Coronary vasospasm. Medical search. Frequent questions

Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S. Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm. (medscape.com)
The mystery of coronary artery spasm. (medscape.com)
Yasue H, Touyama M, Kato H, Tanaka S, Akiyama F. Prinzmetal's variant form of angina as a manifestation of alpha-adrenergic receptor-mediated coronary artery spasm: documentation by coronary arteriography. (medscape.com)
Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. (medscape.com)
Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene. (medscape.com)
The endothelial nitric oxide synthase gene -786T/C polymorphism is a predictive factor for reattacks of coronary spasm. (medscape.com)
Nakano T, Osanai T, Tomita H, Sekimata M, Homma Y, Okumura K. Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm. (medscape.com)
Stern S, Bayes de Luna A. Coronary artery spasm: a 2009 update. (medscape.com)
Adlam D, Azeem T, Ali T, Gershlick A. Is there a role for provocation testing to diagnose coronary artery spasm? (medscape.com)
Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography. (medscape.com)
Frequency of provoked coronary spasms in patients undergoing coronary arteriography using a spasm provocation test via intracoronary administration of ergonovine. (medscape.com)
What is a coronary artery spasm? (healthline.com)
A coronary artery spasm is a sudden tightening of the muscles within the arteries of your heart. (healthline.com)
What are the symptoms of a coronary artery spasm? (healthline.com)
It's also possible you're able to detect other symptoms of a coronary artery spasm. (healthline.com)
What causes a coronary artery spasm? (healthline.com)
Researchers don't know exactly what causes a coronary artery spasm. (healthline.com)
Researchers think this system plays a role, since coronary artery spasm often happens at night and can be activated by the neurotransmitter acetylcholine and the hormone catecholamine. (healthline.com)
In some people with coronary artery spasm, the cells do not release enough nitric oxide. (healthline.com)
Differences in how this muscle functions may lead to coronary artery spasm. (healthline.com)
There is no genetic test for coronary artery spasm. (healthline.com)
What are the risk factors for a coronary artery spasm? (healthline.com)
How is a coronary artery spasm diagnosed? (healthline.com)
A coronary artery spasm indicates that there's a potential problem in your heart. (healthline.com)
How is a coronary artery spasm treated? (healthline.com)
Treatment for a coronary artery spasm focuses on relieving chest pain. (healthline.com)
Cardiac anaphylaxis is accompanied by coronary spasm and decreased left ventricular (LV) contractility. (viamedica.pl)
In response to antigen administrations, sensitized anaphylaxis group rat hearts showed decreases in CBF and the maximum increasing rate of systolic LV pressure (dP/dt max ) with an increased coronary vascular resistance as evidence of coronary spasm. (viamedica.pl)
The contractile failure during cardiac anaphylaxis is caused mainly by decreased CBF due to coronary spasm. (viamedica.pl)
4. A case of coronary spasm induced by 5-fluorouracil. (nih.gov)
7. Coronary spasm induced by capecitabine mimicks ST elevation myocardial infarction. (nih.gov)
10. A case of severe coronary spasm associated with 5-fluorouracil chemotherapy. (nih.gov)
14. [Cardiotoxicity of 5-fluorouracil: coronary spasm? (nih.gov)
18. Postmyocardial infarction angina and coronary spasm. (nih.gov)
Damage to the inner walls of the larger coronary arteries can cause them to spasm (suddenly tighten). (nih.gov)
Cocaine use has been associated with cardiovascular complications such as coronary atherosclerosis, coronary artery spasm, cardiac arrhythmias, acute myocardial infarction, myocarditis, and dilated cardiomyopathies. (hindawi.com)
Spasm of the large- or medium-sized coronary arteries. (bvsalud.org)

Coronary artery vasospasm (including Prinzmetal's angina). (empr.com)

