Control group tissue inhibitor of metalloproteinase 2. Medical search. Frequent questions

The activities of matrix metalloproteinase (MMP)-2 and−9 were further inhibited and TIMP-1 and−2, and NM23-H1, the MMPs negative modulators, were further activated in the combined treatment. (frontiersin.org)
The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. (bvsalud.org)
Further studies are needed to establish the relationship between the initial process of resorption of the blood clot, and the involvement of MMPs 2 and 9 and its regulators/tissue inhibitors. (bvsalud.org)
Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). (wikipedia.org)
Due to the role of MMPs in pathological conditions, inhibitors of MMPs may have therapeutic potential. (wikipedia.org)
Most MMP inhibitors are unable to target specific MMPs connected to specific pathological conditions. (wikipedia.org)
α2-Macroglobulin (α2M) is a protease inhibitor which inhibits activated MMPs. (wikipedia.org)
MMPs are associated with the cell surface or bound to the extracellular matrix which prevents them from diffusing away and keeps the MMP under control of the cell. (wikipedia.org)
The structural difference MMPs' is mainly in the S1' side and by modifying the P1' group, inhibitor selectivity can be developed. (wikipedia.org)
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. (cancerindex.org)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C). Tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring inhibitors of MMPs, which inhibit the activity of MMPs and control the breakdown of ECM. (biomedcentral.com)
Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
The levels of cytokines, VEGF, MMPs, and COX-2 were higher in the endometriosis group than the control group, while TIMP was lower. (endonews.com)
Cytokines may induce degradation of the extracellular matrix, which is carried out by matrix metalloproteinases (MMPs) enzymes. (endonews.com)
Excessive proteolytic activity, which relates to an imbalance of the elastase/alpha1-antitrypsin system or metalloprotease (MMPs) and their inhibitors (tissue inhibitors of metalloproteases [TIMPs]), may be important in lung destruction and formation of cysts. (medscape.com)
Matrix metalloproteinases (MMPs) are zinc-dependent proteases that play a major role in extracellular matrix (ECM) remodeling but have also been shown to be involved in the regulation of multiple stages of cancer progression [ 4 ]. (oncotarget.com)
Matrix metalloproteinases (MMPs) and Tissue Inhibitor of Matrix Metalloproteinases (TIMPs) may be associated with atherogenesis and plaque rupture. (opencardiovascularmedicinejournal.com)

Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. (bvsalud.org)
The aim of this report is to analyze the effects of high fluoride (F) intake on matrix metalloproteinase-2 (MMP-2), tissue inhibitors of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) levels. (omu.edu.tr)
MMP-2, TIMP-1, and TGF-beta levels in the bone matrix were determined by immunohistochemical staining. (omu.edu.tr)
In previous investigations of wound healing in dental pulp, we found that organic dentin matrix components (DMCs) were degraded by matrix metalloproteinase-20, and DMC degradation products containing protein S100A7 (S100A7) and protein S100A8 (S100A8) promoted the pulpal wound-healing process. (nagoya-u.ac.jp)
During the whole period of woman life there are many processes which involve degradation of extracellular matrix (tissue morphogenesis, angiogenesis, bone remodelling, wound healing, trophoblast implantation, involution of postpartum uterus or involution of postlactation mammary gland). (ispub.com)
These results suggest that LDL, after prolonged incubations with HMC, causes a PA/inhibitor imbalance favoring accumulation of matrix. (ispub.com)
Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas. (cancerindex.org)
3 ] showed that estradiol affects the expression of anabolic and catabolic genes (e.g., those encoding aggrecan (AGC)1, matrix metalloproteinase (MMP)2, MMP14, and tissue inhibitor of metalloproteinase (TIMP)2, transforming growth factor (TGF)B2, and TGFB3) in bovine cartilage explants. (biomedcentral.com)
Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)
Saikosaponins A and D inhibited the formation of resorptive pits by reducing the secreted levels of matrix metalloproteinase- (MMP-) 2, MMP-9, and cathepsin K in RANKL-induced osteoclasts. (hindawi.com)
Thus, emerging therapies, including cathepsin K, matrix metalloproteinase, or nonreceptor tyrosine kinase Src inhibitors, are being introduced for prevention and treatment of osteoporosis and cancer bone metastasis. (hindawi.com)
Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
Associated with these changes was an induction of the matrix metalloproteinase protein 2 (MMP2) and MMP9 systems. (biomedcentral.com)
The levels of fibrinogen, C-reactive protein (CRP), tumor necrosis factor-alpha, interleukin 6 (IL-6), and matrix metalloproteinase-9 were measured. (nih.gov)
Objective -To identify matrix metalloproteinases (MMP) 2 and 9 in canine tumor tissue and to compare the amount of activity to that in unaffected stromal tissue. (avma.org)
matrix metalloproteinases activity in tumor tissue is higher than in unaffected stromal tissue, indicating that canine MMP may be involved in the pathogenesis of tumor growth and metastasis. (avma.org)
Our studies in mouse C3H10T1/2 fibroblasts suggested that a number of TGF-ß-induced genes that regulate matrix turnover are selectively regulated by HDACs. (uea.ac.uk)
The effects of iPLA 2 β (Ca 2+ -independent Phospholipase A 2 β) and MMP-9 (Matrix Metalloproteinase-9) on the migration of cancer cells have been a recent focus for biomedical research and have been found to be over-expressed. (eku.edu)
At the cellular levels, previous studies observed an absence of the transforming growth factor (TGF)-β1 and the insulin-like growth factor (IGF)-1, as well as increased levels of matrix metalloproteinases and decreased levels of their inhibitors [ 7 ]. (biomedcentral.com)
The mRNA and protein expression of matrix metalloproteinase 2 (MMP2) and vascular endothelial growth factor (VEGF) in Tβ4-treated RP cells was assessed by quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. (spandidos-publications.com)

