Consists nucleic acid conformation. Medical search. Frequent questions

The end-stage consists of large aggregates of these misfolded proteins, which cause massive tissue and cell damage. (scienceagogo.com)
Interactions between nucleic acids and proteins form the foundation of the central dogma of molecular biology. (ku.edu)
This notion is also perfectly applicable to viruses, which can be crudely approximated as infectious sub-micrometer particles consisting of genetic material encapsulated by proteins, forming a so-called nucleocapsid. (ku.edu)
Prions are not viruses - they are infectious proteins that lack nucleic acids. (virology.ws)
Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure. (lookformedical.com)
PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). (lookformedical.com)
Ribosomes are structures that consist of proteins and nucleic acids responsible for producing proteins according to instructions that arrive from the DNA in the cell's nucleus. (weizmann.ac.il)
Important steps in the folding of proteins into the three-dimensional conformation required for their function, as well as quality control processes that determine whether these proteins will proceed in the production process or will become degraded, occur within the ER network's inner space. (weizmann.ac.il)
active site - A region in proteins and nucleic acids (that participate in chemical reactions), where reacting molecules (substrates) bind and make specific contacts necessary for chemical catalysis. (rcsb.org)
amino acid - A building block of proteins is an alpha amino acid which contains a basic amino group, an acidic carboxyl group, and a hydrogen or organic side chain attached to the central carbon atom. (rcsb.org)
There are 20 different alpha amino acids commonly found in nature that can covalently link with each other to form short peptides or longer proteins. (rcsb.org)
The translated polyprotein consists of three structural [capsid (C), membrane (M) and envelope (E)] and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). (spandidos-publications.com)
Changes in temperature are typically sensed as a result of conformation changes of protein structure as well as misfolded proteins. (springer.com)
Life is based on carbon compounds including carbohydrates, lipids, proteins and nucleic acids. (ivy-way.com)
The four families of organic compounds with important biological functionsâ carbohydrates, lipids, proteins, and nucleic acidsâ are covered here. (compnetsys.com)
Monomers and Polymers of Carbs, Lipids, Proteins and Nucleic Acids. (compnetsys.com)
They are therefore also called polymers Carbohydrates, lipids, proteins, and nucleic acids are all examples of polymers which is why polymers are a key component of human composition. (compnetsys.com)

A lipids is made out of a carbon backbone and fatty acid tails. (compnetsys.com)
For example, the formation of lipid domains in a copolymer-rich membrane was described with lipids of high T m such as hydro-genated soy phosphatidylcholine (HSPC) [15] or DPPC (1,2-dipal- Lipids are the polymers of fatty acids that contain a long, non-polar hydrocarbon chain with a small polar region containing oxygen. (compnetsys.com)

Apart from the membrane transport of glucose, insulin also regulates the transport of some amino acids, some fatty acids, potassium, magnesium, and certain other monosaccharides. (weeksmd.com)
Fatty acids can be saturated, monounsaturated or polyunsaturated. (ivy-way.com)
Unsaturated fatty acids can be cis or trans isomers. (ivy-way.com)
Triglycerides are formed by condensation from three fatty acids and one glycerol. (ivy-way.com)
The structure of the fatty acids determines whether or not the fat is considered saturated or unsaturated. (compnetsys.com)
Fatty acids are lipid monomers that consist of a hydrocarbon chain with a carboxyl group attached at the end. (compnetsys.com)
The monomers that make up a lipid are glycerol and fatty acids. (compnetsys.com)

Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them to release their zinc from its binding site, disrupting the conformation of the polypeptide chain and rendering the zinc fingers ineffective, thereby preventing them from performing their associated cellular functions. (wikipedia.org)
The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)

