Consumption aspartame. Medical search. Frequent questions

The World Health Organization's (WHO) cancer research agency on Friday classified the commonly used artificial sweetener aspartame as "possibly carcinogenic to humans", although another UN committee reaffirmed that there was a safe daily level of consumption. (globalissues.org)
Artificial sweetener consumption is associated with urinary tract tumors. (greenmedinfo.com)
Diet soda is a widely consumed product that contains the artificial sweetener aspartame. (medicalnewstoday.com)
Aspartame is a common artificial sweetener ingredient in diet sodas, chewing gum, and other products. (medicalnewstoday.com)
Aspartame is an artificial sweetener widely used in various food and beverage products since the 1980s. (medicalnewstoday.com)
In 2022, a study in France among 100,000 adults concluded that people consuming larger amounts of artificial sweeteners - including aspartame - had a slightly higher risk of cancer. (medicalnewstoday.com)
Aspartame is an artificial non-saccharide sweetener 200 times sweeter than sucrose and is commonly used as a sugar substitute in foods and beverages. (wikipedia.org)
The sweetness of aspartame lasts longer than that of sucrose, so it is often blended with other artificial sweeteners such as acesulfame potassium to produce an overall taste more like that of sugar. (wikipedia.org)
A significant body of research has tied consumption of these foods - awash in added sugar, salt, fat, artificial colors, or preservatives - to cancer, diabetes, and heart disease. (medscape.com)
One of the most commonly used additives in UPFs, the artificial sweetener aspartame, garnered headlines this summer when the World Health Organization (WHO) classified it as a likely carcinogen in humans. (medscape.com)
MANILA, Philippines-Aspartame, an artificial sweetener widely used in various food and beverage products, has been classified by the cancer research arm of the World Health Organization (WHO) as "possibly carcinogenic"-what does this mean? (inquirer.net)
As described by WHO, aspartame is an artificial sweetener widely used in everyday food and beverage products like diet drinks, chewing gum, gelatin, ice cream, dairy products (yogurt, cereal, toothpaste) and some medication. (inquirer.net)
Another animal study reported that the artificial sweetener aspartame increases the number of some bacterial strains that are linked with metabolic disease. (medicalnewstoday.com)
Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. (researchgate.net)
Aspartame is one of the most widely used artificial sweeteners. (oaoa.com)
If you chose aspartame, or any artificial sweetener, use it in moderation. (oaoa.com)
A new study links the consumption of sugary drinks, but not artificial sweeteners, to an increased risk of liver cancer. (aboutlawsuits.com)
Prior research has raised concerns about a link between fibromyalgia and aspartame, which is the artificial sweetener more commonly known as Nutrasweet or Equal. (aboutlawsuits.com)
Unfortunately, diet sodas are full of artificial flavors and chemicals, as well as artificial sweeteners, like aspartame and saccharin. (diabetesdaily.com)
A recent study (via PLOS Medicine Journal ) tries to correlate cancer hazards with the consumption of artificial sugar substitutes such as acesulfame-K, aspartame, and sucralose. (slashgear.com)
Based on the data submitted by these users, the researchers developed an understanding that artificial sweeteners, and especially aspartame, pose a high cancer risk among the people who consume them through packaged foods and beverages or as a sugar substitute sold by brands such as Equal and NutraSweet. (slashgear.com)
The study suggests consumption of artificial sweeteners increases a person's risk of breast and obesity-related cancers. (slashgear.com)
Previous research has linked the probability of obesity to artificial sweetener consumption , while others have also highlighted an obese person's higher likeliness to have cancer. (slashgear.com)
The researchers also suggests the study must be replicated on a larger scale with different demographic groups to verify the concerns around the consumption of artificial sweeteners. (slashgear.com)
A number of artificial sweeteners have been approved in North America by the U.S. Food and Drug Administration, including aspartame and sucralose (sold as Splenda), but there are also natural "high-intensity sweeteners" found in plants. (nutritionfacts.org)
A review of studies from Penn Medicine reveals that regular consumption of soda is associated with obesity and diabetes, because it contains artificial sweeteners that slow the metabolism, while causing spikes in blood sugar levels. (healthnews.com)
Artificial sweeteners, particularly aspartame, seems the main culprit for the link between drinking soda and increased risk of heart attacks and other heart diseases. (healthnews.com)
In an effort to combat obesity, many adults try to reduce sugar intake by turning to nonnutritive or artificial sweeteners, such as aspartame, saccharin, or sucralose. (sciencedaily.com)
Does artificial sweetener aspartame really cause cancer? (9news.com.au)
Aspartame is an artificial sweetener that is 200 times sweeter than sugar, but without any kilojoules. (9news.com.au)
View the Aspartame Q&A Aspartame is an artificial sweetener commonly used since the 1980s. (who.int)
Aspartame, an artificial sweetener, appears to be safe during pregnancy when it is consumed in small amounts, such as in amounts used in normal portions of artificially sweetened foods and beverages. (msdmanuals.com)

