Control virulence. Medical search. Frequent questions

Besides conferring methicillin resistance, the SCCmecIV genes also code for the arginine catabolic mobile element (ACME) and Panton-Valentine leukocidin (PVL) virulence factor. (medscape.com)
The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. (leibniz-hki.de)
Overall, our results show that Ahr1 and Tup1 are key contributors in the complex regulation of virulence-associated genes in the different C. albicans morphologies.IMPORTANCE Candida albicans is a major human fungal pathogen and the leading cause of systemic Candida infections. (leibniz-hki.de)
These observations identified a new aspect of regulation in the complex transcriptional control of virulence-associated genes in C. albicans . (leibniz-hki.de)
Here, we identified and characterized YdgT as a negative modulator of the SPI-2 pathogenicity island and established that this negative regulation is central to systemic pathogenesis because ydgT mutants overexpressing typhoid virulence genes were ultimately attenuated during infection. (mcmaster.ca)
Phage-encoded virulence genes of group A streptococci were detected in 10 (55.6%) of 18 isolates of group C streptococci that had caused bovine mastitis. (cdc.gov)
Virulence genes are identified by genetic screens as well as by analysis of the completed genome. (stjude.org)
No significant effects on AMR profiles due to virulence genes, parity, or previous antimicrobial treatments within the current lactation period were detected. (cdc.gov)

Virulence can be understood in terms of proximate causes-those specific traits of the pathogen that help make the host ill-and ultimate causes-the evolutionary pressures that lead to virulent traits occurring in a pathogen strain. (wikipedia.org)
This perspective outlines possibilities of how epigenetic control of Avr effector gene expression may have arisen and persisted in filamentous plant pathogens, and how it presents special problems for diagnosis and detection of specific pathogen strains or pathotypes. (frontiersin.org)
CsrRS (or CovRS) is a two-component system implicated in the control of multiple virulence determinants in the important human pathogen, group A Streptococcus (GAS). (lu.se)

The pathogenicity of an organism-its ability to cause disease-is determined by its virulence factors. (wikipedia.org)
Many virulence factors are so-called effector proteins that are injected into the host cells by specialized secretion apparati, such as the type three secretion system. (wikipedia.org)
The virulence factors of bacteria are typically proteins or other molecules that are synthesized by enzymes. (wikipedia.org)
Therefore, strategies to combat certain bacterial infections by targeting these specific virulence factors and mobile genetic elements have been proposed. (wikipedia.org)
These virulence factors allow the bacteria to enter host cells and facilitate entry into the body across epithelial tissue layers at the body surface. (wikipedia.org)
Immune response inhibitors Many bacteria produce virulence factors that inhibit the host's immune system defenses. (wikipedia.org)
Toxins Many virulence factors are proteins made by bacteria that poison host cells and cause tissue damage. (wikipedia.org)
Virus virulence factors allow it to replicate, modify host defenses, and spread within the host, and they are toxic to the host. (wikipedia.org)
Some viral virulence factors confer ability to replicate during the defensive inflammation responses of the host such as during virus-induced fever. (wikipedia.org)
These enzymes are considered emerging virulence factors during infection because the host glycan changes. (researchgate.net)
This can occur by epiallelic variation or by conventional mutations to cis -elements or flanking sequences that provide regulatory control of Avr gene transcription or translation, or possibly by changes to trans-acting elements, such as transcription- or epigenetic-factors that control Avr gene expression. (frontiersin.org)
In recent years, Als3 and Ece1 were identified as important factors for fungal virulence. (leibniz-hki.de)
Yet research into the factors, whether parasite or host, which control virulence in Human African trypanosomiasis is in its infancy. (unboundmedicine.com)
ETEC virulence factors, specifically enterotoxins and colonization factors (CFs), were detected using multiplex PCR, and prevalence in the total isolate population was compared to ESBL-positive isolates. (biomedcentral.com)
However, nutritional factors, interactions with the microbiota, and the presence of salivary antibodies have been suggested as possible influencing factors in the incidence of these yeasts, which are usually controlled by local factors, such as competition with bacterial cells of the resident microbiota [ 3 - 6 ]. (biomedcentral.com)
is related to a combination of factors contributing to their virulence, such as their ability to grow at 37 °C, their phenotypic variability (switching), their transition from budding-to-hyphae or pseudo-hyphae and biofilm formation. (biomedcentral.com)
The book also focuses on the identification of CoNS, virulence factors responsible for the symptoms and severity of infections caused by Staphylococcus spp. (novapublishers.com)
However, channels in this cell wall are still needed to secrete virulence factors. (vu.nl)
What a repertoire of virulence factors! (asmblog.org)
SATURN aimed to respond to an urgent need, as stated in the EU Council conclusions (June 2008) on AMR, in which the EU "stresses the need of research in the area of AMR, e.g. to increase the understanding of the mechanisms and underlying risk factors that advance the development of AMR and to increase the knowledge of the effectiveness of current and future control measures. (europa.eu)
Mortality depends on stress factors, virulence of strain, species and age of bird, and extent of treatment or prophylaxis. (cdc.gov)
Future studies should include more participating farm s and more samples and should control for potential confounding factors of AMR that may underlie individual farm variation. (cdc.gov)
In Paraguay, there are few records aboutmethicillin resistance and virulence factors at community level. (bvsalud.org)

