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  • artery
  • percutaneous transluminal coronary angioplasty (PTCA) percutaneous transluminal angioplasty to enlarge the lumen of a sclerotic coronary artery (see accompanying illustration). (thefreedictionary.com)
  • an operation for enlarging the narrowed lumen of a coronary artery by inflating and withdrawing through the stenotic region a balloon on the tip of an angiographic catheter. (thefreedictionary.com)
  • It offers advantages in symptom improvement and exercise tolerance when compared with medical therapy, particularly in the short term, and is less hazardous and has a shorter recovery period than coronary artery bypass grafting (CABG). (thefreedictionary.com)
  • It is also contraindicated in people without demonstrated significant vascular obstruction, as well as in those with severe multivessel disease or more than 50% stenosis of the left main coronary artery. (thefreedictionary.com)
  • In spontaneous (carotid or coronary) artery dissection (SCAD), the layers separate and blood seeps in between the layers. (clevelandclinic.org)
  • SCAD
  • Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement. (clinicaltrials.gov)
  • heart
  • a technique in the treatment of atherosclerotic coronary heart disease and angina pectoris in which some plaques in the arteries of the heart are flattened against the arterial walls, resulting in improved circulation. (thefreedictionary.com)
  • percutaneous coronary int
  • Background- With the reduction in restenosis rates by drug-eluting stents, there is new controversy concerning the optimal management of incidental, nontarget lesions identified during percutaneous coronary intervention (PCI). (ahajournals.org)
  • Thus, focal prophylactic treatment of potentially vulnerable plaques is not performed because percutaneous coronary intervention (PCI) of intermediate lesions has been shown previously to have restenosis rates similar to those of PCI for symptom-causing lesions, thereby obviating the potential benefits of a prophylactic strategy. (ahajournals.org)
  • It is used in a procedure called percutaneous coronary intervention (PCI). (wikipedia.org)
  • Results demonstrate that it is in fact safe to administer the Ad-hHGF vector into patients with coronary artery disease in hopes of re-vascularizing damaged tissue in patients for which coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) are not available or possible. (wikipedia.org)
  • Percutaneous coronary intervention, however, involves the use of mechanical stents to increase blood flow to previously blocked (or occluded) vessels. (wikipedia.org)
  • If necessary, the physician can utilize percutaneous coronary intervention techniques, including the use of a stent (either bare-metal or drug-eluting) to open the blocked vessel and restore appropriate blood flow. (wikipedia.org)
  • Two major randomized controlled trials comparing CABG and DES are either completed or ongoing, and have published results - Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) and Future Revascularization Evaluation in Patients With Diabetes Mellitus-Optimal Management of Multivessel Disease (FREEDOM). (wikipedia.org)
  • CABG
  • Methods and Results -To determine the independent prognostic importance of preoperative ischemia severity for predicting outcomes of CABG among patients with extensive CAD, we monitored 167 stable patients with angiographically documented 3-vessel CAD (average follow-up of 9 years in event-free patients) who previously had undergone rest and exercise radionuclide cineangiography. (ahajournals.org)
  • Conclusions -Assessment of ischemia severity based on LVEF response to exercise enables effective prognostication among patients with 3-vessel CAD and defines the likelihood of life-prolonging and event-reducing benefits from CABG. (ahajournals.org)
  • Coronary artery bypass graft (CABG) surgery is one of the most common elective surgical procedure. (centerwatch.com)
  • Differences between outcomes with stenting and with coronary artery bypass surgery (CABG) are a point of controversy. (wikipedia.org)
  • lumen
  • Although dual-inversion-recovery [ 2 ] (DIR) is the gold standard for vessel wall imaging, optimal lumen-vessel wall contrast is sometimes difficult to obtain and the time-window available for imaging is limited due to the competing requirements between TI* (blood signal nulling time) and TD (period of minimal myocardial motion). (biomedcentral.com)
  • Using TI less than TI*, Fig. 3 shows that PS-DIR enables delineation of the coronary artery vessel wall and supports an increased wall-lumen contrast when compared with the conventional DIR in which TI was too short for adequate blood signal-nulling. (biomedcentral.com)
  • However, eventually, typically as a result of rupture of vulnerable plaques and clots within the lumen over the plaque, stenosis (narrowing) of the vessel develops in some areas. (wikipedia.org)
  • The endothelium (the cell monolayer on the inside of the vessel) and covering tissue, termed fibrous cap, separate atheroma from the blood in the lumen. (wikipedia.org)
  • The rupture results in both (a) a shower of debris occluding smaller downstream vessels (debris larger than 5 microns are too large to pass through capillaries)) combined with (b) platelet and clot accumulation over the rupture (an injury/repair response) resulting in narrowing, sometimes closure, of the lumen. (wikipedia.org)