In products that may require a longer shelf life, such as syrups for fountain beverages, aspartame is sometimes blended with a more stable sweetener, such as saccharin. (wikipedia.org)
Equal (aspartame) is 160-200 times sweeter than sugar , and Sweet'n'Low (saccharin) is 300-500 times sweeter than natural sugar. (diabetesdaily.com)
The aim of the this study was to evaluate the effect of an intensive treatment with chlorhexidine (CHX) gel, containing either saccharin or aspartame, in deaf children highly infected with mutans streptococci (MS). Methods: Eighteen children were randomly divided into two groups, according to the sweetener used to improve the CHX gel bitter taste: saccharin or aspartame. (bvsalud.org)
Thus, the aims of this study were: (a) to compare the effect of intensive treatment with CHX gel, containing saccharin or aspartame, in decreasing the MS levels in deaf children and (b) to evaluate the reappearance pattern of MS over time after the CHX applications in those subjects. (bvsalud.org)
Little wonder then that consumption of aspartame, saccharin, stevia and similar ingredients is increasing. (medscape.com)
Examples of sweetening agents include ASPARTAME, sucralose, and saccharin. (bvsalud.org)

IARC classified aspartame as possibly carcinogenic to humans (Group 2B) on the basis of limited evidence for cancer in humans (specifically, for hepatocellular carcinoma, which is a type of liver cancer)", a joint press release noted. (globalissues.org)
On July 14, the World Health Organization's International Agency for Research on Cancer (IARC) declared aspartame "possibly carcinogenic to humans" for the first time. (medicalnewstoday.com)
Aspartame being labeled by IARC as 'possibly carcinogenic to humans' does not mean that aspartame is actually linked to cancer," FDA officials said in a statement . (medicalnewstoday.com)
The International Agency for Research on Cancer used a classification system to rank the potential of aspartame to cause cancer in humans, landing on 2B, which translates to "possibly carcinogenic to humans. (wmuk.org)
And it certainly did that with aspartame this past week when the World Health Organization declared aspartame as "possibly carcinogenic to humans. (oaoa.com)

Reuters first reported in June that the IARC would place aspartame in Group 2B as a "possible carcinogen" along with aloe vera extract and traditional Asian pickled vegetables. (gulfnews.ca)
Assessments released July 14 classified aspartame, widely used in food and beverage products, as a possible carcinogen. (surreynowleader.com)
Aspartame was classified as a possible carcinogen to humans, according to the assessments released July 14. (ashcroftcachecreekjournal.com)
WHO says aspartame is a 'possible carcinogen. (wmuk.org)
In its written response, the FDA said it disagrees with the conclusion that studies support classifying aspartame as a possible carcinogen to humans. (wmuk.org)

He said the problem is for "high consumers" of diet soda or other foods that contain aspartame. (wmuk.org)
The cola giants have large stakes in the sugar-free space with Coke Zero, Diet Coke, Pepsi Zero Sugar and Diet Pepsi - all four of which contain aspartame. (fooddive.com)
It's hard to even find a stick of gum that doesn't contain aspartame. (laleva.org)
Food products such as yogurt and confectionery may also contain aspartame, but it's not stable at warm temperatures and thus not used in baked goods. (9news.com.au)

The IARC Monographs have evolved nitrobenzene, 2,4Dichloro1nitrobenzene into the World Health Organization's Aspartame and sucralose encyclopaedia on the roles of Bisphenol A environmental agents in human cancer 1Bromopropane causation. (who.int)

A comprehensive systematic review of human, experimental animal and mechanistic data by Borghoff et al (2023) concluded that aspartame consumption is not carcinogenic in humans, as also supported by regulatory bodies that evaluated aspartame over the years. (sweeteners.org)
In July 2023, the International Agency on Research into Cancer (IARC) and the Joint FAO/WHO Expert Committee on Food Additives (JECFA) released their updated findings on the intense sweetener aspartame. (cancer.org.au)

Aspartame is one of the world's most popular sweeteners, used in products ranging from Coca-Cola diet sodas to Mars Extra chewing gum. (gulfnews.ca)
At a press conference ahead of the announcement, the WHO's nutrition chief, Francesco Branca, advised consumers weighing drinks not to consider aspartame or sweeteners. (gulfnews.ca)
As of 2017,[update] reviews of clinical trials showed that using aspartame (or other non-nutritive sweeteners) in place of sugar reduces calorie intake and body weight in adults and children. (wikipedia.org)
Gains for alternative sweeteners will be fueled by growing concerns regarding the health impact of excess sugar consumption in the average US diet. (freedoniagroup.com)
March 22, 2019 - The continuing study of low- and no-calorie sweeteners (LNCS) allows researchers to utilize the most precise and scientifically relevant research methodologies to evaluate the safety and efficacy of these ingredients for human consumption. (aspartame.org)
The natural plant-based sweeteners stevia and monk fruit (Luo Han Guo) are pitted head-to-head against aspartame and Splenda. (nutritionfacts.org)
Longer, although less rigorous, 'observational' trials suggested a link between routine consumption of non-nutritive sweeteners and a long-term increase in body mass index (BMI) and a higher risk of diabetes , heart disease and high blood pressure . (medscape.com)

