• Do your food products, ingredients and supplements conform to regulatory limits for pyrrolizidine alkaloids? (sgs.com)
  • Pyrrolizidine alkaloids (PAs) are naturally occurring toxins that can have adverse effects on human and animals, including cancer and liver damage. (sgs.com)
  • Why choose pyrrolizidine alkaloid testing services from SGS? (sgs.com)
  • However, depending on floral composition, bee pollen can be contaminated by pyrrolizidine alkaloids (PAs), PA N-oxides (PANOs) and toxigenic fungi found in plants, which may pose a potential health risk for consumers. (nih.gov)
  • Pyrrolizidine Alkaloids in Food on the Italian Market. (bvsalud.org)
  • Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by over 6000 plant species worldwide. (bvsalud.org)
  • On 1 July 2022, the Commission Regulation (EU) 2020/2040 came into force, repealed by Commission Regulation (EU) 2023/915, setting maximum levels for the sum of pyrrolizidine alkaloids in certain food . (bvsalud.org)
  • They found that grain samples gathered from household farms contained low levels of two types of plant-based liver toxins known as pyrrolizidine alkaloids (PAs). (cdc.gov)
  • The tropane alkaloids atropine, scopolamine, and hyoscyamine are highly anticholinergic compounds found in a number of plants. (medscape.com)
  • A subgroup of the alkaloids is the alkaloid amines, which include three major pharmacologic groups: the hallucinogenic alkaloid amines, the stimulant alkaloid amines, and the tropane alkaloids (also called the belladonna alkaloids or bicyclic alkaloids). (medscape.com)
  • Chinese herbal medicines containing tropane alkaloids have been used to treat asthma, chronic bronchitis, pain, and flu symptoms. (medscape.com)
  • Many cultures worldwide add plants with tropane alkaloids (particularly Datura species) to alcoholic beverages to increase intoxication. (medscape.com)
  • The cereal was found to have been contaminated with tropane alkaloids from seeds of Datura stramonium that had invaded grain fields. (medscape.com)
  • Although most tropane alkaloids cause an anticholinergic syndrome, a case report indicates that the tropane alkaloid-containing medicinal herb Erycibe henri Prain ("Ting Kung Teng") contains a tropane alkaloid that may cause a cholinergic syndrome, as well as kidney, liver, and erythrocyte toxicity. (medscape.com)
  • [ 14 ] This is considered atypical for the tropane alkaloids, which are predominantly strongly anticholinergic. (medscape.com)
  • Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. (medscape.com)
  • Symptoms usually occur 30-60 minutes after ingestion and may continue for 24-48 hours because tropane alkaloids delay gastric emptying and absorption. (medscape.com)
  • Alkaloids possess significant medicinal, pharmaceutical, and ecological importance, making them a subject of extensive research by leading companies. (selfgrowth.com)
  • In this article, we will delve into the intriguing world of alkaloids, exploring their sources, structures, and attractive medicinal value. (selfgrowth.com)
  • Because of the medicinal use of alkaloids, proper identification is needed for safety purposes for which, a number of identification tests are available. (novapublishers.com)
  • New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed. (fu-berlin.de)
  • Piperidine alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from piperidine. (wikipedia.org)
  • In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. (selfgrowth.com)
  • Alkaloids represent a large and diverse group of organic compounds characterized by the presence of a nitrogen-containing heterocyclic ring. (selfgrowth.com)
  • Alkaloids are a fascinating group of naturally occurring chemical compounds found in various plants, fungi, and some animals. (selfgrowth.com)
  • It currently covers 21 alkaloids, including 14 compounds that co-elute, which makes individual analytical quantification impossible under current methodologies. (sgs.com)
  • [ 1 ] The alkaloids represent a very diverse group of medically significant compounds that include well-known drugs such as the opiates. (medscape.com)
  • Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. (shabdkosh.com)
  • Some synthetic compounds of similar structure may also be termed alkaloids. (shabdkosh.com)
