AtherosclerosisHardening of the aRelated to coronary heart dCholesterolAssociated with simvastatin therapy10mgEzetimibeActive ingredient simvastatinPatientsMyocardial infarction and strokeHistory of coronary heart dMortality from coronary heart dDose of simvastatinStrokeEffects of simvastatinMorbidityLovastatinPravastatinRiskAngiographyDiabetesNiacinZocorDosageTherapyHypercholesterolemiaStatin treatmentOrallyRevascularization proceduresCardiovascular diseaseAngina2021HypersensitivityPreventionTreatmentTabletsDisease mortalityAttacksAngioplastyScandinavian
Atherosclerosis13
- AFCAPS/TexCAPS, Air Force/Texas coronary atherosclerosis prevention study. (bmj.com)
- Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. (medscape.com)
- LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries (atherosclerosis), while HDL actually protects the arteries against this. (dokteronline.com)
- They reduce the risk of excess cholesterol being deposited in the major blood vessels of the heart (atherosclerosis). (dokteronline.com)
- This helps to reduce the risk of atherosclerosis, angina and heart attacks (coronary heart disease). (dokteronline.com)
- Statin drugs represent the major improvement in the treatment of hypercholesterolemia that constitutes the main origin of atherosclerosis, leading to coronary heart disease. (degruyter.com)
- In 1974 I founded the SCOR Cardiac Cyclists Club to assist with a research grant our hospital had received from the NIH to determine what were the factors that contributed to heart attacks in men between the ages of 40 and 50 years old, "premature" atherosclerosis as it was referred to. (roadbikerider.com)
- By the early 1980s I had treated hundreds of coronary patients in different Cardiac Rehabilitation programs and could see the "Lipid Theory of Atherosclerosis" was not valid as other studies from around the world confirmed our findings at Rancho Los Amigos Hospital where I worked for nine years. (roadbikerider.com)
- Heart attacks are caused by progression of atherosclerosis with a coronary thrombosis being the precipitating factor in most (but not all). (roadbikerider.com)
- Clearly Simvastatin did not affect the progression of the disease in those who already had documented atherosclerosis. (roadbikerider.com)
- Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
- The symptoms of atherosclerosis may look like other heart conditions. (hopkinsmedicine.org)
- 5 Symptomatic PAD patients have a worse prognosis than patients presenting with coronary artery disease or cerebrovascular disease, but their atherosclerosis risk factors are less intensively treated.6 Both asymptomatic and symptomatic PAD patients have a high risk of death from cardiovascular disease (CVD), 2,7 therefore early treatment reduces mortality. (racgp.org.au)
Hardening of the a1
- In these people simvastatin slows down hardening of the arteries, regardless of your cholesterol level. (dokteronline.com)
Related to coronary heart d1
- Children with heterozygous FH do not have symptoms related to coronary heart disease (CHD), and most do not develop tendon xanthomas or corneal arcus. (medscape.com)
Cholesterol43
- Changes in systolic and diastolic blood pressure, smoking rates, blood cholesterol concentrations, total mortality, and mortality from coronary heart disease. (bmj.com)
- It compared 40mg of the lipid-lowering drug pravastatin to placebo in 6, 595 men who had a mean cholesterol of 7 mmol/L but no previous history of a heart attack. (wikipedia.org)
- Significant reductions in recurrent myocardial infarction, stroke, and death have been demonstrated in a series of landmark trials of statins in individuals with coronary heart disease (CHD) and high or normal blood cholesterol concentrations. (bmj.com)
- These benefits have been seen in patients with coronary heart disease and high or normal blood cholesterol concentrations, as well as in asymptomatic patients at increased risk for coronary heart disease. (bmj.com)
- Simvastatin works by reducing the production of cholesterol by the liver. (dokteronline.com)
- Simvastatin decreases the production of LDL cholesterol by blocking the action of the enzyme in the liver (called HMG-CoA reductase) that is responsible for its production. (dokteronline.com)
- Simvastatin also causes a small decrease in the production of other 'bad fats' in the blood called triglycerides, and a small increase in the level of HDL cholesterol. (dokteronline.com)
- Simvastatin is used to lower cholesterol in people who have high levels either due to genetics (familial hypercholesterolaemia) or as a result of diet and lifestyle. (dokteronline.com)