If people consume aspartame as a way to avoid sugar and control weight, "the benefit is not there," Branca says. (wmuk.org)
It also reviewed the evidence from a large French study, the NutriNet-Santé study, published in 2022, that found people who consumed the most aspartame had about a 15% increased risk of cancer , including breast and obesity-related cancers, compared with people who didn't consume aspartame. (wmuk.org)
Some individuals are concerned that changing the ingredients will negatively impact the taste of the soda, while others say it is their choice if they want to consume aspartame. (fooddive.com)
The fact that over two-thirds of adults in our society consume aspartame products, and approximately 40 percent of children, often in prodigious amounts, provides perspective. (wnho.net)

The IARC panel made its ruling on Friday based on three studies in humans in the United States and Europe that indicated a link between hepatocellular carcinoma, liver cancer, and consumption of sweets, the first of which was published in 2016. (gulfnews.ca)
Taken together, available evidence supports that aspartame consumption is not carcinogenic in humans and that the inconsistent findings of the RI studies may be explained by flaws in study design and conduct (despite additional analyses to address study limitations), as acknowledged by authoritative bodies. (sweeteners.org)
Based on the totality of the available data reviewed in this study, the authors conclude that evidence supports a lack of carcinogenic effects associated with aspartame consumption in humans. (sweeteners.org)
The findings of limited evidence of carcinogenicity in humans and animals, and of limited mechanistic evidence on how carcinogenicity may occur, underscore the need for more research to refine our understanding on whether consumption of aspartame poses a carcinogenic hazard," said the IARC's Dr. Mary Schubauer-Berigan. (globalissues.org)
2019), " Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria ," provides further evidence that aspartame is not associated with an increased risk of cancer in humans. (aspartame.org)
These complex variables can partially explain why it is so easy for results of a study to be exaggerated if it appears to have uncovered a previously undetected associated with aspartame consumption, when, in fact, the study did not measure absolute aspartame consumption in humans. (aspartame.org)
A second committee, the Joint Expert Committee on Food Additives, or JECFA, also reviewed the evidence and concluded that "the evidence of an association between aspartame consumption and cancer in humans is not convincing," according to a summary released by the WHO. (wmuk.org)
After reviewing scientific literature, the IARC classified aspartame as possibly carcinogenic "on the basis of limited evidence for cancer in humans," specifically for a type of liver cancer. (inquirer.net)
JECFA, according to Dr. Morez Sanaa of WHO, "also considered the evidence on cancer risk…and concluded that the evidence of an association between aspartame consumption and cancer in humans is not convincing. (inquirer.net)
The recent classification made by IARC, however, does not assess the level of risk that a particular agent-in this case, aspartame-causes cancer in humans. (inquirer.net)
Research by the National Toxicology Program did not find the same link from aspartame to humans. (oaoa.com)
This classification is based on limited evidence of carcinogenicity in humans, limited evidence of carcinogenicity in animal studies and limited evidence of a mechanism by which aspartame could cause cancer. (cancer.org.au)
aspartame has been found to be a possible cause of liver cancer in humans, but only when consumed in high enough levels. (cancer.org.au)
The International Agency for Research on Cancer (IARC), which is the specialised cancer agency of the World Health Organisation , has today declared aspartame may be a possible carcinogenic hazard to humans. (9news.com.au)

The WHO's Joint Expert Committee on Food Additives (JECFA) reaffirmed the acceptable daily limit of aspartame at 40 milligrams for every kilogram of body weight. (medicalnewstoday.com)
The WHO has long set the acceptable daily intake, or ADI, of aspartame at a maximum of 40 milligrams per kilogram of body weight per day. (wmuk.org)
In 1981, JECFA recommended an acceptable daily intake (ADI) of 40 milligrams of aspartame per kilogram of body weight. (inquirer.net)

We note that JECFA did not raise safety concerns for aspartame under the current levels of use and did not change the Acceptable Daily Intake (ADI). (medicalnewstoday.com)
Reviews by over 100 governmental regulatory bodies found the ingredient safe for consumption at the normal acceptable daily intake (ADI) limit. (wikipedia.org)
This means that an adult weighing 70 kilograms would need to consume more than 9-14 cans of diet soft drinks (containing 200-300 milligrams of aspartame) per day to exceed the acceptable daily intake, assuming no other intake from other food sources. (inquirer.net)
1 FSANZ carries out safety assessments based on evaluations and acceptable daily intake levels set internationally, and taking into account current availability and consumption in Australia and New Zealand. (cancer.org.au)
At the same time, JECFA has reviewed the evidence of public health risk associated with aspartame and found no convincing evidence to change the current Acceptable Daily Intake of aspartame (40mg/kg of body weight). (cancer.org.au)
Based on the most recent data, the vast majority of Australians are consuming well below the Acceptable Daily Intake for aspartame. (cancer.org.au)
Following this, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) will update its risk assessment exercise on aspartame, including the reviewing of the acceptable daily intake and dietary exposure assessment for aspartame. (who.int)
IARC will assess the potential carcinogenic effect of aspartame (hazard identification), while JECFA will update its risk assessment exercise, including the reviewing of the Acceptable Daily Intake and aspartame diet exposure assessment. (who.int)

