate malaria species defined a large set of core genes that are shared between RMPs and primate malarias [ 18 ]-[ 20 ]. (biomedcentral.com)

First on our list is histone acetylation, a highly abundant modification that is associated with gene activation. (stratech.co.uk)
Histone tail acetylation counteracts repressive methylation marks at promoters and enhancers, supporting gene activation. (stratech.co.uk)

Children with mutations in the ASNS gene exhibit developmental delays, intellectual disability, microcephaly, intractable seizures, and progressive brain atrophy. (nih.gov)
Thus far, 15 unique mutations in the ASNS gene have been clinically associated with asparagine synthetase deficiency (ASD). (nih.gov)
Inherited causes account for approximately 50% of individuals seen for childhood (prelingual) hearing loss, of which 70% are due to mutations in numerous single genes that impair auditory function alone (nonsyndromic). (medscape.com)
Waardenburg syndrome type IV is autosomal recessive with variable penetrance and is due to SOX10 or endothelin-B receptor ( EDNRB ) gene mutations, which appear to correlate with the intestinal and/or neurological symptoms manifested in patients. (medscape.com)

Since telomere length tends to shorten with age in humans leading to cellular senescence, telomerase was a potential key factor in promoting human aging from human cancer cells that led to the successful cloning of the first human telomerase gene in early 1994. (wikipedia.org)
Functional co-expression analysis linked the identified lncRNAs to several cellular mechanisms implicated in stress/depression neurobiology. (frontiersin.org)
Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7. (nih.gov)
We found that knowing the cell division rates and nongenetic (cellular) memory of gene expression states were necessary for predicting the overall fitness of cell populations in specific antibiotic- and inducer-containing environments. (aps.org)
Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. (biomedcentral.com)
Analysis of such gene expression data provides enormous leverages to understand the principles of cellular systems, diseases mechanisms, molecular networks etc. (biomedcentral.com)
Detecting hub genes and analyzing their roles may facilitate understanding the basal control mechanisms of a certain normal or disease cellular phenotype to develop. (biomedcentral.com)

A number of transcription factors have been shown to be involved in the developmental regulation of FABP gene expression in the brain. (ehu.eus)
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. (thermofisher.com)
Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. (thermofisher.com)
The project is built on a systematic transgenic strategy to perturb the expression of targeted cell-wall component genes and transcription factors (TFs). (osti.gov)
12. Expression of hepatic transcription factors during liver development and oval cell differentiation. (nih.gov)

a , b , Box plots showing the density of strong U1 binding sites (in number of sites per kilobase) in the genic ( a ) and exonic regions ( b ) of genes encoding mRNAs and lncRNAs. (xnetics.com)

Projection neuron subtype identities in the cerebral cortex are established by expressing pan-cortical and subtype-specific effector genes that execute terminal differentiation programs bestowing neurons with a glutamatergic neuron phenotype and subtype-specific morphology, physiology, and axonal projections. (stanford.edu)

Thus mining the temporal expression patterns in such multi-dimensional datasets may not only provide insights into the key biological processes governing organs to grow and develop but also facilitate the understanding of the underlying complex gene regulatory circuits. (biomedcentral.com)
Appropriate computational methods are therefore required to analyze such high-throughput datasets specifically to identify temporal expression patterns over biological replicates and time points. (biomedcentral.com)
This is further supported by their mostly nonoverlapping mRNA expression patterns. (sdbonline.org)
Additional theoretical results demonstrate the enhanced memory storage capacity of such networks, particularly in the face of correlated input patterns. (janelia.org)
Phylogenetic classification of the pir family, combined with pir expression patterns, indicates functional diversification within this family. (biomedcentral.com)
We comprehensively analyzed the expression patterns, prognostic values, immune cell infiltration and biological functions of CREC family in CRC using publicly accessible databases and further verified the bioinformatic results in human CRC cell lines and CRC tissues. (biomedcentral.com)

