• The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
  • Krukenberg tumors are associated with bilateral, asymmetrical enlargement of the ovaries without peritoneal adhesions and deposits while metastases from other tumors are embedded within the ovarian capsule or in the peritoneum [1]. (symptoma.com)
  • Krukenberg tumor , also known as carcinoma mucocellulare , refers to the "signet ring" subtype of metastatic tumor to the ovary . (radiopaedia.org)
  • The estimated incidence of Krukenberg tumor is at approximately 0.16/100000 per year. (radiopaedia.org)
  • Krukenberg tumors are metastatic tumors to the ovary that contain well-defined histological characteristics (mucin-secreting "signet ring" cells) and usually originate in the gastrointestinal tract 4 . (radiopaedia.org)
  • Features will favor towards a Krukenberg tumor if a concurrent gastric or colic mural lesion is seen. (radiopaedia.org)
  • The great majority of Krukenberg tumors are signet ring cell carcinomas arising in the stomach. (radiopaedia.org)
  • Therefore, Krukenberg tumors can occasionally show low or high signal intensity on T2-weighted images 5 . (radiopaedia.org)
  • Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
  • Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)
  • Undescended testes are associated with reduced fertility, increased risk of testicular germ-cell tumors, and psychological problems when fully-grown. (wikipedia.org)
  • MATERIALS AND METHODS: Digital RNA quantification (Nanostring) of previously curated 188 B-cell lymphoma specimens across four subtypes, follicular lymphoma (FL), diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), primary testicular lymphoma (PTL), and plasmablastic lymphoma (PBL), was reanalyzed with focus on TBL1XR1 and NCOR1 expression, juxtaposing them with 730 ontogenically linked genes. (bvsalud.org)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • Twaalhoven 1999,Houck 2000, Tempfer 2007, Brun 2008 Accuracy for malignancy of epithelial OvTu 90-94% Accuracy for borderline tumors approx. (symptoma.com)
  • The stomach followed by colon are the two most common primary tumors to result in ovarian metastases , pursued by the breast, lung, and contralateral ovary. (radiopaedia.org)
  • At diagnosis, 1-2% are bilateral and 90-95% of cases are germ cell tumours (GCT) [ 6 ]. (uroweb.org)
  • For women of childbearing age, simple unilateral oophorectomy via laparoscopy or laparotomy is adequate, provided that the contralateral ovary appears grossly normal. (medscape.com)
  • The gonads present may be bilateral ovotestes, or they may be a combination of a unilateral ovary or testis with an ovotestis on the contralateral side. (medscape.com)
  • The tumors represent 5-10% of all ovarian tumors and up to 50% of all metastatic tumors to the ovary. (radiopaedia.org)
  • There are a variety of metastatic carcinomas to the ovary that can mimic primary ovarian tumors 4 . (radiopaedia.org)
  • The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
  • In the presence of a Y chromosome and the SRY gene, müllerian‐inhibiting substance produced by Sertoli cells causes regression of the MD. Meanwhile, testosterone produced by the Leydig cells induces differentiation of the WD into the efferent ducts that communicate with the rete testis, followed by the epididymis, ductus deferens, seminal vesicle, and ejaculatory duct. (esur2023.com)
  • Cytologic examination often reveals mucoid degeneration and many large cells shaped like signet rings. (radiopaedia.org)
  • Signet ring cells scatter in the ovarian stroma with abundant collagen formation or marked edema. (radiopaedia.org)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Mucinous tumors are most common in the third to fifth decades of life and are only rarely bilateral. (medscape.com)
  • in other instances, the granulosa cells remain productive, with prolonged secretion of estrogen. (medscape.com)
  • Follicle cysts are lined with an inner layer of granulosa cells and an outer layer of theca interna cells. (medscape.com)
  • In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
  • Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
  • BACKGROUND/AIM: B-cell lymphomas are characterized by diverse genetic anomalies affecting B-cell differentiation. (bvsalud.org)
  • Although not essential for initial WD formation, the later differentiation of this embryological structure relies on androgens derived from the Leydig cells. (esur2023.com)
  • Solid epithelial ovarian tumors are almost invariably malignant. (medscape.com)
  • Cancerous tumors from several organ systems, such as gastrointestinal and female genital tract, could spread to the ovaries [2]. (symptoma.com)
  • Lymphatic spread of tumor is faster and more common from the stomach to the ovaries than from the colon while the vascular spread is higher from the colon than from the stomach [2]. (symptoma.com)
  • The exact mechanism of primary tumor metastasize to the ovaries is unclear. (radiopaedia.org)
  • Most malignant post-pubertal GCTs originate from germ cell neoplasia " in situ " (GCNIS). (uroweb.org)
  • There is some evidence that tumors originating from the stomach may be denser on contrast-enhanced CT than those originating from the colon 3 . (radiopaedia.org)
  • In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
  • 2 An associated anatomic defect is usually not present on the contralateral side. (aafp.org)
  • Here, we present two patients with SLCT whose tumor sequencing showed only a somatic missense DICER1 RNase IIIb variant. (bvsalud.org)
  • Clinical manifestations are due to the primary tumor as well as due to the metastases. (symptoma.com)
  • The breakdown by primary tumor location is as follows 7 . (radiopaedia.org)
  • Light will not transmit through a solid tumor, while a hydrocele will glow a soft red color. (aafp.org)
  • Germline pathogenic loss-of-function (pLOF) variants in DICER1 are associated with a predisposition for a variety of solid neoplasms, including pleuropulmonary blastoma and Sertoli-Leydig cell tumor (SLCT). (bvsalud.org)
  • Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
  • Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
  • However, some patients with DICER1-associated tumors have no pLOF variants detected by germline or tumor testing. (bvsalud.org)
  • For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)
  • ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development. (frontiersin.org)
  • The tumors result from either failure of a dominant mature follicle to rupture or failure of an immature follicle to undergo the normal process of atresia. (medscape.com)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • Of these tumors, 75% are benign and are found in women aged 30-50 years. (medscape.com)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)