In a statement issued in reaction to the studies, the United States Food and Drug Administration (FDA), said that it disagreed with IARC's conclusion that the studies support classifying aspartame as possibly carcinogenic. (globalissues.org)

IARC and WHO said that they would "continue to monitor new evidence and encourage independent research groups to develop further studies on the potential association between aspartame exposure and consumer health effects. (globalissues.org)
The primary source for exposure to aspartame in the US is diet soft drinks, though it can be consumed in other products, such as pharmaceutical preparations, fruit drinks, and chewing gum among others in smaller quantities. (wikipedia.org)
Evidence of carcinogenicity is further confounded by reliance on recall for consumption or exposure data, long latency times for tumor development, concurrent exposure to other possible carcinogens, and the lack of a clear dose-response relationship. (aspartame.org)
The agency found "limited" evidence that aspartame may cause liver cancer, based on a review of several studies that used intake of artificially sweetened beverages as a proxy for aspartame exposure. (wmuk.org)
Enough exposure to aspartame can lead to nerve cell death. (drbenkim.com)
It is my further opinion that exposure to aspartame products and other neurotoxins may initiate or aggravate changes in the nervous system that result in multiple sclerosis, parkinsonism, and Alzheimer's disease. (wnho.net)
Some animal studies have reported that long-term exposure can increase food consumption, weight gain and body fat. (medscape.com)

Researchers at Case Western designed a study I highlighted in my video Aspartame and the Brain to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. (nutritionfacts.org)
In a review of the direct and indirect cellular effects of aspartame on the brain, it was noted that there are reports of aspartame causing neurological and behavioral disturbances in sensitive individuals, such as headaches, insomnia, and seizures. (nutritionfacts.org)
The latest study on the neuro-behavioral effects of aspartame consumption put people on a high aspartame diet compared to a low aspartame diet. (nutritionfacts.org)
A recent study investigated the effects of aspartame, a sugar substitute, on the body weight and blood sugar levels of healthy adults. (medicalnewsbulletin.com)
A recent study published in The Journal of Nutrition investigated the effects of aspartame, a widely used sugar alternative, on blood glucose levels. (medicalnewsbulletin.com)
The sequence of these evaluations and the close collaboration between the IARC Monographs and the WHO/JECFA Secretariat will permit a comprehensive evaluation of the health effects of aspartame consumption based on the latest available evidence. (who.int)

However, convincing anti-aspartame consumers to consume products containing aspartame may be challenging, Philipp-Muller added. (surreynowleader.com)
It is also too early to determine how consumer perception or demand for products containing aspartame might change, Philipp-Muller said. (ashcroftcachecreekjournal.com)
To better represent the effects of consuming beverages or other products containing aspartame, the researchers followed four groups of mice for 18 weeks. (eurekalert.org)

The food and beverage industry associations said the results show that aspartame is safe and a good option for people who want to reduce sugar in their diet. (gulfnews.ca)
While we can't rule out other contributing mechanisms, our experiments clearly show that aspartame blocks IAP activity, independent of other effects. (eurekalert.org)

JECFA concluded that it continues to be safe for a person to consume a substantial quantity of aspartame each day. (globalissues.org)
Due to this property, even though aspartame produces 4 kcal (17 kJ) of energy per gram when metabolized, about the same as sucrose, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible. (wikipedia.org)

The prime motive for this ongoing effort was the apparent enormous toll in illness, disability and death attributable to aspartame disease and failure of the medical profession and many governmental and other public health agencies to concern themselves with this ignored epidemic. (wnho.net)

However, it may be challenging for packaged goods companies selling products with aspartame if there is a strong anti-aspartame sentiment among consumers. (surreynowleader.com)
Betty Martini of Mission Possible, an anti-aspartame campaign group , certainly thinks that aspartame may be part of Hillary Clinton's health trouble. (laleva.org)

I continue to urge ALL pregnant women and mothers who breast-feed to avoid aspartame products advice that many of my obstetric colleagues have adopted. (wnho.net)

LONDON, July 13 (Reuters) - The sweetener aspartame is a "potential carcinogen" but safe to consume at levels already agreed upon, two groups linked to the World Health Organization (WHO) said on Friday. (gulfnews.ca)

The US Food and Drug Administration (FDA) strongly disagreed with the WHO's position and is sticking by its recommended daily limit of 50 mg/kg of body weight - equivalent to 75 packets of the sweetener Equal - as safe for human consumption. (medscape.com)
For example, aspartame-the chemical in Equal and Nutrasweet-may modulate brain neurotransmitters such as dopamine and serotonin, although data have been controversial and inconsistent. (nutritionfacts.org)
Commercial names of aspartame include Equal, Nutrasweet, Canderel and Sugar Twin. (9news.com.au)