DNA stands for deoxyribonucleic Acid . (wikibooks.org)
Deoxyribonucleic acid (DNA) is the basic hereditary material found in the nucleus of most cells. (nakb.org)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
alignment - A comparison of two or more gene or protein sequences in order to determine their degree of similarity in amino acid or bases, respectively. (rcsb.org)
Usually located on a microbe's chromosome, CRISPR units consist of "repeats," base-pair sequences ranging from 30 to 60 nucleotides in length, that are separated by "spacers," variable sequences, which are also 30 to 60 nucleotides in length. (lbl.gov)
Cascade will release crRNAs that will bind with foreign nucleic acid sequences - via base pair matching to a "seed" sequence of nucleotides - and silence or otherwise inactivate them. (lbl.gov)
The third class of thermosensing is based on the temperature-dependent conformation of specific RNA sequences, which are termed RNA-thermometer (RNAT). (springer.com)
Predikin now consists of two components: (i) PredikinDB, a database of phosphorylation sites that links substrates to kinase sequences and (ii) a Perl module, which provides methods to classify protein kinases, reliably identify substrate-determining residues, generate scoring matrices and score putative phosphorylation sites in query sequences. (biomedcentral.com)

DNA is a long chain of linear polymers containing deoxyribose sugars and their covalently bonded bases known as nucleic acids. (wikibooks.org)
These nucleic acid polymers encode for the all of the materials an organism needs to live in the form of genes. (wikibooks.org)
Understanding the role of polymers rich in aspartic acid (Asp) and glutamic acid (Glu) is the key to gaining precise control over mineralization processes. (uni-konstanz.de)

In A-form DNA, the ribose sugar adopts 3'-endo conformation, whereas in B-form DNA, the sugar conformation is 2'-endo. (nakb.org)
adenosine triphosphate - A molecule consisting of a ribose sugar molecule at the center with an attached adenine base on one side and a string of three phosphates on the other. (rcsb.org)

These toxic prions have the ability to reproduce, despite the fact that they contain no nucleic acid genome. (scienceagogo.com)
The replication of prions involves the recruitment of the normally expressed prion protein, which has mainly an alpha-helical structure, into a disease-specific conformation that is rich in beta-sheet. (medscape.com)
Highly divergent hypotheses have been put forward regarding the makeup of the prions, including that they consist of nucleic acid only or protein only, are lacking both protein and nucleic acid, or are a polysaccharide. (medscape.com)
This hypothesis suggests that prions contain no nucleic acid and are referred to as PrP Sc . (medscape.com)

In its lifetime, NCp7 facilitates the unwinding of tRNA, acts as a primer for reverse transcription, chaperones nucleic acids within the capsid of HIV-1, helps integrate the viral RNA into budding virions, and is intimately involved in the replication of HIV-1 in both the early phase and late phase. (wikipedia.org)

Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)

The reactive site P1 and the conformation of the reactive site loop is structurally highly conserved, similar to the canonical conformation of small serine proteinase inhibitors. (embl.de)
Crystal structures of protein kinases with bound substrate peptides show that substrate residues at positions -3 to +3 relative to the phosphorylated serine, threonine or tyrosine residue adopt an extended conformation and bind to a pocket in the catalytic domain of the protein kinase [ 8 ]. (biomedcentral.com)

In all cases, the pathogenic protein is the host-encoded PrP C protein with an altered conformation, called PrP sc . (virology.ws)
The infectious agent in the prion disease is composed mainly or entirely of an abnormal conformation of a host-encoded glycoprotein called the prion protein. (medscape.com)

The binding of zinc (II) in the CCHC binding site is necessary for the domain to be functional and for the stabilization of the conformation of the structure, allowing the NCp7 to carry out the processes required for HIV replication. (wikipedia.org)

Following prion infection, the abnormal or misfolded prion protein (PrPSc) converts PrPC into a likeness of itself, by causing it to change its conformation or shape. (scienceagogo.com)

Although extensive studies of the CRISPR-Cas9 system, including X-ray crystallography and cryoelectron microscopy (cryoEM) have revealed detailed views of the system's structural and biological activity, the dynamics of Cas9 and its step-by-step acrobatics with nucleic acids during its merger and cleavage of DNA have remained fuzzy. (sdsc.edu)
3-10 helix - A type of protein secondary structural element that is more tightly coiled than the alpha helix (3 amino acids per turn with 10 atoms in the ring completed by each intra-helical hydrogen bond). (rcsb.org)
allosteric protein - A protein that changes among two or more structural conformations upon binding to a small molecule called an effector. (rcsb.org)
13 , 14 However, the amino acid perfectly maintains the stability of the mutual structural conformation of the virus S-protein and the ACE2 receptor in a holistic manner. (medsci.org)
TFIIS also induces extensive structural changes in Pol II that would realign nucleic acids in the active centre. (embl.de)