There were no differences in the AKI biomarker tissue inhibitor of metalloproteinase 2 (TIMP-2) between trials (P = 0.11). (cdc.gov)
Additionally, the differential findings between IGFBP7 (preferentially secreted in proximal tubules) and TIMP-2 (distal tubules) suggest the proximal tubules as the location of potential renal injury. (cdc.gov)
Eucalyptol upregulated elastin and TIMP-1 levels, and reduced neutrophil elastase (NE) levels, when compared to the CS group. (greenmedinfo.com)
Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
Intra-group comparison revealed significant differences at MMP-2/TIMP-1 and TIMP-1/TGF-beta ratios only in F group (p=0.02 for MMP-2 and p=0.01 for TGF-beta). (omu.edu.tr)
KEY RESULTS: Skin samples of untreated OVX rats showed a decrease in TGF-β1, VEGF, MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 compared with sham OVX rats. (unime.it)
On the other hand, TIMP-1 and -2 levels were lower in women with endometriosis than in controls. (endonews.com)
Gelatinolytic activity could be quenched by the addition of 50 m M EDTA and 1 µg of synthetic tissue inhibitor of metalloproteinase (TIMP) 2 per 100 ml. (avma.org)
Bronchial alveolar lavage fluid (BALF) and lung tissue samples were collected from included patients, and were analyzed for MMP-2 and TIMP-2 expression. (oncotarget.com)
The results showed a higher level of MMP-2 and TIMP-2 expression and secretion in airways of lung cancer patients than that of benign diseases. (oncotarget.com)
A statistically significant correlation was observed between MMP-2 and TIMP-2. (oncotarget.com)
Interesting, BALF MMP-2 and TIMP-2 showed a high sensitivity and specificity in predicting the malignant nature of pulmonary disease in both derivation cohort and validation cohort. (oncotarget.com)
Measurement of MMP-2 and TIMP-2 in BALF might be helpful for differential diagnosis of primary lung cancer. (oncotarget.com)
Blockade of HDAC activity with trichostatin A (TSA) abrogated the induction of a disintegrin and metalloproteinase 12 (Adam12) and tissue inhibitor of metalloproteinases-1 (Timp-1) genes by TGF-ß, whereas plasminogen activator inhibitor-1 (Pai-1) expression was unaffected. (uea.ac.uk)
The TGF-ß induction of Adam12 and Timp-1 was dependent on such non-Smad signalling pathways and, importantly, HDAC inhibitors completely blocked their activation without affecting Smad signalling. (uea.ac.uk)
Analysis of TGF-ß-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs. (uea.ac.uk)
TIMP-1 levels were not significantly different within all 5 groups. (opencardiovascularmedicinejournal.com)
Hazard ratio (95% confidence interval) was for MMP-2 1.126 (1.011-1.255), perlecan 1.0099 (1.0004-1.0196), and TIMP-4 1.037 (1.003-1.071) in age and sex-adjusted Cox-regression model. (lu.se)
The present study indicates that high levels of MMP-2, perlecan, and TIMP-4 are associated with poor survival in PAH. (lu.se)

