Contrast transcription chemotactic factors. Medical search. Frequent questions

On the chorioallantoic membrane the 9E3 protein is chemotactic for monocyte/macrophages and lymphocytes and is angiogenic. (bvsalud.org)
Among these factors, the effect of macrophages on bone has attracted increased attention. (researchpad.co)
M1 macrophages, positive expression of CD86, can produce tumor necrosis factor-α (TNF-α), induced nitrogen monoxide synthase (iNOS), Interleukin-12 (IL-12), and other proinflammatory cytokines to induce immune response. (researchpad.co)
The combination synergistically suppresses release of proinflammatory mediators, including tumour necrosis factor-α, IL-6, chemokine (C-C motif) ligand 5 (RANTES), matrix metalloproteinase-9, and others, from human peripheral blood mononuclear cells and mouse macrophages. (biomedcentral.com)
Transfection of either miR-inhibitor-206-3p or miR-inhibitor-381-3p in macrophages induced chemokine CCL2, CCL3, CCL5, and CXCL8 transcription, whereas FK506 attenuated the miR-inhibitor-206-3p or miR-inhibitor-381-3p-mediated effects. (cdc.gov)
Finally, MDI-GSH conjugate treated macrophages showed increased chemotactic ability to various immune cells, which may be attenuated by FK506.In conclusion, these results indicate that MDI exposure to macrophages/BALCs may recruit immune cells into the airway via induction of chemokines by miR-206-3p and miR-381-3p-mediated calcineurin signaling activation. (cdc.gov)
Using 5′ RACE, we identified three transcription start sites and several splice variants of ChemR23 in both monocytes and macrophages. (aai.org)
Although the promoters P1 and P3 are used equally in unpolarized macrophages, stimulation with LPS or IFN-γ leads to increased transcription from P3 in inflammatory M1 macrophages. (aai.org)
Such ChemR23-expressing M1 macrophages are chemotactic to chemerin, whereas M2 macrophages not expressing ChemR23 surface receptor are not. (aai.org)
Repolarization of ChemR23-expressing M1 macrophages with 10 nM RvE1 increases IL-10 transcription and phagocytosis of microbial particles, leading to a resolution-type macrophage distinct from the M2 phenotype. (aai.org)

We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)
The orderly progress of bone reconstruction is a complex process that involves many factors, including enzymes, hormones, and cytokines ( 2 ). (researchpad.co)
Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
This in turn results in an exponential production of multiple factors such as cytokines and growth factors leading to the clinical manifestations of PE [ 11 ]. (hindawi.com)
Interferon pathway-related cytokines/chemokines, including interleukin (IL) 18, macrophage inflammatory protein 3α, and IL-33, were elevated, but tumor necrosis factor-α, IL-6, CXCL8 (formerly IL-8), and cytokines acting through C-C chemokine receptor 2 and CCR5 were lower among case-patients than controls. (cdc.gov)
Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
Cytokines such as eosinophil chemotactic factor are also elaborated. (pharmacology2000.com)

this contrasts with the BLT1 receptor which appears to have a more limited expression pattern including mainly circulating blood leukocytes and lymphocytes. (wikipedia.org)
During antibiotic treatment for bacterial coinfections, increased BAL fluid levels of several activating and chemotactic factors for monocytes, lymphocytes, and NK cells were detected in patients with COVID-19 whereas concentrations tended to decrease in patients with influenza, highlighting the persistent immunological response to coinfections in COVID-19. (bvsalud.org)

Using primary fibroblasts in culture, we have investigated the signal transduction mechanisms by which phorbol esters, a class of tumor promoters, activate the 9E3 gene and its chemokine product the chicken chemotactic and angiogenic factor. (bvsalud.org)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)

Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
The most widely studied serum markers for PE, to date, are vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). (hindawi.com)
Mesodermal progenitor cells are further differentiated into ECs by utilizing a combination of human vascular endothelial growth factor A165 (VEGF), basic fibroblast growth factor (bFGF), 8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt monohydrate (8Bro) and melatonin (Mel) for 48 h. (biomedcentral.com)
In vivo and in vitro experiments demonstrate that not only vascular endothelial cells growth factor (VEGF) enhances EC fate commitment, but also basic fibroblast growth factor (bFGF) further facilitates EC differentiation [ 17 , 18 , 19 ]. (biomedcentral.com)
Widespread transduction of cardiac and skeletal muscle has been achieved in adult mouse by intravenous administration of rAAV6 vector supplemented with vascular endothelium growth factor (VEGF) (Gregorevic et al. (justia.com)

it also stimulates cells to activate Extracellular signal-regulated kinases (ERKs), Protein kinase B (also known as Akt), c-Jun N-terminal kinases (JNKs), Janus kinase (JAK)-STAT protein (i.e. signal transducer and activator of transcription, NADPH oxidase (NOX), and NF-κB pathways. (wikipedia.org)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
Additionally, activated GR can affect transcription through mechanisms independent of DNA binding that modulate the activity of other transcription factors, including nuclear factor-κB, activator protein-1, and STAT (signal transducer and activator of transcription) [ 4 ]. (biomedcentral.com)
In [12] mRNA synthesis rate is usually modelled as is the basal transcription rate, constants and are concentrations at which the effect of the inhibitor or activator is usually half of its saturating value. (columbiagypsy.net)

The study evaluates the ability of osteoprogenitors treated with platelet-derived growth factor BB (PDGF-BB) delivered on vinyl styrene microbeads (VSM) to regenerate rat calvarial critical-size defects (CSDs). (allenpress.com)
Platelet-derived growth factor BB (PDGF-BB) is the most potent mitogenic and chemotactic member of PDGFs. (allenpress.com)

One prominent cell-activating pathway involves BLT2 receptor activation of NOX2 or NOX1 with the subsequent production of reactive oxygen species which in turn activate the transcription inducing function of NF-κB. (wikipedia.org)
Similarly, sEng is a truncated form of receptor for two subtypes of transforming growth factor beta (TGF β ) specifically, TGF β 1 and TGF β 2 which are highly expressed by vascular endothelial cells and syncytiotrophoblasts. (hindawi.com)
This process was primed by dynamic changes in the epigenetic landscape of CD4+ T cells, generating super-enhancers and recruiting several transcription factors, notably c-JUN, STAT3 and BACH2, which together with VitD receptor shaped the transcriptional response to VitD. (bvsalud.org)

Production of LPC during cell apoptosis serves as a chemotactic signal for macrophage recruitment. (ashpublications.org)
In contrast, the UC cell line enhanced the TRAIL and anti CD95 mediated apoptosis as evidenced by a rise of cell death linked functions studied in numerous check systems. (mi-rna.com)

Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)
Angiogenic factors and their receptors are important regulators of placental vascular development [ 13 ]. (hindawi.com)

One study ( 10 ) reported interferon-γ (IFN-γ), interleukin (IL) 10 (IL-10), and tumor necrosis factor-α (TNF-α) to be associated with high viral load and disease severity. (cdc.gov)
Discussion Proteomic determination of factors expressed by tumor cells and host stromal cells, either inherently or because of tumor additional info host interactions, has been shown to become helpful in elucidating molecular pathways of tumor development, invasion and metastasis. (mi-rna.com)
Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). (frontiersin.org)
In contrast to inhibitor SAR245409 the offered information around the core protein, the data on the NS5A protein are a lot more uniform demonstrat ing a rather anti apoptotic effect for that protein. (mi-rna.com)
Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. (lookformedical.com)

deletion and mutation of these elements abrogates 9E3/chicken chemotactic and angiogenic factor expression. (bvsalud.org)