A subsequent study distinguished this type of angina from classical angina pectoris further by showing normal coronary arteries on cardiac catheterization. (wikipedia.org)
For example, cocaine use can trigger vasospasm in coronary arteries through its actions on adrenergic receptors causing vasoconstriction. (wikipedia.org)
Ultimately, when large coronary arteries undergo vasospasm, this can lead to either complete or transient occlusion of blood flow within the artery. (wikipedia.org)
The large image on the left shows the heart and marks the location of the coronary arteries. (nih.gov)
Coronary microvascular disease in small arteries and obstructive coronary artery disease in large arteries. (nih.gov)
Overview of Coronary Artery Disease Coronary artery disease (CAD) involves impairment of blood flow through the coronary arteries, most commonly by atheromas. (msdmanuals.com)
STUDY OBJECTIVE--The aim of the study was to investigate the receptor events that mediate the vascular effects of 5-hydroxytryptamine (5-HT) on human coronary arteries, since 5-HT has long been thought to play a role in coronary artery vasospasm. (lu.se)
DESIGN--Recently available selective receptor agonists and antagonists were used to examine the 5-HT receptor subtypes present in human epicardial coronary arteries using in vitro organ baths. (lu.se)
EXPERIMENTAL MATERIAL--138 segments of coronary arteries were obtained from 21 patients aged 2-66 years undergoing heart transplantation. (lu.se)
CONCLUSIONS--These results show that both 5-HT1-like and 5-HT2 receptors mediate contraction of human epicardial coronary arteries and indicate that effects mediated by 5-HT1-like receptors but not 5-HT2 receptors are preserved in patients with ischaemic heart disease. (lu.se)

Ergonovine maleate testing during cardiac catheterization: a 10-year perspective in 3,447 patients without significant coronary artery disease or Prinzmetal's variant angina. (medscape.com)
These eicosanoids may contribute to cardiac dysfunction and vasospasm in coronary artery disease. (nih.gov)
These syndromes all involve acute coronary ischemia and are distinguished based on symptoms, ECG findings, and cardiac marker levels. (msdmanuals.com)
Possible cardiac etiologies include arrhythmias, structural heart disease, and coronary artery disease. (hindawi.com)