After Ang II infusion, mouse serum levels of pro-inflammatory cytokines were analysed, and aortic tissues were isolated for histological, RNA, and protein analysis. (molcells.org)
Mechanistically, we found that lycopene and sorafenib could additively inhibit the mitogen-activated protein kinase (MAPK) pathways, as shown by the protein phosphorylation of ERK1/2, JNK1/2 and p38 were reduced additively. (frontiersin.org)
Protein inhibitors such as α2-macroglobulin are known to work with metalloproteinases. (wikipedia.org)
In the design of these inhibitors, the basic protein backbone of collagen is maintained but the amide bond is replaced with a zinc-binding group. (wikipedia.org)
In this study, we identified functional peptides derived from the protein S100 family and investigated their effects on dental pulp tissue. (nagoya-u.ac.jp)
Protein condensation reflects imbalances between entry into (synthesis/translocation) and exit from (secretion/degradation) ESC, and can be also a consequence of altered quality control (QC) mechanisms. (jak-signaling.com)
0.05) COL2A1, aggrecan, cartilage oligomeric protein, tissue inhibitor of metalloproteinases-2 and TGF-β1. (biomedcentral.com)
18]CHEN H,LI Q,YI R,et al.CircRNA casein kinase 1 gamma 1(circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1(MAPK1) J .J Clin Lab Anal,2022,36(2):1-12. (xdzlyx.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
The 9× bamboo salt- and 1× bamboo salt-treated groups exhibited protein contents similar to the standard group. (koreantalks.com)

The most pronounced finding of the studied tissue factors was in bronchial epithelium, mucosal connective tissue and blood vessels of COPD patients, which proves the significant involvement and role of these structures in COPD morphopathogenesis. (rsu.lv)
These enzymes have the ability to break down connective tissue. (wikipedia.org)
Bone is a specialized connective tissue composed of both mineral and organic phases that is exquisitely designed for its role as the load-bearing structure of a body. (hindawi.com)
3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)

To explore the involvement of enzymes of drug metabolism in bladder cancer, in the present study, we analyzed the gene expression profiles of tumor and normal looking tissues obtained from the same patient by cDNA macroarray. (jak-signaling.com)
Procedure -Tumor and nearby stromal tissue (muscle) were obtained at the time of surgery. (avma.org)
The amount of activity in tumor tissue was compared with the amount in stromal tissue. (avma.org)
Results -Gelatinolytic bands were observed from the analysis of all tumor tissues and in most stromal tissues. (avma.org)
There was significantly more gelatinolytic activity in tumor tissue than in stromal tissue. (avma.org)
In mice, basal and nicotine-induced tumor growth was significantly decreased, in comparison with the control group. (eku.edu)
In the 5th edition of the WHO classification, medulloblastoma s, which are representative pediatric brain tumor s, are categorized into four groups: WNT, SHH-TP53 wild, SHH-TP53 mutant, and non-WNT/non-SHH, based on their molecular background. (neurosurgery.directory)
This indicates that during surgery, it may have been challenging to remove the tumor completely, and some cancerous tissue might remain. (neurosurgery.directory)

ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
In addition, dietary antioxidant supplementation modulated the expression levels of pIκBα, HO-1, CuZnSOD, iNOS and COX-2 proteins in the diabetic mice. (biomedcentral.com)
Among the range of proteins shown to co-localize to WPB is angiopoietin-2 (Angpt-2), a ligand of the receptor tyrosine kinase Tie-2. (imperial.ac.uk)
Plasma levels of 14 ECM-related proteins, with altered levels in PAH compared to healthy controls, were analyzed with proximity extension assays, and related to hemodynamics, transplant-free survival time, and ESC/ERS risk score. (lu.se)