In cultured chicken embryo fibroblasts, which have many of the properties of wound fibroblasts, the gene is stimulated by a variety of agents including oncogenes, growth factors, phorbol esters, and thrombin. (bvsalud.org)
Here, the circulating phagocytic hemocytes were chemically depleted by injecting the snails with clodronate liposomes, and the effects on the cephalic tentacle regeneration onset and on Pc-Hemocyanin, Pc-transglutaminase (Pc-TG) and Pc-Allograft Inflammatory Factor-1 (Pc-AIF-1) gene expressions were investigated. (unimore.it)
Applying the BBC algorithm to the yeast expression data, we noticed that most the biclusters we discovered are backed by significant biological evidences, such as for example enrichments of gene features and transcription aspect binding sites in the corresponding promoter sequences. (columbiagypsy.net)
The BBC model can simply handle lacking data via Monte Carlo imputation and gets the potential to end up being extended to integrated study of gene transcription networks. (columbiagypsy.net)

Using a luciferase reporter system, we show that although both the AP-1 and PDRIIkB (a NFkappaB-like factor in chickens) response elements are capable of activation in these normal cells, regions of the 9E3 promoter containing them are unresponsive to PDBu stimulation. (bvsalud.org)
Electrophoretic mobility shift assays and functional studies using PathDetect systems show that stimulation of the cells by phorbol esters leads to activation of the Elk1 transcription factor, which binds to its element in the 9E3 promoter. (bvsalud.org)
Once activated the GR translocates to the nucleus and can bind directly to glucocorticoid response elements (GREs) as a homodimer, resulting in both activation and repression of transcription, depending on promoter structure and interaction with various co-activators and co-repressors. (biomedcentral.com)
Lastly, IL-21 also promotes activation of the STAT3 promoter and other transcriptional factors. (intechopen.com)

These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
In contrast, activation of the renal CB 2 receptors reduces the deleterious effects of these chronic diseases. (degruyter.com)

Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)

These results make the Jagged ligands new promising therapeutic targets in MM to contrast bone disease and the associated co-morbidities. (oncotarget.com)
The crosstalk between bone cells and surrounding cells as well as the relationship between the bone and bone microenvironment has been gradually recognized and regarded as a relatively important factor in bone metabolism ( 9 ). (researchpad.co)
2 , 3 Bone engineering involves the delivery of cells or biologic molecules such as growth factors to a defect site for tissue regeneration. (allenpress.com)
The pretreatment of osteoblastic cells with PDGF-BB before transplantation into osseous defects is investigated in the present study to further investigate the role of this growth factor in bone regeneration. (allenpress.com)

hiPSC-ECs are positive for CD31, VE-Cadherin, von Willebrand factor and CD34. (biomedcentral.com)
Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. (lookformedical.com)

The method included the use of two therapeutic factors: magnetotherapy and electromagnetostimulation of peripheral branches of facial nerve. (maxwellmagneticmeds.co.za)

Moreover, we discuss the deleterious effect of interferon-γ activity in influenza infection and how this observation contrasts with findings in severe COVID-19. (ersjournals.com)
The interaction of PRRSV with the immune system is believed to be of critical importance for defining immunological and clinical outcomes of the infection and, along with other factors, is associated with an inefficient development of the adaptive immunity. (biomedcentral.com)

In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings. (nature.com)

In contrast to basic innate immunity, adaptive immunity is specific and depends on antigenic stimulation. (medscape.com)

How the immune response can activate the cascade process is still unknown but it is proposed to act in synergy with additional exacerbating factors such as predisposing maternal and ambient factors [ 12 ]. (hindawi.com)

Active Notch signaling in MM cells induces the secretion of the key osteoclastogenic factor, RANKL, which can be boosted in the presence of stromal cells. (oncotarget.com)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
This finding has raised an intriguing question: Does C. jejuni sense, inject and secrete putative virulence factors into host cells? (assignster.com)
1 Autografts contain living cells and osteoinductive factors. (allenpress.com)

The activated form then catalyzes the activation of factor X to factor Xa. (lookformedical.com)
It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin. (lookformedical.com)

Like sFlt1, soluble endoglin (sEng) is an antiangiogenic factor capable of inhibiting capillary tube formation in vitro [ 17 ]. (hindawi.com)