The ability of bacteria to cause disease is described in terms of the number of infecting bacteria, the route of entry into the body, the effects of host defense mechanisms, and intrinsic characteristics of the bacteria called virulence factors. (wikipedia.org)

The necessary gain of virulence changes will depend on how the host immune system interacts with the effector ( Stergiopoulos and de Wit, 2009 ). (frontiersin.org)
Gain of virulence changes that leave the open reading frame of the Avr gene itself unchanged may be more easily reversible, should appropriate conditions occur for the re-deployment of an Avr allele that has been suppressed or wiped out of the population through a selective sweep. (frontiersin.org)
ydgT mutants displayed a biphasic virulence phenotype during in vivo competitive infections that consisted of an early "gain-of-virulence" dependent on SPI-2 activation, followed by attenuation later in infection indicating that proper contextual regulation of SPI-2 by YdgT is necessary for full virulence during systemic colonization. (mcmaster.ca)

While in both cases the mechanisms remain to be elucidated, the overall infection virulence phenotype is determined by both parasite and host genotype. (unboundmedicine.com)

Bacterial type IV pili are critical for diverse biological processes including horizontal gene transfer, surface sensing, biofilm formation, adherence, motility, and virulence. (biorxiv.org)
Type IV pili are ubiquitous surface appendages in Gram-negative bacteria that promote diverse activities including attachment, virulence, biofilm formation, horizontal gene transfer, and twitching motility [ 1 - 5 ]. (biorxiv.org)
The test solution had a positive effect on dental biofilm control. (bvsalud.org)
Mechanical control of dental biofilm is an important factor for preventing gingival inflammation and dental caries. (bvsalud.org)
Therefore, the use of substances with a potential of chemical control of dental biofilm may be indicated 1-2 . (bvsalud.org)
With a view to reducing the quantity and virulence of biofilm, these substances promote a reduction in the inflammatory response 3 . (bvsalud.org)
Chlorhexidine has been considered the gold standard regarding chemical control of dental biofilm, presenting the highest values of plaque reduction within oral antiseptics (plaque reduction of 58.3% to 92.9%) 4-5 . (bvsalud.org)
Therefore, the longterm daily use of chlorhexidine is not recommended and alternative substances that present efficacy in biofilm control and reduced adverse effects could be considered an important therapeutic approach. (bvsalud.org)
Although the use of CPC has been shown to be a feasible option as an adjuvant in controlling biofilm, its potential could be increased by the association of other substances that could contribute towards this purpose. (bvsalud.org)

