Coronary myocytes smooth muscle. Medical search. Frequent questions

citation needed] CYP2J2 is readily expressed in the cardiac myocytes and endothelial cells of the coronary artery where various EETs are produced. (wikipedia.org)
Our in vitro cell culture studies suggest that the source of IL-18 in CABG patients with elevated homocysteine is not from vascular smooth muscle or endothelial cells. (edu.au)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. (omeka.net)

The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)
For instance, ion channel proteins and membrane proteins anchoring in lipid rafts of cardiac myocytes govern the electrical-impulse, regulate polarizing of cells, balance metabolic resources, and stabilize the functional microdomains between the actin cytoskeleton and extracellular matrix. (symbiosisonlinepublishing.com)
The loss of myocytes leads to cardiac dilation and an increased afterload and wall tension, which results in further systolic dysfunction. (medscape.com)
Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)
An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)
BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)

Large, multicenter randomized trials of various pharmacologic modalities have recently achieved great success in the treatment of patients with coronary artery atherosclerosis. (medscape.com)
Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in humans. (thieme-connect.com)
There is a strong scientific rationale for recommending combination therapy, especially statins and RAS blockades, to treat or prevent atherosclerosis and coronary heart disease. (radcliffecardiology.com)

These vessels (75 ± 11%) ranged in diameter from 25 to 100 pm and connected to the native coronary vasculature. (pharmaceuticalintelligence.com)
The nonstriated, involuntary muscle tissue of blood vessels. (rush.edu)

Results of the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial confirmed that this practice independently associated with improved graft patency, as demonstrated by coronary angiography and saphenous vein graft intravascular ultrasonography. (medscape.com)

[ 53 ] The risk for MI was reduced after percutaneous coronary intervention and noncardiac surgical procedures, but not for coronary artery bypass grafting (CABG). (medscape.com)
Tissue was obtained from coronary arteries without prior instrumentation (primary lesions, n = 31), aortocoronary saphenous vein bypass grafts with primary lesions (n = 8), coronary arteries with lesions developing after prior balloon angioplasty or mechanical atherectomy (reste-notic lesions, n = 30) and vein bypass grafts with restenotic lesions (n = 4). (elsevierpure.com)
The cutoff values are different for MI in the setting of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). (medscape.com)

Currently, CABG-related MI is defined as (1) biomarker level elevations more than 5 times the upper reference limit plus either new pathological Q waves or new left bundle branch block (LBBB), (2) angiographically documented new graft or native coronary artery occlusion, or (3) imaging evidence of new loss of viable myocardium. (medscape.com)

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. (omeka.net)

We investigated the correlation between P-OPG and coronary artery disease (CAD) in asymptomatic type 2 diabetic patients with microalbuminuria. (regionh.dk)
Homocysteine, cytokines (IL-18, IL-6, IL-8) are involved in vascular inflammation and coronary artery disease. (edu.au)
Homocysteine influences endothelial IL-6 and IL-8 cytokine expression and release, however, an association between homocysteine and IL-18 has not been previously investigated in endothelial/smooth muscle cells and or in coronary artery disease. (edu.au)
Indeed, large-scale clinical studies have demonstrated that statins and RAS blockades prevent and retard the progression of coronary heart disease. (radcliffecardiology.com)
Ghorbel MT, Jia H, Swim MM, Iacobazzi D, Albertario A, Zebele C, Holopherne-Doran D, Hollander A, Madeddu P, Caputo M. Reconstruction of the pulmonary artery by a novel biodegradable conduit engineered with perinatal stem cell-derived vascular smooth muscle cells enables physiological vascular growth in a large animal model of congenital heart disease. (rush.edu)

Restenotic lesions were characterized by an increased proportion of loose fibroproliferative tissue (45% of coronary artery intima, 35% of vein graft intima). (elsevierpure.com)

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. (omeka.net)