During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
In the lung tissues of the control group, we found a mild to moderate increase in the number of immunoreactive cells of all studied factors at different localizations, indicating low, persistent, continuous and adaptive "baseline" level for various factors. (rsu.lv)
Age changes in the relatively healthy lungs are individual, even different for individuals in different age groups, as well as mostly characterized by a lack to maintain inflammation, also, reduced number of immune cells are found. (rsu.lv)
Furthermore, reverse transcription‑quantitative PCR was used to examine the expression levels of circular RNA‑PVT1 (circ‑PVT1), micoRNA‑195‑5p (miR‑195‑5p) and ETS1 in GC tissues and cells. (spandidos-publications.com)
Propofol could inhibit Bcl‑2 and MMP9 expression, and increase P21 expression in GC cells. (spandidos-publications.com)
The expression levels of circ‑PVT1 and ETS1 were increased in GC tissues and cells, and miR‑195‑5p was decreased. (spandidos-publications.com)
Additionally, the effects of transfection with circ‑PVT1 small interfering RNA (si‑circ‑PVT1) on HGC‑27 and AGS cells could be reversed by treatment with miR‑195‑5p inhibitor. (spandidos-publications.com)
Previous studies have investigated the inhibitory effect of propofol on cancer cells in a variety of tumors, such as breast ( 2 ), lung ( 3 ) pancreatic ( 4 ), ovarian ( 5 ), hepatic ( 6 ) and gastric cancer (GC) ( 7 , 8 ). (spandidos-publications.com)
In GC, Yang et al ( 7 ) reported that propofol suppressed the proliferation of SGC-7901 and MGC-803 cells by promoting inhibitor of growth 3 ( 7 ). (spandidos-publications.com)
The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
2]HE G,YAO W,LI L,et al.LOXL1-AS1 contributes to the proliferation and migration of laryngocarcinoma cells through miR-589-5p/TRAF6 axis J .Cancer Cell Int,2020,20(1):504-514. (xdzlyx.com)
23]ZHANG P,LI R,XIAO H,et al.BRD4 inhibitor AZD5153 suppresses the proliferation of colorectal cancer cells and sensitizes the anticancer effect of PARP inhibitor J .Int J Biol Sci,2019,15(9):1942-1954. (xdzlyx.com)
Ito et al ( 2 ) showed that overexpression of Tβ 4 enhanced the formation of actin-based pseudopodia and cell motility in prostate cancer cells, providing direct evidence that Tβ 4 plays a role in cell migration. (spandidos-publications.com)
Tβ 4 is distributed ubiquitously in most tissues and cells, and is also known to concentrate highly at blood platelets ( 12 ). (spandidos-publications.com)
Tissues and Cells. (lu.se)

Tyrosine kinase inhibitors (TKIs) as first-line therapy for Chronic Myeloid Leukemia (CML) show a high success rate. (biomedcentral.com)
CML is treated using Tyrosine Kinase Inhibitors (TKIs). (biomedcentral.com)

Eucalyptol promoted lung repair at the higher dose (10 mg/ml), with de novo formation of alveoli, when compared to the CS group. (greenmedinfo.com)

0.05) upregulated collagen type II (COL2A1) and transforming growth factor (TGF)-β1 and downregulated cyclooxygenase-2 and interleukin (IL)-1β. (biomedcentral.com)
EXPERIMENTAL APPROACH: Six months after ovariectomy, rats were randomly allocated to different groups and treated, daily, with genistein aglycone (1 and 10mg/kg s.c.), raloxifene hydrochloride (0.05 and 0.5mg/kg s.c.) or 17-α-ethinyloestradiol (0.003 and 0.03mg/kg s.c.) for 12 weeks. (unime.it)
0.05) with 2.14 and 2.33-fold down-regulation in both patient groups, respectively meanwhile hsa-miR-182-5p and hsa-miR-26a-5p were significant only in the non-responsive group with 2.08 and 2.39 fold up-regulation. (biomedcentral.com)

The plasminogen activator (PA)-plasmin proteolytic system has recently received considerable attention because of its participation in a wide variety of biological activities and in pathological conditions involving tissue destruction. (ispub.com)

Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls. (molcells.org)
However, messenger RNA of tissue inhibitors of metalloproteinase-1 and tissue inhibitors of metalloproteinase-2 were both significantly upregulated in Vitamin C group. (nih.gov)

Rosuvastatin curtailed the expression of CCL4, IFN-ß, IL-2, IL-4, and IL-10 more effectively than fluvastatin in both types of tissue. (bvsalud.org)
Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. (molcells.org)
Microscopically the process of bone repair was similar in all groups, being noted only a delay of the blood clot resorption and bone formation in the group of 50 ppm F. The expression for MMP-9 showed differences betweengroups only during the initial repair (7 days). (bvsalud.org)
The expression of MMP-1,2,7,9 in 51 cases of IPMN were investigated. (cancerindex.org)
MMP high expression groups (MMP score ≥5) had worse prognosis than low-expression groups. (cancerindex.org)
The nine genes were not the most significantly differentially expressed according to the gene expression ratios in Table 2 showing the significance analysis of microarrays (SAM) results of the patients with NFH. (biomedcentral.com)
We would suggest selecting the genes with extreme gene expression ratio values from the nine functional groups mentioned in Table 2. (biomedcentral.com)
Meanwhile, miR‑195‑5p inhibitor reversed the si‑circ‑PVT1‑induced low expression of ETS1. (spandidos-publications.com)
NF-κB expression was increased in endometriosis than controls. (endonews.com)
7]LU J,WANG Y H,YOON C,et al.Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis J .Cancer Lett,2020,471(2):38-48. (xdzlyx.com)
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. (uea.ac.uk)
The expression of MMP-9 was discovered to have behaved in an iPLA 2 β-dependent manner, which further supports the idea that iPLA 2 β plays a significant role, concerning the mediation of basal and nicotine-induced cancer cell progression. (eku.edu)
The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)
Whole genome analysis of lung, sampled 24 hours after challenge, showed expression changes of not only genes belonging to several Gene Ontology groups with up-regulation of inflammatory-associated genes and those associated with lung remodeling but also genes involved in downsizing these processes. (cdc.gov)

In general, COPD morphopathogenesis is characterized by oxidative stress, chronic inflammation, remodeling, as well as impaired antimicrobial and other locally realized tissue protective responses. (rsu.lv)
Diabetes mellitus (DM) is a disease in which injury of peripheral tissue is induced by oxidative stress caused by chronic hyperglycaemia. (biomedcentral.com)
Besides the effect on cell migration, exogenous Tβ 4 was found to have multifunctional activities such as angiogenesis, anti-apoptosis, anti-oxidative stress and anti-inflammation ( 8 - 11 ), which emphasize its therapeutic potential in the repair of damaged tissues or wound healing. (spandidos-publications.com)

Increased mineralization and high bone turnover was observed in the fluorosis group. (omu.edu.tr)
TGF-beta immunostaining of the mandibular bone in the experimental group was significantly more intense compared with that in the control group (p=0.03). (omu.edu.tr)
Therefore, inhibition of RANKL-induced osteoclastogenesis and osteoclast-induced bone resorption is an important approach in controlling pathophysiology of these skeletal diseases. (hindawi.com)
Under healthy physiological conditions, activities of osteoclasts and osteoblasts are tightly controlled by both systemic and local factors, maintaining bone mineral density and bone microarchitecture. (hindawi.com)
Current medical treatment of osteoporosis and breast cancer bone metastasis is anti-bone resorptive agents, including bisphosphonates and denosumab [ 2 - 4 ]. (hindawi.com)

uPA, PAI-1, and interleukin-6 were significantly higher after abdominal gyneocological operation than before operation in the group of patients who were not treated with vitamin E after operation (P≤ 0.0001). (ispub.com)
uPA and interleukin-6 decreased significantly after abdominal gyneocological operation in the patients treated with vitamin E in comparison with the group of patients without such treatment (P≤ 0.0001). (ispub.com)
Research have reported efficiency from the interleukin (IL)\12/23 inhibitor ustekinumab as well as the IL\17A inhibitors secukinumab and ixekizumab for epidermis clearance in psoriasis over 2C4 many years of follow\up.10, 11, 12 Among 517 sufferers who received ustekinumab 45 mg or 90 mg, a few of whom were withdrawn from. (columbiagypsy.net)

