• It is a major constituent of the plant Ammi visnaga, also known as Bishop's Weed. (wikipedia.org)
  • It is a major constituent of the plant Ammi Visnaga, existing between 0.3 and 1.2% in the leaves and seeds. (wikipedia.org)
  • however, only Ammi Visnaga contains khellin. (wikipedia.org)
  • instead it is found in Ammi Visnaga or "Khella" extract. (wikipedia.org)
  • Regardless of this recommendation, Ammi Visnaga is still often used in the Middle East, Egypt, and surrounding areas. (wikipedia.org)
  • When ammi visnaga extract is taken daily, as a tea or as a pill, calcium oxalate kidney stone formation is inhibited, making it a good treatment for hyperoxaluria (a condition in which there is excessive oxalate excretion in the urine, causing kidney stones). (wikipedia.org)
  • However, studies have shown that khellin is not the active ingredient in Ammi Visnaga extract. (wikipedia.org)
  • Upon studying calcium oxalate nucleation, ammi visnaga extract as a whole was shown to prolong nucleation time as well as change stone conformation, while khellin alone had no effect. (wikipedia.org)
  • For example, the main agent of the extract of khella (Ammi visnaga), named khellin, is completely bioavailable after 10 minutes, but, given alone, it is not fully resorbed until 60 minutes (3). (ani.international)
  • Respiratory System, Herbal Supplement, Khella Liquid Extract, We prepare our Khella extract from the seed of Ammi visnaga plants which are Certified Organically Grown or Sustainably Wildcrafted in their natural habitat. (foodpharmacy.blog)
  • As a result, many healing properties have been attributed to Khellin that are actually due to other constituents in the extract. (wikipedia.org)
  • Ammi (plant) Amikhelline, an antimitotic drug Visnagin Azim Khan, Muhammad (2014). (wikipedia.org)
  • Significantly, khellin also functions as a bronchodilator and expands the bronchi (breathing tubes that guide air from the throat to the lungs). (herbs2000.com)
  • however, the amount of Khellin and other ingredients varies greatly between brands and even batches of the same brand. (wikipedia.org)
  • When taken over a period of time, the main ingredients of khellin accumulate in the body where the medicine has been administered and this is likely to result into nausea and vomiting in the patients even after their recovery. (herbs2000.com)
  • Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)
  • In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. (wikipedia.org)
  • [4] Serious side effects include lung toxicity such as interstitial pneumonitis , liver problems , heart arrhythmias, vision problems, thyroid problems , and death. (cloudfront.net)
  • Khellin has been used to relieve the pain associated with angina pectoris by acting as a selective coronary vasodilator. (wikipedia.org)
  • Hence, the usage of khellin brings instant respite from angina, caused by slender or partially blocked coronary arteries. (herbs2000.com)
  • Intramuscular injections of khellin can also be used to treat asthma. (wikipedia.org)
  • Altounyan deliberately inhaled derivatives of the active ingredient khellin to determine if they could block his asthma attacks. (curecrowd.com)
  • Researchers were disheartened to discover that the usage of khellin often leads to a snowballing toxic effect. (herbs2000.com)
  • Unwanted side effects include dizziness, reversible cholestatic jaundice, pseudoallergic reaction, and elevated levels of liver enzymes (transaminases and gamma-glutamyltransferase). (wikipedia.org)
  • [13] However, clinical studies have failed to demonstrate long-term efficacy and have shown potentially fatal side effects such as pulmonary toxicities. (cloudfront.net)
  • Khellin is found in Egypt, the Middle East, and areas surrounding the Mediterranean. (wikipedia.org)
  • however, the common side effects including nausea present difficulties. (wikipedia.org)
  • however nausea is a major side effect regardless of how the medication is taken. (wikipedia.org)
  • As a result, many healing properties have been attributed to Khellin that are actually due to other constituents in the extract. (wikipedia.org)
  • However, the bad part about using khellin is that along with its healing properties, it also has its share of adverse side effects. (herbs2000.com)
  • Realizing the importance of khellin in alleviating heart problems , scientists have even described it as a discerning coronary vasodilator, which helps in relaxing as well as enlarging the arteries carrying blood to the heart. (herbs2000.com)
  • While Khellin treatment in conjunction with UV therapy is successful, accelerated photoaging and increased risk of skin cancer is another concern. (wikipedia.org)