• The e4 version of the APOE gene increases an individual's risk for developing late-onset Alzheimer's disease. (medlineplus.gov)
  • Alzheimer's disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. (medlineplus.gov)
  • The APOE e4 allele may also be associated with an earlier onset of memory loss and other symptoms compared to individuals with Alzheimer's disease who do not have this allele. (medlineplus.gov)
  • It is not known how the APOE e4 allele is related to the risk of Alzheimer's disease. (medlineplus.gov)
  • A buildup of amyloid plaques may lead to the death of nerve cells (neurons) and the progressive signs and symptoms of Alzheimer's disease. (medlineplus.gov)
  • It is important to note that people with the APOE e4 allele inherit an increased risk of developing Alzheimer's disease, not the disease itself. (medlineplus.gov)
  • Not all people with Alzheimer's disease have the APOE e4 allele, and not all people who have this allele will develop the disease. (medlineplus.gov)
  • It is unclear why some people with the APOE e4 allele develop Alzheimer's disease while others develop dementia with Lewy bodies. (medlineplus.gov)
  • Objective Physical Function in the Alzheimer's Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study. (cdc.gov)
  • Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer's disease. (cdc.gov)
  • Obesity reduces hippocampal structure and function in older African Americans with the APOE-?4 Alzheimer's disease risk allele. (cdc.gov)
  • Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
  • Many of the Alzheimer's disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD pathophysiology remains unclear. (massgeneral.org)
  • Telomere attrition is one of biological aging hallmarks and may be intervened to target multiple aging-related diseases, including Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). (bvsalud.org)
  • They applied DISCO-MS to an Alzheimer's disease mouse model and to atherosclerotic plaques in the human heart to identify spatial-molecular maps. (isd-research.de)
  • however, some people with the APOE e4 allele never develop this condition. (medlineplus.gov)
  • It is unclear how the APOE e4 allele contributes to the development of this condition. (medlineplus.gov)
  • It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
  • People who carry at least one copy of the APOE e4 allele have an increased chance of developing atherosclerosis, which is an accumulation of fatty deposits and scar-like tissue in the lining of the arteries. (medlineplus.gov)
  • The APOE e2 allele has been shown to greatly increase the risk of a rare condition called hyperlipoproteinemia type III. (medlineplus.gov)
  • Most people with this disorder have two copies of the APOE e2 allele, leading researchers to conclude that the e2 allele plays a critical role in the development of the condition. (medlineplus.gov)
  • The risk of allele E4 which is a reliable marker for lipid profiles, but did not correlate with ApoE alleles. (edu.pl)
  • In a polygenic risk predictor the lifetime (or age-range) risk for the disease is a numerical function captured by the score which depends on the states of thousands of individual genetic variants (i.e., single nucleotide polymorphisms, or SNPs). (wikipedia.org)
  • I ca. 100 områder i det humane genom er der identificeret single nucleotide polymorphisms (SNPs), som enkeltvis korrelerer med en - ofte - let øget risiko for udvikling af koronarsygdom. (ugeskriftet.dk)
  • A total of 37 single nucleotide polymorphisms (SNPs) were genotyped and individually tested for association with the score, adjusting for confounding variables. (biomedcentral.com)
  • For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
  • For these reasons, the leukotriene pathway may represent an alternative therapeutic target in the treatment of atherosclerotic vessel diseases [ 6 , 13 , 14 ]. (hindawi.com)
  • Vascular calcification is a hallmark of atherosclerotic disease and serves as a strong predictor and risk factor for cardiovascular events. (massgeneral.org)
  • Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. (e-dmj.org)
  • Improvement in metabolic risk factors for coronary heart disease associated with cilazapril treatment. (nhri.edu.tw)
  • Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk of heart disease, stroke and diabetes. (biomedcentral.com)
  • Many studies suggested that deep CMBs may relate to hypertensive small vessel disease (HTN-SVD) and strictly lobar CMBs for cerebral amyloid angiopathy (CAA), 1 but the risk factors of CMBs are not entirely clear. (dovepress.com)
  • Recent progress in genetics has enabled the creation of polygenic predictors of complex human traits, including risk for many important complex diseases, which are typically affected by many genetic variants that each confer a small effect on overall risk. (wikipedia.org)
  • Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease. (edu.pl)
  • To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. (scienceopen.com)
  • The authors evaluated the entire genome of a 40-year old man and compared it to several databases of disease-related gene variants. (blogspot.com)
  • The genome analysis revealed variants associated with diseases in the man's family (osteoarthritis, vascular disease and early sudden death). (blogspot.com)
  • It also uncovered variants linked to conditions not in his family (iron overload and thyroid and parathyroid diseases). (blogspot.com)
  • Some variants suggested that he might have unusual responses to certain heart medications, which is meaningful in light of his risk for cardiovascular disorders. (blogspot.com)
  • Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. (mdpi.com)
  • FGF23 Concentration and APOL1 Genotype Are Novel Predictors of Mortality in African Americans With Type 2 Diabetes. (wakehealth.edu)
  • Improvements in methodology and studies with large cohorts have enabled mapping many traits, some of which are diseases, to the human genome. (wikipedia.org)
  • The development of cardiovascular diseases (CVDs) is due to a complex interaction between the genome and the environment. (scienceopen.com)
  • As genome technologies evolve, genotyping of individuals could be available to all patients using a simple saliva test. (scienceopen.com)
