When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate, the mesylate salt of imatinib). (wikipedia.org)
Imatinib mesylate (GLEEVEC, GLIVEC, formerly STI571) has demonstrated unprecedented efficacy as first-line therapy for treatment for all phases of chronic myelogenous leukemia and metastatic and unresectable malignant gastrointestinal stromal tumors. (aspetjournals.org)
Disposition and biotransformation of imatinib were studied in four male healthy volunteers after a single oral dose of 239 mg of 14 C-labeled imatinib mesylate. (aspetjournals.org)
Patients receive oral imatinib mesylate twice daily on days 1-28. (knowcancer.com)
Imatinib mesylate (IkT-001Pro) is under development for the treatment of chronic myeloid leukemia. (globaldata.com)
Preclinical data shows improvements in response for the combination of imatinib mesylate (IM, Gleevec) and gemcitabine (GEM) therapy compared with GEM alone. (aacrjournals.org)
Imatinib mesylate and AMN107 are tyrosine kinase inhibitors that inhibit fibroblast proliferation and collagen production in lungs and skin. (eur.nl)
This study was conducted to determine whether imatinib mesylate and AMN107 inhibit orbital fibroblast proliferation and hyaluronan production induced by PDGF-BB and TGF-β1and whether expression of the genes PDGF-B and TGF-B1(growth factors suggested to play a role in GO) are increased in GO orbital tissues. (eur.nl)
Orbital fibroblasts were cultured from eight patients with GO and three control patients and the effect of imatinib mesylate and AMN107 on PDGF-BB and TGF-β1-induced orbital fibroblast proliferation, signaling cascades, hyaluronan synthase (HAS) gene expression and hyaluronan production were determined. (eur.nl)
Imatinib mesylate and AMN107 inhibited PDGF-BB-induced orbital fibroblast proliferation, HAS induction and hyaluronan production by blocking PDGFreceptor phosphorylation. (eur.nl)
This induction was not inhibited by imatinib mesylate or AMN107, due to the inability of TGF-β1to activate c-Abl kinase activity in orbital fibroblasts. (eur.nl)
Nevertheless, imatinib mesylate and AMN107 should be considered as treatment candidates for GO. (eur.nl)
Imatinib mesylate is currently the drug of choice to treat chronic myeloid leukemia. (altmetric.com)
According to IQVIA, US sales of Imatinib Mesylate Tablets were approximately $831 million in the 12 months ending August 2018. (hikma.com)
Imatinib mesylate is often associated with edema and occasionally serious fluid retention. (hikma.com)
65 years) or those taking higher doses of imatinib mesylate. (hikma.com)
Severe superficial edema was reported in 1.5% of newly diagnosed CML patients taking imatinib mesylate, and in 2%-6% of other adult CML patients taking imatinib mesylate. (hikma.com)
In addition, other severe fluid retention (e.g., pleural effusion, pericardial effusion, pulmonary edema, and ascites) reactions were reported in 1.3% of newly diagnosed CML patients taking imatinib mesylate, and in 2%-6% of other adult CML patients taking imatinib mesylate. (hikma.com)
In a randomized trial in patients with newly diagnosed Ph+ CML in chronic phase comparing imatinib mesylate and nilotinib, severe (Grade 3 or 4) fluid retention occurred in 2.5% of patients receiving imatinib mesylate and in 3.9% of patients receiving nilotinib 300 mg twice daily. (hikma.com)
Effusions (including pleural effusion, pericardial effusion, ascites) or pulmonary edema were observed in 2.1% (none were Grade 3 or 4) of patients in the imatinib mesylate arm and 2.2% (0.7% Grade 3 or 4) of patients in the nilotinib 300 mg twice daily arm. (hikma.com)
Imatinib mesylate for unmutated hypereosinophilic syndromes: Does it work? (efim.org)
The high efficacy of tyrosine kinase inhibitor, imatinib mesylate (IM), is well-documented in patients with hypereosinophilic syndromes (HES) and detectable rearrangements of platelet-derived growth factor receptor α or β (PDGFRA/B) [1]. (efim.org)
Imatinib mesylate is FDA approved for the treatment of all phases of Philadelphia chromosome-positive chronic myelogenous leukemia and it is also approved for the treatment of c-Kit positive gastrointestinal stromal tumors (GIST). (thegiconnection.com)
Imatinib mesylate is administered orally, in the form of a capsule, and the dose depends on several factors, including the condition being treated, the size of the patient, the particular regimen being used, and the overall health of the patient. (thegiconnection.com)
Patients will usually have scheduled meetings with their healthcare provider while they are being treated with imatinib mesylate. (thegiconnection.com)
What are the common (occur in 30% or more of patients) side effects of treatment with imatinib mesylate? (thegiconnection.com)
What are the less common (occur in 10% to 29% of patients) side effects of treatment with imatinib mesylate? (thegiconnection.com)
The standard treatment of choice is now imatinib mesylate (Gleevec), which is a specific small-molecule inhibitor of BCR/ABL in all phases of CML. (medscape.com)
Furthermore, the advent of imatinib mesylate has dramatically improved the duration of hematologic and, indeed, cytogenetic remissions. (medscape.com)
Imatinib mesylate (Gleevec) is a tyrosine kinase inhibitor that inhibits the abnormal bcr-abl tyrosine kinase created by the Philadelphia (Ph1) chromosome translocation abnormality. (medscape.com)
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing stages of disease. (lu.se)
Found in atropine and diphenhydramine1
Benztropine Mesylate is a synthetic compound containing structural features found in atropine and diphenhydramine. (nih.gov)
Tirilazad mesylate2