- It is important to continue to follow a cholesterol-lowering diet and exercise regime while taking simvastatin. (dokteronline.com)
- These recommendations were based on numerous studies showing that statins are effective in reducing low-density lipoprotein cholesterol levels, and the risk of death and recurrent coronary and cardiovascular events in those with a history of ASCVD, even in older adults. (jabfm.org)
- Molecular mechanisms of toxicity of simvastatin, widely used cholesterol-lowering drug. (degruyter.com)
- Statins are widely used and well tolerated cholesterol-lowering drugs, and when used for therapy purposes reduce morbidity and mortality from coronary heart disease. (degruyter.com)
- Simvastatin is one of nine known statins, specific inhibitors of hepatic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting step of cholesterol biosynthesis, and is believed to reduce plasma cholesterol levels by decreasing the activity of this enzyme. (degruyter.com)
- Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? (koreamed.org)
- Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). (koreamed.org)
- At that time I was a brainwashed PT who was told by all the cardiologists I trained with that "cholesterol" causes heart disease. (roadbikerider.com)
- Despite 60 years of low cholesterol, low saturated fat propaganda put out by the AHA, Big Pharma and Academia heart disease remains the number one cause of death for the last 60 years! (roadbikerider.com)
- Unfortunately, by the mid-1980s the first statin drug studies emerged claiming lowering LDL cholesterol reduced cardiovascular death rates in those who previously had a heart attack by "20 to 25 percent. (roadbikerider.com)
- Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
- Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. (nih.gov)
- AHA/ACC /AACVPR/AAPA/ ABC/ACPM/ ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (thieme-connect.com)
- Remnant cholesterol as a causal risk factor for ischemic heart disease. (thieme-connect.com)
- Aggressive low-density lipoprotein cholesterol-lowering therapy for working-age people at high risk for cardiovascular events and with a history of heart disease appears to have a significant potential to reduce the rate of clinical events and is cost-neutral for payers. (ahdbonline.com)
- 1 Hypercholesterolemia, particularly elevated lowdensity lipoprotein cholesterol (LDL-C), is strongly associated with an increased risk of CVD, including coronary heart disease (CHD) events (ie, myocardial infarction [MI], angina, coronary revascularization) and stroke. (ahdbonline.com)
- It is also used to decrease the risk of heart attack, stroke, or death regardless of whether cholesterol levels are high or not for people who have coronary heart disease (CHD) or have other arteries in the body that are blocked, or for those who have diabetes and are over the age of 40. (pharmasave.com)
- Simvastatin works by blocking an enzyme that helps create cholesterol in the body. (pharmasave.com)
- Simvastatin lowers the level of total cholesterol and low-density lipoprotein (LDL, or 'bad' cholesterol) and raises high-density lipoprotein (HDL, or 'good' cholesterol) levels. (pharmasave.com)
- Before or when starting simvastatin, you should be placed on a cholesterol-lowering diet. (pharmasave.com)
- Prior to initiating therapy with Simvastatin, secondary causes for hypercholesterolemia (e.g., poorly controlled diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemias, obstructive liver disease, other drug therapy, alcoholism) should be exclude and a lipid profile performed to measure Total cholesterol, HDL cholesterol and triglycerides (TG). (bernofarm.com)
- The patients should be placed on a standard cholesterol-lowering diet before receiving and should continue on this diet during treatment with Simvastatin. (bernofarm.com)
- If LDL-cholesterol concentration decreases under 75 mg/dl (1.94 mmol/l) or plasma cholesterol total concentration decreases under 140 mg/dl (3.6 mmol/l), it should be considered to reduce Simvastatin dose. (bernofarm.com)
- Cholesterol examination should be done periodically during therapy with Simvastatin. (bernofarm.com)
- The FDA has approved the prescription of statins to people at low risk for heart disease and stroke, who don't even have high cholesterol. (thehealthyskeptic.org)
- Dr. Weil's claim that saturated fat and cholesterol promote heart disease is not supported by the evidence. (thehealthyskeptic.org)