In this DNA, the basic building block consists of two nucleotides, each with different conformations. (nakb.org)
The naked RNA of viroids consists of 246 to 375 nucleotides and has a molecular weight of 1.1 to 1.3 x 10 6 Daltons. (biologydiscussion.com)

Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. (nih.gov)

The prefix "deoxy" distinguishes DNA from its close relative RNA (ribonucleic acid). (wikibooks.org)
Ribonucleic acid (RNA) is present in several forms - messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). (nakb.org)
An interesting speculation regarding the origin of viroids is that they evolved from introns which are segments of ribonucleic acid spliced out during formation of messenger RNA in eukaryotic systems. (biologydiscussion.com)

NCp7 is initially formed as part of the gag polypeptide and follows a gag-knuckle zinc finger conformation. (wikipedia.org)
The binding site then performs a disulfide exchange, forming new intermolecular disulfide bonds, and rearrangement occurs placing the zinc finger in a conformation that inhibits its function. (wikipedia.org)
They react with the cysteine residues on the zinc finger of the NCp7 and cause a covalent conformation change which ejects the zinc from the zinc finger domain. (wikipedia.org)
The zinc finger folds in a conformation termed a zinc ribbon [ ( PUBMED:7626141 ) ] characterised by a three-stranded antiparallel beta-sheet and two beta-hairpins. (embl.de)

The particularly created single-stranded primer is included create double-stranded DNA during PCR and the fluorescence signal from the PdCs incorporated in the guide is as necessary minimized due to its conformation-dependent fluorescence buildings. (wap227.us)
A DNA (A-form DNA) - A conformation of right-handed, double stranded DNA in which the bases are tilted with reference to the helix axis. (rcsb.org)

Nucleic-acid-binding motif in transcriptional elongation factor TFIIS and RNA polymerases. (embl.de)

The antimicrobial functionality of LF is dependent on its protein conformation and milieu conditions (Naidu and Arnold, 1997). (ift.org)

These motifs contain two peptide units of Cys-X2-Cys-X4-His-X4-Cys (CCHC), where the X represents a substituted amino acid, that make up the zinc (II) ion binding sites. (wikipedia.org)
The second factor, termed peptide specificity, describes the interaction between amino acid residues in the catalytic domain of the protein kinase and the substrate residues that surround the phosphorylated residue. (biomedcentral.com)

It is characterized by hydrogen bonds between the carbonyl group (-C=O) of one amino acid and the amino (N-H) group of the amino acid 4 residues below it along the helix. (rcsb.org)

For example, the backbone carbon atom linked to the carbonyl group in an alpha amino acid, to which the side chain is attached. (rcsb.org)

The nucleotide unit consists of a base, a deoxyribose sugar, and a phosphate. (nakb.org)

Accordingly, our lab uses these single-molecule methods, in conjunction with conventional ensemble techniques, to study a variety of nucleic acid-protein interactions. (ku.edu)
Last year, researchers from the McCammon Lab at UC San Diego used the Comet supercomputer at SDSC to perform atomistic molecular dynamics - a method that captures a more complete vision of the myriad shapes and conformations that a target protein molecule may go through - at petascale speeds (one quadrillion arithmetic calculations per second). (sdsc.edu)

In DNA a sequence of three bases, which is called a codon, is responsible for the encoding of a single amino acid. (wikibooks.org)

Pol II and Pol III are protein complexes consisting of 12 and 17 subunits. (cipsm.de)
The insulin receptor consists of two alpha subunits (Mr 135 000) and two beta subunits (Mr 95 000) which are linked together by disulfide bonds. (weeksmd.com)
This movie shows the conformation of Cascade's subunits - CasA (purple), CasB (yellow) and CasE (magenta) - being rearranged while the helical spine of the complex remains relatively undisturbed. (lbl.gov)