This review provides an overview of the importance of microbiota in the regulation of gut-brain communication in immune-related neurological disorders. (biomedcentral.com)
Alterations in the gut microbiota and microbial metabolite production have been linked to a wide range of immune-related neurological disorders, including developmental disorders, neurodegeneration, and emotional dysregulation. (biomedcentral.com)

The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (eurekalert.org)

To explore the possible regulatory roles of the altered lncRNAs, we constructed co-expression networks composed of the lncRNAs and mRNAs. (frontiersin.org)
mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (eurekalert.org)
Several steps, such as transcription, RNA splicing and translation are involved in the process of gene expression, which is subject to a great many of regulatory mechanisms. (biomedcentral.com)

In humans, smoking is negatively correlated with the development of Parkinson's and Alzheimer's disease. (tamu.edu)
Long days (LD) and day-length extension with far-red wavelength (FR) light substantially activated the expression of FvFT1, which correlated negatively with flowering in the seasonal flowering woodland strawberry. (luke.fi)

4) In many cases, purely computational reconstruction of developmental trajectories from the single-cell transcriptomic data does not accurately reproduce the known cell lineage. (upenn.edu)

Twenty candidate genes that may be involved in spur development were screened and verified by qPCR, such as SBP, IAA and ABP. (biomedcentral.com)
WGCNA identified six modules related to seed oil content and seed weight, and 76 candidate genes were screened from modules and network. (biomedcentral.com)

EMOA- δ -TRIMAX has proven instrumental in identifying groups of genes in transcriptomic data sets that represent the functional categories constituting the biological process under study. (biomedcentral.com)

We profiled a panel of human melanoma cell lines and control melanocytes for altered expression of hedgehog pathway members and determined the consequences of both genetic and pharmacological inhibition of the hedgehog pathway activator Smoothened (SMO) in melanoma, both in vitro and in vivo . (mdpi.com)
Genes with proximity to body mass index (BMI)-associated genetic variants were mapped to the developmentally expressed genesets, and enrichment significance was assessed with Fisher's exact test. (duke.edu)
Exploratory analysis of multi-dimensional high-throughput datasets, such as microarray gene expression time series, may be instrumental in understanding the genetic programs underlying numerous biological processes. (biomedcentral.com)

Villeponteau was awarded a Molecular Biology Postdoctoral Fellowship in the UCLA Department of Chemistry and Biochemistry from 1978 to 1980, where he carried out genomic cloning of the B-globin gene cluster in Chickens. (wikipedia.org)
Join us and publish in a specialized journal in Developmental Biology, university-based, with a long and prestigious history. (ehu.eus)
They could be used to study normal developmental biology or disease pathogenesis, or for drug screening. (nih.gov)
Complete RMP genomes, RNA-seq and genotypic diversity data are excellent and important resources for gene-function and post-genomic analyses and to better interrogate Plasmodium biology. (biomedcentral.com)

The model suggests that heterochromatin provides a fundamental epigenetic mechanism that underlies most of the changes in gene expression in senescence. (wikipedia.org)
Loss of insulator activity can result in substantial positive or negative changes in gene expression, culminating in disease, defects in development, and/or lethality. (nih.gov)

1986) Persistence of DNA synthesis arrest sites in the presence of T4 DNA polymerase and T4 gene 32, 44, 45 and 62 DNA polymerase accessory proteins, Nucl. (nih.gov)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (eurekalert.org)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (eurekalert.org)
17. Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins. (nih.gov)
Oxygen tension and cytokines have been shown to influence trophoblast VEGF expression, suggesting that this particular family of angiogenic proteins plays an important role in placental angiogenesis [3]. (who.int)
We continue to delve into the mechanisms by which these mRNAs function and the roles of associated RNA-binding proteins in insulator regulation. (nih.gov)

namely learned helplessness, RNA-seq, Gene Ontology and co-expression network analyses to profile the expression pattern of lncRNA and mRNA in the hippocampus of mice. (frontiersin.org)

The mammalian gene family of Cab45/reticulocalbin/ERC-45/calumenin (CREC) consists of RCN1, RCN2, RCN3, SDF4 and CALU. (biomedcentral.com)

