• mutation
  • The extent to which a sequence is conserved can be affected by varying selection pressures, its robustness to mutation, population size and genetic drift. (wikipedia.org)
  • Mutation of the conserved sequence causes premature translation of a transgene containing a fusion between the human growth hormone coding sequence and the protamine 1 3' untranslated region. (jax.org)
  • base pairs
  • Between the strand-biased microsatellite repeats and G:C mononucleotide repeats, all sequence variations retained one or two base pairs with A (purine) interrupting the pyrimidine-rich strand and T (pyrimidine) interrupting the purine-rich strand. (wikipedia.org)
  • Drosophila
  • The vasa gene, is essential for germ cell development and was first identified in Drosophila melanogaster, but has since been found to be conserved in a variety of vertebrates and invertebrates including humans. (wikipedia.org)
  • functional
  • Many functional sequences are also modular, containing regions which may be subject to independent selection pressures, such as protein domains. (wikipedia.org)
  • Intron sequences may be conserved, often because they contain expression regulating elements that put functional constraints on their evolution. (wikipedia.org)
  • His research focuses on developing new algorithms for the detection of functional regions in DNA sequences. (wikipedia.org)
  • His research focuses on developing computational methods for detecting functional regions in DNA sequences. (wikipedia.org)
  • Analysis
  • PSORT II analysis predicts that there is a coiled_coil_region from 88 to 117 with sequence MNYTNRVEFLEEHHRVLESRLGSVTREITD. (wikipedia.org)
  • variations
  • Sequence variations in the gene products PYPAF1/CIAS1 and NOD2/CARD15 have been associated with several autoinflammatory diseases that, although clinically different, share a similar inflammatory pathophysiology. (uni-kiel.de)
  • Variations among cloned RU sequences were characterized by the number of microsatellite repeats, and also by the lengths of C and G stretches where triple stranded structures formed. (wikipedia.org)
  • Whereas
  • The datA locus is instrumental in conversion of DnaA ATP to DnaA ADP ( datA dependent DnaA ATP hydrolysis) whereas DnaA rejuvenation sequences 1 and 2 ( DARS1 and DARS2 ) reactivate DnaA ADP to DnaA ATP . (frontiersin.org)
  • structures
  • These strand biased pyrimidine:purine repeating sequences were shown to adopt triple-stranded structures under superhelical stress or at slightly acidic pH. (wikipedia.org)
  • different
  • The name "satellite DNA" refers to the phenomenon that repetitions of a short DNA sequence tend to produce a different frequency of the bases adenine, cytosine, guanine and thymine, and thus have a different density from bulk DNA - such that they form a second or 'satellite' band when genomic DNA is separated on a density gradient. (wikipedia.org)
  • similar
  • According to the latter, the sequences are aligned in a predetermined order dictated usually by the guide tree which groups similar sequences together with the subsequent addition of more dissimilar ones. (pubmedcentralcanada.ca)