• Inbred mice have shown to benefit significantly less from CR interventions than non-inbred mice, with some inbred mice strains not benefiting at all from CR. (longevitywiki.org)
  • This yields offspring with an isogenic SS background for all but the target chromosome as shown in (B). Selected male and female rats are then mated resulting in approximately 25% of the offspring being homozygous for the chromosome of interest. (comprehensivephysiology.com)
  • Shown is the mean arterial pressure (MAP) in conscious SS ( n = 18), SS‐13 BN ( n = 15), and BN ( n = 16) rats exposed to a high‐salt (4.0% NaCl) diet for 4 weeks. (comprehensivephysiology.com)
  • METHODS@#Fifty-four male Wistar rats were randomly divided into normal control (NC, n=14) and high-fat diet (HFD) groups (n=40). (bvsalud.org)
  • Abstract The present study was conducted to evaluate the chemical composition, antioxidant activity and hypoglycemic effects of whole kumquat (Ku) powder in diabetic rats fed a high-fat-high-cholesterol (HFHC) diet. (bvsalud.org)
  • A total of 90 albino rats were used in the present study. (bvsalud.org)
  • Authors argued that strong differences in longevity were not noted possibly because wild animals have a higher genetic variation than inbred mice, which could affect CR strength. (longevitywiki.org)
  • Thirty rats with fasting blood glucose higher than 11.7 mmol/L were randomly divided into diabetes (DM) and TSF groups, 15 rats in each group. (bvsalud.org)
  • C) The transgenically labeled human 231 Luc+ breast cancer cells were orthotopically implanted in the MFP (see dashed lines) of SS IL2R γ and SS.BN3 IL2R γ rats. (comprehensivephysiology.com)
  • OBJECTIVE@#To explore the effect of Tangshen Formula (, TSF), a Chinese herbal medicine, on interstitial cells of Cajal (ICC) in the colon of diabetic rats. (bvsalud.org)
  • Recently, it has been proposed that Dahl salt-sensitive (SS) rats are a model of spontaneous superimposed preeclampsia when maintained on a normal salt diet. (bvsalud.org)
  • diabetic rats (non-treated), diabetic + HFHC diet (non-treated), HFHC (non-treated), Diabetic (treated), HFHC (treated) and Diabetic + HFHC (treated). (bvsalud.org)
  • Diet supplemented with Kumquat at different concentrations have a hypoglycemic effect and improve the thyroid hormones of both diabetic rats and HFHC diabetic rats. (bvsalud.org)
  • Additionally, we conducted simulations to predict the effects of inhibition and knockout of the ENaC and H+-K+-ATPase transporters on virgin and pregnant rat kidneys. (bvsalud.org)
  • In the present, work we induced diabetes with streptozotocin in spontaneously hypertensive rats and treated them either with PACAP or olaparib and alternatively with both agents. (bvsalud.org)
  • We showed that increased expression of complement 3 (C3) induces dedifferentiation of mesenchymal cells and epithelial mesenchymal transition, which activate the local renin-angiotensin system (RAS) that contributes to cardiovascular and renal remodeling in spontaneously hypertensive rats (SHRs). (bvsalud.org)
  • Methods and Results - To identify the physiological role of the kinase in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), we used adenoviral vectors to transfer the human AKTI gene selectively to the common carotid endothelium. (cnr.it)
  • In the present study, to investigate contributions of C3 to the development of the pathogenesis of hypertension, we evaluated the formation of renin-producing cells and roles of C3 in renin generation during differentiation of primary bone marrow-mesenchymal stem cells (MSCs) from C57BL/6 mice, Wistar-Kyoto (WKY) rats, and SHRs to smooth muscle cells (SMCs) with transforming growth factor-ß1. (bvsalud.org)
  • The expression of renin transiently increased with increases in transcription factor liver X receptor α (LXRα), and expression of C3 and Krüppel-like factor 5 (KLF5) increased during differentiation of MSCs from C57BL/6 mice, WKY rats, and SHRs to SMCs. (bvsalud.org)
  • Nevertheless, there are some physiological and genetic differences between humans and rats, which should be carefully considered when rats are chosen as a model organism. (biomedcentral.com)
  • To date, there exist numerous well-established procedures to mimic different forms of injury patterns in rats, animals that are uncomplicated in handling and housing. (biomedcentral.com)