The presence of EETs relaxes vascular smooth muscle cells by hyperpolarizing the cell membrane, thus highlighting the protective anti-inflammatory function of CYP2J2 in the circulatory system. (wikipedia.org)
Immunohistochemical stains confirmed this proliferative tissue to be primarily smooth muscle cells. (elsevierpure.com)
OPG is a bone-related glycopeptide produced by vascular smooth muscle cells and increased P-OPG may reflect arterial damage. (regionh.dk)
Here, endogenous GRK isoenzymes and arrestin proteins were selectively depleted using RNA-interference in rat arterial smooth muscle cells (RASM) and the consequences of this for ß2AR- and A2BR-mediated adenylyl cyclase (AC) signalling were determined by assessing cAMP accumulation. (bvsalud.org)
To counteract vasoconstrictor-induced contraction, GPCR/PLC signaling can be desensitized by G protein-coupled receptor kinases (GRKs), with GRK2 playing a predominant role in isolated arterial smooth muscle cells. (bvsalud.org)
Сontractile properties of smooth muscle cells of the horn, cervix and broad ligament of the pig uterus. (cardiologymedjournal.com)
Chakraborti S, Roy S, Chowdhury A, Mandal A, Chakraborti T. Role of PKCα-p38 MAPK-Giα axis in peroxynitrite-mediated inhibition of β-adrenergic response in pulmonary artery smooth muscle cells. (cardiologymedjournal.com)
Smooth muscle cells do not contain troponins. (medscape.com)

Petasites seems most specific for pain of the vasculature and for other smooth muscle spasms in hollow organs such as the bronchi and, to a lesser extent, the ureters and possibly the bladder. (ndnr.com)

Systemic hypertension, hypercholesterolaemia and diabetes are associated with endothelial dysfunction that promotes inflammation, oxidation of lipoproteins, smooth-muscle proliferation, extracellular matrix deposition or lysis, accumulation of lipid-rich material, platelet activation, thrombus formation and insulin resistance. (radcliffecardiology.com)

Most recently, targeting lipid rafts modification has become a unified strategy in immunotherapy of cancer, diabetes, cardiovascular diseases and Regenerative medicine for replacing neuron and human coronary artery smooth muscle cell. (symbiosisonlinepublishing.com)

Prolonged vasoconstrictor signalling found in hypertension, increases arterial contraction, and alters vessel architecture by stimulating arterial smooth muscle cell (ASMC) growth, underpinning the development of re-stenosis lesions and vascular remodelling. (bvsalud.org)
Generation of cAMP through Gs-coupled G protein-coupled receptor (GPCR) [e.g. ß2-adrenoceptor (ß2AR), adenosine A2B receptor (A2BR)] activation, induces arterial smooth muscle relaxation, counteracting the actions of vasoconstrictors. (bvsalud.org)
However, despite numerous studies indicating that ß2AR and A2BR can be substrates for GRK/arrestin proteins, currently little is known regarding GRK/arrestin regulation of these endogenous receptors in arterial smooth muscle. (bvsalud.org)
This study provides a first demonstration of how different complements of GRK and arrestin proteins contribute to the regulation of signalling and desensitization of these important receptors mediating vasodilator responses in arterial smooth muscle. (bvsalud.org)
The pathophysiology behind hypertension in the elderly is a complex process that is not entirely understood, but it is attributed to an increase in peripheral vascular resistance caused by decreased elasticity and increased stiffness due to smooth muscle hypertrophy in arterial walls. (uspharmacist.com)

Vasoconstrictors interact with their cognate G protein coupled receptors activating a variety of signalling pathways to promote smooth muscle proliferation. (bvsalud.org)

These lesions frequently contained cholesterol crystals (45% of coronary arteries, 50% of vein grafts) and calcium deposits (65% of coronary arteries, 38% of vein grafts). (elsevierpure.com)

It is shown, that separate dilutions of human serum and animal (as a source of ESBAR) and analogs of ESBAR ways to enhance the effectiveness of activation of beta-adrenoceptors (AR) of smooth muscle (uterus, coronary and renal arteries, trachea, stomach), myocardium, erythrocytes and platelets (respectively influenced of histidine and tryptophan). (cardiologymedjournal.com)

The physiological properties of the smooth muscles of the vagina and uterine cornua and cervix of the rabbit. (cardiologymedjournal.com)
Physiological properties of smooth muscle of the cervix uteri in the rat. (cardiologymedjournal.com)

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. (thieme-connect.com)

In Part II, we discovered that neo-angiogenesis occurs without evidence of myocyte generation. (pharmaceuticalintelligence.com)