A total of 265 ETEC isolates were obtained from acute diarrheal samples (263/265) or patient control samples (2/265) at traveler's clinics or regional hospitals in Nepal from 2001 to 2016. (biomedcentral.com)
Virulence characterization of the pathogenic M. phaseolina isolates is currently underway. (usda.gov)
Several current aspects related to the virulence of S. aureus and CoNS are discussed, including isolates of different origins, phenotypic and genotypic techniques for the detection of these toxins, and the gene regulation mechanism involved in the expression of these toxins. (novapublishers.com)

Not surprisingly, TAs have been directly implicated in the virulence of Listeria monocytogenes , Group B strep, Staphylococcus aureus , and others. (asmblog.org)
Staphylococcus aureus (S. aureus) es actualmente el agente etiológico más frecuente en infecciones de piel y tejidos blandos. (bvsalud.org)

The virulence of various strains of Helicobacter pylori tends to correlate with the level of production of urease. (wikipedia.org)
Although virulence is typically attributed to single pathogenic strains, here we investigated whether effectors secreted by a population of non-virulent strains could function as public goods to enable the emergence of collective virulence. (nature.com)
The results consistently showed that strains unable to metabolize proline exhibit significantly reduced virulence properties and a clearly diminished capacity to undergo morphological transitions. (sciencedaily.com)
The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. (microbiologyresearch.org)
strains isolated from OGC patients exhibited better adherence to BEC ( p = 0.05) than did the control group. (biomedcentral.com)

The age of virulence refers to several emerging and zoonic infectious diseases and underscores how quickly viruses and other deadly pathogens evolve. (mckesson.com)
In an age of virulence, which refers to several emerging and zoonotic infectious diseases and the quickness in which deadly pathogens evolve, the role of the infection preventionist and the need for the entire healthcare organization to support them is critical. (mckesson.com)
This method can be applied to testing other pathogens and their mutants, as well as virulence infect in mice. (jove.com)
These structures are critical for the virulence of many pathogens and represent one major way that bacteria share DNA with one another, which contributes to the spread of antibiotic resistance. (biorxiv.org)

Therefore, this descriptive observational study was performed to determine the frequency of MRSA and factor virulence of Panton-Valentine leukocidin (PVL) as well as the antimicrobial resistance profile accompanying methicillin resistance in S. aureusisolated from skin and soft tissue infections in ambulatory patients from two laboratories of Asuncion, Paraguay from October, 2012 to February, 2014. (bvsalud.org)

At least five five randomized, placebo-controlled studies have shown that prolonged courses of IV antibiotics do not improve long-term outcome for patients with a diagnosis of chronic Lyme disease (e.g., this one ). (scienceblogs.com)
In recent years there has also been a sharp increase in C. diff infections in otherwise healthy individuals who are neither hospitalized nor taking antibiotics, thus attesting to this bug's high degree of virulence and contagiousness. (asmblog.org)

Strikingly, genetic dissection of the Proline UTilization (PUT) pathway and of the control mechanisms governing proline use led to the discovery that proline is toxic to cells unable to catabolize it. (sciencedaily.com)
In this paper we review the clinical evidence for virulence variation and the epidemiological and experimental data that give clues as to the mechanisms involved. (unboundmedicine.com)
SPI-2 virulence is induced upon entry into macrophages, but the mechanisms of SPI-2 gene control in vivo remain unclear, particularly with regard to negative regulators that control the contextual activation of SPI-2. (mcmaster.ca)
Germ cells - from which egg cells and sperm cells develop - are particularly vulnerable as they contain sensitive quality control mechanisms that kill any cell that contain damaged DNA. (elifesciences.org)

The capacity of Candida albicans to reversibly change its morphology between yeast and filamentous stages is crucial for its virulence. (leibniz-hki.de)

Bacteria need to understand their surroundings to control their metabolism. (ucalgary.ca)
Unfortunately, these attributes are also important virulence weapons for bacteria to infect human bodies. (ucalgary.ca)

In the specific context of gene for gene systems, often in plants, virulence refers to a pathogen's ability to infect a resistant host. (wikipedia.org)
In this case, the bacterium needs to change its virulence, which is its ability to efficiently infect the host. (ucalgary.ca)
It also controls the weapons that P. aeruginosa uses to infect and kill its host. (ucalgary.ca)

