• Zinc
  • Zinc will reduce copper absorption. (purdue.edu)
  • Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency Aceruloplasminemia Greater-than-normal ceruloplasmin levels may indicate or be noticed in: copper toxicity / zinc deficiency pregnancy oral contraceptive pill use lymphoma acute and chronic inflammation (it is an acute-phase reactant) rheumatoid arthritis Angina Alzheimer's disease Schizophrenia Obsessive-compulsive disorder Normal blood concentration of ceruloplasmin in humans is 20-50 mg/dL. (wikipedia.org)
  • Certain
  • Certain copper-associated disorders, such as chronic active hepatitis in Doberman pinschers and Skye terrier hepatitis are characterized by copper retention secondary to the underlying disease, thus resembling primary biliary cirrhosis in humans. (islandscholar.ca)
  • Once the build-up reaches a certain threshold, the copper may spill into the bloodstream. (purdue.edu)
  • diet
  • Copper is regularly used in the diet at about 8-11 parts per million. (purdue.edu)
  • A diet should never have copper level above 25 parts per million to be safe for most sheep. (purdue.edu)
  • iron
  • Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state. (wikipedia.org)
  • Animal
  • The animal needs to have the source of the copper removed. (purdue.edu)
  • The animal may also be drenched with electrolytes and sodium thiomolybdate to flush the kidneys and bind the copper. (purdue.edu)