• Metabolites
  • MR spectroscopy (MRS) allows tissue to be interrogated for the presence and concentration of various metabolites. (radiopaedia.org)
  • On 23 January 2007, the Human Metabolome Project, led by Dr. David Wishart of the University of Alberta, Canada, completed the first draft of the human metabolome, consisting of a database of approximately 2500 metabolites, 1200 drugs and 3500 food components. (wikipedia.org)
  • measurements
  • An NMR spectrometer typically consists of a spinning sample-holder inside a very strong magnet, a radio-frequency emitter and a receiver with a probe (an antenna assembly) that goes inside the magnet to surround the sample, optionally gradient coils for diffusion measurements and electronics to control the system. (wikipedia.org)
  • Whereas, measurements of diffusion constants (diffusion ordered spectroscopy or DOSY) are done the sample stationary and spinning off, and flow cells can be used for online analysis of process flows. (wikipedia.org)
  • Urine
  • Subjects who meet screening criteria will return for visit 2, which consists of a urine collection, 12-hour fasting blood draw, dual-energy X-ray absorptiometry (DXA) for body composition, magnetic resonance spectroscopy analysis of the liver, and resting echocardiogram for analysis of heart structure and function. (clinicaltrials.gov)
  • Pigments excreted in urine are partially absorbed by urate sediments ( sedimentum latrerium ), which consists of cell debris and sedimented urinary components formed when the acidified urine is stored below room temperature. (wikipedia.org)
  • metabolism
  • In this study, we used [2- 13 C]-labeled acetate to selectively measure the contribution of astroglial oxidative metabolism to total substrate oxidation and the rate of total glial/neuronal glutamate trafficking in human brain by 13 C NMR spectroscopy. (jneurosci.org)
  • As sensitivity has improved with the evolution of higher magnetic field strengths and magic angle spinning, NMR continues to be a leading analytical tool to investigate metabolism. (wikipedia.org)
  • atoms
  • These properties are fundamentally the same as those used in the more familiar magnetic resonance imaging (MRI), but the molecular applications use a somewhat different approach, appropriate to the change of scale from millimeters (of interest to radiologists) to nanometers (bonded atoms are typically a fraction of a nanometer apart), a factor of a million. (wikipedia.org)
  • This type of spectroscopy determines the physical and chemical properties of atoms or the molecules in which they are contained. (wikipedia.org)
  • electron
  • For example, the source for 57Fe consists of 57Co, which decays by electron capture to an excited state of 57Fe, which in turn decays to a ground state emitting a gamma-ray of the appropriate energy. (wikipedia.org)
  • brain
  • 30 years of diabetes have a similar cognitive profile and less brain structural magnetic resonance imaging (MRI) abnormalities than age- and education-matched type 2 diabetic patients with only 7 years of diabetes ( 2 ). (diabetesjournals.org)
  • Functional magnetic resonance imaging (fMRI) has opened an unprecedented opportunity for studying brain activity in vivo and thus for better understanding plasticity in the visual cortex [ 3 ]. (hindawi.com)
  • Other methodologies, such as psychophysics and in particular electroencephalography (EEG) and transcranial magnetic stimulation (TMS) may also offer the opportunity to investigate human brain functioning and plasticity. (hindawi.com)
  • EEG used to be a first-line method of diagnosis for tumors, stroke and other focal brain disorders, but this use has decreased with the advent of high-resolution anatomical imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT). (wikipedia.org)
  • hydrogen
  • 1896 - Pieter Zeeman first observes the Zeeman splitting effect by passing the light emitted by hydrogen through a magnetic field. (wikipedia.org)
  • analysis
  • In addition, magnetic resonance spectroscopy analysis of the liver and resting echocardiogram analysis of the heart will be performed to determine if there have been any changes in liver fat or heart function during the 12-week intervention. (clinicaltrials.gov)
  • The facility is divided into three core facilities: Macromolecular Structure Analysis, NMR Spectroscopy, and Transgenic and Genetically Defined Mouse facilities. (wikipedia.org)
  • field
  • Modern NMR spectrometers have a very strong, large and expensive liquid helium-cooled superconducting magnet, because resolution directly depends on magnetic field strength. (wikipedia.org)
  • For example, in a 21 Tesla magnetic field, protons resonate at 900 MHz. (wikipedia.org)
  • The ions are trapped in a Penning trap (a magnetic field with electric trapping plates), where they are excited (at their resonant cyclotron frequencies) to a larger cyclotron radius by an oscillating electric field orthogonal to the magnetic field. (wikipedia.org)
  • atom
  • However such resonances can be identified by the disappearance of a peak when reacted with D2O, as deuterium will replace a protium atom. (wikipedia.org)
  • sample
  • Usually, the sample consists of between 300 and 600 microlitres with a protein concentration in the range 0.1 - 3 millimolar. (wikipedia.org)
  • In its most common form, Mössbauer absorption spectroscopy, a solid sample is exposed to a beam of gamma radiation, and a detector measures the intensity of the beam transmitted through the sample. (wikipedia.org)
  • spectrum
  • These problems may be alleviated by using heteronuclear NMR spectroscopy which allows the proton spectrum to be edited with respect to the 15N and 13C chemical shifts, and also reduces the overlap of resonances by increasing the number of dimensions of the spectrum. (wikipedia.org)
  • The spectrum of ethyl chloride consists of a triplet at 1.5 ppm and a quartet at 3.5 ppm in a 3:2 ratio. (wikipedia.org)
  • The spectrum of benzene consists of a single peak at 7.2 ppm due to the diamagnetic ring current. (wikipedia.org)
  • human
  • We wished to determine if an NMR approach to exploring follicular physiology was warranted before initiating an in vivo study to examine animal and, ultimately, human folliculogenesis using proton NMR spectroscopy of extracted follicular fluid. (pubmedcentralcanada.ca)
  • Structure
  • The solution structure of monomeric NAP-2 has been investigated by two-dimensional 1H-n.m.r. spectroscopy. (biochemj.org)
  • The NAP-2 monomer consists of a triple-stranded anti-parallel beta-sheet arranged in a 'Greek key' and a C-terminal helix (residues 59-70) and is very similar to that found in the n.m.r. solution conformation of dimeric interleukin-8 and the crystal structure of tetrameric bovine platelet factor-4. (biochemj.org)
  • Ensembles are models consisting of a set of conformations that together attempt to describe the structure of a flexible protein. (wikipedia.org)
  • treatment
  • Half the patients will receive treatment consisting of daily conditioning exercise plus nutraceutical supplements (ENT), that has been shown to be beneficial for patients with mitochondrial dysfunction, while the other half will receive daily conditioning exercise and placebo tablets. (clinicaltrials.gov)
  • therapy
  • Therapy consisting of daily conditioning exercise, dietary recommendations, and nutraceutical supplements (ENT) has been show to be beneficial in treating patients with mitochondrial disorders. (clinicaltrials.gov)
  • state
  • Using steady-state saturation of γ-ATP, a significant 24±14% and 11±7% increase in the forward creatine kinase (CK) pseudo-first-order reaction rate constant, k₁, was observed upon visual stimulation in the first and second cycles respectively of a paradigm consisting of 10min-rest followed by 10min-stimulation, with the measured baseline k₁ being 0.35±0.04 s⁻¹. (nottingham.ac.uk)