On the other hand, hospitals are now doing a better job of controlling C. diff infection by paying more attention to hygiene (washing hands and bleaching surfaces in rooms where patients have been housed), by segregating C. diff patients, and, in some places, by instituting strict guidelines for antibiotic use. (asmblog.org)

Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
He pointed to monkeypox, which the Centers for Disease Control and Prevention (CDC) has recently tracked in countries - like the United States - that don't normally report this disease. (mckesson.com)
Canada, more specifically Toronto, Ontario (yellow), is the fifth-ranked area, although community transmission of SARS now appears to be contained, according to the US Centers for Disease Control and Prevention. (medscape.com)
I'm Kondra Williams, and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
Dr. Morris is a medical officer at the Centers for Disease Control and Prevention and she is currently serving as CDC's Incident Manager for the hepatitis A outbreaks occurring in 13 states. (cdc.gov)

It is required to strengthen surveillance, prevention and control of bacterial resistance strategies in hospital and community environments. (bvsalud.org)

This protocol is significant for creating and determining mind-body desired mutations in the genome of Pseudomonas aeruginosa, as well as the testing the effect of mutations on virulence reduction in a reproducible mouse model. (jove.com)

Lassa fever is an acute viral zoonotic disease with high virulence. (who.int)

Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis. (bvsalud.org)
Since Cdc42 is a pivotal molecule in establishing and maintaining polarized growth for diverse cell types, as well as during pathogenesis of certain fungi , we evaluated its role during cell growth and virulence of the yeast -form of P. brasiliensis. (bvsalud.org)

Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
The control Microbiology Laboratory, located in the Department of of microorganism growth aims to obtain healthier food Food Science and Technology of the Federal University of products, resulting on the elimination or reduction of Santa Catarina in isothermal boxes containing ice. (bvsalud.org)

In most, especially in animal systems, virulence refers to the degree of damage caused by a microbe to its host. (wikipedia.org)

The epidemiology of MRSA infections is discussed highlights the importance of understanding why specific clones predominated in different regions in order to develop more effective control strategies and to choose more appropriate antimicrobial therapy. (novapublishers.com)

Entomopathogenic nematodes (EPNs) are important biological control agents of insect pests. (allenpress.com)

From an ecological standpoint, virulence is the loss of fitness induced by a parasite upon its host. (wikipedia.org)
Sternberg JM, Maclean L. A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence. (unboundmedicine.com)
TY - JOUR T1 - A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence. (unboundmedicine.com)

Using a combination of biophysical methods as well as cell and ovary culture experiments we explain how TAp63α is kept inactive in the absence of DNA damage but causes rapid oocyte elimination in response to a few DNA double strand breaks thereby acting as the key quality control factor in maternal reproduction. (elifesciences.org)

Her presentation will focus on the role of hepatitis A vaccination in controlling outbreaks and will discuss recent changes to the Advisory Committee on Immunization Practices recommendation for hepatitis A vaccine. (cdc.gov)

This study will investigate the efficacy of a novel mucosal adhesive patch with slow-delivery of a potent corticosteroid agent in controlling painful symptoms and inducing healing of lichenoid ulceration. (ucl.ac.uk)
As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)

Below are several key points from the webinar regarding infection control and infection prevention. (mckesson.com)
Surveillance, Case Management and Infection Prevention and Control (IPC), Laboratory, Logistics and Risk Communication. (who.int)
Participants were grouped into 6 thematic areas namely coordination, surveillance, laboratory, case management / infection prevention and control, logistics and risk communication. (who.int)

Signs depend on the species of bird, virulence of the strain, stresses on the bird, and route of exposure. (cdc.gov)

A challenge in virology is quantifying relative virulence ( V R ) between two (or more) viruses that exhibit different replication dynamics in a given susceptible host. (microbiologyresearch.org)

iii) Inocula must be formulated both to have long shelf life of inocula as well as being formulated to establish on, and control the target pest. (weizmann.ac.il)
iv) After fulfilling these three criteria, the product must be biosafe: not produce mammalian toxins that affect users and consumers, and have a host range that does not include crops and beneficial organisms, and in most cases that it will not spread from application sites or have environmental residues beyond those needed to control the target pest. (weizmann.ac.il)