This graph shows the total number of publications written about "Muscle, Smooth, Vascular" by people in this website by year, and whether "Muscle, Smooth, Vascular" was a major or minor topic of these publications. (rush.edu)

coronary: is to the health and actions. (seabaygame.com)

[ 51 ] The risk for MI was reduced after percutaneous coronary intervention and noncardiac surgical procedures, but not for coronary artery bypass grafting (CABG). (medscape.com)
The aim of this study was to evaluate plasma levels of CC cleavage fragments (C3a, C5a, and C5b9), sphingosine (SP), sphingosine-1-phosphate (S1P), and free hemoglobin (fHb) in AMI patients treated with primary percutaneous coronary intervention (pPCI) and stable coronary artery disease (SCAD) undergoing CABG. (hindawi.com)

In the normal heart, there may be many immature, undeveloped anastomoses between coronary arteries that carry little, if any, perfusion in the absence of a pressure gradient driving flow across them. (nih.gov)
With the development of proximal obstruction in one of the coronary arteries, there is the simultaneous development of a pressure gradient between the nonobstructed and obstructed arteries, inducing flow across the collateral vessel (Fig. 1). (nih.gov)
the coronary arteries supply the heart muscle with blood. (wise-geek.com)
In human coronary arteries, vascular media and plaque, high abundance of fibronectin expression, and colocalization with TG2 were observed. (johnshopkins.edu)
In addition, the combination of biglycan overexpression and Ang II infusion resulted in marked increases in vascular smooth muscle cell proliferation and migration in the coronary arteries, as well as increases in fibrosis surrounding the vessels. (elsevierpure.com)

citation needed] CYP2J2 is readily expressed in the cardiac myocytes and endothelial cells of the coronary artery where various EETs are produced. (wikipedia.org)
Low-serum cell culture medium for endothelial cells from microvascular vessels, the coronary artery, and the aorta. (promocell.com)
Furthermore, although CRP is primarily made by liver, new studies have shown that CRP is also produced by diseased tissues (eg, atherosclerotic lesions) and by various cell types including macrophages, smooth muscle cells, and endothelial cells. (ahajournals.org)
BBHV and Atherosclerosis and Vascular Inflammation (AVI) have shared interests in endothelial cells, smooth muscle cells, and inflammatory cells. (nih.gov)
Applications that emphasize endothelial cells, smooth muscle cells, and inflammatory cells in the context of atherosclerosis will be reviewed in AVI. (nih.gov)
Certain circRNAs, such as circRNA ankyrin repeat domain 36, circRNA homeodomain‑interacting protein kinase 3 (circHIPK3) and circRNA WD repeat domain 77, are associated with inflammation, endothelial cell apoptosis and smooth muscle cell proliferation, leading to vascular endothelial dysfunction and atherosclerosis. (spandidos-publications.com)
Intravascular thrombogenesis, the main pathogenic mechanism of the coronary artery disease (CAD), is influenced by a complex interplay of procoagulant, anticoagulant, fibrin lytic, endothelial damage/ dysfunction and inflammatory processes [1]. (ijcrr.com)
In vitro, biglycan caused an increase in thymidine incorporation and migration of vascular smooth muscle cells, whereas these parameters were unchanged or reduced in endothelial cells. (elsevierpure.com)

This is especially true in critically ill patients with a diagnosis other than acute coronary syndrome, in whom elevated troponin levels have been shown to be associated with increased mortality. (medscape.com)
They play a pivotal role in the diagnosis, risk stratification, and treatment of patients with chest pain and suspected acute coronary syndrome (ACS) as well as those with acute exacerbations of heart failure[8, 9]. (ijcrr.com)

To determine whether the addition of an angiotensin converting enzyme (ACE) inhibitor to standard therapy in patients with known coronary artery disease and preserved left ventricular function will reduce the risk of cardiovascular mortality, myocardial infarction, the occurrence of a coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. (nih.gov)

Decades of studies and the major implementations of risk factor modification (primary prevention) have clearly led to impressive reductions in the age-adjusted risk of coronary heart disease and death.1 In many respects, these important lifestyle modifications have postponed the clinical manifestation of coronary heart disease to a more advanced age. (nih.gov)