Aspartame has been studied extensively and evaluated for its safety in foods and beverages yet concerns for its potential carcinogenicity have persisted, driven primarily by animal studies conducted at the Ramazzini Institute (RI). (sweeteners.org)
The National Institutes of Health AARP study of hundreds of thousands of Americans followed for years found that frequent consumption of sweetened beverages, especially diet drinks, may increase depression risk among older adults. (nutritionfacts.org)
Some experts recommend limiting coffee consumption and drinking decaffeinated beverages when possible. (msdmanuals.com)

World Health Organization (WHO) officials declared aspartame a potential carcinogen on July 14. (medicalnewstoday.com)

Nigel Brockton, vice president of research at the American Institute for Cancer Research, said he expects research on aspartame to take the form of large, observational studies that account for any intake of aspartame. (gulfnews.ca)
No significant association between higher aspartame/ low/no calorie sweetener intake and overall risk of cancer, as well as breast or prostate cancer was found. (sweeteners.org)
These reviews have found that even the high levels of intake of aspartame, studied across multiple countries and different methods of measuring aspartame consumption, are well below the ADI for safe consumption of aspartame. (wikipedia.org)
A 2017 review of metabolic effects by consuming aspartame found that it did not affect blood glucose, insulin, total cholesterol, triglycerides, calorie intake, or body weight. (wikipedia.org)
There were only three human studies that looked at cancer and aspartame intake. (9news.com.au)
These large observational studies used the intake of soft drinks as an indicator of aspartame intake. (9news.com.au)

IARC has assessed the potential carcinogenic effect of aspartame (hazard identification). (who.int)
The IARC Monographs , a programme of cancer hazard identification conducted according to a published Preamble , has never evaluated aspartame. (who.int)

The safety of aspartame has been studied since its discovery, and it is a rigorously tested food ingredient. (wikipedia.org)
Earlier this summer, the global health body's cancer research arm said for the first time that aspartame is "possibly carcinogenic" after reviewing "limited evidence," but a different agency within WHO added that it's safe to consume the ingredient within a certain limit. (fooddive.com)
Aspartame is a hugely popular ingredient beyond just soda. (fooddive.com)

At current consumption levels, the WHO said a person weighing 60-70kg, for example, would need to drink more than 9-14 cans of soda daily to exceed the limit, based on the average aspartame content in the drinks - about 10 times what most people consume. (gulfnews.ca)
Most soft-drinks have a pH between 3 and 5, where aspartame is reasonably stable. (wikipedia.org)
Indeed, monk fruit "may be used for daily consumption as an additive in foods and drinks to prevent or treat pancreatic cancer"-in your pet mouse. (nutritionfacts.org)
The authors recommend that older individuals who drink diet soda daily, particularly those at high cardiometabolic risk, should try to curb their consumption of artificially sweetened drinks. (sciencedaily.com)
You can identify aspartame in drinks and foods by looking for additive number 951. (9news.com.au)

Our results do not indicate that occasional consumption poses a risk to most consumers," Branca said. (gulfnews.ca)
In our view, this is really a call to the research community to better clarify and understand the cancer risk that may or may not be caused by aspartame consumption," said Mary Schubauer-Berrigan, Executive Director of the IARC Monographs Program. (gulfnews.ca)
Weight gain and obesity are a bigger problem and a bigger risk factor than aspartame," said Therese Bevers, MD, medical director of the Cancer Prevention Center at the University of Texas MD Anderson Cancer Center in Houston. (gulfnews.ca)
It seems like their main purpose for releasing the report might be to stimulate more research in the area to look at if aspartame is really associated with increased risk or chances of getting cancer. (surreynowleader.com)
An adult weighing 60 kg (132 pounds) would have to drink 12 to 36 cans of diet soda - depending on the amount of aspartame in the beverage -daily to be at risk, according to Reuters . (medicalnewstoday.com)
However, the first study could not prove that aspartame caused the increased cancer risk and questions have been raised about the methodology of the second study. (medicalnewstoday.com)
While it can be confusing and distressing to hear of this news around aspartame, it is essential to understand that the IARC does not consider the scale of risk of these carcinogens and a Class 2B carcinogen does not equate to a definite or even possible cause of cancer," Karimi said. (medicalnewstoday.com)
In a report released on 10 December 2013, the EFSA said that, after an extensive examination of evidence, it ruled out the "potential risk of aspartame causing damage to genes and inducing cancer" and deemed the amount found in diet sodas safe to consume. (wikipedia.org)
Objective To examine the association between consumption of ultra-processed foods and risk of colorectal cancer among men and women from three large prospective cohorts. (bmj.com)
Main outcome measure Association between ultra-processed food consumption and risk of colorectal cancer, estimated using time varying Cox proportional hazards regression models adjusted for potential confounding factors. (bmj.com)
No association was observed between overall ultra-processed food consumption and risk of colorectal cancer among women. (bmj.com)
Conclusions In the three large prospective cohorts, high consumption of total ultra-processed foods in men and certain subgroups of ultra-processed foods in men and women was associated with an increased risk of colorectal cancer. (bmj.com)
Now, a growing number of studies also link them to poor brain health, including an increased risk of dementia, depression , and anxiety, and some experts are calling for public health policies aimed at reducing UPF consumption. (medscape.com)
When evaluating the studies about aspartame consumption and cancer risk the researchers reported additional variables that clouded their work. (aspartame.org)
Our results do not indicate that occasional consumption should pose a risk to most consumers," said Dr. Francesco Branca , director of the Department of Nutrition and Food Safety at the WHO, during a press conference in Geneva. (wmuk.org)
The risk of experiencing nerve cell death from ingesting too much aspartame is higher in people who smoke, have high blood pressure, or have diabetes, as all of these factors potentially increase the permeability of the blood-brain barrier that is supposed to protect your nerve cells against excitotoxins. (drbenkim.com)
WHO is expected to classify aspartame as a possible cancer risk in the coming weeks, according to a new report. (aboutlawsuits.com)
This is based on limited evidence that consumption of aspartame is associated with increased risk of hepatocellular cancer, the most common form of liver cancer. (cancer.org.au)
A 2018 study of New Yorkers found that, while sugary soda was strongly linked to diabetes risk, switching to diet soda "may not lower the risk of diabetes, as diet soda consumption cannot be ruled out as an independent diabetes risk factor. (diabetesdaily.com)
According to the Centers for Disease Control and Prevention the consumption of 4 oz. of kombucha does not present a risk for the consumer's health. (healthnews.com)
Findings raise concerns about the safety of chronic diet soda consumption, which may increase belly fat and contribute to greater risk of metabolic syndrome and cardiovascular diseases. (sciencedaily.com)
Another branch of the WHO, the Joint WHO and Food and Agriculture Organisation's Expert Committee on Food Additives has assessed the risk and developed recommendations on how much aspartame is safe to consume. (9news.com.au)

