• The prodrug strategy implementation in the last 20 y has led to a steady advancement in the biopharmaceutical, physicochemical and/or pharmacokinetic attributes of the pharmacologically active compounds. (ijpsonline.com)
  • Suicide genes code for enzymes, such as cytosine deaminase (CD), that convert non-toxic compounds (prodrugs) into toxic products. (invivogen.com)
  • The prodrug approach is rapidly becoming a crucial part in the stratagem of delivery of drugs. (ijpsonline.com)
  • TDF is rapidly converted to TFV following absorption and is readily catalyzed to the active diphosphate form, TFV-DP (Fig. 1 ) [ 3 ]. (biomedcentral.com)
  • Prodrugs are derivatives of drug molecules that are pharmacologically inactive but require either chemical or enzymatic transformation to release the active drug in vivo in order to exert a pharmacological effect. (ijpsonline.com)
  • Once in the liver, enzymes convert prodrugs to active metabolites or convert active drugs to inactive forms. (msdmanuals.com)
  • Some drugs, called prodrugs, are administered in an inactive form, which is metabolized into an active form. (msdmanuals.com)
  • Examples of both marketed and investigational prodrugs using several promoieties are discussed with their advantages and future prospects. (ijpsonline.com)
  • A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy. (invivogen.com)
  • Prodrug concept is justified because it enables the active drug to overcome the barrier that would impede it from reaching the site of action to exert the required pharmacological activity. (ijpsonline.com)
  • A bioprecursor prodrug is transformed chemically through hydration (for example, lactones such as some statins), reduction (for example, sulindac, platinum (IV) complexes) or oxidation (for example, dexpanthenol, nabumetone) or metabolically to the active agent [ 5 , 9 - 11 ]. (ijpsonline.com)
  • These prodrugs subsequently undergo enzymatic or non-enzymatic cleavage to release the active drug moiety (figure 1) [ 12 , 13 ]. (ijpsonline.com)
  • Carrier-linked prodrugs are for drugs with major drawbacks, which are linked to a nontoxic carrier or promoiety through covalent linkage to change or get rid of their undesirable physicochemical properties. (ijpsonline.com)
  • During the life cycle of HBV, RT utilizes a single-stranded viral genomic RNA as a template to synthesize a hybrid RNA-DNA duplex, and then converts it to double-stranded DNA (ds-DNA). (biomedcentral.com)
  • Prodrugs have better delivery properties that surpass the parent drug molecule [ 1 ]. (ijpsonline.com)
  • It is a prodrug , being converted in vivo to aciclovir . (wikidoc.org)
  • In vivo delivery of TK-NTR and administration of prodrugs led to the effective killing of both targeted cells and surrounding tumor cells via TK-NTR-mediated conversion of co-delivered prodrugs into active cytotoxic agents. (regenerativemedicine.net)