The CCL20 and CCR2 levels reduced more extensively with rosuvastatin treatment only in abdominal aortic tissue. (bvsalud.org)
The aortic dilatation ratio was measured, and aortic tissues were further examined using biochemical and histologic techniques. (nih.gov)

The VWF-Angpt-2 complex did not inhibit the binding of Angpt-2 to Tie-2 and did not significantly interfere with VWF-platelet capture. (imperial.ac.uk)

Lung tissue in COPD patients is characterized by variable and various localized changes with chronic inflammation and tissue remodeling including inflammatory cell infiltration, granulation tissue, thickened basement membrane, bronchial gland and smooth muscle hypeplasia and hypertrophy, also thickened vascular fibrosis, moreover, fibrosis and epithelial metaplasia. (rsu.lv)
Experimental studies on animals showed anti-inflammatory effects of statins on the lung tissue. (nih.gov)
the presence of nicotine-induced tumors in lung tissue was reduced significantly. (eku.edu)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. (cdc.gov)
Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)

This has important clinical implications as, in contrast to advanced-stage NSCLC, chemotherapy can also be offered to patients with SCLC and a poor or bad performance status (World Health Organization performance status of 2-3), since a rapid amelioration of the patient's symptoms and general condition can be expected together with an improved outcome 7 . (ersjournals.com)
Clinical and synovial inflammatory signs were quicker reduced in MSC-treated groups and repeated allogeneic administration did not produce adverse reactions, but MSC-primed group showed slight and transient local inflammation after second injection. (biomedcentral.com)
HHcy is a significant clinical risk factor for stroke, cardiovascular disease and type 2 diabetes. (biomedcentral.com)
The groups did not differ significantly in terms of demographic data, clinical symptoms, pharmacological treatment, spirometry, and lipid profile at baseline. (nih.gov)
Clinical scores and plasma and cutaneous concentrations of linoleic acid, arachidonic acid, α-linolenic acid (α-LLA), EPA, DHA, prostaglandin E 2 , and leukotriene B 4 were determined. (avma.org)
Conclusions and Clinical Relevance -MMP 2 and 9 are detectable in canine neoplastic tissue. (avma.org)
In the ceramide group, a significant increase in skin hydration and an improvement in clinical signs of dryness were observed at the end of three months. (lifeextension.com)
SHH medulloblastomas are further subdivided into two groups based on the presence or absence of TP53 mutation, as their clinical characteristics and prognosis differ. (neurosurgery.directory)
Group 3 and Group 4 medulloblastomas, recognized as distinct molecular groups in clinical practice, are combined into a single group called "non-WNT/non-SHH", because they lack specific molecular pathway activation. (neurosurgery.directory)
Understanding the unique clinical characteristics and prognosis associated with each group is crucial. (neurosurgery.directory)
Approval was based on 2 phase 3 clinical trials (AK003 and AK004) that evaluated the safety and efficacy of tirbanibulin topical in adults (N=702) with facial or scalp actinic keratosis. (medscape.com)
Exogenous Tβ 4 was also reported to accelerate the tissue repair of damaged cardiac, corneal and dermal tissues ( 4 , 6 , 13 ), which demonstrates potential for clinical applications in wound healing. (spandidos-publications.com)
In this double blind clinical trial, 80 patients with chronic moderate periodontitis and a healthy systemic status were chosen, and divided into two 40-subject groups. (bvsalud.org)
Four and eight weeks after the treatment, the clinical periodontal indicators were measured and recorded in both groups. (bvsalud.org)
Administration of oral Anaheal medication after nonsurgical periodontal treatments reduced all the clinical periodontal indices among patients with chronic periodontitis as compared to the control group. (bvsalud.org)

This study used 4 groups of Wistar rats with 80 days of life (n = 160) which received drinking water containing different doses of fluoride (NaF): 5, 15, 50 ppm and deionized water (control) throughout the experiment. (bvsalud.org)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The high rates illness and death, lack of vaccines or approved treatments, and potential to cause a public health emergency led to the US Centers for Disease Control and Prevention to classify LF as a category A bioterrorism agent ( https://emergency.cdc.gov/agent/agentlist-category.asp ) and the World Health Organization to classify LF as a priority disease ( https://www.who.int/dg/priorities ). (cdc.gov)