- Results of a clinical study in people with heart disease and well-controlled cholesterol levels that compared people who took niacin and simvastatin with people who took simvastatin alone and found similar results for the two groups in the rate of heart attacks or strokes. (medlineplus.gov)
- It is also one of the most misdiagnosed, misunderstood and mistreated health conditions in healthcare-with many claims that "high cholesterol causes heart disease. (drlauryn.com)
- Epidemiological studies have shown that both low HDL-cholesterol and high LDL-cholesterol are independent risk factors for coronary heart disease. (nih.gov)
- In the primary prevention component of the Helsinki Heart Study, in which 4081 male patients between the ages of 40 and 55 were studied in a randomized, double-blind, placebo-controlled fashion, Gemfibrozil therapy was associated with significant reductions in total plasma triglycerides and a significant increase in high density lipoprotein cholesterol. (nih.gov)
- The study involved subjects with serum non-HDL-cholesterol of over 200 mg/dL and no previous history of coronary heart disease. (nih.gov)
- Among Fredrickson types, during the 5-year double-blind portion of the primary prevention component of the Helsinki Heart Study, the greatest reduction in the incidence of serious coronary events occurred in Type IIb patients who had elevations of both LDL-cholesterol and total plasma triglycerides. (nih.gov)
- Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks This drug can also lower the risk for heart attack or stroke in patients with diabetes . (medika.life)
- In November 2013, the American College of Cardiology and American Heart Association (ACC/AHA) released cholesterol guidelines which did not endorse LDL-C and non-HDL-C treatment goals [ 9 ], but this deletion has been rejected by several professional national and international societies [ 10 - 12 ]. (biomedcentral.com)
- A meta-analysis of randomized controlled trials including 170,000 participants found that participants on statin therapy had a 22% reduction in risk, per every 1-mmol/L (39 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C), for major vascular events ( coronary heart disease , ischemic stroke, and revascularization procedures) compared with those on placebo or standard therapy. (medscape.com)
Associated with simvastatin therapy2
- Adverse events associated with simvastatin therapy are uncommon, but potentially serious. (degruyter.com)
- Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
10mg2
- One example of the benefits of this change is the recent announcement that Ministers have accepted the advice of the Committee on Safety of Medicines (CSM) that simvastatin 10mg (Zocor Heart Pro) could be safely sold through pharmacies to reduce the risk of a first major coronary event in people likely to be at a moderate risk of coronary heart disease (CHD). (news-medical.net)
- Simvastatin 10mg, 20mg, and 40 mg contain red and yellow ferric oxide. (hipaaspace.com)
Ezetimibe8
- Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin. (nih.gov)
- Adults (=18 years),Prevention of Cardiovascular Disease EZETIMIBE/SIMVASTATIN-MEDIS is indicated in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS) taking their maximum tolerated dose of simvastatin and in need of additional lowering of LDL-C in the expectation of a modest further reduction in the risk of cardiovascular events following at least one year of therapy (see Clinical Trials). (healthdirect.gov.au)
- Primary Hypercholesterolaemia EZETIMIBE/SIMVASTATIN-MEDIS is indicated as adjunctive therapy to diet in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia or mixed hyperlipidaemia where use of a combination product is appropriate: Patients not appropriately controlled with a statin or ezetimibe alone. (healthdirect.gov.au)
- Homozygous Familial Hypercholesterolaemia (HoFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated in patients with HoFH. (healthdirect.gov.au)
- Children and Adolescents 10-17 years (pubertal status: boys Tanner Stage II and above and girls who are at least one year post- menarche),Heterozygous Familial Hypercholesterolaemia (HeFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated as adjunctive therapy to diet in adolescent patients (10-17 years old) with heterozygous familial hypercholesterolaemia where use of a combination product is appropriate: Patients not appropriately controlled with a statin or ezetimibe alone. (healthdirect.gov.au)
- Homozygous Familial Hypercholesterolaemia (HoFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated in adolescent patients (10-17 years old) with HoFH. (healthdirect.gov.au)