Its aim is to make optimal use of δ -TRIMAX in extracting groups of co-expressed genes from time series gene expression data, or from any 3D gene expression dataset, by adding the powerful capabilities of an evolutionary algorithm to retrieve overlapping triclusters. (biomedcentral.com)
Our dataset defines the succession of gene expression changes associated with almost every cell division in an animal's embryonic cell lineage. (upenn.edu)

Comparative genomic approaches described composition BCAT gene family in durum wheat. (genprofiling.com)
The expression levels of CREC family had correlations with genomic mutation and methylation, and with the infiltration levels of CD4 + T cells, macrophages, neutrophils, and dendritic cells in the microenvironment of CRC. (biomedcentral.com)

To facilitate this commitment, NIMH invites proposals for the formation of cross- disciplinary networks of scientists interested in the role of hypothalamic- pituitary-adrenal axis (HPA) regulation in development and psychopathology. (nih.gov)
Furthermore, individual differences in HPA regulation could be involved in the development of psychopathology. (nih.gov)
These changes were correlated with dramatic development defects in leaves, roots, and flowers, showing that microRNA-mediated regulation of ARF17 is essential for normal plant development. (eurekalert.org)
with these three reports, we are beginning to understand the consequences of this regulation for the development of the plant. (eurekalert.org)
A recent study by Hand and colleagues advances our understanding of these processes further by demonstrating that disruption of circadian clock regulation in mesenchymal cells not only has an impact on the development of joint structures, but on the inflammatory response and on the onset/pathogenesis of arthritis. (medscape.com)
[ 6 ] Transgenic mouse models have begun to shed light on the role of circadian clock rhythm in bone and joint development, maturation, and homeostasis, as mice with deficient clock regulation display abnormal joint morphology and increased susceptibility to inflammatory arthritis. (medscape.com)
[ 1 ] However, given that Bmal1 was inactivated in all Col6a1-expressing cells throughout the development of the animal, it remains difficult to dissect what proportion of the observed effects were due to the loss of Bmal1 during developmental processes vs. post-induction of arthritis. (medscape.com)
The importance of genes related to cell cycle, cell division, cell elongation and hormones in spur development was clarified. (biomedcentral.com)
Thus, together with its role in early development, the dynamic regulation of m 6 A in the adult brain serves as an important epitranscriptomic mechanism associated with behavioral adaptation. (jneurosci.org)
Overall, these results contribute to an understanding of seed lipid metabolism and seed size during seed development, and identify potential functional genes for improving soybean yield and seed oil quantity. (biomedcentral.com)
This can impair brain development, particularly via the adverse influence of oxidative stress on epigenetic regulation. (hindawi.com)
I am interested in studying how gene environmental interactions shape the brain during development. (tamu.edu)
In particular, Foxp1 regulation of gene expression appears to be crucial for normal hippocampal development, CA1 plasticity, and spatial learning. (jneurosci.org)
2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)
10. Patterning the expression of a tissue-specific transcription factor in embryogenesis: HNF1 alpha gene activation during Xenopus development. (nih.gov)
Regulation of osmoprotectants, detoxification of excess reactive oxygen species (ROS), expression of heat-responsive/shock genes, and change of plant phenology help in the development of heat tolerance. (benthamscience.com)
Overall, differential regulation of expression levels with the progress of on-tree fruit development was more evident in the middle and downstream genes of carotenoid biosynthetic pathway. (biomedcentral.com)
Over the past decade, it has been known that the communication in the microbiota-gut-brain axis enables the gut microbiota to connect to immune and hormonal systems in the regulation of brain function and development [ 1 , 2 , 3 , 4 ]. (biomedcentral.com)
Examples include metazoan Hox genes, master regulators of body segmentation, and the vertebrate beta-globin locus, which changes in expression during erythroid development. (nih.gov)