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. (lookformedical.com)

The maintenance of tissue homeostasis and proper wound healing is, therefore, a critical process that can be disturbed by a plethora of external and internal factors. (biomedcentral.com)

Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. (lookformedical.com)
It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation. (lookformedical.com)

Masks are often characterized using filtration efficiency, airflow resistance, and manikin or human fit factors, which are standard metrics used for personal protective devices. (cdc.gov)

Both, obesity which is a major risk factor for the insulin resistance development and type 2 diabetes (T2DM), and the chronic hyperglycemia itself play an important role in its pathogenesis. (medsci.org)

A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia. (lookformedical.com)

The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease. (lookformedical.com)

Stromal desmin expression was significantly greater in stage III tumors when in contrast to the two stage I and II tumors, P 0. (mi-rna.com)
The messenger RNA expression and methylation of Rho GTPases (RhoA, Rac1, DOCK180, ELMO1, and CDC42) were evaluated in H. pylori -negative (control) human gastric tissues and H. pylori -positive GCs by using real-time reverse transcription-polymerase chain reaction and the quantitative MethyLight assay, respectively. (gutnliver.org)

In contrast, α-1 antitrypsin levels and net proteolytic activity were comparable in COVID-19 and influenza BAL fluids. (bvsalud.org)

In contrast, NLPHL is an indolent disorder. (haematologica.org)
A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (lookformedical.com)

Similar to influenza, advanced age has emerged as the leading host risk factor for developing severe COVID-19. (ersjournals.com)
Little is known about the host factor in the response to PRRSV vaccination. (biomedcentral.com)

6 It has been shown that these microbeads are capable of delivering transforming growth factor-β (TGF-β) to rat calvarial critical-size defects. (allenpress.com)
To make the most of these approaches, we have constructed chimeric mRNAs encoding single-chain IL-12 fused to single-chain fragment variable (scFv) antibodies that bind to transforming growth factor b (TGF-b) and CD137 (4-1BB). (unav.edu)

Filtration efficiencies for the cloth masks ranged from 1.4% to 98%, while the fit factors were 1.3 to 7.4 on headforms and 1.0 to 4.0 on human subjects. (cdc.gov)

In contrast, our study showed a high abundance of XET homologue transcripts in three week old somatic embryos as compared to cultures three days after induction. (igf-1rinhibitors.com)

These measurements were compared with filtration efficiencies, airflow resistances, and fit factors measured on manikin headforms and humans. (cdc.gov)

A second dose of DETA NO, administered after 4 hours, did not pro long the growth inhibition, suggesting that stress response factors and NO defence mecha nisms may have been activated by the first dose. (igf-1rinhibitors.com)

Finally, activated GR elicits a variety of transcription-independent effects through modulation of mRNA stability via 3'-untranslated region binding [ 5 ]. (biomedcentral.com)

Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. (lookformedical.com)

Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)

genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease). (lookformedical.com)

Factor XIa then activates factor IX to factor IXa in the presence of calcium. (lookformedical.com)

Factors that influence aerosol therapy efficacy include those that affect drug delivery to distal elements of the airway. (pharmacology2000.com)

Anatomy18

Organisms8

Diseases7

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes68

Disciplines and Occupations2

Information Science3

Health Care1

Macrophages10

Cytokines7

Lymphocytes2

Chemokine2

VEGF5

Activator4

Platelet-derive2

Receptor3

Apoptosis2

Vascular3

Tumor3

Protein3

Angiogenic1

Gene4

Promoter4

Receptors2

Phagocytosis1

Bone4

Willebrand2

Therapeutic1

Infection2

Findings1

Adaptive immunity1

Immune1

Cells4

Activation2

Soluble1

Pathways1

Tissue1

Activate2

Metrics1

Role1

Defect1

Absence1

Expression2

Levels1

Disorder2

Interaction1

Host2

Growth factor2

Human1

Study1

Humans1

Response1

Effects1

Acts1

Risk factor1

Disease2

Presence1

Affect1