- Simvastatin with or without ezetimibe in familial hypercholesterolemia. (thehealthyskeptic.org)
- Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. (thehealthyskeptic.org)
Active ingredient simvastatin1
- Zocor tablets contain the active ingredient simvastatin, which is a type of medicine called a statin. (dokteronline.com)
Patients39
- Patients provided written informed consent and were randomly divided into 2 groups (65 in the simvastatin group and 65 in the control group) by assigning random numbers from a random number table. (hindawi.com)
- Patients in the simvastatin group took simvastatin 20 mg orally daily during two perioperative periods: from the 7th to the 5th preoperative day and from the 2nd day after decannulation until the 7th postoperative day. (hindawi.com)
- Aggressive statin treatment has been found to prevent or defer subsequent events in patients after coronary bypass graft surgery 6 and to be as effective as angioplasty in delaying events in patients with stable angina. (bmj.com)
- Treatment of risk factors in patients who have had coronary artery bypass surgery improves their prognosis. (bmj.com)
- However, audits usually identify patients by a diagnosis of myocardial infarction or the prescription of drugs for angina and may not identify coronary bypass patients. (bmj.com)
- Our results suggest that this project has the potential to improve secondary prevention in many patients with coronary heart disease, but it will need to be assessed by future audit. (bmj.com)
- Simvastatin 80 mg daily dosage is restricted to patients who have been taking simvastatin 80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity. (nih.gov)
- For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving simvastatin 40 mg daily, prescribe alternative LDL-C lowering treatment. (nih.gov)
- Use another simvastatin product to initiate dosing in such patients. (nih.gov)
- Temporarily discontinue simvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. (nih.gov)
- Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing simvastatin dosage. (nih.gov)
- The aim of this study was to evaluate the influence of simvastatin on inflammatory markers in patients with COPD. (nih.gov)
- Fifty-six patients (aged 44-80 years) with stable COPD (a mean forced expiratory volume in 1 second [FEV1] 55%), were randomly assigned (1:1) to receive simvastatin 40 mg/day or to receive no statin treatment. (nih.gov)
- In COPD patients, a 3-month treatment with simvastatin does not reduce circulating inflammatory markers. (nih.gov)
- The patients were obese, 20% were current smokers, and 65% had coronary heart disease. (medscape.com)
- Effects of atorvastatin on fasting and postprandial lipoprotein subclasses in coronary heart disease patients versus control subjects. (koreamed.org)
- Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
- Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
- ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
- In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
- In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR can be started simultaneously with diet. (druglib.com)
- Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. (druglib.com)
- We aimed to investigate the antidepressant effects of simvastatin as an adjuvant therapy in patients with moderate to severe depression. (druglib.com)
- Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (druglib.com)
- It is important to determine whether you are considering primary prevention or secondary prevention (i.e. patients with established cardiovascular disease such as coronary heart disease, stroke or TIA or peripheral arterial disease), when thinking about prescribing medication to reduce cardiovascular risk. (sps.nhs.uk)
- It is also used in certain patients to reduce the risk of heart attack, stroke, and death due to coronary heart disease. (24med.net)
- It is also used in certain patients to reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina. (24med.net)
- Patients taking immunosuppressive drugs concomitantly with HMG-CoA reductase inhibitor, should be given the recommended lowest dose of Simvastatin. (bernofarm.com)
- Patients in renal insufficiency : Dosage adjustment is not necessary, because Simvastatin does not undergo significant renal excretion. (bernofarm.com)
- However, caution should be exercised when Simvastatin is administered to patient with severe renal insufficiency, such patients should be started at 5 mg/day and be closely monitored. (bernofarm.com)