  • No new alkaloid analogues appeared to be produced from the compounds fed to D. stramonium. (gla.ac.uk)
  • This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. (fu-berlin.de)
  • The term ergot alkaloid refers to a diverse group of about forty different toxins which are formed by Claviceps spp. (thebeefsite.com)
  • This fungus produces the ergot responsible for the ergot alkaloid group of mycotoxins and parasitizes the seed heads of plants at the time of flowering. (thebeefsite.com)
  • Non-ergot alkaloid with beta-blocking properties that may be effective for migraine prophylaxis. (pharmacology2000.com)
  • Recent trends in pharmacological activity of alkaloids in animal colitis: potential use for inflammatory bowel disease. (novapublishers.com)
  • Pharmacological activity of alkaloids: a review. (novapublishers.com)
  • These pharmacological features discard direct anxiolytic or analgesic actions of gelsemine through GABARs but support a role of GABARs on the alkaloid induced toxicity. (iasp-pain.org)
  • Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. (ijpsonline.com)
  • that is necessary for the production of a novel family of tetrahydropyridine alkaloids that are structural analogs of plant alkaloids. (nih.gov)
  • Thanks to exceptional affinity of plant alkaloids to various biomolecules they can be used in analytical chemistry as a probes. (muni.cz)
  • Biosynthesis of Quinolizidine Alkaloids Previous work has revealed that cadaverine is a good precursor of quinolizidine alkaloids. (gla.ac.uk)
  • Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and pharmacologic activity. (medscape.com)
  • Metabolites were isolated based on biological activity and were characterized using tandem mass spectrometry, multidimensional nuclear magnetic resonance, and Mosher ester analysis, leading to the discovery of a new family of bacterial tetrahydropyridine alkaloids, koreenceine A to D (metabolites 1 to 4). (nih.gov)
  • Three of these metabolites are analogs of the plant alkaloid γ-coniceine. (nih.gov)
  • This work suggests that Pseudomonas and plants convergently evolved the ability to produce similar alkaloid metabolites that can mediate interbacterial competition in the rhizosphere. (nih.gov)
  • As a result, alkaloids find applications in various industries, including medicine, agriculture, and even the synthesis of fine chemicals. (selfgrowth.com)
  • Quinine, an alkaloid found in the bark of the cinchona tree, has been traditionally used as a natural remedy for malaria by interfering with the parasite's protein synthesis. (selfgrowth.com)
  • Synthesis of pyrrole and carbazole alkaloids. (novapublishers.com)
  • H. J (ed) Alkaloid synthesis. (novapublishers.com)
  • The third chapter covers the author's total synthesis of stemoamide, a 1-azabicyclo[5.3.0]decane motif containing alkaloid. (jyu.fi)
  • 1975. [Pharmacology of the alkaloid nitramine. (cdc.gov)
  • The present paper reports results of the effect of Potato virus X (PVX) on the contents of total phenols and alkaloids in leaves of Datura stramonium. (scielo.br)
  • In 2014, the CORESTA (Cooperation Centre for Scientific Research Relative to Tobacco) Routine Analytical Chemistry Sub-Group (RAC) undertook a study to compare a new, safer method of determining total alkaloids (as nicotine) in tobacco. (seal-analytical.com)
  • In addition to the total alkaloid nicotine methods, SEAL also offers many methods for tobacco analysis including the following CRMs: No.36 - Nitrate, No.37 - Reducing Substances (total sugars), and No.38 - Reducing Carbohydrates (sugars). (seal-analytical.com)
  • Since ancient times, people have used plants containing alkaloids as remedies in the form of teas, poultices, potions, etc. to treat some diseases or sometimes as poison and dyes. (novapublishers.com)
  • It is well known that alkaloid levels in various plants can be manipulated. (shroomery.org)
  • The word or phrase alkaloids refers to natural bases containing nitrogen found in plants. (shabdkosh.com)
  • After ten to fourteen days the plants were macerated and the alkaloids extracted. (gla.ac.uk)
  • Gelsemine, one of the most abundant alkaloids in the plants, have replicated these therapeutic and toxic actions in experimental behavioral models. (iasp-pain.org)