Given the essential role that acoustic communication serves in reproduction for many organisms and that receivers can exert strong influence on the evolution of signals, understanding the evolutionary developmental basis of mate recognition will provide new insights into the evolution of communication systems. (hindawi.com)
This paper hypothesizes that environmental factors resulting from a mismatch between environment of evolutionary adaptedness and culture initiate or perpetuate early motor and sensory-motor lesions, triggering a butterfly effect of multi-directional cascades of atypical developmental in the complex adaptive system of the parent and ASD-susceptible infant. (frontiersin.org)

K-means clustering of the longitudinal data was conducted to identify co-regulation and microRNA control of biological processes. (duke.edu)
In recent years, such expression signatures have increasingly been monitored for sets of time points in order to follow the course of biological processes. (biomedcentral.com)

Example for the expression of the alpha7 nAChR subunit in the hippocampus of a newborn rat pup. (tamu.edu)
Son J.H., Winzer-Serhan U.H. (2009) Chronic neonatal nicotine exposure increases expression of neurotrophic factors in the rat hippocampus. (tamu.edu)

MiDAC upregulates gene expression of pro-neural genes such as those encoding the secreted ligands SLIT3 and NETRIN1 (NTN1) by a mechanism suggestive of H4K20ac removal on promoters and enhancers. (elifesciences.org)

In general, an altered balance of excitatory and inhibitory transmission could have major implications not only for our understanding of developmental nicotine exposure, but will also shed light on the role of the nicotinic cholinergic system on developmental disorders such as schizophrenia, bipolar and autism disorders. (tamu.edu)
Mitchell MR, Mendez IA, Vokes CM, Damborsky JC, Winzer-Serhan UH, Setlow B. (2012) Effects of developmental nicotine exposure on decision-making in adulthood. (tamu.edu)

Most primary cells in 2-D cultures quickly lose in vivo properties such as tissue-specific gene expression, cell polarity, and cell-cell and cell-matrix contacts. (nih.gov)

Chronic sympathetic nervous system/hypothalamic-pituitary-adrenal axis hyperarousal and disrupted parent-infant biobehavioral synchrony are the key biologic and behavioral mechanisms perpetuating these atypical developmental cascades. (frontiersin.org)
Genes having similar expression profiles are frequently found to be regulated by similar mechanisms. (biomedcentral.com)

We also examined the relationship between altered expression of hedgehog pathway mediators and survival in a well-characterized cohort of metastatic melanoma patients with prospectively collected follow up information. (mdpi.com)
This project, investigates a possible connection between nAChRs and regulation of neurotrophic factors and survival genes such as SIRT and Nampt, and Ku70, which are critical in the aging process. (tamu.edu)
In this study, the expression, survival and biological functions of CREC family in CRC were determined via bioinformatic datasets analysis and experimental verification on clinical CRC specimen. (biomedcentral.com)

To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. (ispub.com)

This diagram demonstrates the role of STK11/LKB1 in neoplasia: regulation of cell polarity and metabolism. (medscape.com)

Whether pan-cortical glutamatergic and subtype-specific characteristics are regulated by the same genes or controlled by distinct programs remains largely unknown. (stanford.edu)

We demonstrate that MiDAC functions as a modulator of a neurodevelopmental gene expression program and binds to important regulators of neurite outgrowth. (elifesciences.org)
Conversely, MiDAC inhibits gene expression by reducing H3K27ac on promoter-proximal and -distal elements of negative regulators of neurogenesis. (elifesciences.org)

The miRNA expression profiles are provided and will prove useful for future studies of drug-metabolizing enzymes in infants and adults. (aspetjournals.org)

At Michigan, Villeponteau mostly worked on human gene regulation Villeponteau also studied human cell aging using senescent human cells. (wikipedia.org)
The third strategy uses targeted delivery of therapeutic genes (using viral and non-viral vectors) that either transduce host cells in vivo or stably transduce cells in vitro for subsequent implantation in vivo. (ispub.com)
Currently it remains unclear how a cell population's growth rate and its subpopulation fractions in specific environments emerge from the stochastic molecular-level kinetics of gene networks and the division rates of single cells. (aps.org)
14. Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells. (nih.gov)
2) Genes that distinguish sister cells are often first coexpressed in the parent and then selectively retained in one daughter but not the other. (upenn.edu)
We investigated the relationship between synapse-level and cell-level memory encodings by mapping synaptic plasticity and cFos expression in hippocampal CA1 pyramidal cells upon contextual fear conditioning (CFC). (janelia.org)
We also detected and experimentally confirmed nAChRα6 expression in fat body cells and male germline cells. (janelia.org)
Through examination of microRNA (miRNA) expression in liver from infants and adults and studies in cells, we showed that expression of GSTZ1 is controlled by miRNA. (aspetjournals.org)