Atherosclerotic coronary disease is much more common, and its presence confers a worse prognosis, regardless of the cause of symptoms. (medscape.com)
You have an increased risk of getting coronary artery spasms if you also have an increased risk of developing heart disease. (healthline.com)
It is strongly recommended that AXERT ® not be given to patients in whom unrecognized coronary artery disease (CAD) is predicted by the presence of risk factors. (nih.gov)
evaluate for coronary artery disease in patients at high risk. (drugs.com)
12. [Coronary artery disease attack caused by cytotoxic chemotherapy]. (nih.gov)
Aldehyde dehydrogenase 2 (ALDH2) plays a central role in the biotransformation of glyceryl trinitrate (GTN) or nitroglycerin, which is widely used for the treatment of coronary artery disease (CAD). (nih.gov)
Coronary heart disease may have more than one cause, including plaque buildup or problems that affect how the heart's blood vessels work. (nih.gov)
This is the main cause of obstructive coronary artery disease. (nih.gov)
Small amounts of plaque can also develop in the small blood vessels in the heart, causing coronary microvascular disease. (nih.gov)
Problems with how the heart's blood vessels work can cause of coronary heart disease. (nih.gov)
If you have coronary heart disease, the size of these blood vessels may not change, or the blood vessels may even narrow. (nih.gov)
Figure A shows the small coronary artery network, which includes a normal artery and an artery with coronary microvascular disease. (nih.gov)
We are committed to advancing science and translating discoveries into clinical practice to promote the prevention and treatment of heart, lung, blood, and sleep disorders, including coronary heart disease. (nih.gov)
Your risk of coronary heart disease goes up based on the number of risk factors you have and how serious they are. (nih.gov)
Also, changes in the small blood vessels of the heart as you age raise the risk for coronary microvascular disease. (nih.gov)
In men, the risk for coronary heart disease starts to increase around age 45. (nih.gov)
Before menopause, women have a lower risk of coronary heart disease than men. (nih.gov)
Air pollution in the environment can put you at higher risk of coronary heart disease. (nih.gov)
Air pollution may cause or worsen other conditions that are known to increase your risk of coronary heart disease, such as atherosclerosis and high blood pressure . (nih.gov)
Acute coronary syndrome (ACS) is a spectrum of disease characterized by limitations in the amount of blood perfusing the heart and resulting in ischemia. (saem.org)
Contemporary Management of Stable Coronary Artery Disease. (nih.gov)
Prevalence of Coronary Microvascular Disease and Coronary Vasospasm in Patients With Nonobstructive Coronary Artery Disease: Systematic Review and Meta-Analysis. (nih.gov)
Cath was negative for evidence of obstructive coronary disease. (amwa-doc.org)
Recurrent reversible cardiogenic shock triggered by emotional distress with no obstructive coronary artery disease. (amwa-doc.org)
Use RELPAX with caution if you have a history of cardiovascular disease like coronary artery disease of coronary artery vasospasm. (canadapharmacy.com)
The differential diagnosis for etiologies of HFrEF is broad (Table 1 ) with coronary artery disease and hypertension as the most common precipitants. (hindawi.com)
He had no known history of coronary artery or structural heart disease. (hindawi.com)
Coronary artery bypass grafting (CABG) is a preferred revascularization strategy over percutaneous coronary intervention (PCI) in diabetics with multivessel coronary artery disease (MVD). (bvsalud.org)
OBJECTIVES: This study sought to examine the different prognostic effects of revascularization strategies according to the diabetes status from the randomized BEST (Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease) trial. (bvsalud.org)
As reported by Wynder and Lemon (285), the Seventh Day Adventists have experienced excep- tionally low coronary heart disease as well as low cancer mortality. (nih.gov)
Mormon men and women in comparison with non-Mormon men and women living in Utah experienced 25 percent and 29 percent fewer deaths, respectively, from coronary heart disease. (nih.gov)
Below the age of 65, Mormon men and women experienced CHD mortality rates only 66 percent and 51 percent, respectively, of the rates for coronary heart disease that were experienced by U.S. whites. (nih.gov)
Cigarette smoking is a major cause of coronary heart disease in the United States for both men and women. (nih.gov)

When coronary vasospasm occurs, the occlusion temporarily produces ischemia. (wikipedia.org)
There are cases of coronary vasospasm that occur without any symptoms at all, leading to episodes of silent or asymptomatic myocardial ischemia. (wikipedia.org)
Type 2 MIs can result from ischemia due to imbalance of oxygen supply and demand, or nonatherosclerotic causes such as spontaneous coronary artery dissection, coronary vasospasm, coronary embolism, coronary vasculitis, coronary ectasia, and anatomic coronary artery anomaly. (mhmedical.com)
Acute coronary syndrome (ACS) denotes the presence of myocardial ischemia that can result in a spectrum of clinical symptoms and presentations, including unstable angina, ST-elevation myocardial infarction (STEMI), and non-ST-elevation MI (NSTEMI). (mhmedical.com)
Acute coronary syndrome ( ACS ) refers to a spectrum of conditions resulting from acute myocardial ischemia and/or infarction that is most often due to an abrupt reduction in coronary blood flow . (wikidoc.org)
The electrocardiographic ischemia and changes in hemodynamics indicate actions on coronary resistance and myocardial depression. (nih.gov)

We describe a case of a 61-year-old female presenting with recurrent episodes of acute dyspnea and found to have coronary artery vasospasm leading to variable wall motion abnormalities, myocardial infarction and fatal arrhythmias. (fortunepublish.com)
The management of type 2 MIs and nonischemic causes of myocardial injury depends on the underlying etiology, and thus discerning these "mimickers" of non-type 1 MI is pertinent for prompt and appropriate management of acute coronary syndromes. (mhmedical.com)
STEMI is the most severe type of acute coronary syndrome and, untreated, has the worst mortality and morbidity. (saem.org)
Acute coronary syndromes result from acute obstruction of a coronary artery. (msdmanuals.com)
They discuss a fascinating case of Embolic Acute Coronary Syndrome from PFO and Pulmonary Hypertension. (cardionerds.com)