The International Agency for Research on Cancer (IARC), based in Lyon, France, said in its first announcement of the additive early Friday that aspartame is a "probable carcinogen. (gulfnews.ca)
Several scientists unaffiliated with the criticism said the evidence linking aspartame to cancer was weak. (gulfnews.ca)
There is also some limited evidence that aspartame has certain chemical properties associated with cancer, according to the IARC. (gulfnews.ca)
Scientists unrelated to the WHO reviews said the evidence that aspartame caused cancer was weak. (gulfnews.ca)
But there's been a lot of misinterpretation or especially on social media about headlines like aspartame causes cancer and things like that. (surreynowleader.com)
Aspartame may be linked to increasing brain cancer rates. (greenmedinfo.com)
Despite the health risks, the WHO noted there's "limited evidence" that aspartame can cause cancer and listed the sweetener as a Class 2B carcinogen. (medicalnewstoday.com)
However, agency officials said there was only "limited evidence" that aspartame can cause human cancer, so it was listing the sweetener as an IARC Group 2B carcinogen. (medicalnewstoday.com)
A committee of 25 international experts has determined that aspartame may "possibly" cause cancer in people, according to a report released Thursday by the World Health Organization. (wmuk.org)
The research agency concluded that these were "high-quality" studies, however it could not rule out that the findings weren't due to chance, bias, or "confounding variables,'' meaning it wasn't sure that the increase in cancer was due to aspartame. (wmuk.org)
On July 14, the International Agency for Research on Cancer (IARC), WHO and Food and Agriculture Organization (FAO) Joint Expert Committee on Food Additives (JECFA) released assessments of the health impacts of aspartame. (inquirer.net)
We evaluated the association of use of aspartame and other AS with cancer. (researchgate.net)
For breast cancer and haematological cancers (non-Hodgkin lymphoma and multiple myeloma), a consistent association with aspartame consumption could not be demonstrated. (cancer.org.au)
On the whole, no studies have proven causation between diet soda consumption and cancer. (diabetesdaily.com)
They found there was some limited evidence in human studies linking aspartame and cancer (specifically liver cancer) and limited evidence from animal studies as well. (9news.com.au)
They also considered the biological mechanism studies which showed how cancer may develop from the consumption of aspartame. (9news.com.au)
In this case they found there was limited evidence for how aspartame might cause cancer. (9news.com.au)
But they have also said more and better research is needed to further understand the relationship between aspartame and cancer. (9news.com.au)

12 imp fl oz) can of diet soda contains 0.18 grams (0.0063 oz) of aspartame, and, for a 75-kilogram (165 lb) adult, it takes approximately 21 cans of diet soda daily to consume the 3.7 grams (0.13 oz) of aspartame that would surpass the FDA's 50 mg/kg of body weight ADI of aspartame from diet soda alone. (wikipedia.org)
Animals in the normal diet group that received aspartame consumed an amount equivalent to an adult human's drinking about three and a half cans of diet soda daily, and aspartame-receiving animals in the high-fat group consumed the equivalent of almost two cans. (eurekalert.org)