We have therefore investigated how [H+]i co-ordinates their initiation and frequency.Spontaneous Ca2+ waves were imaged (fluo-3) in rat isolated ventricular myocytes, subjected to modest Ca2+-overload. (ox.ac.uk)

Noma A. ATP-regulated K+ channels in cardiac muscle. (ukrbiochemjournal.org)
Where does calcium come from for use in cardiac muscle contraction? (freezingblue.com)
The myocardium consists of cardiac muscle , a type of muscle unlike any other muscle in the body. (wise-geek.com)
Cardiac muscle combines features of skeletal muscle , which controls voluntary body movement, and smooth muscle , which controls the movement of all body organs other than the heart. (wise-geek.com)
The cardiac muscle that makes up this structure is involuntary, like the smooth muscle in the body's other organs. (wise-geek.com)
Cardiac muscle is more similar in structure, however, to skeletal muscle than to smooth muscle. (wise-geek.com)
Both cardiac muscle and skeletal muscle are striated, meaning the muscle fibers are arranged into parallel bundles, and have alternating thick and thin protein filaments. (wise-geek.com)
The cells that make up cardiac muscle are called cardiac myocytes, or cardiomyocytes. (wise-geek.com)

2 This action can eventually lead to myocyte hypertrophy and vascular smooth muscle cell proliferation. (drugbank.com)
We hypothesized that expression of allograft inflammatory factor-1 (AIF-1), a cytokine-inducible, calcium-binding protein associated with vascular smooth muscle cell proliferation, would be associated with allograft rejection and development of CAV. (psu.edu)

BBHV and Integrative Myocardial Physiology/Pathophysiology A (MPPA) have shared interests in the area of myocyte cardiac hypertrophy, myocyte interactions, cardiomyocyte contractile function as well at metabolism and energetics aspects of heart disease. (nih.gov)

The epidemiological data reflects the global trend for Europe, where coronary artery disease (CAD) with its complication in the form of acute myocardial infarction (AMI) and, in the longer-term, heart failure, accounts for 20% of all deaths among Europeans [ 2 , 3 ]. (hindawi.com)

These questions have been a focus of the Physiology and Pharmacology Section of the Cardiology Branch, and based on our investigations in an animal model, we have now concluded that coronary collateral growth can be stimulated by using angiogenic peptides, at least in experimental animals (3,4). (nih.gov)
The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth. (omeka.net)
Coronary collateral growth is a process involving coordination between growth factors expressed in response to ischemia and mechanical forces. (omeka.net)

Pressure-controlled intermittent coronary sinus occlusion (PICSO), known to induce angiogenetic and vasoactive molecules as well as to reduce regional ischemia, may activate endogenous regenerative processes in failing myocardium. (eur.nl)
The presence of functional collaterals enables the heart to maintain essentially normal perfusion under resting conditions, despite near-total occlusion of a major coronary artery. (nih.gov)

Conclusions: Here, we show for the first time that PICSO, a trans-coronary sinus catheter intervention, is associated with an increase in morphogens secreted into cardiac veins, normally present during cardiac development, and a significant induction of cell proliferation. (eur.nl)

These results suggest that this extracellular matrix SLRP may be involved in the regulation of vascular smooth muscle growth and migration through cdk2- and p27-dependent pathways. (elsevierpure.com)

True or false, chordae tendonae connect papillary muscles to the pulmonary and aortic valves. (freezingblue.com)

tissue with workers may help in a adherence of derivatives, the most oral of which suggest post-implant cardiomyocytes, smooth as failure, proton, and ischaemic solid team. (xtenddigital.com)

To test immediate molecular responses, in both patient groups, coronary venous blood samples were taken at baseline and after 20 min, the time required for the intervention. (eur.nl)

Role of potassium channels in coronary vasodilation. (ukrbiochemjournal.org)
1-4 In vascular smooth muscle, opening of K ATP channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. (silverchair.com)

Involuntary muscle is not under conscious control, and contrasts with voluntary skeletal muscle, which is attached to the skeleton and used for skeletal movement like walking and standing. (wise-geek.com)

NBP exits mainly in myocytes of ventricle. (biomedres.info)
Primary human cardiac myocytes isolated from normal human ventricle tissue of the adult heart, plus optimized myocyte media. (sigmaaldrich.com)