The standard procedure for defining coronary anatomy and assessing the degree of coronary artery stenosis is still coronary angiography [4] . (wikidoc.org)
This study examined whether there are differences in nitroglycerine-mediated dilation (NMD) and flow-mediated dilation (FMD) response between wildALDH2*1/*1and variantALDH2*2patients with CAD.Methods and Results:The study subjects comprised 55 coronary spastic angina (CSA) patients, confirmed by coronary angiography and intracoronary injection of acetylcholine (42 men and 13 women, mean age 68.0±9.0 years). (nih.gov)
In patients with angina despite pharmacotherapy or who have symptomatic ventricular arrhythmias, invasive coronary angiography is recommended. (medscape.com)

described a type of chest pain resulting from coronary vasospasm, referring to it as a variant form of classical angina pectoris. (wikipedia.org)
Unlike classical angina pectoris, traditional cardiovascular risk factors are not thought to be significantly associated with coronary vasospasm. (wikipedia.org)

You should take steps to minimize such risk factors if you have a history of coronary artery spasms. (healthline.com)

3. [Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil]. (nih.gov)
However, magnesium deficiency can result in disturbances in nearly every organ system and can cause potentially fatal complications (eg, ventricular arrhythmia, coronary artery vasospasm, sudden death). (medscape.com)
6,7 Other proposed mechanisms include coronary artery vasospasm and microvascular dysfunction, as well as mid-cavity or left ventricular outflow tract obstruction resulting in apical dysfunction. (amwa-doc.org)

Some of the factors that have been proposed to contribute to coronary vasospasm include the following: Endothelial dysfunction Certain vasodilatory agents exert their effects by working via the endothelium, the cells that make up the lining of blood vessels. (wikipedia.org)
Endothelial dysfunction wherein there is a deficiency in the production of nitric oxide has been found to be associated with coronary vasospasm in some but not all cases. (wikipedia.org)
Vasodilatory agents with mechanisms dependent on a functional endothelial nitric oxide synthase can cause vasoconstriction instead in the setting of endothelial dysfunction, leading to coronary vasospasm. (wikipedia.org)
However, it has not been determined experimentally whether LV dysfunction during anaphylaxis is induced mainly by reduced coronary blood flow (CBF) or direct negative inotropic actions of chemical mediators. (viamedica.pl)
Takotsubo cardiomyopathy (TC), also known as stress cardiomyopathy, is characterized by transient systolic dysfunction of the left ventricle in the absence of coronary artery obstruction. (amwa-doc.org)

Coronary vasospasm classically produces chest pain at rest, also known as vasospastic angina. (wikipedia.org)
Coronary artery vasospasm is an important cause of chest pain but not the exclusive cause. (medscape.com)
Systolic bridging does cause chest pain and also smoking can cause vasospasm that is, constriction of vessels. (icliniq.com)

Figure B shows a large coronary artery with plaque buildup. (nih.gov)

Technical limitations of both noninvasive and invasive coronary evaluations may lead to misleading results. (medscape.com)
Type 1 myocardial infarctions (MIs) are due to atherosclerotic plaque rupture/erosion with thrombus formation and typically require invasive management for restoration of coronary perfusion. (mhmedical.com)
Therefore, the decision for invasive coronary catheterization requires a detailed history and dedicated biochemical tests. (bvsalud.org)

We propose a two-step model for AA induction of CA vasospasm and resultant myocardial necrosis: (1) metabolism of AA to acrolein by coronary arterial SSAO activity and (2) acrolein induction of CA vasospasm independent of endothelial injury-a novel path. (nih.gov)

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization. (wikidoc.org)

They discuss a informative case of ST-segment elevation (STEMI) due to coronary vasospasm. (cardionerds.com)

On the right, the top image is an enlarged drawing of a normal coronary artery with typical blood flow. (nih.gov)

ACS is characterized by a sudden imbalance between myocardial oxygen consumption and demand, which is usually the result of coronary artery obstruction. (wikidoc.org)