Background: Scientific publications related to epidemic diseases are crucial for controlling and treating such diseases. (bvsalud.org)

Each coisogenic strain was individually unfit, but the metaclone was collectively as virulent as the wild-type strain on Arabidopsis thaliana , suggesting that effectors can drive the emergence of cooperation-based virulence through their public action. (nature.com)

The noun virulence derives from the adjective virulent, meaning disease severity. (wikipedia.org)
Our research suggests that intensively treating gum disease can help patients with diabetes control the condition. (ucl.ac.uk)
The usual systems of disease control, such as isolating patients and personal protection for health workers-which had brought previous outbreaks in Africa to a halt-had not worked, said Kieny. (bmj.com)
This compendium provides information on AC (also known as psittacosis, ornithosis, and parrot fever) and psittacosis (also known as parrot disease, parrot fever, and chlamydiosis) to public health officials, veterinarians, physicians, the companion-bird industry, and others concerned with control of the disease and protection of public health. (cdc.gov)
These recommendations provide effective, standardized disease control procedures for AC in companion birds and will be reviewed and revised as necessary. (cdc.gov)
This report provides an epidemiological description of selected vaccine-preventable diseases in New South Wales (NSW), Australia, for 2014 to inform ongoing disease monitoring and control efforts. (who.int)

Flupyradifurone (FPF) is a neonicotinoid insecticide that effectively controls the spread of various pests. (cabi.org)
Despite biocontrol conceptually being a useful way to control specific pests, there are very few products that are used beyond the glasshouse level, into the field. (weizmann.ac.il)
Our results indicate that S. websteri is a promising biological control agent against A. segetum, which is one of the most serious subsoil pests plaguing agricultural crops and fruits worldwide. (tubitak.gov.tr)

A crossover, double-blind, placebo-controlled study was conducted and divided into two phases of 21 days each with a time interval of 10 days between them. (bvsalud.org)

Do control measures force viruses to evolve greater virulence? (thenakedscientists.com)

In early 2020 when the pandemic became a reality for everyone in healthcare, the need for consensus regarding infection control practices became more urgent. (mckesson.com)

Understanding these weak spots in the cell wall will give rise to new strategies for the control of tuberculosis. (vu.nl)

Cognitive control of micturition is achieved by communication from a number of brain structures to the periaqueductal gray matter, which then exerts control over the pontine micturition center to suppress or trigger a voiding reflex. (medscape.com)

Virulence is a pathogen's or microorganism's ability to cause damage to a host. (wikipedia.org)
The ability of the brain to control the PMC is part of the social training that children experience during growth and development. (medscape.com)

In a recent trial, patients with poorly-controlled Type -2 diabetes who received intensive gum therapy were better off in terms of blood glucose levels, kidney and blood vessel function. (ucl.ac.uk)

The size, spread, and virulence of the current Ebola outbreak have made it the most severe on record. (bmj.com)

Quantifying V R using canonical parameters, like maximum specific growth rate ( μ max ), can fail to provide reliable information regarding virulence. (microbiologyresearch.org)

Anatomy3

Organisms14

Diseases4

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes20

Information Science4

Genes9

Pathogen3

Factors23

Called virulence factors1

Gain of virulence3

Phenotype1

Biofilm9

Isolates3

Staphylococcus2

Strains5

Pathogens4

Antimicrobial Resistance1

Antibiotics2

Mechanisms4

Candida1

Bacteria2

Infect3

Antibiotic1

Centers for Diseas7

Bacterial1

Mutations1

Viral1

Yeast2

Reduction2

Refers1

Infections1

Entomopathogenic1

Parasite3

Factor1

Advisory Committee1

Symptoms2

Prevention3

Depend1

Exhibit1

Pest2

Crucial1

Effectors1

Disease6

Pests3

Placebo-controlled1

Viruses1

Infection control1

Tuberculosis1

Structures1

Ability2

Type1

Current1

Provide1