- Therapy with Simvastatin should be stopped temporarily or discontinued in patients with an acute and severe myopathy or having a risk secondary renal failure due to rhabdomyolysis or elevation of creatinine phosphokinase (CPK). (bernofarm.com)
- Simvastatin is not effective in patients with homozygous form of familial hypercholesterolemia. (bernofarm.com)
- HMG-CoA reductase inhibitors (statins) are the medications of choice for the treatment of LDLc elevations in patients with heterozygous FH because they have the greatest efficacy and are easily tolerated and because multiple randomized, placebo-controlled trials have shown that lowering LDLc levels with statins reduces coronary morbidity and mortality and, in some cases, total mortality. (medscape.com)
- 20mg to 40mg daily, given as a single dose in the evening in patients at high risk of coronary heart disease with or without hyperlipidaemia. (medscape.co.uk)
- Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. (thehealthyskeptic.org)
- Rosuvastatin in older patients with systolic heart failure. (thehealthyskeptic.org)
- In contrast, "secondary prevention" is individual treatment efforts to reduce the recurrence of coronary events and reduce mortality among patients who already have heart disease. (blogspot.com)
- Lowering LDL-C, non-HDL-C and apoB with niacin has the potential to reduce coronary risk in patients with T2DM. (biomedcentral.com)
- Aggressive treatment of dyslipidemia is recommended for patients with T2DM to reduce coronary heart disease (CHD) risk, with the cornerstone of treatment being statin therapy. (biomedcentral.com)
Myocardial infarction and stroke1
- To reduce the risk of total mortality by reducing risk of coronary heart disease death, non-fatal myocardial infarction and stroke, and the need for coronary and non-coronary revascularization procedures in adults with established coronary heart disease, cerebrovascular disease, peripheral vascular disease, and/or diabetes, who are at high risk of coronary heart disease events. (nih.gov)
History of coronary heart d2
- The target population consists of working-age people who are considered high-risk for cardiovascular disease events because of a history of coronary heart disease. (ahdbonline.com)
- Using Framingham risk scoring system, the probability of myocardial infarction or stroke events was calculated for a representative sample population, ages 35 to 69 years, of people at high risk for cardiovascular disease, with a history of coronary heart disease. (ahdbonline.com)
Mortality from coronary heart d2
- To assess the effectiveness of multiple risk factor intervention in reducing cardiovascular risk factors, total mortality, and mortality from coronary heart disease among adults. (bmj.com)
- Plasma triglyceride level and mortality from coronary heart disease. (thieme-connect.com)
Dose of simvastatin1
- The usual starting dose of simvastatin to reduce the risk of heart attack or stroke is 40 mg taken by mouth once a day, in the evening. (pharmasave.com)
Stroke4
- However, when a major artery is blocked, signs and symptoms may be severe, such as those occurring with heart attack, stroke, or blood clot. (hopkinsmedicine.org)
- The high-risk cohort (those with coronary heart disease) comprises 4% of the 35- to 69-year-old commercially insured population but generates 22% of the risk for coronary heart disease and stroke. (ahdbonline.com)
- 2-4 Landmark statin studies targeting LDL-C lowering have shown dramatic reductions in heart attacks, stroke, and cardiac death. (ahdbonline.com)
- Numerous randomized controlled trials have found that statins reduce myocardial infarction (MI), ischemic stroke , and vascular mortality, starting with the Scandinavian Simvastatin Survival Study. (medscape.com)
Effects of simvastatin1
- In this review some details about statins including their adverse effects in humans and animals, the effects of simvastatin on various intracellular and mitochondrial processes, and molecular mechanisms underlying simvastatin cytotoxicity are discussed. (degruyter.com)
Morbidity1
- Primary prevention programmes in many countries attempt to reduce mortality and morbidity due to coronary heart disease through modifying risk factors. (bmj.com)
Lovastatin1
- Taking niacin along with simvastatin or lovastatin also has not been shown to reduce the risk of heart disease or death compared with the use of niacin, simvastatin, or lovastatin alone. (medlineplus.gov)
Pravastatin1
- They include simvastatin, atorvastatin, and pravastatin among others. (hopkinsmedicine.org)
Risk25