Here, we performed a targeted lipidomic analysis of ex vivo-generated oxylipins from porcine aorta, coronary artery, pulmonary artery and perivascular adipose. (nih.gov)
The 11-HETE, 15-HETE, and 9-HODE were also induced by LPS from the aorta and pulmonary artery but not coronary artery. (nih.gov)

A cardioprotective ebook human capital in private will help that Neonatal rules explain more many than smooth cases. (xtenddigital.com)

Low plasma adiponectin levels, also known as hypoadiponectinemia, are closely associated with the increased prevalence of obesity-linked disorders including type 2 diabetes, coronary heart disease, and hypertension. (ahajournals.org)

The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)

IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes. (icm-mhi.org)
The vasodilator effect of carvedilol increases the insulin dependent glucose influx into the myocytes and increases insulin sensitivity. (escardio.org)

2,3 High levels of CRP are also associated with obesity and coronary heart disease, 4,5 suggesting that CRP is a useful biomarker for obesity-linked chronic inflammatory states. (ahajournals.org)
Cholesterol is needed for of any attempt to prevent coronary heart disease (CHD). (onlinepdfcatalog.com)
BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)

Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. (nih.gov)

MI may be the first manifestation of coronary artery disease (CAD) or it may occur, repeatedly, in patients with established disease [5]. (ijcrr.com)

Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)

Local acidosis thus simultaneously inhibits and stimulates arrhythmogenic Ca2+-signalling in the same myocyte. (ox.ac.uk)

Cardiac myocytes: Contractile function and mechanical stress generation. (nih.gov)

however, with the hemodynamic alterations and/or metabolic derangements that accompany occlusive coronary artery disease, their development is stimulated, and they provide an alternative source of myocardial perfusion to the territory of the impeded artery. (nih.gov)

The muscle tissue of the HEART . (nih.gov)

Such mediators might be synthesized or released by the vascular wall and/or the myocardium in response to the development of significant coronary artery occlusions. (nih.gov)
The myocardium is the muscle layer of the heart, responsible for the heart's pumping action, which supplies the entire body with blood. (wise-geek.com)

By contrast, the coronary artery produced significantly higher levels of oxylipins from CYP450 pathways than other tissues. (nih.gov)

Product bundle consisting of human cardiac myocytes, optimized media and subculture reagents. (promocell.com)
Nielsen JJ, Kristensen M, Hellsten Y, Bangsbo J, Juel C. Localization and function of ATP-sensitive potassium channels in human skeletal muscle. (ukrbiochemjournal.org)

This powerful muscle sends blood loaded with oxygen and nutrients through every part of the body. (wise-geek.com)

Because the small leucine-rich proteoglycan (SLRP) biglycan is overexpressed in arteriosclerotic lesions, we produced mice constitutively overexpressing biglycan in the vascular smooth muscle, in order to examine the effects on vascular pathology. (elsevierpure.com)

joined 31-JUL-2003 and physiological reconstruction d and muscle vein diabetes to a tactile study in series vitro. (xtenddigital.com)

Anatomy60

Organisms15

Diseases26

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes44

Disciplines and Occupations2

Information Science3

Health Care8

Endothelial cells5

Cardiac7

Atherosclerosis3

Vessels2

Angiography1

Bypass3

CABG1

Acute1

Disease5

Graft1

Dilation1

Cells8

Vasculature1

Inflammation1

Regenerative1

Arterial5

Receptors1

Calcium1

Myocardium1

Physiological2

Cell1

Evidence1

Topic1

Actions1

Percutaneous coronary int2

Arteries5

Endothelial8

Acute Coronary2

Artery bypass graft surgery1

Manifestation of coronary heart d1

Ventricular myocytes1

Cardiac muscle8

Vascular smooth musc2

Hypertrophy1

Myocardial infarction1

Collateral growth3

Occlusion2

Proliferation1

Extracellular1

Aortic1

Cardiomyocytes1

Venous1

Vasodilation2

Involuntary1

Ventricle2

Pulmonary2

Neonatal1

Type 2 diabet1

Thrombolytic1

Increases2

Heart disease3

Transcriptional1

Patients1

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Inhibits1

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Tissue1

Myocardium2

Pathways1

Human2

Oxygen1

Mice1

Physiological1