• He leads a basic and translational laboratory at the Translational Research Institute investigating the interaction between the innate immune system and the gut microbiome, as well as genetic contributions to disease. (edu.au)
  • Their findings unravel a so-far unknown role of the adaptive immune system during brain aging. (isd-research.de)
  • In contrast, histone deacetylases promote gene expression in the mitochondrial stress response, immunity, and metabolism. (biomedcentral.com)
  • Mitochondria are also platforms for antiviral signalling2 and, due to their bacterial origin, mtDNA and other mitochondrial components trigger innate immune responses and inflammatory pathology2,3. (regenerativemedicine.net)
  • Macrophages are components of innate immunity derived from the myeloid progenitor cell namely known as the granulocyte-macrophage colony forming unit (GM-CFU) inside bone marrow. (encyclopedia.pub)
  • IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. (wikipedia.org)
  • Besides their central role in energy metabolism, mitochondria are primary mediators of inflammation, and impaired mitochondria can modulate innate immunity via redox-signaling or direct inflammasome activation [ 11 ]. (biomedcentral.com)
  • mediators that likely regulate immunity and immune-mediated diseases within the skin. (syksignaling.com)
  • The new incoming challenge is now therefore to overcome these resistance and new recent data presented epigenetic modifications as promising targets to restore anti-tumor immunity. (oaepublish.com)
  • Our laboratory investigates X-chromosome Inactivation, and how this epigenetic process contributes to female-biased autoimmunity. (upenn.edu)
  • Therefore, combined anti-angiogenesis therapy and programmed death-1 (PD-1) inhibitors might stimulate tumor immunity. (bvsalud.org)
  • In 2018, the Nobel Prize in medicine was awarded to James P. Allison and Tasuku Honjo for their work on the description of immune checkpoint inhibitors which contributed to the development of new anti-cancer immunotherapies. (oaepublish.com)
  • The chronic state and dormancy of tuberculosis implies that M. tuberculosis has developed sophisticated strategies to modify and evade the innate and adaptive immune surveillance mechanisms of humans [ 2 ]. (biomedcentral.com)
  • IFN-γ plays an important role in both innate and adaptive immunity. (wikipedia.org)
  • Eichenberger R.M., Dent L.A., Robertson A.A.B., Kupz A., Brough D., Loukas A., Sutherland T.E ., Allen J.E., Giacomin P.R. Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung. (manchester.ac.uk)
  • To this end and within their broad functionality and operationality, Tregs are able to adopt unique features of skin cells and contribute to the skin's role as an immune barrier. (biomedcentral.com)
  • The components of the innate immunity implement the recognition and elimination of microbes through a complex machinery involving factors that require a post-translational proteolytic activation step to perform their effector functions. (oncotarget.com)
  • 2019). It has been reported that improving the immunity of fish is a feasible strategy to defend against diseases (Ahmadniaye Motlagh et al. (peroxidasessignaling.com)
  • Combined anti-angiogenic and anti-PD-1 therapy stimulates tumor immunity through TA-HEVs formation. (bvsalud.org)
  • Type II IFN is primarily secreted by adaptive immune cells, more specifically CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. (wikipedia.org)
  • IFN-γ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response. (wikipedia.org)
  • IFN-γ is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s. (wikipedia.org)
  • Associate Professor Jakob Begun is the IBD Group leader in the Immunity, Infection, and Inflammation Program at Mater Research University of Queensalnd, and has a basic and translational laboratory at the Translational Research Institute in Brisbane. (edu.au)
  • My tranlsational research program contributes to KNOWLEDGE IMPACT by discovering the function of IBD-susceptibility genes and anti-inflammatory bio-actives produced by the gut microbiota. (edu.au)
  • Clinical Immunology is at the crossroad where biologically and clinically relevant research intersect with clinical practice in infectious disease and cancer, yet there is often not a structured cross-fertilizing interface between these disciplines. (fchampalimaud.org)
  • Nonspecific symptoms, heterogeneity within study populations, and variability among current diagnostic criteria contribute to misdiagnosis and underdiagnosis of this syndrome. (biomedcentral.com)
  • J. Strauss and C.R. Heery contributed equally to this article. (aacrjournals.org)
  • In addition to inducing apoptosis, caspase inhibition contributes to necroptosis and/or autophagy depending on the cell type and cellular context. (molcells.org)
  • HLA-B27 is the main genetic factor contributing to spondyloarthritis. (anr.fr)
  • Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide, which has created a heavy burden on society. (wjgnet.com)