The findings determined from the most robust studies will be reviewed in assessing potential carcinogenic risks of aspartame consumption and compared to results of studies which were assessed using Castle Ottawa Scale and Oxford classification. (aspartame.org)
This change reflects new research and knowledge about the risks of aspartame for human health. (cancer.org.au)

Aspartame has been deemed safe for human consumption by over 100 regulatory agencies in their respective countries, including the US Food and Drug Administration (FDA), UK Food Standards Agency, the European Food Safety Authority (EFSA), Health Canada, and Food Standards Australia New Zealand. (wikipedia.org)
It is also one of the most studied food additives in existence and has been found to be safe for human consumption under certain guidelines. (oaoa.com)
Yet time and again, study after study, aspartame has been given the "all clear" for human consumption. (bakersjournal.com)

The WHO's announcement also conflicts with major food manufacturers who widely use aspartame, mostly as a sugar substitute. (medicalnewstoday.com)
A team of Massachusetts General Hospital (MGH) investigators has found a possible mechanism explaining why use of the sugar substitute aspartame might not promote weight loss. (eurekalert.org)

Given the availability of new research results, aspartame was recommended as high priority for evaluation by both the IARC Monographs programme and JECFA (the priority list of substances proposed for evaluation by JECFA ). (who.int)

In their report published online in Applied Physiology, Nutrition and Metabolism , the researchers show how the aspartame breakdown product phenylalanine interferes with the action of an enzyme previously shown to prevent metabolic syndrome - a group of symptoms associated with type 2 diabetes and cardiovascular disease. (eurekalert.org)
Phenylalanine is known to inhibit the action of IAP, and the fact that phenylalanine is produced when aspartame is digested led the researchers to investigate whether its inhibitory properties could explain aspartame's lack of a weight-loss effect. (eurekalert.org)
IAP is primarily produced in the small intestine, and the researchers found that injecting an aspartame solution into segments of the small intestines of mice significantly reduced the enzyme's activity. (eurekalert.org)
Researchers from the Florida State University College of Medicine have unveiled findings from an ongoing study revealing a potential link between aspartame consumption and learning and memory deficits in mice. (lexblog.com)
The researchers managed to get their hands on some, and within a week, there were significantly more adverse effects reported in the aspartame group than in the placebo group. (nutritionfacts.org)
The researchers go even further and propose that excessive aspartame ingestion might be involved in the development of certain mental disorders and also in compromised learning and emotional functioning. (nutritionfacts.org)

In another 2020 study of mice and rats found a link between aspartame and leukemia and lymphoma. (oaoa.com)
A 2020 study from Saudi Arabia found that diet soda consumption was associated with "poor glycemic control and retinopathy. (diabetesdaily.com)

It noted that the chief ingredients of aspartame are two building blocks of protein "just like those founds in eggs, fruit cheese or fish and even in mother's milk. (wnho.net)

An early 2000s study by the Ramazzini Institute in Italy reported some cancers in mice and rats were linked to aspartame. (medicalnewstoday.com)

Two separate World Health Organization committees examined the evidence on aspartame. (wmuk.org)

After conducting its own extensive review, JECFA said on Friday it had no conclusive evidence of harm from aspartame and continued to recommend that people keep their consumption below 40mg/kg per day. (gulfnews.ca)
Other non-specific mechanistic data (e.g., mixed findings of oxidative stress across study models, tissues, and species) do not provide evidence of a biologically plausible carcinogenic pathway associated with aspartame. (sweeteners.org)
The evidence base included 12 animal studies and over 40 epidemiological studies which collectively demonstrate a lack of carcinogenic effect of aspartame. (sweeteners.org)
Other mechanistic data do not provide evidence of a biologically plausible carcinogenic pathway associated with aspartame. (sweeteners.org)
A: Some research indicates possible negative effects from aspartame, but there's no definitive evidence linking it to health problems in the general population. (factcheck.org)
There has been some evidence that they actually can make you more hungry and may be associated with increased calorie consumption. (eurekalert.org)
This decision placed aspartame in Group 2B, a classification of agents that are possibly carcinogenic but with limited to insufficient evidence. (inquirer.net)

When you introduce abnormally large amounts of phenylalanine and aspartic acid (synthetically bound together by an ester bond) into your bloodstream - which is exactly what happens whenever you drink a can of soda that is sweetened with aspartame - your cells can be overwhelmed. (drbenkim.com)

The ongoing trend towards healthier alternatives in the beverage industry might continue, independent of the aspartame discussion. (surreynowleader.com)
In a series of experiments the team first found that the activity of IAP was reduced when the enzyme was added to a solution containing an aspartame-sweetened soft drink but remained unchanged if added to a solution with a sugar-sweetened beverage. (eurekalert.org)
The beverage, which contains aspartame, was popular among school-age children (6-12 years old), adolescents (19-59 years old), and adults (19-59 years old). (inquirer.net)