The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease in rats. (aspetjournals.org)
The 21-aminosteroid tirilazad mesylate (U74006F) is a lipophilic antioxidant and free radical scavenger that has been reported to attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. (aspetjournals.org)
Pergolide Mesylate4
Pergolide Mesylate is a dopamine agonist used to treat pituitary pars intermedia dysfunction (PPID), commonly known as equine Cushings disease. (thrivingpets.com)
Pergolide Mesylate is only approved for use in horses. (thrivingpets.com)
ThrivingPets recommends a maximum supply of 100 days for Pergolide Mesylate capsules. (thrivingpets.com)
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Paroxetine mesylate9
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Benztropine mesylate15
Each tablet, for oral administration, contains 0.5 mg, 1 mg or 2 mg of benztropine mesylate. (nih.gov)
Benztropine mesylate possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism. (nih.gov)
Hypersensitivity to benztropine mesylate tablets. (nih.gov)
Benztropine mesylate may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. (nih.gov)
When benztropine mesylate is given concomitantly with phenothiazines, haloperidol, or other drugs with anticholinergic or antidopaminergic activity, patients should be advised to report gastrointestinal complaints, fever or heat intolerance promptly. (nih.gov)
Paralytic ileus, hyperthermia and heat stroke, all of which have sometimes been fatal, have occurred in patients taking anticholinergic-type antiparkinsonism drugs, including benztropine mesylate, in combination with phenothiazines and/or tricyclic antidepressants. (nih.gov)
Since benztropine mesylate contains structural features of atropine, it may produce anhidrosis. (nih.gov)
Since benztropine mesylate has cumulative action, continued supervision is advisable. (nih.gov)
Urinary retention has been reported with benztropine mesylate. (nih.gov)
BENZTROPINE MESYLATE TABLETS USP are white coloured, circular, biconvex tablets with break line on one side and "SGP" embossed on the other side. (sgpharma.com)
BENZTROPINE MESYLATE TABLETS USP is recommended for all forms of parkinsonism including arteriosclerotic, postencephalitic, idiopathic, as well as medicine-induced extrapyramidal disorders (except tardive dyskinesia). (sgpharma.com)
BENZTROPINE MESYLATE TABLETS USP often is helpful in patients who have become unresponsive to other agents. (sgpharma.com)
BENZTROPINE MESYLATE TABLETS USP is a powerful anticholinergic agent which is mainly effective in relieving tremor and rigidity. (sgpharma.com)
Because of cumulative action of BENZTROPINE MESYLATE TABLETS USP, therapy should be initiated with a low dose which is increased gradually at five or six-day intervals to the smallest amount necessary for optimal relief. (sgpharma.com)
When BENZTROPINE MESYLATE TABLETS USP is started, do not terminate therapy with other antiparkinsonian agents abruptly. (sgpharma.com)
Osimertinib Mesylate2
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TAS-115 mesylate is a potent inhibitor of VEGFR and hepatocyte growth factor receptor ( c-Met/HGFR )-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively). (targetmol.com)
RESCRIPTOR tablets contain delavirdine mesylate, a synthetic non-nucleoside reverse transcriptase inhibitor (NNRTI) of the human immunodeficiency virus type 1 (HIV-1). (drugs.com)
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Deferoxamine2
Deferoxamine Mesylate Improves the Survival Rate of Transplanted Fat by Promoting Angiogenesis. (bvsalud.org)
Deferoxamine mesylate (DFO) is a drug approved by the FDA that is safe, has antioxidant effects , and can promote angiogenesis. (bvsalud.org)
Bromocriptine6
Parlodel (bromocriptine mesylate) is a dopamine receptor agonist used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia), and to treat these disorders when they are caused by brain tumors that can produce prolactin. (rxlist.com)
Our Parlodel (bromocriptine mesylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Parlodel® (bromocriptine mesylate) is an ergot derivative with potent dopamine receptor agonist activity. (rxlist.com)
Each Parlodel® (bromocriptine mesylate) SnapTabs® tablet for oral administration contains 2½ mg and each capsule contains 5 mg bromocriptine (as the mesylate). (rxlist.com)
Bromocriptine mesylate is chemically designated as Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-monomethanesulfonate (salt). (rxlist.com)
Parlodel (bromocriptine mesylate) is indicated for the treatment of dysfunctions associated with hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism . (rxlist.com)
Fluoroquinolone antibiotic1
Trovafloxacin mesylate is a fluoroquinolone antibiotic. (rndsystems.com)
Active Ingredient1
Mechanism of Action Phentolamine mesylate, the active ingredient in OraVerse, produces an alpha-adrenergic block of relatively short duration resulting in vasodilatation when applied to vascular smooth muscle. (handlebar-online.com)
Oral1
Each RESCRIPTOR tablet, for oral administration, contains 200 mg of delavirdine mesylate (henceforth referred to as delavirdine). (drugs.com)
Selective1
Dolasetron mesylate is a selective 5-HT3 receptor antagonist. (xcessbio.com)
Drug2
Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor. (handlebar-online.com)
Phentolamine Description Phentolamine Mesylate for Injection, USP is an antihypertensive, available in vials for intravenous and intramuscular administration. (handlebar-online.com)
Replication1
Prexasertib mesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis . (medchemexpress.com)