CONCLUSIONS: Together, these data demonstrate a direct binding interaction between Angpt-2 and VWF that persists after secretion. (imperial.ac.uk)

The aim of the study was to determine and evaluate the morphological characteristics of bronchial tissues affected by COPD and analyze the tissue distribution of markers relevant to chronic inflammation, changes in tissue remodeling and local protective mechanisms. (rsu.lv)

Serum samples were collected from 80 women with endometriosis and 80 control women with tubal factor infertility. (endonews.com)

COPD is characterised by tissue destruction and inflammation. (bmj.com)

Eucalyptol alsoreduced all inflammatory (MPO, TNF-α, IL-1β, IL-6, KC, and TGF-β1) and redox marker levels (MDA) when compared to the CS group (at least p (greenmedinfo.com)
After 2 weeks as well as 3 months of simvastatin treatment, no significant reduction of any measured inflammatory markers was observed. (nih.gov)
On infusion, culture-expanded MSCs regulate inflammatory and immune responses and tissue repair. (bmj.com)
During the inflammatory stage, the first stage in the wound healing process, neutrophils and macrophages infiltrate the wound site and phagocytose infectious agents and fragments of tissue degradation release proteases and various reactive oxygen species (ROS) into the wound environment [ 2 ]. (biomedcentral.com)

2 Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, People's Republic of China. (nih.gov)
Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)

5 Functional in vitro assays indicate different physiological roles of MSCs related to their heterogeneity and tissue location of origin. (bmj.com)
In-vitro and in-vivo results suggest that MMP-9 behaves in an iPLA 2 β-dependent manner and consequently mediates nicotine-induced breast cancer cell migration and proliferation. (eku.edu)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

The study included 40 COPD and 49 relatively healthy control patients. (rsu.lv)
Tissue material from COPD patients was collected during bronchoscopy. (rsu.lv)

In 2015, the World Health Organization reclassified lymphangioleiomyomatosis with PEComa benign and malignant tumors in a new PEComatous tumors group. (medscape.com)
In the World Health Organization Classification of Tumors of the Central Nervous System 2021 , Group 3 medulloblastoma and group 4 medulloblastoma s are grouped together under Medulloblastoma non-WNT/non-SSH , which is in turn divided into 8 subgroups. (neurosurgery.directory)

Transcriptome profiling of the early stages in Atlantic cod revealed the presence of transcripts involved in patterning and development of tissues and organs long before activation of the zygotic genome. (biomedcentral.com)
During the following segmentation stage major events in the formation of tissues and organs take place. (biomedcentral.com)

In patients with HAE caused by C1-inhibitor deficiency or dysfunction, normal regulation of plasma kallikrein activity is not present, which leads to uncontrolled increases in plasma kallikrein activity and results in angioedema attacks. (medscape.com)
Alpha-1 Antitrypsin Deficiency Alpha-1 antitrypsin deficiency is congenital lack of a primary lung antiprotease, alpha-1 antitrypsin, which leads to increased protease-mediated tissue destruction and emphysema in adults. (msdmanuals.com)
alpha-1 antiprotease inhibitor deficiency). (msdmanuals.com)

This group of inhibitors contain a hydroxamate (-CONHOH) group that binds the zinc atom in the active site of the MMP enzyme. (wikipedia.org)
The inhibitor binds to the zinc at the active center of the enzyme, thereby blocking its activity. (wikipedia.org)

Two molecular features of most MMP inhibitors are responsible for the affinity. (wikipedia.org)
Useful markers associated with molecular aggressiveness might have a role in prognostication of malignancies and to better recognize patient groups that need more antagonistic treatment options. (biomedcentral.com)
These bands migrated in the same molecular weight area as the human MMP 2 and 9 standards. (avma.org)

Among comorbidities only arterial hypertension was more frequent in the statin group (32.1% vs. 17.9%, P = 0.03). (nih.gov)

Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)