  • Serum of cattle mixed with a pilocarpine solution shows no more alkaloids present if tested directly with an alkaloidal reagent (potassium mercuric iodide) after about one hour. (aspetjournals.org)
  • Serum of rabbit which binds more pilocarpine can not be tested directly in the same way, as the reagent splits off the bound alkaloids. (aspetjournals.org)
  • The most important representative of piperidine alkaloids is piperine, which is responsible for the pungent taste of pepper. (wikipedia.org)
  • Information on the chemical and toxicological properties of individual ergot alkaloids is too limited at the present time for their selection as individual marker toxins when it comes to monitoring the extent of contamination. (thebeefsite.com)
  • Endophytic toxins in grasses include ergot alkaloids in tall fescue and tremorgens (e.g., lolitrem B) in perennial ryegrass. (thebeefsite.com)
  • These selected substances bind ergot alkaloids in the gastrointestinal tract, reduce their bioavailability and increase their excretion as an adsorbent-toxin complex, thus helping control the negative impacts of these mycotoxins. (thebeefsite.com)
  • Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the Amphibia. (harvard.edu)
  • Secologanin Tryptamine Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Solanaceous alkaloids cause anticholinergic symptoms including blurred vision, dry mouth, dizziness and confusion. (gov.hk)
  • Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • TY - JOUR T1 - Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). (bvsalud.org)
  • Caffeine and Sodium Benzoate Injection (caffeine alkaloid ) is used along with supportive measure to treat respiratory depression associated with over dosage with CNS depressant drugs, such as narcotics. (rxlist.com)
  • Our Caffeine and Sodium Benzoate Injection (caffeine alkaloid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Caffeine and Sodium Benzoate Injection, USP (caffeine alkaloid ) is a clear, sterile, nonpyrogenic, solution of Caffeine Alkaloid. (rxlist.com)
  • Caffeine and Sodium Benzoate Injection (caffeine alkaloid) may be administered by intramuscular or slow intravenous injection Some clinicians suggest that when used as a mild CNS stimulant to overcome fatigue, oral doses of 100 200 mg of anhydrous caffeine are required. (rxlist.com)
  • Augmentation of Caffeine Alkaloids by Exogenous Indoleamines in Coffea canephora P. Ex. (asic-cafe.org)
  • Caffeine is an alkaloid that is known to have psychoactive stimulatory effects. (cdc.gov)
  • Ergot alkaloids (also named ergolines) exert toxic effects in all animal species, and the most prominent toxic signs can be attributed to the interaction of ergot alkaloids with adrenergic, serotinergic and dopaminergic receptors. (thebeefsite.com)
  • The widespread distribution of alkaloids and their wide array of structures makes their classification often difficult, hence, there are different classification methods are been reported for better understanding. (novapublishers.com)
  • Herein, this work is a comprehensive revision of the web of knowledge on the introductory sight of alkaloids, their classification, extraction techniques, identification tests and pharmaceutical applications. (novapublishers.com)
  • Tentative studies towards a divergent route to other stemona alkaloids from a key precursor were also carried out. (jyu.fi)
  • It has been established that feeding certain modified precursors of a natural precursor to biological systems may result in new or modified alkaloids being produced. (gla.ac.uk)
  • N-Alkylcadaverines were fed to both species with the aim of discovering whether any new alkaloid analogues were formed. (gla.ac.uk)
  • In modern days, the biological significance of alkaloids depends on their significant relationship with health benefits. (novapublishers.com)
  • In the present study, we not only investigated the therapeutic effect of the combinational treatment of Sophora moorcroftiana alkaloids and albendazole against echinococcosis in an experimental rats model, but also explored the underlying molecular mechanism of this strategy by proteomics. (hindawi.com)