  • Astrocytes are the most abundant glial cells in the CNS, and their dysfunction contributes to the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). (bvsalud.org)
  • Elucidation of the actions of these disease genes at a systems level with novel functional and cellular outcomes from our neural circuit mouse model and characterization of additional neurodegenerative disease genes in this model system hopefully will contribute to the development of effective therapies. (nih.gov)
  • Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. (biomedcentral.com)
  • We explore different strategies of L. monocytogenes that allow it to infect and replicate efficiently within mammalian cells, evade recognition by the innate immune system and manipulate host cellular pathways. (tau.ac.il)
  • Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. (seattlechildrens.org)
  • Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity. (seattlechildrens.org)
  • Whereas few results from clinical metagenomic studies in liver disease are available, evidence is accumulating that in liver cirrhosis an oral microbiome is overrepresented in the lower intestinal tract, potentially contributing to disease process and severity. (bmj.com)
  • Type II IFN is primarily secreted by adaptive immune cells, more specifically CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. (wikipedia.org)
  • IFN-γ is also produced by non-cytotoxic innate lymphoid cells (ILC), a family of immune cells first discovered in the early 2010s. (wikipedia.org)
  • The intracellular signaling via SYK has become a paradigm in adapative immunity but more recent studies underline its role outside of this context including several functions of innate immune cells and non-immune functions such as osteoclastogenesis [10]. (researchsquare.com)
  • After an acute stroke, sensors of the innate immune system such as Toll-like receptors (TLRs) and innate immune cells, are activated by brain ischemia, leading to amplification of the inflammatory cascade. (en-journal.org)
  • IFN-γ, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. (wikipedia.org)
  • Several years ago, we uncovered a novel and highly dynamic example of a pathogen-prophage interaction, in which a prophage promotes the virulence of its host, the intracellular bacterial pathogen Listeria monocytogenes (Lm), via an adaptive behaviour. (tau.ac.il)
  • These observations indicated an intriguing adaptive behaviour of the prophage to the intracellular lifestyle of its host, serving as a molecular switch that controls bacterial gene expression to promote virulence. (tau.ac.il)
  • In this review, we highlight recent studies regarding the effects and mechanism of immunosuppression on the pathophysiology of stroke, with the hope that a better understanding of the function of both of innate and adaptive immunity in this setting will facilitate the development of effective therapies for post-stroke inflammation. (en-journal.org)
  • Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. (medscape.com)
  • In addition to initial studies indicating the capability of miRNAs to modulate the magnitude of the innate immune response, participating as integral components of feedback loop regulatory mechanisms, which significantly shape the inflammatory response, recent studies have also established their role in tuning macrophage differentiation and polarization. (frontiersin.org)
  • In this way, DCs integrate signals from the innate and adaptive immune system and shape T cell responses toward either immunity or tolerance [5, 6]. (researchsquare.com)
  • Although it is clear that chronic antigen contributes to CD8 T cell exhaustion, less is known about how stress responses in tissues regulate T cell function. (salk.edu)
  • IFN-γ is produced predominantly by natural killer cells (NK) and natural killer T cells (NKT) as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops as part of the adaptive immune response. (wikipedia.org)
  • Inflammasomes are cytosolic multimolecular protein complexes which respond to innate immune recognition induced by microbial infections and endogenous danger signals [ 9 , 10 ]. (biomedcentral.com)
  • Additionally, adaptive immunosuppression merits further consideration as a potential endogenous protective mechanism. (en-journal.org)
  • Thus, NAMPT-NAD+-CD38 circuitry in astrocytes controls their ability to meet their energy demands and drives the expression of proinflammatory transcriptional modules, contributing to CNS pathology in EAE and, potentially, MS. Our results identify candidate therapeutic targets in MS. (bvsalud.org)
  • Some researchers believe it has anti-tumorigenic properties, while others suggest that it contributes to tumor growth and progression. (biomedcentral.com)
  • He has reviewed and written cases for the National Center for Case Study Teaching in Science and contributed to the ebook Science Stories You Can Count On: 51 Case Studies with Quantitative Reasoning in Biology . (textbooks.dad)