- 3 4 Given the evidence from quasi-experimental studies, such as the North Karelia project 5 6 and the Stanford heart disease prevention programme, 7 8 9 multiple risk factor intervention using counselling and educational methods is widely believed to be efficacious and cost effective and worthy of expansion. (bmj.com)
- 1-3 Primary prevention with statins has also been shown in large populations of asymptomatic individuals at increased risk for coronary disease 4 , 5 (fig 1). (bmj.com)
- Myopathy and Rhabdomyolysis: Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher simvastatin dosage. (nih.gov)
- There is growing evidence that chronic obstructive pulmonary disease (COPD) is a risk factor for coronary heart disease. (nih.gov)
- 30 kg/m2], smoking history programme to state that, in terms of car- (either active or less than 5 years since ces- diovascular risk, DM was equivalent to sation of smoking) were recorded from the having ischaemic heart disease [ 3 ]. (who.int)
- Simvastatin can also be used to reduce the risk of coronary heart disease in people who have already had a heart attack, or who suffer from angina or diabetes. (dokteronline.com)
- It reduces the risk of needing procedures to improve blood supply to the heart, such as a balloon dilation of an artery or a heart bypass graft. (dokteronline.com)
- It also reduces the risk of heart attack and death. (dokteronline.com)
- A statistical analysis of all their risk factors and blood chemistries was done to correlate what contributed to coronary artery disease progression. (roadbikerider.com)
- When I read the Scandinavian Simvastatin Survival Study (4S Study) in detail which was published in 1984, the actual absolute risk reduction between the statin and placebo groups was "0.8 percent per year" over a five year period. (roadbikerider.com)
- Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. (thieme-connect.com)
- Changes in triglyceride levels and risk for coronary heart disease in young men. (thieme-connect.com)
- Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. (thieme-connect.com)
- Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration. (thieme-connect.com)
- Learning about your risk factors and how to manage them is the best way to prevent future blockages in your coronary arteries. (ottawaheart.ca)
- For adults, the maximum recommended daily dose is 80 mg, which may be used for some people who have been taking this amount for a long time with no muscle problems or people at high risk of heart disease who have problems taking other 'statins. (pharmasave.com)
- The risk factors for coronary artery disease (CAD) include hypertension, dyslipidemia, obesity, and smoking. (ahdbonline.com)
- Diabetes is associated with a 2- to 4-fold increased risk for CVD and is identified as a coronary artery disease (CAD) risk equivalent. (ahdbonline.com)
- A statin, in conjunction with a strict diet, is useful in a patient with coronary heart disease (CHD), or at high risk of developing CHD, because of hyperlipidaemia. (gpnotebook.com)
- 5) Evans A, Tolonen H, Hense HW, Ferrario M, Sans S, Kuulasmaa K. Trends in coronary risk factors in the WHO MONICA project. (guiasalud.es)
- A major medical paper on primary heart disease prevention admitted that cardiovascular disease risk factors have proven useless for predicting heart disease among our population and that reducing risks factors doesn't translate into reduced clinical disease or fewer premature deaths. (blogspot.com)
- According to the March issue of American Family Physicians, using U.S. National Center for Health Statistics, a woman's risk of dying in 10 years from a heart attack rises with age: from 0.4% at age 50, 1.4% at age 60, 5% at age 70, 15.3% at age 80, to 27.2% by age 90 among nonsmokers. (blogspot.com)
- According to the AHA: "Primary prevention means the effort to modify risk factors or prevent their development with the aim of delaying or preventing new-onset coronary heart disease. (blogspot.com)
- The most commonly used measure to predict our 10-year risks of dying from heart disease has long been the Framingham Risk Score . (blogspot.com)
- LDL-C, ApoB and non-HDL-C are markers of coronary risk. (biomedcentral.com)
Angiography1
- Coronary angiography was performed on all men prior to entering the study and my role was to establish and keep these men complying with the exercise program. (roadbikerider.com)
Diabetes1
- Prevent or treat diseases that are more common in older adults, including diabetes, heart disease, high blood pressure, and declines in brain function. (msdmanuals.com)
Niacin1
- Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. (medscape.com)
Zocor6
- Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
- ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus . (druglib.com)
- Purchase Simvastatin without a prescription or Generic Zocor from 500mg.org and get exceptional drug on reduced international prices. (llclinic.com)
- Buy generic Zocor online at the finest affordable cost from 500mg.org and get your Simvastatin pills sent at your doorstep in time. (llclinic.com)
- Simvastatin (Flolipid or Zocor) belongs to a class of drugs called statins and is currently the 10th most prescribed drug in America. (medika.life)
- Simvastatin is available under the following different brand names: Flolipid, Zocor. (medika.life)
Dosage3
- Maximum recommended dosage is simvastatin 40 mg once daily. (nih.gov)
- See full prescribing information for simvastatin dosage modifications due to drug interactions. (nih.gov)
- 500mg.org offers you the possibility to purchase inexpensive Simvastatin 5, 10, 20, 40 mg online and also find out more about Simvastatin side effects, dosage information and drug interactions. (llclinic.com)
Therapy1
- Concomitant therapy with other drug : Simvastatin is effective alone or in combination with bile acid sequestrants. (bernofarm.com)
Hypercholesterolemia2
- However, one parent will have severe hypercholesterolemia and will also probably have either a personal or family history for premature coronary artery disease (CAD). (medscape.com)
- Familial hypercholesterolemia and coronary heart disease: a HuGE association review. (medscape.com)
Statin treatment1
- The study concluded that statin treatment for primary prevention reduced coronary heart disease (CHD) events by 31% after nearly five years of treatment. (wikipedia.org)
Orally1
- Take simvastatin orally once daily in the evening. (nih.gov)
Revascularization procedures1
- Reduce the need for coronary and non-coronary revascularization procedures. (druglib.com)
Cardiovascular disease1
- The paper was the American Heart Association's new Guidelines for Cardiovascular Disease Prevention in Women . (blogspot.com)
Angina2
- This can cause chest pain (angina) and in severe cases can result in a heart attack (myocardial infarction). (dokteronline.com)
- Betablokkeren revolusjonerte behandlingen av angina pectoris, og tre store randomiserte betablokkerstudier på 80-tallet viste en formidabel beskyt-tende effekt etter et hjerteinfarkt. (indremedisineren.no)
20211
- Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Hypersensitivity1
- Hypersensitivity to Simvastatin and any component of the drug. (bernofarm.com)
Prevention4
- The West of Scotland Coronary Prevention Study, also known as WOSCOPS, was a randomized, double-blind, placebo-controlled clinical trial, published in 1995. (wikipedia.org)
- Simvastatin is a hypolipemic drug with proven efficacy in the prevention of cardiovascular diseases. (nih.gov)
- Statins have an important role in the prevention of coronary heart disease. (dokteronline.com)
- 13. Shepherd J. Preventing coronary artery disease in the West of Scotland: implications for primary prevention. (koreamed.org)
Treatment4
- After 2 weeks as well as 3 months of simvastatin treatment, no significant reduction of any measured inflammatory markers was observed. (nih.gov)
- 50% during simvastatin treatment. (nih.gov)
- An extended follow-up of the Heart Protection Study examined the long-term efficacy and safety of LDLc-lowering with simvastatin treatment. (medscape.com)
- Over the five-year study period, the Gemfibrozil group experienced a 1.4% absolute (34% relative) reduction in the rate of serious coronary events (sudden cardiac deaths plus fatal and nonfatal myocardial infarctions) compared to placebo, p=0.04 (see Table I). There was a 37% relative reduction in the rate of nonfatal myocardial infarction compared to placebo, equivalent to a treatment-related difference of 13.1 events per thousand persons. (nih.gov)
Tablets3
- These highlights do not include all the information needed to use SIMVASTATIN TABLETS safely and effectively. (nih.gov)
- See full prescribing information for SIMVASTATIN TABLETS. (nih.gov)
- SIMVASTATIN tablets, for oral use. (nih.gov)
Disease mortality1
Attacks1
- Also not reported too loudly was that there was no difference in subsequent second heart attacks nor strokes in either group. (roadbikerider.com)
Angioplasty1
- Although angioplasty is done in other blood vessels elsewhere in the body, percutaneous coronary intervention (PCI) refers to angioplasty in the coronary arteries to permit more blood flow into the heart. (hopkinsmedicine.org)
Scandinavian1
- 12. The Scandinavian Simvastatin Survival Study Group. (koreamed.org)