  • The stereochemistry of discarines C ( 1 ) and D ( 2 ) and myrianthine A ( 3 ), three cyclopeptide alkaloids isolated from Discaria febrifuga , was determined by a combination of NMR studies of 1 - 3 , enantioselective gas chromatography, and comparison of NMR data with those of synthetic tripeptides. (figshare.com)
  • In conclusion, we have demonstrated that natural products, phenantridine alkaloids, can be used as alternative probes to synthetic DNA dyes such as ethidium bromide. (muni.cz)
  • Alkaloids have demonstrated considerable potential in combatting various fungal pathogens, providing alternative treatment options for these debilitating infections. (selfgrowth.com)
  • The Department of Health (DH) is today (August 15) investigating two cases of solanaceous alkaloid poisoning after consumption of Chinese herbs. (gov.hk)
  • Another female patient, aged 63, developed similar symptoms and signs compatible with solanaceous alkaloid poisoning on August 3, including delirium and lower limb weakness about three hours after consuming a broth prepared from Chinese herbs prescribed for dyspepsia by a CMP at the Haven of Hope - The Chinese University of Hong Kong CMCTR (Sai Kung District). (gov.hk)
  • According to the Chinese medicine literature, the concerned herbs could not account for the presence of the solanaceous alkaloids detected. (gov.hk)
  • This dissertation, "The Effects of L-tetrahydropalmatine and Rhynchophylline, Alkaloids Derived From Herbal Medicines, on Cellular and Molecular Neurotoxicity of Cocaine in PC12 Cells" by Xiao, Zhang, 弹瀜, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. (google.ru)
  • These alkaloids bind to specific receptors in the central nervous system, effectively alleviating severe pain and inducing sedation. (selfgrowth.com)
  • Modulation of GABA receptors and of GABAergic synapses by the natural alkaloid gelsemine. (iasp-pain.org)
  • In general, many alkaloids are pharmacologically active and possess various physiological activities in humans and animals. (novapublishers.com)
  • It turns out that these locally-available and popular vegetables are rich in natural alkaloids that support the healthy function of the brain and prevent the onset of neurodegenerative diseases. (naturalnews.com)
  • Ang mga alkaloid ay ginagawa ng isang malakaing kasamu't sarian ng mga organismo, katulad ng mga bakterya , mga halamang singaw , mga halaman , at mga hayop at kabahagi ng pangkat ng mga produktong natural (tinatawag din na mga metabolite na sekundaryo ). (wikipedia.org)
  • Alkaloids have different and dose-dependent receptor selectivity (binding affinity). (thebeefsite.com)
  • Alkaloids with a piperidine building block are widespread and are usually further subdivided according to their occurrence and biogenetic origin. (wikipedia.org)
  • The response of luminescence intensity to low concentrations of double stranded DNA in presence of alkaloids was found to be linear and can be potentially used for quantification of DNA by means of luminescence spectrometry. (muni.cz)
  • Gas chromatography/mass spectroscopy revealed amounts of scopolamine in samples submitted to all treatments, except X-I, in which the amount of this alkaloid was low. (scielo.br)
  • In order to explore the effect and mechanism of SA treatment against echinococcosis, we established animal echinococcosis model and treated rats with albendazole alone, alkaloids alone, and combined therapy. (hindawi.com)
  • On the other hand, the presynaptic effects of the alkaloid provide an additional mechanism to explain their beneficial effects. (iasp-pain.org)
  • Oram & Williams reported CPI 19305 to show variable results with total alkaloid content both higher (under controlled conditions) and lower (in field trials) than cv. (erowid.org)
  • This graph shows the total number of publications written about "Secologanin Tryptamine Alkaloids" by people in Harvard Catalyst Profiles by year, and whether "Secologanin Tryptamine Alkaloids" was a major or minor topic of these publication. (harvard.edu)
  • This means that neither the total alkaloid content, nor a single alkaloid can be recommended as reliable indicators of the potential adverse effects to livestock associated with the ingestion of ergot contaminated feeds. (thebeefsite.com)
  • Clewell A , Hirka G, Glávits R, Palmer PA , Endres JR , Murbach TS , Marx T , Pasics Szakonyiné I. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. (aibmr.com)