Recombinant Fusion ProteinsGenes, ablFusion Proteins, bcr-ablMembrane FusionViral Fusion ProteinsCell FusionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProto-Oncogene Proteins c-bcrMolecular Sequence DataSignal TransductionAmino Acid SequenceOncogene Proteins, FusionProto-Oncogene Proteins c-ablBenzamidesPyrimidinesPiperazinesBase SequenceMutationCell LineProtein-Tyrosine KinasesCell Transformation, NeoplasticK562 CellsPhosphorylationTransfectionGene FusionEnzyme ActivationSpinal FusionTumor Cells, CulturedSTAT5 Transcription FactorDNA-Binding ProteinsProto-Oncogene ProteinsCell Line, TumorPhiladelphia ChromosomeProtein BindingProtein Structure, TertiaryBlast CrisisApoptosisSTAT3 Transcription FactorTrans-ActivatorsGreen Fluorescent ProteinsMilk ProteinsCloning, MolecularTranscription FactorsJanus Kinase 2Oncogene Proteins v-ablCell DivisionTranslocation, GeneticMembrane Fusion ProteinsGene Expression Regulation, LeukemicBlotting, WesternDNA PrimersCell Line, TransformedLuminescent ProteinsCOS CellsMyeloproliferative DisordersEscherichia coliRecombinant Proteins3T3 CellsBinding SitesProtein-Serine-Threonine KinasesTyrosinePhosphatidylinositol 3-KinasesReceptors, Antigen, B-CellCell ProliferationCells, CulturedAntineoplastic AgentsTranscription, GeneticRNA, MessengerMembrane ProteinsHematopoietic Stem CellsProto-Oncogene Proteins c-aktPoint MutationNF-kappa BGene Expression Regulation, NeoplasticGene ExpressionSequence Homology, Amino Acidsrc Homology DomainsProtein Kinase InhibitorsPlasmidsDrug Resistance, NeoplasmMice, TransgenicMutagenesis, Site-DirectedOncogenesPromoter Regions, GeneticInterleukin-3Chromosomes, Human, Pair 22Genetic VectorsLeukemiaCarrier ProteinsCell SurvivalReverse Transcriptase Polymerase Chain ReactionOncogene ProteinsNeoplasm ProteinsCell MembraneLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeMitogen-Activated Protein KinasesPhenotypeAdaptor Proteins, Signal TransducingEnzyme InhibitorsCell Nucleus