  • Development of a neointima is variable but can at times be so severe as to re-occlude the vessel lumen (restenosis), especially in the case of smaller diameter vessels, which often results in reintervention. (wikipedia.org)
  • This cap may rupture in unstable angina, allowing blood clots to precipitate and further decrease the area of the coronary vessel's lumen. (wikipedia.org)
  • In general, occlusions greater than 70% of the width of the vessel lumen are thought to require intervention. (wikipedia.org)
  • Angioplasty
  • We examined the influence of vessel size using an intention-to-treat approach in 259 patients who underwent stent implantation and in 257 patients who underwent balloon angioplasty alone in the BENESTENT trial. (biomedsearch.com)
  • In the balloon angioplasty population small vessel size conveyed an increased requirement for revascularization but did not increase the risk of procedural failure or myocardial infarction during follow-up. (biomedsearch.com)
  • Logistic regression indicated that decreasing vessel size (as a continous variable) was associated with an increasing risk of a cardiac event for both the stent and balloon angioplasty populations. (biomedsearch.com)
  • Recent evidence suggests that higher restenosis rate is observed after coronary angioplasty of an infarct-related artery. (unimi.it)
  • Play media Treating a blocked ("stenosed") coronary artery with a stent follows the same steps as other angioplasty procedures with a few important differences. (wikipedia.org)
  • Once the catheter is in place, it can be used to perform a number of procedures including, coronary angioplasty, balloon septostomy, electrophysiology study or catheter ablation. (wikipedia.org)
  • The stent is usually placed within the peripheral or coronary artery by an interventional cardiologist or interventional radiologist during an angioplasty procedure. (wikipedia.org)
  • humans
  • Conclusions -In vivo free-breathing coronary vessel wall and plaque imaging with MR has been successfully implemented in humans. (ahajournals.org)
  • Conclusions -Long-term oral l -arginine supplementation for 6 months in humans improves coronary small-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations. (ahajournals.org)
  • We recently demonstrated that coronary endothelial dysfunction in humans is characterized by increased coronary and circulating endothelin and decreased production of the second messenger of NO, cGMP. (ahajournals.org)
  • Blood vessel epicardial substance (BVES) also known as popeye domain-containing protein 1 (POPDC1) is a protein that in humans is encoded by the BVES gene. (wikipedia.org)
  • clinical
  • 5,6 However, the incidence of clinical plaque progression in a large, contemporary cohort of patients treated with culprit vessel PCI and medical therapy for secondary prevention is unknown. (ahajournals.org)
  • There was no difference between the two study groups in clinical characteristics or in the coronary blood flow in the response to acetylcholine at baseline. (ahajournals.org)
  • Their course was correlated with data obtained during initial radionuclide testing, coronary arteriography, and clinical evaluation at study entry. (ahajournals.org)
  • A phase I clinical trial entailed injecting an adenovirus vector with the human HGF (Ad-hHGF) gene into the coronary vessels localized to ischemic tissue. (wikipedia.org)
  • endothelium
  • Background -Coronary endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilating and vasoconstricting factors and coronary vasoconstriction in response to the endothelium-dependent vasodilator acetylcholine. (ahajournals.org)
  • Endothelium-dependent coronary blood flow reserve to acetylcholine (10 −6 to 10 −4 mol/L) was assessed at baseline and after 6 months of therapy. (ahajournals.org)
  • The coronary vascular endothelium modulates vascular tone through release of vasodilating and vasoconstricting substances. (ahajournals.org)
  • 1 2 Endothelin-1, on the other hand, is an endothelium-derived peptide that produces coronary vasoconstriction at pathophysiological concentrations by binding to specific receptors on the vascular smooth muscle. (ahajournals.org)
  • therapeutic
  • 1. The digitalis derivatives, K -strophanthin, ouabain and digifoline at times have a direct coronary constrictor action even in therapeutic doses. (aspetjournals.org)
  • Thus, an understanding of the mechanisms of embryonic coronary vasculogenesis and angiogenesis may prove invaluable in developing novel strategies for cardiovascular regeneration and therapeutic coronary angiogenesis. (ox.ac.uk)
  • stent implantation
  • We retrospectively analyzed the results of 381 consecutive patients treated with Palmaz-Schatz coronary stent implantation between May 1992 and January 1996. (unimi.it)
  • patients
  • At study entry, these patients had angiographically confirmed 3-vessel CAD and underwent rest and exercise radionuclide cineangiography for determination of ischemia severity by LVEF analysis. (ahajournals.org)
  • noninvasive
  • We therefore sought to develop a noninvasive free-breathing MR technique for coronary vessel wall imaging. (ahajournals.org)
  • 6 A noninvasive technique that would allow for visualization of plaque area and luminal vessel area narrowing and that also allowed for characterization of the plaque constituents would therefore be of great interest. (ahajournals.org)