We have previously shown that VWF itself regulates angiogenesis, raising the hypothesis that some of the angiogenic activity of VWF may be mediated by its interaction with Angpt-2. (imperial.ac.uk)

It is particularly useful in guiding non-coronary cardiac interventions, defining location, morphology and possible pathology selleck inhibitor of cardiac structure of interest, its anatomical relation to neighbouring landmarks while providing improved spatial resolution and, in addition, allowing online monitoring of the procedure. (jak-signaling.com)

BACKGROUND AND PURPOSE: Ovariectomy accelerates age-related skin changes as adequate oestrogen levels are required to control structural integrity and functional capacity of skin. (unime.it)
The study discovered that K-Lava Salt has the highest concentration of antioxidant components and properties compared to other salts through a thorough investigation of mineral elements, pH levels, OH groups, and redox potential. (koreantalks.com)
Further analysis showcased that the activities of skin antioxidant-related enzymes, superoxide dismutase (SOD), and catalase (CAT), were higher in the 9× bamboo salt- and 1× bamboo salt-treated groups compared to other groups, resembling levels observed in the standard group. (koreantalks.com)
Methods: Plasma VWF, ADAMTS-13, angiopoietin-2 (Ang2), and syndecan-1 levels were determined by ELISA. (imperial.ac.uk)
or (c) because of differences in nicotine dependency levels between the 2 groups. (who.int)

Despite the relatively rapid wound healing, however, tissues damaged during periodontal and implant surgery are continuously challenged by bacterial infection in the oral cavity, necessitating meticulous maintenance of oral hygiene and additional plaque control. (spandidos-publications.com)

Other MMP inhibitors have exhibited serious side effects during preclinical trials. (wikipedia.org)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

MMP inhibitors can broadly be subdivided into non-synthetic (e.g. endogenous) or synthetic. (wikipedia.org)

Knowledge of the genetic networks controlling embryogenesis has been obtained principally by mutagenesis screens in model species. (biomedcentral.com)

ACSVL1 is expressed primarily in the liver, but absent in most peripheral tissues. (medscape.com)

Aging causes changes in the structural foundations of skin, hair, and nail tissue. (lifeextension.com)

High plasma MMP-2, correlated with poor prognosis in PAH. (lu.se)

However, the zymography showed no significant differences between treated and control groups. (bvsalud.org)
Radiology and MRI did not show significant differences between treated and control groups, whereas ultrasonography suggested reduced synovial effusion in MSC-treated groups. (biomedcentral.com)
Cartilage histopathology did not reveal differences but histochemistry suggested delayed progression of proteoglycan loss in MSC-treated groups. (biomedcentral.com)

48 male New Zealand rabbits were divided into eight groups, each including 6 animals. (bvsalud.org)
Twenty-seven rabbits were divided into control and F groups. (omu.edu.tr)

Moreover, collagen deposit around the peribronchiolar area was reduced with eucalyptol treatment when compared to the CS group. (greenmedinfo.com)
The first generation of MMP inhibitors were based on the structure of the collagen molecule. (wikipedia.org)
Compared to the control and other salt-treated groups, the 9x bamboo salt and 1 bamboo salt-treated groups displayed thinner epidermal thickness, well-preserved sebaceous glands, and higher dermal collagen and elastic fiber content. (koreantalks.com)

Anatomy44

Organisms12

Diseases21

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care8

MMPs21

Matrix23

TIMP19

Protein11

Connective tissue4

Tumor8

Proteins6

Cells18

Tyrosine2

Promoted lung1

0.053

Plasminogen1

Significantly upregulated2

Expression14

Oxidative Stress3

Bone5

Interleukin3

Aortic2

Inhibit1

Lung Tissue5

Clinical15

Fluoride1

Centers for Diseas3

Conclusions1

Morphological1

Serum1

Inflammation1

Inflammatory4

Vascular3

Vitro3

COPD2

Tumors2

Organs2

Deficiency3

Binds2

Molecular3

0.031

Regulators1

Angiogenesis1

Cardiac1

Levels5

Periodontal1

Preclinical1

Cellular1

Synthetic1

Genetic1

Peripheral1

Structural1

Prognosis1

Differences3

Rabbits were divided2

Collagen3