  • Large-scale genome-wide association studies and meta analyses have provided powerful insights into polymorphisms that may be predictive of disease and an individual's response to certain nutrients, but moving forward it is imperative that these insights can be applied in the medical setting to reduce the incidence and mortality of CVDs. (scienceopen.com)
  • What: Scientists at Stanford and Harvard Universities collaborated to assess the clinical usefulness of analyzing a patient's full genome for disease risks and unusual drug responses. (blogspot.com)
  • The paper concludes that the transition to genome-informed medical care will require an integrated team including medical and genetics professionals, ethicists and health-care delivery organizations. (blogspot.com)
  • Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions. (wakehealth.edu)
  • Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. (mdpi.com)
  • Most significant were public health advances that reduced premature death by decreasing the risk of infant mortality, increasing the chances of surviving childhood, and avoiding infection and communicable disease. (foobrdigital.com)
  • The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. (massgeneral.org)
  • Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize that there are common genetic components involved in the clustering of MetS traits. (biomedcentral.com)
  • Genotyping, a process used to determine genetic differences within an individual's DNA, can provide doctors with relevant information to identify individuals who are at high risk of developing CVDs. (scienceopen.com)
  • We are delighted to announce the fifth Ending Age-Related Diseases conference on August 11-14, 2022! (fightaging.org)
  • December 2022 - Identifying subtle tissue changes at disease initiation or characterizing the molecular perturbations that trigger disease progression remains difficult in animal models or post-mortem human organs. (isd-research.de)
  • In Krabbe's disease patient cells, GalCer is the primary lipid species accumulated, its de-N-acylated psychosine is also accumulated and psychosine was suggested as a cause of toxicity. (sphingolipidclub.com)
  • MRI was performed at 3Tesla and cardiovascular risk factors (eg, age, smoking history, and hypertension), cerebral small vessel disease (CSVD) markers (eg, white matter hyperintensities, lacunar infarction, and enlarged perivascular space) and genetic information (eg, APOE, CR1) were recorded. (dovepress.com)
  • Environmental improvements beginning in the 1900s extended the average life span dramatically with significant improvements in the availability of food and clean water, better housing and living conditions, reduced exposure to infectious diseases, and access to medical care. (foobrdigital.com)
  • NIGMS is a part of NIH that supports basic research to increase our understanding of life processes and lay the foundation for advances in disease diagnosis, treatment and prevention. (blogspot.com)
  • Diabetes Drug Avandia Ups Heart Risk, Reviews Conc. (blogspot.com)
  • APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND. (wakehealth.edu)
  • Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. (wakehealth.edu)
  • Described by Joutel et al , 3 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a Mendelian form of hereditary small-vessel disease and vascular dementia. (bmj.com)
  • Understanding how genetic differences in individuals contribute to their susceptibility to CVDs can help guide practitioners to give the best advice to achieve a favorable outcome for the patient. (scienceopen.com)
  • Understanding your genetic susceptibility can guide you towards preventing future diseases. (geneticlifehacks.com)
  • With unprecedented insights into anatomical and functional connections among multiple organs and systems, wildDISCO promises to revolutionize disease understanding, drug development, and medical education. (isd-research.de)
  • Common polymorphisms (rs429358 and rs7412) were selected from the ApoE gene and we then performed the genotyping as the TaqMan assay. (edu.pl)
  • The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
  • Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
  • Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management? (mdpi.com)
  • this is based on biochemical, clinical, and genetic studies and FH disease, which was documented even with limited mutations. (edu.pl)
  • The relation of ApoE and COMT gene-gene interactions to cognitive and motor function in community-dwelling older adults: a pilot study. (cdc.gov)
  • This study was also the first to use the term polygenic score for a prediction drawn from a linear combination of single-nucleotide polymorphism (SNP) genotypes, which was able to explain 3% of the variance in schizophrenia. (wikipedia.org)
  • It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. (fightaging.org)
  • Until recently, the majority of the research investigating vitamin K's potential for the prevention and treatment of age-associated diseases has been conducted using pharmacological doses of supplemental K1 or MK-4. (vitamindwiki.com)
  • APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. (wakehealth.edu)
  • Modern genotyping platforms permit a systematic search for inherited components of complex diseases. (scienceopen.com)
  • Folstein SE, Rosen-Sheidley B . Genetics of autism: complex aetiology for a heterogeneous disorder. (nature.com)
  • In other words, it gives an estimate of how likely an individual is to have a given trait only based on genetics, without taking environmental factors into account. (wikipedia.org)
  • These methods were first applied to humans in the late 2000s, starting with a proposal in 2007 that these scores could be used in human genetics to identify individuals at high risk for disease. (wikipedia.org)
  • Collectively, our work suggests that targeting Spns2 and/or SphKs/S1P/S1PR axis would be a useful therapeutic for several human diseases including metastatic cancers. (sphingolipidclub.com)
  • The duration of human life (longevity) is influenced by genetics, the environment, and lifestyle. (foobrdigital.com)
  • Psychosine (Galactosyl-sphingosine) is a lyso-form of galactosyl-ceramide (GalCer), accumulated in the genetic disorder of galactosylceramidase, Krabbe's disease. (sphingolipidclub.com)
  • It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. (blogspot.com)