  • 1-3 Noninvasive imaging and coronary angiography have as yet not been able to identify those plaques with a higher propensity for future instability. (ahajournals.org)
  • angina
  • Although about 250 cases of SCAD have been reported in the literature, to the best of our knowledge, spontaneous three vessel coronary dissection associated with typical effort angina has never been reported. (bmj.com)
  • Worsening angina attacks, sudden-onset angina at rest, and angina lasting more than 15 minutes are symptoms of unstable angina (usually grouped with similar conditions as the acute coronary syndrome). (wikipedia.org)
  • this is a form of acute coronary syndrome) is defined as angina pectoris that changes or worsens. (wikipedia.org)
  • Heart
  • Coronary artery anomalies (or malformation of coronary vessels) are congenital abnormalities in the coronary anatomy of the heart. (wikipedia.org)
  • The Congenital Heart Surgeons' Society has started a long-term ongoing study called anomalous aortic origin of a coronary artery (AAOCA) to identify the best way to treat this defect. (wikipedia.org)
  • The backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood. (wikipedia.org)
  • The left coronary artery distributes blood to the left side of the heart, the left atrium and ventricle, and the interventricular septum. (wikipedia.org)
  • This is because blockage of one coronary artery generally results in death of the heart tissue due to lack of sufficient blood supply from the other branch. (wikipedia.org)
  • There, he continued research, studying the chemistry of heart attacks, developing techniques for high-speed photography of the coronary vessels, and measurement of blood flow using nitric oxide. (wikipedia.org)
  • blockage
  • An anastomosis is an area where vessels unite to form interconnections that normally allow blood to circulate to a region even if there may be partial blockage in another branch. (wikipedia.org)
  • This technique is also used to assess the amount of occlusion (or blockage) in a coronary artery, often described as a percentage of occlusion. (wikipedia.org)
  • Left
  • Infusion of Ucn2 into rat hearts resulted in an immediate and significant improvement in left ventricle function, increased coronary flow, significantly altered intracellular calcium handling and increased SR calcium. (wikipedia.org)
  • The circumflex artery arises from the left coronary artery and follows the coronary sulcus to the left. (wikipedia.org)
  • Small branches of the LAD (left anterior descending/anterior interventricular) branch of the left coronary join with branches of the posterior interventricular branch of the right coronary in the interventricular sulcus(groove). (wikipedia.org)
  • tissue
  • Platelet activation can occur through different mechanisms such as a vessel wall breach that exposes collagen, or tissue factor encryption. (wikipedia.org)
  • artery
  • percutaneous transluminal coronary angioplasty (PTCA) percutaneous transluminal angioplasty to enlarge the lumen of a sclerotic coronary artery (see accompanying illustration). (thefreedictionary.com)
  • an operation for enlarging the narrowed lumen of a coronary artery by inflating and withdrawing through the stenotic region a balloon on the tip of an angiographic catheter. (thefreedictionary.com)
  • It offers advantages in symptom improvement and exercise tolerance when compared with medical therapy, particularly in the short term, and is less hazardous and has a shorter recovery period than coronary artery bypass grafting (CABG). (thefreedictionary.com)
  • It is also contraindicated in people without demonstrated significant vascular obstruction, as well as in those with severe multivessel disease or more than 50% stenosis of the left main coronary artery. (thefreedictionary.com)
  • In spontaneous (carotid or coronary) artery dissection (SCAD), the layers separate and blood seeps in between the layers. (clevelandclinic.org)
  • SCAD
  • Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement. (clinicaltrials.gov)
  • heart
  • a technique in the treatment of atherosclerotic coronary heart disease and angina pectoris in which some plaques in the arteries of the heart are flattened against the arterial walls, resulting in improved circulation. (thefreedictionary.com)
  • CABG
  • Ex vivo gene therapy during coronary artery bypass grafting (CABG) holds great potential to prevent excessive smooth muscle cell (SMC) proliferation, neointima formation and graft failure. (ebscohost.com)
  • relaxes
  • This relaxes your blood vessels, which can reduce the amount of work the heart has to do. (kramesonline.com)
  • Following amyl nitrite inhalation, all animals exhibited decreased arteriolar resistance and eventually an increase in total vascular volume, These results indicate that amyl nitrite, like other nitrite compounds, dilates vascular smooth muscle and relaxes resistance and capacitance vessels. (ebscohost.com)
  • cells
  • In a Nature Medicine paper receiving advance online publication, the investigators describe how microOCT - which provides 10 times greater resolution than standard OCT - was able to show individual arterial and inflammatory cells, including features that may identify vulnerable plaques, within coronary artery samples. (innovations-report.com)
  • The ability to track and follow cells in three dimensions could help us prove or disprove many theories about coronary artery disease and better understand how clots form on a microscopic level. (innovations-report.com)