Potential etiologies like coronary vasospasm and catecholamine-associated myocardial injury were suggested. (bvsalud.org)

AA or acrolein produced a similar pattern of responses in both CA and TA rings at 100 and 1000 microM, including (1) increased basal tension, (2) enhanced agonist-induced contraction (hypercontractility or vasospasm), (3) remarkable, agonist-induced slow wave vasomotion (vasospasm), and (4) irreversible reduction in vessel contractility after 1 mM exposure. (nih.gov)

Isolated hearts from Wistar rats in the ovalbumin-sensitized anaphylaxis, non-sensitized flow reduction, and non-sensitized time control group were subjected to coronary perfusion with blood at a constant pressure and measurements of CBF and LV pressure. (viamedica.pl)

The etiology of most STEMIs are the rupture of an atherosclerotic plaque which subsequently occludes a coronary artery causing transmural myocardial infarction. (saem.org)

5. Prinzmetal angina (Coronary vasospasm) associated with 5-fluorouracil chemotherapy. (nih.gov)

For example, a coronary event caused by rupture of a nonobstructive atherosclerotic plaque with thrombosis, followed by spontaneous reperfusion, may lead to a seemingly normal or innocuous coronary evaluation. (medscape.com)

Coronary artery spasms are brief and temporary. (healthline.com)
Coronary artery spasms are also known as coronary artery contractions. (healthline.com)
Many coronary artery spasms go undiagnosed because they don't always cause noticeable symptoms. (healthline.com)

MEASUREMENTS AND MAIN RESULTS--5-HT produced only concentration dependent contractions of coronary artery segments. (lu.se)

We studied the effect of intracoronary leukotriene B4, C4, D4 and E4 (0.1-3 micrograms) on coronary artery blood flow and resistance in anesthetized pigs. (nih.gov)
Thromboxane B2 concentration in coronary sinus blood plasma increased by 132-176% (P less than 0.05) at peak leukotriene effects on blood flow. (nih.gov)
The child has a coronary heart rate of 120 beats/min, respiratory fee of forty breaths/min, and blood stress is sixty five/45 mm Hg taken in the proper leg. (ehd.org)
After a coronary artery bypass graft (CABG), the nurse notes the patient has muffled heart tones, jugular vein distention, and decreased blood pressure. (floridiancecourses.org)

Coronary vasospasm refers to when a coronary artery suddenly undergoes either complete or sub-total temporary occlusion. (wikipedia.org)
STEMIs are recognized by their characteristic ECG findings of having ST-elevations and are associated with complete or near-complete occlusion of a coronary artery. (saem.org)

Coronary vasospasm is also associated with symptoms of fatigue and tiredness, dyspnea, and palpitations. (wikipedia.org)

Chronic inflammation Various markers of low-grade chronic inflammation have been found in cases of coronary vasospasm. (wikipedia.org)

The patient was admitted to the telemetry unit with presumptive diagnosis of pericarditis versus cocaine-induced coronary vasospasm. (hindawi.com)

Coronary artery vasospasm: which can occur with the use of sympathomimetic drugs (cocaine, methamphetamine). (saem.org)

Pathogenetic mechanisms, estimated incidence and clinical and coronary arteriographic findings in 138 patients. (medscape.com)

Endothelium-dependent acetylcholine-induced relaxation was not altered during vasospasm in either vessel. (nih.gov)

Anatomy2

Diseases13

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes2

Spasm37

Including Prinzmetal's angina1

Arteries10

Cardiac4

Disease33

Ischemia6

Acute5

Angiography3

Angina pectoris2

History of coronary artery1

Ventricular3

Dysfunction5

Chest3

Large coronary1

Invasive3

Endothelial1

Revascularization1

STEMI1

Normal coronary1

Artery obstruction1

Myocardial injury1

Contraction1

Perfusion1

Etiology1

Chemotherapy1

Atherosclerotic plaque1

Spasms3

Contractions1

Blood4

Occlusion2

Palpitations1

Chronic1

Diagnosis1

Occur1

Patients1

Acetylcholine1