The RNA modification N 6 -methyladenosine (m 6 A) influences mRNA stability and cell-type-specific developmental programming, and is highly abundant in the adult brain. (jneurosci.org)
28 proposed a 'Latent Early-life Associated Regulation' model, postulating that latent changes in the expression of specific genes initially primed at the developmental stage of life. (nature.com)
During abiotic stress, metabolic adaptation is very important for stress tolerance, and specific accumulation of amino acids and / or as secondary metabolites derived from the metabolism of amino acids can be correlated with increased tolerance to adverse environmental conditions. (genprofiling.com)
Marker genes known to be expressed in specific lineages were critical for correct annotation. (upenn.edu)
GEPIA2 ( http://gepia2.cancer-pku.cn/ ) provides the analysis of RNA sequencing expression data from 198,619 isoforms and 84 cancer subtypes as well as the analysis of a specific cancer subtype, and comparison between subtypes [ 13 ]. (biomedcentral.com)

v DISSERTATION ABSTRACT DIFFERENTIAL MODULATION OF GLUTAMATERGIC SYNAPTIC TRANSMISSION BY POLYSIALIC ACID Catrina Sims-Robinson Doctor of Philosophy, December 17, 2007 (B.S., Auburn University, 2004) 180 Typed Pages Directed by Vishnu Suppiramaniam Controlled modulation and regulation of glutamate receptors are essential for synaptogenesis and synaptic plasticity. (auburn.edu)

There is evidence that ASNS expression levels may also be inversely correlated with asparaginase efficacy in certain solid tumors as well. (nih.gov)
In vivo , the expression of Fto and the m 6 A methyltransferase, Mettl3 correlated with the observed increase in m 6 A levels post-training. (jneurosci.org)
Bioinformatic analysis showed that the expression levels of most CREC family genes were higher in CRC tissues than in normal colorectal tissues. (biomedcentral.com)
The online gene expression array database Oncomine [ 12 ] ( http://www.oncomine.org ) was used to analyze the transcription levels of CREC family in different cancers. (biomedcentral.com)

The Murray laboratory develops and uses whole-organism live-cell imaging, and genomics methods, combined with classical genetics, to study gene regulation across the entire embryo. (upenn.edu)

Anatomy25

Organisms17

Diseases6

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes105

Disciplines and Occupations3

Information Science7

Health Care4

Target genes5

Differentially6

Neuronal7

Loci4

Different developmental stages2

Transcriptional9

Correlation3

Proliferation4

Stages11

Pathways4

Regulate4

Physiological5

Transcriptome3

Protein14

Highly correlated1

Glutathione S-transfera2

LncRNAs significantly1

Upregulation3

Positively3

Chromatin structure3

Significantly enriched1

Tumor8

Genome9

Histone2

Mutations4

Cellular7

Transcription factors5

MRNAs and lncRNAs1

Neurons1

Patterns6

Neurological2

Several genes1

Regulatory3

Negatively2

Trajectories1

Candidate genes2

Transcriptomic data1

Genetic3

Biology4

Changes in gene expression2

Proteins6

Analyses1

Mammalian gene1

Dataset2

Genomic2

Development19

Evolutionary2

Processes2

Hippocampus2

Promoters and enhancers1

Exposure2

Tissue specific1

Mechanisms2

Survival3

Differentiation1

Cell polarity1

Distinct1

Regulators2

Enzymes1

Cells8

Specific5

Synaptic Plasticity1

Levels4

Genetics1