• Bowman's
  • Bowman's layer (also known as the anterior limiting membrane): when discussed in lieu of a subepithelial basement membrane, Bowman's Layer is a tough layer composed of collagen (mainly type I collagen fibrils), laminin, nidogen, perlecan and other HSPGs that protects the corneal stroma. (wikipedia.org)
  • When discussed as a separate entity from the subepithelial basement membrane, Bowman's Layer can be described as an acellular, condensed region of the apical stroma, composed primarily of randomly organized yet tightly woven collagen fibrils. (wikipedia.org)
  • peripheral
  • Thus, if corneal topography is used for diagnosis, it should be in conjunction with clinical findings of peripheral, inferior corneal thinning. (wikipedia.org)
  • Terrien marginal degeneration is a noninflammatory, unilateral or asymmetrically bilateral, slowly progressive thinning of the peripheral corneal stroma. (wikipedia.org)
  • Cells
  • Cloned corneal SP cells under chondrogenic conditions produced matrix staining with toluidine blue and expressed cartilage-specific markers: collagen II, cartilage oligomatrix protein, and aggrecan. (mendeley.com)
  • These results demonstrate the presence of a population of cells in the human corneal stroma expressing stem cell markers and exhibiting multipotent differentiation potential. (mendeley.com)
  • Further analysis of these cells will aid elucidation of molecular mechanisms of corneal development, differentiation, and wound healing. (mendeley.com)
  • These cells may be a resource for bioengineering of corneal stroma and for cell-based therapeutics. (mendeley.com)
  • The healing corneal wounds consist of newly abutting corneal stroma, fibroblastic cells, and irregular fibrous connective tissue. (wikipedia.org)
  • During development of the embryo, the corneal stroma is derived from the neural crest (a source of mesenchyme in the head and neck) which has been shown to contain mesenchymal stem cells. (wikipedia.org)
  • Keratoconus
  • Corneal cross-linking appears to be a safe and effective procedure to halt the progression of keratectasias, such as keratoconus or post-LASIK ectasia. (arvojournals.org)
  • Pellucid marginal degeneration (PMD), is a degenerative corneal condition, often confused with keratoconus. (wikipedia.org)
  • infection
  • They provide an inherent barrier against corneal infection while also serving as a primary mode of defense that is present from birth. (wikipedia.org)
  • Treatment of corneal ulcers includes topical antibiotic therapy to prevent infection, and pain medications, including topical atropine to stop spasms of the ciliary muscle. (wikipedia.org)
  • However, there are two possible causes of the corneal inflammatory response: an infection and/or an immunological response, such as a hypersensitivity type reaction, or (rarely) Cogan syndrome. (wikipedia.org)
  • fluorescein
  • Diagnosis is through direct observation of the ulcer with the use of fluorescein stain, which is taken up by exposed corneal stroma and appears green (see photos above and below). (wikipedia.org)
  • photorefractive keratectomy
  • In 1983, Stephen Trokel, a scientist at Columbia University, in collaboration with Srinivasan, performed the first Photorefractive Keratectomy (PRK), or keratomileusis in situ (without separation of corneal layer) in Germany. (wikipedia.org)
  • vivo
  • Appearance of myofibroblasts in the injured corneal stroma was suppressed by lacking NOS2 in vivo, although the loss of NOS2 promoted myofibroblast generation in vitro in monolayer culture. (arvojournals.org)
  • contact lenses
  • Patients wearing contacts dont report increased problems with glare and contrast sensitivity, but it is not clear if this is due to the corneal disease, or the contact lenses themselves. (wikipedia.org)
  • outcomes
  • Factoring patient age and refractive index of the corneal stroma into the treatment profile improved the predictability of LASIK outcomes, according to a study.The prospective study included 133 eyes, of which 107 were myopic and 26 were hyperopic. (linkoph.com)
  • inflammatory
  • Infectious causes include syphilis (commonest), followed by other bacterial infections (TB, Leprosy and Lyme disease) and parasitic infections (Acanthamoeba, Onchocerciasis or river blindness, Leishmaniasis, Trypanosoma cruzi or Chagas disease, Trypanosoma brucei or African sleeping sickness and microsporidia) The corneal scarring is the end result of the initial invasion of blood vessels into the corneal stroma as part of the inflammatory response. (wikipedia.org)
  • anterior chamber
  • Iridogoniodysgenesis, dominant type (type 1, IRID1) refers to a spectrum of diseases characterized by malformations of the irido-corneal angle of the anterior chamber of the eye. (wikipedia.org)
  • involves
  • It involves removing a corneal layer, freezing it so that it could be manually sculpted into the required shape, and finally reimplanting the reshaped layer into the eye. (wikipedia.org)
  • keratomileusis
  • In situ keratomileusis effected at a later age increases the incidence of corneal higher-order wavefront aberrations. (wikipedia.org)
  • His technique, called keratomileusis, meaning corneal reshaping (from Greek κέρας (kéras: horn) and σμίλευσις (smileusis: carving)), enabled the correction, not only of myopia, but also of hyperopia. (wikipedia.org)
  • layer
  • After the bubble was inflated to the point of popping, no further bubble could be formed from further injection, indicating that the bubble was being trapped by a distinct layer of material, not a random variation in the corneal stroma. (wikipedia.org)
  • Mark Terry, clinical ophthalmology professor at Oregon Health & Science University stated: "I applaud the fresh approach to corneal anatomy that Dr. Dua has taken, and I look forward to further documentation of the unique benefits of this layer in treatment. (wikipedia.org)
  • In February 2014, McKee et al criticized the validity of the discovery, as well as the self-chosen name Dua's Layer: "We read the recent claim of the discovery of a new corneal layer by Dua et al with incredulity. (wikipedia.org)
  • Their further investigation of this pre-Descemet stroma confirms that it is stroma, and not a new corneal layer. (wikipedia.org)
  • invasion
  • Healing of an incision injury in corneal stroma was delayed with less invasion of macrophages and reduction in expression of aSMA and fibronectin in a KO mouse as compared with a WT mouse. (arvojournals.org)
  • NOS2 is required for macrophage invasion and primary healing of injured corneal stroma folowing incision injury. (arvojournals.org)