Coca-Cola began blending aspartame into Diet Coke in the 1980s. (wmuk.org)
She has been a heavy user of Diet Coke with aspartame. (laleva.org)
Dr. H. J. Roberts authored the medical text: Aspartame Disease: An Ignored Epidemic, available at www.sunsentpress.com Also, he had dinner with President Bill Clinton and tried to get him off of Diet Coke years ago, giving him a couple of his books on the subject. (laleva.org)
If Dr. James Bowen who has Lou Gehrig's from aspartame hadn't busted into Intensive Care and told them to take away his Diet Coke he was drinking he wouldn't be alive today. (laleva.org)
Aspartame is so addictive and I only have hear-say of someone very close who heard Hillary Clinton say she was off of Diet Coke on national TV. (laleva.org)

2019) published " Systematic review and evaluation of aspartame carcinogenicity bioassays using quality criteria " in the same issue of Regulatory Toxicology and Pharmacology in which this current paper appears, and is summarized here . (aspartame.org)

The assessments of aspartame have indicated that, while safety is not a major concern at the doses which are commonly used, potential effects have been described that need to be investigated by more and better studies," said Dr. Francesco Branca, Director of the Department of Nutrition and Food Safety, WHO. (surreynowleader.com)

FDA scientists do not have safety concerns when aspartame is used under the approved conditions", the statement said, adding that Health Canada and the European Food Safety Authority had both evaluated the sweetener and consider it safe at current permitted levels. (globalissues.org)
Since 1981, WHO regulators have said aspartame is safe within accepted daily limits. (medicalnewstoday.com)
The Joint FAO/WHO Expert Committee on Food Additives (JECFA) and the European Commission's Scientific Committee on Food (later becoming EFSA) have determined this value is 40 mg/kg of body weight per day for aspartame, while the FDA has set its ADI for aspartame at 50 mg/kg per day - an amount equated to consuming 75 packets of commercial aspartame sweetener per day to be within a safe upper limit. (wikipedia.org)
Reviews have also found that populations that are believed to be especially high consumers of aspartame, such as children and diabetics, are below the ADI for safe consumption, even considering extreme worst-case scenario calculations of consumption. (wikipedia.org)
Aspartame is safe when consumed within certain limits, according to the U.S. Food and Drug Administration. (factcheck.org)
Aspartame: Carcinogenic or safe? (inquirer.net)
Is aspartame a safe alternative to sugar? (medicalnewsbulletin.com)

Our findings regarding aspartame's inhibition of IAP may help explain why the use of aspartame is counterproductive," says Hodin, who is a professor of Surgery at Harvard Medical School. (eurekalert.org)

The objective of the current research was to conduct a comprehensive analysis of the available epidemiology studies of aspartame using the National Institute of Health quality appraisal tool to assess quality. (aspartame.org)
Even the WHO admits their research is not conclusive and recommended that it's guidelines for use of aspartame not change. (oaoa.com)
A growing body of research links consumption with an increased incidence of type 2 diabetes , high blood pressure , obesity , dementia , stroke, and non-fatty liver disease . (diabetesdaily.com)
They conclude that "due to all the adverse effects caused by aspartame, it is suggested that serious further testing and research be undertaken to eliminate any and all controversies," to which someone responded in the journal that "there really is no controversy," arguing that aspartame was conclusively toxic. (nutritionfacts.org)
At the heart of this medical thriller lies the mysteriously named "Project 259," a research study which ran from 1967 to 1971 to examine the link between sucrose consumption and coronary heart disease. (corbettreport.com)

Aspartame was approved by the US Food and Drug Administration (FDA) in 1974, and then again in 1981, after approval was revoked in 1980. (wikipedia.org)

The World Health Organization's July announcement that aspartame is "possibly carcinogenic" has not impacted consumers' feelings on diet soda brands from companies such as Coca-Cola, PepsiCo and Keurig Dr Pepper, according to a HundredX survey of 150,000 respondents. (fooddive.com)

At the end of the study period, while there was little difference between the weights of the two groups fed a normal diet, mice on a high-fat diet that received aspartame gained more weight than did those on the same diet that received plain water. (eurekalert.org)
A recent study even proved the connection between aspartame and heart attacks and strokes, but we've known for years. (laleva.org)
A study in 2007, published in the journal "Ultrastructural Pathology," showed that in rabbits fed aspartame, an interference was detected with the coagulation process that could cause a delayed fibrin breakup after clot formation. (laleva.org)
This study aimed to identify the variables related to NNS consumption in São Paulo state, Brazil. (bvsalud.org)

Its dramatic increase in the body can cause severe neurological and other damage if aspartame abstinence and other dietary precautions are not instituted. (wnho.net)

Organisms1

Chemicals and Drugs9

Psychiatry and Psychology2

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Saccharin6

Possibly carcinogenic to humans5

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Contain aspartame4

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Sweeteners7

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Humans14

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Sweetener aspartame1

Equal3

Beverages3

Potential carcinogen1

Intake6

Hazard2

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Drinks5

Risk22

Cancer18

Cans of diet soda2

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Human consumption3

Sugar substitute2

IARC Monographs1

Researchers6

20202

Ingredients1

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Evidence7

Phenylalanine1

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Diet Coke5

Carcinogenicity1

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