Rousettus bats in Africa have been identified as Marburgvirus hosts ( 2 ), and viral nucleic acid and serologic evidence suggests that bats are also natural hosts of Ebolavirus spp. (cdc.gov)

In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (bvsalud.org)

The blood-brain barrier (BBB) is a special conformation of cellular membranes that has at times served to confound effective drug therapy for intra-CNS conditions, most notably tertiary neurosyphilis. (weeksmd.com)

The occurrence of natural antimicrobial agents in milk, eggs, plants, probiotics, salts, and acids has been well recognized for centuries, but the structure-function relationship of such bioactive compounds has been scientifically proven only in recent years. (ift.org)

Identified phosphosites were mapped on the Pol II structure which provided indications that they might play a role in regulating the conformation of the clamp region and, as a consequence, interaction of Pol II with nucleic acids. (cipsm.de)

By studying these dynamic structure-function relationships, we are able to identify the mechanisms that govern the biochemical processes arising from these nucleic acid-protein interactions. (ku.edu)
The structure of this form of the PrP Sc protein reveals that it consists of two intertwined fibrils (red in the image) which most likely consist of a series of repeated beta-strands, or rungs, called a beta-solenoid . (virology.ws)
3D reconstruction and quantitative morphometric analysis of GA structure in the rat hippocampi upon kainic acid (KA) induced seizures, as well as in vitro studies with the use of Ca2+ chelator BAPTA-AM in primary hippocampal neurons upon activation were performed. (bvsalud.org)
Through a combination of cryo-electron microscopy and three-dimensional image reconstruction, they have determined the structure of a protein complex called "Cascade," that acts as a surveillance system for detecting and inactivating the nucleic acid of invading pathogens. (lbl.gov)

13 , 14 Despite the presence of amino acid mutations in its receptor binding domain, multiple key amino acids are changed. (medsci.org)

Viroids differ from viruses in having no coat enclosing the nucleic acid which in these agents is a small single stranded circular RNA. (biologydiscussion.com)

PGC7/Dpp3a/Stella is targeted to the genome via binding to the heterochromatic histone mark H3K9me2 (this refers to a specific amino acid lysine in position 9 on histone H3 that has 2 methyl groups added). (i-sis.org.uk)
Multiple conformation- or misfolded-specific antibodies for human SOD1 were compared. (nature.com)

PBP is responsible for crosslinking between N-acetylmuramic acid and N-acetylglucosamine which forms the architecture of the bacterial cell wall. (randox.com)
Organisms consisting of only one cell carry out all functions of life in that cell. (ivy-way.com)

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task. (lookformedical.com)
It consists of a database of biologically significant sites and patterns formulated in such a way that with appropriate computational tools it can rapidly and reliably identify to which known family of protein (if any) the new sequence belongs. (open-bio.org)
CRISPRs are transcribed and the long primary transcript is processed into a library of short CRISPR-derived RNAs (crRNAs), each of which contains a unique sequence that is complementary to a foreign nucleic acid challenger. (lbl.gov)

The functional importance of these biomolecules hinges on their ability to sample multiple conformations. (ku.edu)

This conformation has more base pairs per turn compared to the cannonical B-form DNA. (rcsb.org)
Amino acids are linked together by condensation to form polypeptides. (ivy-way.com)

With these novel qPCR techniques, we successfully evaluated target nucleic acids stemmed from sexually transferred condition (SEXUALLY TRANSMITTED DISEASE) microorganisms with high accuracy. (wap227.us)
This approach is advanced than the first one since it produces signal-on fluorescence response and allows the use of a solitary PdC-incorporated DNA probe for the discovery of numerous target nucleic acids, remarkably reducing the assay expense. (wap227.us)

In addition, the second, signal-on technique is devised by designing the primers to consist of 5 ′-overhang series corresponding to the PdC-incorporated DNA probes. (wap227.us)
The course consists of a series of lectures that cover available databases relevant to chemistry, search strategies, and relevant search terms within chemistry. (lu.se)

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